fMRI biomarkers of social cognitive skills training in psychosis: Extrinsic and intrinsic functional connectivity.

Social cognitive skills training interventions for psychotic disorders have shown improvement in social cognitive performance tasks, but little was known about brain-based biomarkers linked to treatment effects. In this pilot study, we examined whether social cognitive skills training could modulate extrinsic and intrinsic functional connectivity in psychosis using functional magnetic resonance imaging (fMRI). Twenty-six chronic outpatients with psychotic disorders were recruited from either a Social Cognitive Skills Training (SCST) or an activity- and time-matched control intervention. At baseline and the end of intervention (12 weeks), participants completed two social cognitive tasks: a Facial Affect Matching task and a Mental State Attribution Task, as well as resting-state fMRI (rs-fMRI). Extrinsic functional connectivity was assessed using psychophysiological interaction (PPI) with amygdala and temporo-parietal junction as a seed region for the Facial Affect Matching Task and the Mental State Attribution task, respectively. Intrinsic functional connectivity was assessed with independent component analysis on rs-fMRI, with a focus on the default mode network (DMN). During the Facial Affect Matching task, we observed stronger PPI connectivity in the SCST group after intervention (compared to baseline), but no treatment-related change in the Control group. Neither group showed treatment-related changes in PPI connectivity during the Mental State Attribution task. During rs-fMRI, we found treatment-related changes in the DMN in the SCST group, but not in Control group. This study found that social cognitive skills training modulated both extrinsic and intrinsic functional connectivity in individuals with psychotic disorders after a 12-week intervention. These findings suggest treatment-related changes in functional connectivity as a potential brain-based biomarker of social cognitive skills training

Preliminary tools assisting collected building performance measurements

Investigating on-site building performance in architectural science is increasing. However, the simplest forms of measurement often lack any analytical support other than presentation on a time-series plot. Here, we present instrumentation and analytical tools to assist in reporting building performance. The intention is to explore formats for observing performance of buildings based on collected data. Sometimes data are presented directly, but more often, information is revealed by calculation. We introduce examples of tools pertaining to interior-exterior climatic comparisons, occupant comfort and thermal performance, such as weather data plotted against a neutral temperature so that adaptive model comfort tolerances can be illustrated. We plot the interior and exterior air condition on the ASHRAE psychrometric chart to understand conditioning requirements. Other tools calculate the ISO 7730 (Fanger) comfort model, and an adaptive model of comfort is provided for the interior measurements alongside an 80 – 90% comfort band. These tools add value to reporting data by displaying in several formats, so the researcher can observe and report quickly and clearly on the potential of various conditioning periods within a building.A case study is presented for a house in Darwin during the wet-season

Disturbances in the spontaneous attribution of social meaning in schizophrenia

Background. Schizophrenia patients show disturbances on a range of tasks that assess mentalizing or 'Theory of Mind' (ToM). However, these tasks are often developmentally inappropriate, make large demands on verbal abilities and explicit problem-solving skills, and involve after-the-fact reflection as opposed to spontaneous mentalizing. Method. To address these limitations, 55 clinically stable schizophrenia out-patients and 44 healthy controls completed a validated Animations Task designed to assess spontaneous attributions of social meaning to ambiguous abstract visual stimuli. In this paradigm, 12 animations depict two geometric shapes' interacting' with each other in three conditions: (1) ToM interactions that elicit attributions of mental states to the agents, (2) Goal-Directed (GO) interactions that elicit attributions of simple actions, and (3) Random scenes in which no interaction occurs. Verbal descriptions of each animation are rated for the degree of Intentionality attributed to the agents and for accuracy. Results. Patients had lower Intentionality ratings than controls for ToM and GO scenes but the groups did not significantly differ for Random scenes. The descriptions of the patients less closely matched the situations intended by the developers of the task. Within the schizophrenia group, performance on the Animations Task showed minimal associations with clinical symptoms. Conclusions. Patients demonstrated disturbances in the spontaneous attribution of mental states to abstract visual stimuli that normally evoke such attributions. Hence, in addition to previously established impairment on mentalizing tasks that require logical inferences about others' mental states, individuals with schizophrenia show disturbances in implicit aspects of mentalizing

Effect of Strain of Holstein-Friesian Cow and Feed System on Reproductive Performance in Seasonal-Calving Milk Production Systems Over Four Years

In Ireland most dairy farms operate seasonal calving grass-based milk production systems. Feed demand and supply are matched by having calving highly concentrated in spring. This requires high pregnancy rates within a short time following the start of mating in late April or early May, but has become increasingly difficult to achieve due to declining fertility in Irish dairy herds (Mee, 2004). In New Zealand, cows of North American Holstein-Friesian origin have poorer fertility than New Zealand Holstein-Friesians on pasture-based seasonal calving systems (Harris & Kolver, 2001). The present study sought to determine the effect of strain of Holstein-Friesian (HF) cow and feed system on reproductive performance within Irish milk production systems

