Feedback cooling of a nanomechanical resonator

Cooled, low-loss nanomechanical resonators offer the prospect of directly observing the quantum dynamics of mesoscopic systems. However, the present state of the art requires cooling down to the milliKelvin regime in order to observe quantum effects. Here we present an active feedback strategy based on continuous observation of the resonator position for the purpose of obtaining these low temperatures. In addition, we apply this to an experimentally realizable configuration, where the position monitoring is carried out by a single-electron transistor. Our estimates indicate that with current technology this technique is likely to bring the required low temperatures within reach.Comment: 10 pages, RevTex4, 4 color eps figure

On the algebraic K-theory of the complex K-theory spectrum

Let p>3 be a prime, let ku be the connective complex K-theory spectrum, and let K(ku) be the algebraic K-theory spectrum of ku. We study the p-primary homotopy type of the spectrum K(ku) by computing its mod (p,v_1) homotopy groups. We show that up to a finite summand, these groups form a finitely generated free module over a polynomial algebra F_p[b], where b is a class of degree 2p+2 defined as a higher Bott element.Comment: Revised and expanded version, 42 pages

Optimised mixing and flow resistance during shear flow over a rib roughened boundary

A series of numerical investigations has been performed to study the effect of lower boundary roughness on turbulent flow in a two-dimensional channel. The roughness spacing to height ratio, w/k, has been investigated over the range 0.12 to 402 by varying the horizontal rib spacing. The square roughness elements each have a cross-sectional area of (0.05 H)2, where H is the full channel height. The Reynolds number, Reτ is fixed based on the value of the imposed pressure gradient, dp/dx, and is in the range 6.3 × 103 − 4.5 × 104. A Reynolds Averaged Navier–Stokes (RANS) based turbulence modelling approach is adopted using a commercial CFD code, ANSYS-CFX 14.0. Measurements of eddy viscosity and friction factor have been made over this range to establish the optimum spacings to produce maximum turbulence enhancement, mixing and resistance to flow. These occur when w/k is approximately 7. It is found that this value is only weakly dependent on Reynolds number, and the decay rate of turbulence enhancement as a function of w/k ratio beyond this optimum spacing is slow. The implications for heat transfer design optimisation and particle transport are considered

Magnetic Field Amplification in Galaxy Clusters and its Simulation

We review the present theoretical and numerical understanding of magnetic field amplification in cosmic large-scale structure, on length scales of galaxy clusters and beyond. Structure formation drives compression and turbulence, which amplify tiny magnetic seed fields to the microGauss values that are observed in the intracluster medium. This process is intimately connected to the properties of turbulence and the microphysics of the intra-cluster medium. Additional roles are played by merger induced shocks that sweep through the intra-cluster medium and motions induced by sloshing cool cores. The accurate simulation of magnetic field amplification in clusters still poses a serious challenge for simulations of cosmological structure formation. We review the current literature on cosmological simulations that include magnetic fields and outline theoretical as well as numerical challenges.Comment: 60 pages, 19 Figure

Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy

We review HB stars in a broad astrophysical context, including both variable and non-variable stars. A reassessment of the Oosterhoff dichotomy is presented, which provides unprecedented detail regarding its origin and systematics. We show that the Oosterhoff dichotomy and the distribution of globular clusters (GCs) in the HB morphology-metallicity plane both exclude, with high statistical significance, the possibility that the Galactic halo may have formed from the accretion of dwarf galaxies resembling present-day Milky Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the second-parameter problem is presented. A technique is proposed to estimate the HB types of extragalactic GCs on the basis of integrated far-UV photometry. The relationship between the absolute V magnitude of the HB at the RR Lyrae level and metallicity, as obtained on the basis of trigonometric parallax measurements for the star RR Lyrae, is also revisited, giving a distance modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are studied. Finally, the conductive opacities used in evolutionary calculations of low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and Space Scienc

Numerical study on a two-stage metal hydride hydrogen compression system

A multistage Metal Hydride Hydrogen Compression (MHHC) system uses a combination of hydride materials in order to increase the total compression ratio, whilst maximizing the hydrogenation rate from the supply pressure at each stage. By solving the coupled heat, mass and momentum conservation equations simultaneously the performance of a MHHC system can be predicted. In the current work a numerical model is proposed to describe the operation of a complete compression cycle. Four different MHHC systems are examined in terms of maximum compression ratio, cycle time and energy consumption and it was found that the maximum compression ratio achieved was 22:1 when operating LaNi5 (AB5-type) and a Zr–V–Mn–Nb (AB2-type intermetallic) as the first and second stage alloys respectively in the temperature range of 20°C (hydrogenation) to 130°C (dehydrogenation)

The SAMI Galaxy Survey: Cubism and covariance, putting round pegs into square holes

We present a methodology for the regularization and combination of sparse sampled and irregularly gridded observations from fibre-optic multiobject integral field spectroscopy. The approach minimizes interpolation and retains image resolution on combining subpixel dithered data. We discuss the methodology in the context of the Sydney-AAO multiobject integral field spectrograph (SAMI) Galaxy Survey underway at the Anglo-Australian Telescope. The SAMI instrument uses 13 fibre bundles to perform high-multiplex integral field spectroscopy across a 1° diameter field of view. The SAMI Galaxy Survey is targeting ~3000 galaxies drawn from the full range of galaxy environments. We demonstrate the subcritical sampling of the seeing and incomplete fill factor for the integral field bundles results in only a 10 per cent degradation in the final image resolution recovered. We also implement a new methodology for tracking covariance between elements of the resulting data cubes which retains 90 per cent of the covariance information while incurring only a modest increase in the survey data volume

CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study

Serological correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after vaccination (“vaccine breakthrough”) have been described. However, T cell correlates of protection against breakthrough are incompletely defined, especially the specific contributions of CD4+ and CD8+ T cells. Here, 279 volunteers in the Protective Immunity from T Cells in Healthcare Workers (PITCH) UK cohort study were enrolled in a nested case-control study. Cases were those who tested SARS-CoV-2 PCR or lateral flow device (LFD) positive after two vaccine doses during the Delta-predominant era (n = 32), while controls were those who did not report a positive test or undergo anti-nucleocapsid immunoglobulin G (IgG) seroconversion during this period (n = 247). Previous SARS-CoV-2 infection prior to vaccination was associated with reduced odds of vaccine breakthrough. Using samples from 28 d after the second vaccine dose, before all breakthroughs occurred, we observed future cases had lower ancestral spike (S)- and receptor binding domain-specific IgG titers and S1- and S2-specific T cell interferon gamma (IFNγ) responses compared with controls, although these differences did not persist when individuals were stratified according to previous infection status before vaccination. In a subset of matched infection-naïve cases and controls, vaccine breakthrough cases had lower CD4+ and CD8+ IFNγ and tumor necrosis factor (TNF) responses to Delta S peptides compared with controls. For CD8+ responses, this difference appeared to be driven by reduced responses to Delta compared with ancestral peptides among cases; this reduced response to Delta peptides was not observed in controls. Our findings support a protective role for T cells against Delta breakthrough infection