Creation of 3D models from large unstructured image and video datasets

Exploration of various places using low-cost camera solutions over decades without having a photogrammetric application in mind has resulted in large collections of images and videos that may have significant cultural value. The purpose of collecting this data is often to provide a log of events and therefore the data is often unstructured and of varying quality. Depending on the equipment used there may be approximate location data available for the images but the accuracy of this data may also be of varying quality. In this paper we present an approach that can deal with these conditions and process datasets of this type to produce 3D models. Results from processing the dataset collected during the discovery and subsequent exploration of the HMAS Sydney and HSK Kormoran wreck sites shows the potential of our approach. The results are promising and show that there is potential to retrieve significantly more information from many of these datasets than previously thought possible

Introducing mobile fracture prevention services with DXA in Northern Scotland : A comparative study of three rural communities

The authors would like to thank the Grampian Osteoporosis Trust for funding the purchase of the mobile DXA scanner and the set-up costs of the service, and the University of Aberdeen Development Trust for funding the project evaluation.Peer reviewedPostprin

Risk of severe COVID-19 in patients with inflammatory rheumatic diseases treated with immunosuppressive therapy in Scotland

Objective: To investigate the association of severe coronavirus disease 2019 (COVID-19) in patients with inflammatory rheumatic diseases (IRDs) treated with immunosuppressive drugs. Method: A list of 4633 patients on targeted – biological or targeted synthetic – DMARDs in March 2020 was linked to a case– control study that includes all cases of COVID-19 in Scotland. Results: By 22 November 2021, 433 of the 4633 patients treated with targeted DMARDS had been diagnosed with COVID-19, of whom 58 had been hospitalized. With all those in the population not on DMARDs as the reference category, the rate ratio for hospitalized COVID-19 associated with DMARD treatment was 2.14 [95% confidence interval (CI) 2.02–2.26] in those on conventional synthetic (cs) DMARDs, 2.01 (95% CI 1.38–2.91) in those on tumour necrosis factor (TNF) inhibitors as the only targeted agent, and 3.83 (95% CI 2.65–5.56) in those on other targeted DMARDs. Among those on csDMARDs, rate ratios for hospitalized COVID-19 were lowest at 1.66 (95% CI 1.51–1.82) in those on methotrexate and highest at 5.4 (95% CI 4.4–6.7) in those on glucocorticoids at an average dose > 10 mg/day prednisolone equivalent. Conclusion: The risk of hospitalized COVID-19 is elevated in IRD patients treated with immunosuppressive drugs compared with the general population. Of these drugs, methotrexate, hydroxychloroquine, and TNF inhibitors carry the lowest risk. The highest risk is associated with prednisolone. A larger study is needed to estimate reliably the risks associated with each class of targeted DMAR

Stratified glucocorticoid monotherapy is safe and effective for most cases of giant cell arteritis

Funding: We are grateful to Versus Arthritis (grant 12159) for supporting our work.Peer reviewedPublisher PD

Diversity of Pol IV Function Is Defined by Mutations at the Maize rmr7 Locus

Mutations affecting the heritable maintenance of epigenetic states in maize identify multiple small RNA biogenesis factors including NRPD1, the largest subunit of the presumed maize Pol IV holoenzyme. Here we show that mutations defining the required to maintain repression7 locus identify a second RNA polymerase subunit related to Arabidopsis NRPD2a, the sole second largest subunit shared between Arabidopsis Pol IV and Pol V. A phylogenetic analysis shows that, in contrast to representative eudicots, grasses have retained duplicate loci capable of producing functional NRPD2-like proteins, which is indicative of increased RNA polymerase diversity in grasses relative to eudicots. Together with comparisons of rmr7 mutant plant phenotypes and their effects on the maintenance of epigenetic states with parallel analyses of NRPD1 defects, our results imply that maize utilizes multiple functional NRPD2-like proteins. Despite the observation that RMR7/NRPD2, like NRPD1, is required for the accumulation of most siRNAs, our data indicate that different Pol IV isoforms play distinct roles in the maintenance of meiotically-heritable epigenetic information in the grasses

