An analysis of human-coyote relationship in metropolitan Atlanta, Ga

Human-coyote interactions are an increasing challenge for North American wildlife managers. My objectives were to: 1) provide data on the types and general spatial distribution of human-coyote interactions in metropolitan Atlanta; 2) identify landscapes associated with human-coyote interactions; and 3) investigate the validity of claims of coyote-pet attacks and the potential effects of assuming a coyote attacked a pet. Human-coyote interactions were positively correlated with open space landscapes. A change in scale led to differences in both how correlated a variable was with interactions and relationships among variables. Sixty-four percent of individuals who reported that a coyote attacked their pet did not actually witness it. I provide evidence that such assumptions led to more negative views towards coyotes, lethal removal of coyotes, and entered news media. I recommend managers conduct investigations to verify attacks to avoid unwarranted negative feelings towards coyotes, unnecessary management actions and inappropriate broadcast of risk messages

Where Do Riders Park Dockless, Shared Electric Scooters? Findings from San Jose, California

Dockless, shared, electric kick-scooters started popping up on U.S. city streets without warning in 2017. Reaction to the shared scooters came swiftly and strongly. On the one hand, the scooters have proven popular with riders, attracting investment capital and expanding service to additional cities. But others have been less enthusiastic, with a central complaint being how shared scooters are parked. This perspective explores the extent to which parked shared scooters pose a problem to others on streets, sidewalks, and public spaces, using empirical evidence documenting where scooters have been parked in downtown San Jose, California

A Decade of Building the Community-Engaged School of Health and Human Sciences at The University of North Carolina Greensboro

This case example illustrates key opportunities, processes, and outcomes of nearly a decade of intentional efforts to build and support community-engaged faculty culture and institutionalization in the School of Health and Human Sciences at the University of North Carolina Greensboro. Situated within a university-wide, faculty-led movement to institutionalize support for community engagement through policy and practice, we describe the motivation of faculty and administrative leadership to integrate support for community engagement across teaching, research and service roles in the Health and Human Sciences unit at UNCG. We present critical moments of opportunity that were leveraged by faculty and administrative leadership to integrate community engagement into visioning and planning documents, faculty rewards and awards, curricular programming, and trans-disciplinary scholarly work through community-engaged partnerships. Using information collected through faculty focus groups and document analysis, and as part of a multi-institutional research program sponsored by the American Association of State Colleges and Universities and the New England Resource Center for Higher Education, we describe key outcomes of efforts to institutionalize community engagement at the school level and areas in which community engagement is integrated into the School’s strategic plan. Of special importance are areas related to tenure and non-tenure track faculty recruitment, faculty promotion and tenure policies, faculty grants and awards programs, and school-level strategic planning. Finally, we describe various choices made about where to locate various activities, efforts, and resources, whether at the department, school, or university-wide level

Influence of sugar type on the bioavailability of cocoa flavanols.

The beneficial effects of cocoa on vascular function are mediated by the absorption of monomeric flavanols into the circulation from the small intestine. As such, an understanding of the impact of the food matrix on the delivery of flavanols to the circulation is critical in assessing the potential vascular impact of a food. In the present study, we investigated the impact of carbohydrate type on flavanol absorption and metabolism from chocolate. A randomised, double-blind, three-arm cross-over study was conducted, where fifteen volunteers were randomly assigned to either a high-flavanol (266 mg) chocolate containing maltitol, a high-flavanol (251 mg) chocolate with sucrose or a low-flavanol (48 mg) chocolate with sucrose. Test chocolates were matched for micro- and macronutrients, including the alkaloids theobromine and caffeine, and were similar in taste and appearance. Total flavanol absorption was lower after consumption of the maltitol-containing test chocolate compared with following consumption of its sucrose-containing equivalent (P = 0·002). Although the O-methylation pattern observed for absorbed flavanols was unaffected by sugar type, individual levels of unmethylated ( - )-epicatechin metabolites, 3'-O-methyl-epicatechin and 4'-O-methyl-epicatechin metabolites were lower for the maltitol-containing test chocolate compared with the sucrose-containing equivalent. Despite a reduction in the total plasma pool of flavanols, the maximum time (T max) was unaffected. The present data indicate that full assessment of intervention treatments is vital in future intervention trials with flavanols and that carbohydrate content is an important determinant for the optimal delivery of flavanols to the circulation

Dark Matter Signals from Cascade Annihilations

A leading interpretation of the electron/positron excesses seen by PAMELA and ATIC is dark matter annihilation in the galactic halo. Depending on the annihilation channel, the electron/positron signal could be accompanied by a galactic gamma ray or neutrino flux, and the non-detection of such fluxes constrains the couplings and halo properties of dark matter. In this paper, we study the interplay of electron data with gamma ray and neutrino constraints in the context of cascade annihilation models, where dark matter annihilates into light degrees of freedom which in turn decay into leptons in one or more steps. Electron and muon cascades give a reasonable fit to the PAMELA and ATIC data. Compared to direct annihilation, cascade annihilations can soften gamma ray constraints from final state radiation by an order of magnitude. However, if dark matter annihilates primarily into muons, the neutrino constraints are robust regardless of the number of cascade decay steps. We also examine the electron data and gamma ray/neutrino constraints on the recently proposed "axion portal" scenario.Comment: 36 pages, 11 figures, 7 tables; references adde

Differential processing of consonants and vowels in the auditory modality: A cross-linguistic study

