Investigation of the Degradation of Chelate Complexes in Liquid Redox Desulfurization Processes

Metal complexes such as Fe‐EDTA, which are used as pseudo‐catalysts or oxygen carriers in wet oxidative desulfurization processes, are subject to a degradation mechanism that significantly influences the economics of such processes. Therefore, this study presents a methodology for determining the degree of degradation during the reactive hydrogen sulfide absorption in a Fe‐EDTA solution within a continuously operating semi‐batch reactor system. For this purpose, the reactive conversion of H2S in the liquid phase was used as a reference, and a clear dependence of the degradation on the pH could be shown. In addition, indicators are introduced that evaluate the observed pH dependency of the degradation and distinguish pH‐induced effects such as the pH‐dependent absorption performance of H2S.TU Berlin, Open-Access-Mittel - 202

Mode competition in broad-ridge-waveguide lasers

The lateral brightness achievable with high-power GaAs-based laser diodes having long and broad waveguides is commonly regarded to be limited by the onset of higher-order lateral modes. For the study of the lateral-mode competition two complementary simulation tools are applied, representing different classes of approximations. The first tool bases on a completely incoherent superposition of mode intensities and disregards longitudinal effects like spatial hole burning, whereas the second tool relies on a simplified carrier transport and current flow. Both tools yield agreeing power-current characteristics that fit the data measured for 5 to 23 µm wide ridges. Also, a similarly good qualitative conformance of the near and far fields is found. However, the threshold of individual modes, the partition of power between them at a given current, and details of the near and far fields show differences. These differences are the consequence of a high sensitivity of the mode competition to details of the models and of the device structure. Nevertheless, it can be concluded concordantly that the brightness rises with increasing ridge width irrespective of the onset of more and more lateral modes. The lateral brightness 2W · mm¯¹ 1mrad¯¹ at 10MW · cm¯²2 power density on the front facet of the investigated laser with widest ridge (23 µm) is comparable with best values known from much wider broad-area lasers. In addition, we show that one of the simulation tools is able to predict beam steering and coherent beam

Mode competition in broad-ridge-waveguide lasers

The lateral brightness achievable with high-power GaAs-based laser diodes having long and broad waveguides is commonly regarded to be limited by the onset of higher-order lateral modes. For the study of the lateral-mode competition two complementary simulation tools are applied, representing different classes of approximations. The first tool bases on a completely incoherent superposition of mode intensities and disregards longitudinal effects like spatial hole burning, whereas the second tool relies on a simplified carrier transport and current flow. Both tools yield agreeing power-current characteristics that fit the data measured for 5 to 23 µm wide ridges. Also, a similarly good qualitative conformance of the near and far fields is found. However, the threshold of individual modes, the partition of power between them at a given current, and details of the near and far fields show differences. These differences are the consequence of a high sensitivity of the mode competition to details of the models and of the device structure. Nevertheless, it can be concluded concordantly that the brightness rises with increasing ridge width irrespective of the onset of more and more lateral modes. The lateral brightness 2W · mm¯¹ 1mrad¯¹ at 10MW · cm¯²2 power density on the front facet of the investigated laser with widest ridge (23 µm) is comparable with best values known from much wider broad-area lasers. In addition, we show that one of the simulation tools is able to predict beam steering and coherent bea