Coulomb gauge Gribov copies and the confining potential

We study the approach, initiated by Marinari et al., to the static inter-quark potential based on Polyakov lines of finite temporal extent, evaluated in Coulomb gauge. We show that, at small spatial separations, the potential can be understood as being between two separately gauge invariant colour charges. At larger separations Gribov copies obstruct the non-perturbative identification of individually gauge invariant colour states. We demonstrate, for the first time, how gauge invariance can be maintained quite generally by averaging over Gribov copies. This allows us to extend the analysis of the Polyakov lines and the corresponding, gauge invariant quark-antiquark state to all distance scales. Using large scale lattice simulations, we show that this interpolating state possesses a good overlap with the ground state in the quark-antiquark sector and yields the full static inter-quark potential at all distances. A visual representation of the Gribov copies on the lattice is also presented.Comment: 22 pages, 9 figures, v2: minor changes, references adde

Section on Prospects for Dark Matter Detection of the White Paper on the Status and Future of Ground-Based TeV Gamma-Ray Astronomy

This is a report on the findings of the dark matter science working group for the white paper on the status and future of TeV gamma-ray astronomy. The white paper was commissioned by the American Physical Society, and the full white paper can be found on astro-ph (arXiv:0810.0444). This detailed section discusses the prospects for dark matter detection with future gamma-ray experiments, and the complementarity of gamma-ray measurements with other indirect, direct or accelerator-based searches. We conclude that any comprehensive search for dark matter should include gamma-ray observations, both to identify the dark matter particle (through the charac- teristics of the gamma-ray spectrum) and to measure the distribution of dark matter in galactic halos.Comment: Report from the Dark Matter Science Working group of the APS commissioned White paper on ground-based TeV gamma ray astronomy (19 pages, 9 figures

Measurement of 1.7 to 74 MeV polarised gamma rays with the HARPO TPC

Current {\gamma}-ray telescopes based on photon conversions to electron-positron pairs, such as Fermi, use tungsten converters. They suffer of limited angular resolution at low energies, and their sensitivity drops below 1 GeV. The low multiple scattering in a gaseous detector gives access to higher angular resolution in the MeV-GeV range, and to the linear polarisation of the photons through the azimuthal angle of the electron-positron pair. HARPO is an R&D program to characterise the operation of a TPC (Time Projection Chamber) as a high angular-resolution and sensitivity telescope and polarimeter for {\gamma} rays from cosmic sources. It represents a first step towards a future space instrument. A 30 cm cubic TPC demonstrator was built, and filled with 2 bar argon-based gas. It was put in a polarised {\gamma}-ray beam at the NewSUBARU accelerator in Japan in November 2014. Data were taken at different photon energies from 1.7 MeV to 74 MeV, and with different polarisation configurations. The electronics setup is described, with an emphasis on the trigger system. The event reconstruction algorithm is quickly described, and preliminary measurements of the polarisation of 11 MeVphotons are shown.Comment: Proceedings VCI201

INTEGRAL observations of the blazar Mrk 421 in outburst (Results of a multi-wavelength campaign)

We report the results of a multi-wavelength campaign on the blazar Mrk 421 during outburst. We observed four strong flares at X-ray energies that were not seen at other wavelengths (partially because of missing data). From the fastest rise in the X-rays, an upper limit could be derived on the extension of the emission region. A time lag between high-energy and low-energy X-rays was observed, which allowed an estimation of the magnetic-field strength. The spectral analysis of the X-rays revealed a slight spectral hardening of the low-energy (3 - 43 keV) spectral index. The hardness-ratio analysis of the Swift-XRT (0.2 - 10 keV) data indicated a small correlation with the intensity; i. e., a hard-to-soft evolution was observed. At the energies of IBIS/ISGRI (20 - 150 keV), such correlations are less obvious. A multiwavelength spectrum was composed and the X-ray and bolometric luminosities are calculated.Comment: 15 pages, 18 figures; accepted by Astronomy & Astrophysic

Topological structures of adiabatic phase for multi-level quantum systems

The topological properties of adiabatic gauge fields for multi-level (three-level in particular) quantum systems are studied in detail. Similar to the result that the adiabatic gauge field for SU(2) systems (e.g. two-level quantum system or angular momentum systems, etc) have a monopole structure, the curvature two-forms of the adiabatic holonomies for SU(3) three-level and SU(3) eight-level quantum systems are shown to have monopole-like (for all levels) or instanton-like (for the degenerate levels) structures.Comment: 15 pages, no figures. Accepted by J.Phys.