International audienceFollowing the proposal by Nespor, Peña, and Mehler (2003) that consonants are more important in constraining lexical access than vowels, New, Araújo, and Nazzi (2008) demonstrated in a visual priming experiment that primes sharing consonants (jalu-JOLI) facilitate lexical access while primes sharing vowels do not (vobi-JOLI). The present study explores if this asymmetry can be extended to the auditory modality and whether language input plays a critical role as developmental studies suggest. Our experiments tested French and English as target languages and showed that consonantal information facilitated lexical decision to a greater extent than vocalic information, suggesting that the consonant advantage is independent of the language’s distributional properties. However, vowels are also facilitatory, in specific cases, with iambic English CVCV or French CVCV words. This effect is related to the preservation of the rhyme between the prime and the target (here, the final vowel), suggesting that the rhyme, in addition to consonant information and consonant skeleton information is an important unit in auditory phonological priming and spoken word recognition

A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study

© 2015 Clive et al. Introduction: Animal studies have shown Zoledronic Acid (ZA) may diminish pleural fluid accumulation and tumour bulk in malignant pleural disease (MPD). We performed a pilot study to evaluate its effects in humans. Methods: We undertook a single centre, double-blind, placebo-controlled trial in adults with MPD. Patients were randomised (1:1) to receive 2 doses of intravenous ZA or placebo, 3 weeks apart and were followed-up for 6 weeks. The co-primary outcomes were change in Visual Analogue Scale (VAS) score measured breathlessness during trial follow-up and change in the initial area under the curve (iAUC) on thoracic Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) from randomisation to week 5. Multiple secondary endpoints were also evaluated. Results: Between January 2010 and May 2013, 30 patients were enrolled, 24 randomised and 4 withdrew after randomisation (1 withdrew consent; 3 had a clinical decline). At baseline, the ZA group were more breathless, had more advanced disease on radiology and worse quality of life than the placebo group. There was no significant difference between the groups with regards change in breathlessness (Adjusted mean difference (AMD) 4.16 (95%CI -4.7 to 13.0)) or change in DCE-MRI iAUC (AMD -15.4 (95%CI -58.1 to 27.3). Two of nine (22%) in the ZA arm had a >10% improvement by modified RECIST (vs 0/11 who received placebo). There was no significant difference in quality of life measured by the QLQ-C30 score (global QOL: AMD -4.1 (-13.0 to 4.9)), side effects or serious adverse event rates. Conclusions: This is the first human study to evaluate ZA in MPD. The study is limited by small numbers and imbalanced baseline characteristics. Although no convincing treatment effect was identified, potential benefits for specific subgroups of patients cannot be excluded. This study provides important information regarding the feasibility of future trials to evaluate the effects of ZA further. Trial Registration: UK Clinical Research Network ID 8877 ISRCTN17030426 www.isrctn.com

Women’s subsistence strategies predict fertility across cultures, but context matters

While it is commonly assumed that farmers have higher, and foragers lower, fertility compared to populations practicing other forms of subsistence, robust supportive evidence is lacking. We tested whether subsistence activities—incorporating market integration—are associated with fertility in 10,250 women from 27 small-scale societies and found considerable variation in fertility. This variation did not align with group-level subsistence typologies. Societies labeled as “farmers” did not have higher fertility than others, while “foragers” did not have lower fertility. However, at the individual level, we found strong evidence that fertility was positively associated with farming and moderate evidence of a negative relationship between foraging and fertility. Markers of market integration were strongly negatively correlated with fertility. Despite strong cross-cultural evidence, these relationships were not consistent in all populations, highlighting the importance of the socioecological context, which likely influences the diverse mechanisms driving the relationship between fertility and subsistence

Expression of Neurog1 Instead of Atoh1 Can Partially Rescue Organ of Corti Cell Survival

In the mammalian inner ear neurosensory cell fate depends on three closely related transcription factors, Atoh1 for hair cells and Neurog1 and Neurod1 for neurons. We have previously shown that neuronal cell fate can be altered towards hair cell fate by eliminating Neurod1 mediated repression of Atoh1 expression in neurons. To test whether a similar plasticity is present in hair cell fate commitment, we have generated a knockin (KI) mouse line (Atoh1KINeurog1) in which Atoh1 is replaced by Neurog1. Expression of Neurog1 under Atoh1 promoter control alters the cellular gene expression pattern, differentiation and survival of hair cell precursors in both heterozygous (Atoh1+/KINeurog1) and homozygous (Atoh1KINeurog1/KINeurog1) KI mice. Homozygous KI mice develop patches of organ of Corti precursor cells that express Neurog1, Neurod1, several prosensory genes and neurotrophins. In addition, these patches of cells receive afferent and efferent processes. Some cells among these patches form multiple microvilli but no stereocilia. Importantly, Neurog1 expressing mutants differ from Atoh1 null mutants, as they have intermittent formation of organ of Corti-like patches, opposed to a complete ‘flat epithelium’ in the absence of Atoh1. In heterozygous KI mice co-expression of Atoh1 and Neurog1 results in change in fate and patterning of some hair cells and supporting cells in addition to the abnormal hair cell polarity in the later stages of development. This differs from haploinsufficiency of Atoh1 (Pax2cre; Atoh1f/+), indicating the effect of Neurog1 expression in developing hair cells. Our data suggest that Atoh1KINeurog1 can provide some degree of functional support for survival of organ of Corti cells. In contrast to the previously demonstrated fate plasticity of neurons to differentiate as hair cells, hair cell precursors can be maintained for a limited time by Neurog1 but do not transdifferentiate as neurons