DynaMod: Dynamische Analyse für modellgetriebene Software-Modernisierung

Erfolgreiche Softwaresysteme leben lange. Gleichzeitig sind diese jedoch der enormen Geschwindigkeit der Fortentwicklung der technischen Komponenten und Plattformen unterworfen, so dass die Anwendungen technisch sehr schnell altern. Von dieser Alterung sind jedoch nicht nur Programmiertechniken betroffen, sondern auch die Softwarearchitekturen erodieren sehr schnell. Um dieser Alterung entgegenzuwirken, neue technologische Potentiale zu nutzen und auch auf zukünftige Anforderungen flexibel reagieren zu können, ist eine kontinuierliche Modernisierung von Softwaresystemen erforderlich. Bei der Neuentwicklung von Softwaresystemen hat sich mit der Modellgetriebenen Softwareentwicklung (Model-Driven Software Development, MDSD) ein Konzept etabliert, das eine elegante Lösung dieser Problematik bietet: Anstatt das System vollständig in einer technischen Programmiersprache zu entwickeln, werden fachliche Aspekte mittels geeigneter, abstrakter Modellierungssprachen dargestellt. Hierbei handelt es sich oftmals um sogenannte domänenspezifische Sprachen (Domain Specific Languages, DSLs), die speziell auf die betreffende Anwendungsdomäne zugeschnitten sind und dadurch eine knappe und präzise Formulierung der relevanten Sachverhalte ermöglichen. Die Überführung dieser abstrakten Modelle in technische Artefakte, beispielsweise Quellcode in einer Programmiersprache, wird automatisiert durch Codegeneratoren vorgenommen. Auf diese Weise ist es möglich, durch Anpassung der Generatoren die Implementierung der Modelle zu verändern, ohne Modifikationen an den zugrundeliegenden Modellen vornehmen zu müssen. Im Gegensatz zu Neuentwicklungen stehen bei vielen Bestandssystemen keine derartigen Modelle zur Verfügung. Klassische Ansätze der Modernisierung von Bestandssystemen versuchen stattdessen, die im Quellcode unmittelbar codierten Strukturen des bestehenden Systems automatisiert in Quellcode des Neusystems zu überführen. Da durch diesen Ansatz eine Transformation auf sehr elementarer Ebene stattfindet, kann dieser Ansatz der zuvor erwähnten Erosion der Anwendungsarchitektur nicht begegnen. Zudem ist auch die Übertragung elementarer Strukturen zwischen Programmiersprachen nicht trivial; häufig muss in der Zielsprache das originäre Konstrukt mit zusätzlichem Aufwand simuliert werden. Dadurch kommt es zu einer Aufblähung des Quellcodes, was der Wartbarkeit abträglich ist. Zuletzt bleiben technologische Potentiale der Zielplattform häufig ungenutzt, da das ursprüngliche System letztlich strukturuell unverändert übertragen wird. Im DynaMod-Projekt wurde mit der modellgetriebenen Modernisierung (Model Driven Modernisation, MDM) ein neuer, innovativer Ansatz untersucht, Modelle aus bestehenden Softwaresystemen abzuleiten, die in einem MDSD-Prozess genutzt werden können und dem Bestandssystem auf diese Weise die zuvor beschriebene Flexibilität der Implementierung verleiht. Zur Ableitung dieser Modelle werden nicht nur die statischen Strukturen des Softwaresystems betrachtet; ein besonderer Schwerpunkt ist die Nutzung dynamischer Analyseverfahren, d.h. der Untersuchung des Verhaltens des Softwaresystems zur Laufzeit. Diese dynamischen Analysen erlauben Einblick in die tatsächliche Nutzung des Systems durch die Nutzer und produziert somit Informationen, die zur Modernisierung eines Systems unabdingbar sind. Von besonderem Interesse ist eine gleichzeitige Betrachtung statisch und dynamisch gewonnener Informationen, eine sogenannte hybride Analyse. Hierbei entfaltet die Nutzung abstrakter Modelle eine besondere Stärke, da die Modelle eine Plattform bieten, auf der die verschiedenen Daten zusammengeführt werden können. Auch Daten aus anderen Quellen, beispielsweise Expertenwissen, können den Modellen hinzugefügt werden und führen Wissen auf der Semantikebene hinzu, das automatisiert nicht erhoben werden kann. Auf diese Weise zeigen die Modelle ein strukturiertes und umfangreiches Bild der Anwendung, das als Grundlage für eine Modernisierung dienen kann. Neben der eigentlichen Modernisierung lag ein weiterer Fokus auf der Nutzung der gewonnenen Analysedaten zum systematischen Testen der modernisierten Anwendung. Hier bestand das Ziel darin, Methoden zu entwickeln und zu erproben, die Tests zur Prüfung funktionaler und nicht-funktionaler Eigenschaften der Anwendung aus den Analysedaten generieren können

Anti-L1CAM radioimmunotherapy is more effective with the radiolanthanide terbium-161 compared to lutetium-177 in an ovarian cancer model

