Display/control requirements for VTOL aircraft

Quantative metrics were determined for system control performance, workload for control, monitoring performance, and workload for monitoring. Pilot tasks were allocated for navigation and guidance of automated commercial V/STOL aircraft in all weather conditions using an optimal control model of the human operator to determine display elements and design

The mtDNA diversity of captive ruffed lemurs (Varecia spp.): Implications for conservation

Ruffed lemurs (Varecia variegata and V. rubra) are considered Critically Endangered, and genetic studies are therefore needed for assessing the conservation value of captive populations. Using 280 mitochondrial DNA (mtDNA) D-loop sequences, we studied the genetic diversity and structure of captive ruffed lemurs in Madagascar, Europe and North America. We found 10 new haplotypes, one from the European captive V. rubra population, three from captive V. variegata subcincta (one from Europe and two from Madagascar), and six from other captive V. variegata in Madagascar. There was low mtDNA genetic diversity in the European and North American captive populations of V. variegata. Several founder individuals shared the same mtDNA haplotype, and therefore should perhaps not be considered as unrelated founders for making breeding recommendations. The captive population in Madagascar has high genetic diversity, including haplotypes not yet identified in wild populations. The likely geographical provenance of founders of captive populations was determined by comparison with previous studies; all reported haplotypes from captive ruffed lemurs were identical to, or clustered with, haplotypes from wild populations located north of the Mangoro River in Madagascar. Effective conservation strategies for wild populations, with potentially unidentified genetic diversity, should still be considered the priority for conserving ruffed lemurs. However, our results illustrate that the captive population in Madagascar has conservation value as a source of potential release stock for reintroduction or reinforcement projects, and that cross-regional transfers within the global captive population could increase the genetic diversity and therefore the conservation value of each regional population

The institutional shaping of management: in the tracks of English individualism

Globalisation raises important questions about the shaping of economic action by cultural factors. This article explores the formation of what is seen by some as a prime influence on the formation of British management: individualism. Drawing on a range of historical sources, it argues for a comparative approach. In this case, the primary comparison drawn is between England and Scotland. The contention is that there is a systemic approach to authority in Scotland that can be contrasted to a personal approach in England. An examination of the careers of a number of Scottish pioneers of management suggests the roots of this systemic approach in practices of church governance. Ultimately this systemic approach was to take a secondary role to the personal approach engendered by institutions like the universities of Oxford and Cambridge, but it found more success in the different institutional context of the USA. The complexities of dealing with historical evidence are stressed, as is the value of taking a comparative approach. In this case this indicates a need to take religious practice as seriously as religious belief as a source of transferable practice. The article suggests that management should not be seen as a simple response to economic imperatives, but as shaped by the social and cultural context from which it emerges

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh) cell differentiation of antigen-stimulated CD4(+) T cells. Intriguingly, we found that Bcl6 was also highly and transiently expressed during the CD4(+)CD8(+) (double positive [DP]) stage of T cell development, in association with the E3 ligase cullin 3 (Cul3), a novel binding partner of Bcl6 which ubiquitinates histone proteins. DP stage-specific deletion of the E3 ligase Cul3, or of Bcl6, induced the derepression of the Bcl6 target genes Batf (basic leucine zipper transcription factor, ATF-like) and Bcl6, in part through epigenetic modifications of CD4(+) single-positive thymocytes. Although they maintained an apparently normal phenotype after emigration, they expressed increased amounts of Batf and Bcl6 at basal state and produced explosive and prolonged Tfh responses upon subsequent antigen encounter. Ablation of Cul3 in mature CD4(+) splenocytes also resulted in dramatically exaggerated Tfh responses. Thus, although previous studies have emphasized the essential role of Bcl6 in inducing Tfh responses, our findings reveal that Bcl6-Cul3 complexes also provide essential negative feedback regulation during both thymocyte development and T cell activation to restrain excessive Tfh responses

