66 research outputs found
Psychology and aggression
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68264/2/10.1177_002200275900300301.pd
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets
Indigenous games and play behaviour of children in Gauteng Province, South Africa
Research on play behaviour and games within the South African context has over the years been ad hoc, guided by considerations for practical applications and often lacking in a clear theoretical framework. A national survey launched in 2001 set the theoretical and methodological parameters of which the research in central and southern Gauteng region served as a pilot. The conceptual framework for this research predominantly draws on interpretive anthropological traditions and ethnology in which the participants' perceptions and lived realities are mediated and reflected upon. Quantitative (questionnaire) and qualitative methods (focus groups, case studies and visually recorded observations) were triangulated to constitute context and content. Data was collected from 61 senior citizens and 267 grade seven learners, representing the ethnic, gender, age, geographical (urban and rural), and socio-economic diversity of the region. A total of 379 games were collected and categorized in a ‘game map' according to a participant-constructed classification. Socio-cultural and ecological dimensions of games relate to the play behaviour, game preference and role identification. Children are the main creators of indigenous games to which significant others contribute through the socialization process. Recommendations are offered for future research and the dissemination of results.
Keywords: Indigenous games, play, Gauteng, South Africa.
(Af. J. Physical, Health Education, Recreation and Dance: 2003 Special Edition: 15-25
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