Alpha backgrounds in NaI(Tl) crystals of COSINE-100

COSINE-100 is a dark matter direct detection experiment with 106 kg NaI(Tl) as the target material. 210Pb and daughter isotopes are a dominant background in the WIMP region of interest and are detected via beta decay and alpha decay. Analysis of the alpha channel complements the background model as observed in the beta/gamma channel. We present the measurement of the quenching factors and Monte Carlo simulation results and activity quantification of the alpha decay components of the COSINE-100 NaI(Tl) crystals. The data strongly indicate that the alpha decays probabilistically undergo two possible quenching factors but require further investigation. The fitted results are consistent with independent measurements and improve the overall understanding of the COSINE-100 backgrounds. Furthermore, the half-life of 216Po has been measured to be 143.4 +/- 1.2 ms, which is consistent with and more precise than recent measurements

Search for solar bosonic dark matter annual modulation with COSINE-100

We present results from a search for solar bosonic dark matter using the annual modulation method with the COSINE-100 experiment. The results were interpreted considering three dark sector bosons models: solar dark photon; DFSZ and KSVZ solar axion; and Kaluza-Klein solar axion. No modulation signal that is compatible with the expected from the models was found from a data-set of 2.82 yr, using 61.3 kg of NaI(Tl) crystals. Therefore, we set a 90$\%$ confidence level upper limits for each of the three models studied. For the solar dark photon model, the most stringent mixing parameter upper limit is $1.61 \times 10^{-14}$ for dark photons with a mass of 215 eV. For the DFSZ and KSVZ solar axion, and the Kaluza-Klein axion models, the upper limits exclude axion-electron couplings, $g_{ae}$, above $1.61 \times 10^{-11}$ for axion mass below 0.2 keV; and axion-photon couplings, $g_{a\gamma\gamma}$, above $1.83 \times 10^{-11}$ GeV$^{-1}$ for an axion number density of $4.07 \times 10^{13}$ cm$^{-3}$. This is the first experimental search for solar dark photons and DFSZ and KSVZ solar axions using the annual modulation method. The lower background, higher light yield and reduced threshold of NaI(Tl) crystals of the future COSINE-200 experiment are expected to enhance the sensitivity of the analysis shown in this paper. We show the sensitivities for the three models studied, considering the same search method with COSINE-200.Comment: 13 pages, 16 figure

Search for Boosted Dark Matter in COSINE-100

We search for energetic electron recoil signals induced by boosted dark matter (BDM) from the galactic center using the COSINE-100 array of NaI(Tl) crystal detectors at the Yangyang Underground Laboratory. The signal would be an excess of events with energies above 4MeV over the well-understood background. Because no excess of events are observed in a 97.7 kg$\cdot$years exposure, we set limits on BDM interactions under a variety of hypotheses. Notably, we explored the dark photon parameter space, leading to competitive limits compared to direct dark photon search experiments, particularly for dark photon masses below 4MeV and considering the invisible decay mode. Furthermore, by comparing our results with a previous BDM search conducted by the Super- Kamionkande experiment, we found that the COSINE-100 detector has advantages in searching for low-mass dark matter. This analysis demonstrates the potential of the COSINE-100 detector to search for MeV electron recoil signals produced by the dark sector particle interactions.Comment: 7 pages, 4 figure

Hypoxia Sensitive Metal β-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis

A series of ruthenium and iridium complexes have been synthesised and characterised with 20 novel crystal structures discussed. The library of β-ketoiminate complexes has been shown to be active against MCF-7 (human breast carcino-ma), HT-29 (human colon carcinoma), A2780 (human ovarian carcinoma) and A2780cis (cisplatin resistant human ovarian carcinoma) cell lines, with selected complexes being more than three times as active as cisplatin against the A2780cis cell line. Complexes have also been shown to be highly active under hypoxic conditions, with the activities of some complexes increasing with a decrease in O2 concentration. The enzyme thioredoxin reductase is over-expressed in cancer cells and complexes reported herein have the advantage of inhibiting this enzyme, with IC50 values measured in the nanomolar range. The anti-cancer activity of these complexes was further investigated to determine whether activity is due to effects on cellular growth or cell survival. The complexes were found to induce significant cancer cell death by apoptosis with levels induced correlating closely with activity in chemosensitivity studies. As a possible cause of cell death, the ability of the complexes to induce damage to cellular DNA was also assessed. The complexes failed to induce double strand DNA break or DNA crosslinking but induced significant levels of single DNA strand breaks indi-cating a different mechanism of action to cisplatin