Personalized scaffolding technologies for alveolar bone regenerative medicine

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149271/1/ocr12275.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149271/2/ocr12275_am.pd

Electromagnetic design for SuperSpec: a lithographically-patterned millimetre-wave spectrograph

SuperSpec is an innovative, fully planar, compact spectrograph for mm/sub-mm astronomy. SuperSpec is based on a superconducting filter-bank consisting of a series of planar half-wavelength filters to divide up the incoming, broadband radiation. The power in each filter is then coupled into titanium nitride lumped element kinetic inductance detectors, facilitating the read out of a large number of filter elements. We will present electromagnetic simulations of the different components that will make up an R = 700 prototype instrument. Based on these simulations, we discuss optimisation of the coupling between the antenna, transmission line, filters and detectors

Experiment, monitoring, and gradient methods used to infer climate change effects on plant communities yield consistent patterns

Inference about future climate change impacts typically relies on one of three approaches: manipulative experiments, historical comparisons (broadly defined to include monitoring the response to ambient climate fluctuations using repeat sampling of plots, dendroecology, and paleoecology techniques), and space-for-time substitutions derived from sampling along environmental gradients. Potential limitations of all three approaches are recognized. Here we address the congruence among these three main approaches by comparing the degree to which tundra plant community composition changes (i) in response to in situ experimental warming, (ii) with interannual variability in summer temperature within sites, and (iii) over spatial gradients in summer temperature. We analyzed changes in plant community composition from repeat sampling (85 plant communities in 28 regions) and experimental warming studies (28 experiments in 14 regions) throughout arctic and alpine North America and Europe. Increases in the relative abundance of species with a warmer thermal niche were observed in response to warmer summer temperatures using all three methods; however, effect sizes were greater over broad-scale spatial gradients relative to either temporal variability in summer temperature within a site or summer temperature increases induced by experimental warming. The effect sizes for change over time within a site and with experimental warming were nearly identical. These results support the view that inferences based on space-for-time substitution overestimate the magnitude of responses to contemporary climate warming, because spatial gradients reflect long-term processes. In contrast, in situ experimental warming and monitoring approaches yield consistent estimates of the magnitude of response of plant communities to climate warming

Inclusion of organ deformation in dose calculations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135079/1/mp9039.pd

Research perspectives of sediment waves and drifts: Monitors of global change in deepwater circulation

The purpose of this special section in Paleoceanography is to present interdisciplinary approaches for contributing to the reconstruction of ocean circulation and its response to climate changes. A high-priority objective for understanding the causes and mechanisms of climate change is the monitoring of past ocean circulation and oceanic heat and nutrient transport. Lehman and Keigwin [1992] have shown that cooling, for example, during the younger Dryas event, may have culminated in a cessation of the oceans conveyor circulation. The cooling in the North Atlantic was apparently the result of reduced northward heat transport in the upper water masses of the North Atlantic conveyor belt. In contrast, intervals with a strong surface and deepwater circulation were marked by a high northward heat transport. For the understanding of the causes and the timing of such rapid,highfrequency events, marine records of high deposition ratecores are needed. These cores should provide evidence for changes in abyssal circulation and heat transport, as well as arecord of surface and deepwater characteristics. The sediment drifts of the North Atlantic and in other ocean basins are one of the major targets for the recovery of sediments with high deposition rates (>10 cm/kyr) and for reconstructing the role of both intermediate and deepwater production in the conveyor belt, that is drawing low-latitude heat northward. We stress the need for international programs targeting high deposition rate areas on sediment drifts and sediment waves in order to understand (1) the evolution of the conveyor belt and (2) its dynamics and variability. The North Atlantic, where sediment drifts are concentrated, will provide ideal study areas with time resolutions comparable to those of ice core records but with records linked directly to the record of changing bottom water flow. Therefore one can address the changes in circulation, heat and carbon budget on high and ultrahigh resolution records