Purpose: The L1 cell adhesion molecule (L1CAM) is considered a valuable target for therapeutic intervention in different types of cancer. Recent studies have shown that anti-L1CAM radioimmunotherapy (RIT) with 67Cu- and 177Lu-labelled internalising monoclonal antibody (mAb) chCE7 was effective in the treatment of human ovarian cancer xenografts. In this study, we directly compared the therapeutic efficacy of anti-L1CAM RIT against human ovarian cancer under equitoxic conditions with the radiolanthanide 177Lu and the potential alternative 161Tb in an ovarian cancer therapy model. Methods: Tb was produced by neutron bombardment of enriched 160Gd targets. 161Tb and 177Lu were used for radiolabelling of DOTA-conjugated antibodies. The in vivo behaviour of the radioimmunoconjugates (RICs) was assessed in IGROV1 tumour-bearing nude mice using biodistribution experiments and SPECT/CT imaging. After ascertaining the maximal tolerated doses (MTD) the therapeutic impact of 50% MTD of 177Lu- and 161Tb-DOTA-chCE7 was evaluated in groups of ten mice by monitoring the tumour size of subcutaneous IGROV1 tumours. Results: The average number of DOTA ligands per antibody was 2.5 and maximum specific activities of 600MBq/mg were achieved under identical radiolabelling conditions. RICs were stable in human plasma for at least 48h. 177Lu- and 161Tb-DOTA-chCE7 showed high tumour uptake (37.8-39.0 %IA/g, 144h p.i.) with low levels in off-target organs. SPECT/CT images confirmed the biodistribution data. 161Tb-labelled chCE7 revealed a higher radiotoxicity in nude mice (MTD: 10MBq) than the 177Lu-labelled counterpart (MTD: 12MBq). In a comparative therapy study with equitoxic doses, tumour growth inhibition was better by 82.6% for the 161Tb-DOTA-chCE7 than the 177Lu-DOTA-chCE7 RIT. Conclusions: Our study is the first to show that anti-L1CAM 161Tb RIT is more effective compared to 177Lu RIT in ovarian cancer xenografts. These results suggest that 161Tb is a promising candidate for future clinical applications in combination with internalising antibodies

Biomonitoring of polycyclic aromatic hydrocarbons in firefighters at fire training facilities and in employees at respiratory protection and hose workshops

IntroductionPolycyclic aromatic hydrocarbons (PAHs) are carcinogenic to humans and are formed by incomplete combustion. PAHs are always present during firefighting operations, and fire department members can be exposed to them in the workplace.MethodsIn this study, we analyzed 1-hydroxypyrene (1-OHP) in 36 urine samples from nine firefighters, collected before and after fire training sessions, and 32 urine samples from eight employees at respiratory protection and hose workshops. To assess breakthrough PAH exposure through personal protective equipment and potential dermal uptake, some of the workshop employees wore cotton garments under their regular workwear. Cotton samples were then examined for the presence of 17 semi-volatile and low-volatility PAHs.ResultsAfter firefighting exercises, we observed approximately a fivefold increase in mean 1-OHP concentrations in samples from firefighters, from 0.24 μg/L to 1.17 μg/L (maximum: 5.31 μg/L). In contrast, 1-OHP levels in workshop employees were found to be low, with the majority of urine samples yielding concentrations below the limit of quantification (LOQ: 0.05 μg/L, maximum: 0.11 μg/L). Similarly, low PAH levels were found on the workshop employees' cotton undergarments, with maximum concentrations of 250 and 205 ng/g for pyrene and benzo[a]pyrene, respectively.DiscussionIn conclusion, significant increases in 1-OHP in urine were observed in firefighters after training sessions, whereas work-related exposure remained low among workshop employees

Electron-Rich EDOT Linkers in Tetracationic bis-Triarylborane Chromophores: Influence on Water Stability, Biomacromolecule Sensing, and Photoinduced Cytotoxicity

Three novel tetracationic bis-triarylboranes with 3, 4-ethylenedioxythiophene (EDOT) linkers, and their neutral precursors, showed significant red-shifted absorption and emission compared to their thiophene-containing analogues, with one of the EDOT-derivatives emitting in the NIR region. Only the EDOT-linked trixylylborane tetracation was stable in aqueous solution, indicating that direct attachment of a thiophene or even 3-methylthiophene to the boron atom is insufficient to provide hydrolytic stability in aqueous solution. Further comparative analysis of the EDOT-linked trixylylborane tetracation and its bis-thiophene analogue revealed efficient photo-induced singlet oxygen production, with the consequent biological implications. Thus, both analogues bind strongly to ds-DNA and BSA, very efficiently enter living human cells, accumulate in several different cytoplasmic organelles with no toxic effect but, under intense visible light irradiation, they exhibit almost instantaneous and very strong cytotoxic effects, presumably attributed to singlet oxygen production. Thus, both compounds are intriguing theranostic agents, whose intracellular and probably intra-tissue location can be monitored by strong fluorescence, allowing switching on of the strong bioactivity by well-focused visible light

The Electron Capture in 163^{163} Ho Experiment - a Short Update

The definition of the absolute neutrino mass scale is one of the main goals of the Particle Physics today. The study of the end-point regions of the β- and electron capture (EC) spectrum offers a possibility to determine the effective electron (anti-)neutrino mass in a completely model independent way, as it only relies on the energy and momentum conservation. The ECHo (Electron Capture in 163Ho) experiment has been designed in the attempt to measure the effective mass of the electron neutrino by performing high statistics and high energy resolution measurements of the 163 Ho electron capture spectrum. To achieve this goal, large arrays of low temperature metallic magnetic calorimeters (MMCs) implanted with with 163Ho are used. Here we report on the structure and the status of the experiment

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar