Obedience, justice & progress: a Kantian account of revolution

In his political writings, Immanuel Kant explicitly denies the right to revolution. In this thesis, I argue that this denial is inconsistent with Kant's teleological view of history and the duty to work towards political progress. Given Kant's understanding of human nature as selfish and violent, we cannot always rely on a top-down model of progress and must not assume a passive role of civil obedience in all circumstances. Kant's duty to obey should be tempered by the right to resist in political societies where the constitution restricts or destroys mechanisms for future change. Contrary to the views of Christine M. Korsgaard, whose interpretation of the good revolutionary I refute, a modified Kantian account permits a principled justification for revolution

Honolulu Honey

https://digitalcommons.library.umaine.edu/mmb-vp/4118/thumbnail.jp

Differential responses of two nearshore infaunal assemblages to experimental petroleum additions

Empirical support is provided for the hypothesis that benthic communities found in relatively constant and predictable environments are less stable (resistant and resilient) following unusual disturbances than lower-diversity communities found in more inconstant and unpredictable environments. A less diverse benthic community (i.e., the Streblospio-Tubificoides assemblage) inhabiting an inconstant and unpredictable, shallow marsh cove was disturbed less and recovered faster from an experimental addition of No. 2 fuel oil, than the more diverse benthos (i.e., the Nucula-Mediomastus assemblage) inhabiting a relatively more constant and predictable, deeper coastal embayment. Disturbed sediment had a stimulatory effect on most populations in the marsh and an inhibitory effect on most populations in the bay. Initial amount and subsequent behavior of oil were similar in the two environments. Thus, differential responses of the two communities are attributable to intrinsic biological properties rather than differences in levels or composition of oil

Combined data analysis of fossil and living mammals: a Paleogene sister taxon of Placentalia and the antiquity of Marsupialia

The Cretaceous–Paleogene (KPg) boundary, one of Earth’s five major extinction events, occurred just before the appearance of Placentalia in the fossil record. The Gobi Desert, Mongolia and the Western Interior of North America have important fossil mammals occurring just before and after the KPg boundary (e.g. Prodiacodon, Deltatheridium) that have yet to be phylogenetically tested in a character-rich context with molecular data. We present here phylogenetic analyses of >6000 newly scored anatomical observations drawn from six untested fossils and added to the largest existing morphological matrix for mammals. These data are combined with sequence data from 27 nuclear genes. Results show the existence of a new eutherian sister clade to Placentalia, which we name and characterize. The extinct clade Leptictidae is part of this placental sister clade, indicating that the sister clade survived the KPg event to co-exist in ancient ecosystems during the Paleogene radiation of placentals. Analysing the Cretaceous metatherian Deltatheridium in this character-rich context reveals it is a member of Marsupialia, a finding that extends the minimum age of Marsupialia before the KPg boundary. Numerous shared-derived features from multiple anatomical systems support the assignment of Deltatheridium to Marsupialia. Computed tomography scans of exquisite new specimens better document the marsupial-like dental replacement pattern of Deltatheridium. The new placental sister clade has both Asian and North American species, and is ancestrally characterized by shared derived features such as a hind limb modified for saltatorial locomotion

Minimum data set to measure rehabilitation needs and health outcome after major trauma : application of an international framework

BACKGROUND: Measurement of long term health outcome after trauma remains non-standardized and ambiguous which limits national and international comparison of burden of injuries. The World Health Organization (WHO) has recommended the application of the International Classification of Function, Disability and Health (ICF) to measure rehabilitation and health outcome worldwide. No previous poly-trauma studies have applied the ICF comprehensively to evaluate outcome after injury. AIM: To apply the ICF categorization in patients with traumatic injuries to identify a minimum data set of important rehabilitation and health outcomes to enable national and international comparison of outcome data. DESIGN: A mixed methods design of patient interviews and an on-line survey. SETTING: An ethnically diverse urban major trauma center in London. POPULATION: Adult patients with major traumatic injuries (poly-trauma) and international health care professionals (HCPs) working in acute and post-acute major trauma settings. METHODS: Mixed methods investigated patients and health care professionals (HCPs) perspectives of important rehabilitation and health outcomes. Qualitative patient data and quantitative HCP data were linked to ICF categories. Combined data were refined to identify a minimum data set of important rehabilitation and health outcome categories. RESULTS: Transcribed patient interview data (N.=32) were linked to 234 (64%) second level ICF categories. Two hundred and fourteen HCPs identified 121 from a possible 140 second level ICF categories (86%) as relevant and important. Patients and HCPs strongly agreed on ICF body structures and body functions categories which include temperament, energy and drive, memory, emotions, pain and repair function of the skin. Conversely, patients prioritised domestic tasks, recreation and work compared to HCP priorities of self-care and mobility. Twenty six environmental factors were identified. Patient and HCP data were refined to recommend a 109 possible ICF categories for a minimum data set. CONCLUSIONS: The comprehensive measurement of health outcomes after trauma is important for patients, health professionals and trauma systems. An internationally applied ICF minimum data set will standardize the language used and concepts measured after major trauma to enable national and international comparison of outcome data

The Welcome Project Brochure 2009

The Welcome Project is a diverse group of URI students, faculty, and staff organized to examine and address the climate for Gay, Lesbian, Bisexual, Transgender, Queer, and Questioning (GLBT) individuals on the URI campuses and beyond. The purpose of the Welcome Project is to affirm the dignity of all members of the URI community regardless of sexual orientation and gender identity/ expression, as well as to promote a safe, comfortable, and inclusive environment for all. The Welcome Project strives to identify and eliminate various forms of discrimination based on sexual orientation and gender identity/expression, and works toward developing a tradition of visibility and respect for GLBT people within our community. This is the 2009 edit of the brochure and its Ms Publisher file

Parallel heuristic search in forward partial-order planning

[EN] Most of the current top-performing planners are sequential planners that only handle total-order plans. Although this is a computationally efficient approach, the management of total-order plans restrict the choices of reasoning and thus the generation of flexible plans. In this paper, we present FLAP2, a forward-chaining planner that follows the principles of the classical POCL (Partial-Order Causal-Link Planning) paradigm. Working with partial-order plans allows FLAP2 to easily manage the parallelism of the plans, which brings several advantages: more flexible executions, shorter plan durations (makespan) and an easy adaptation to support new features like temporal or multi-agent planning. However, one of the limitations of POCL planners is that they require far more computational effort to deal with the interactions that arise among actions. FLAP2 minimizes this overhead by applying several techniques that improve its performance: the combination of different state-based heuristics and the use of parallel processes to diversify the search in different directions when a plateau is found. To evaluate the performance of FLAP2, we have made a comparison with four state-of-the-art planners: SGPlan, YAHSP2, Temporal Fast Downward and OPTIC. Experimental results show that FLAP2 presents a very acceptable trade-off between time and quality and a high coverage on the current planning benchmarks.This work has been partially supported by the Spanish MINECO project TIN2014-55637-C2-2-R and cofounded by FEDER.Sapena Vercher, O.; Torreño Lerma, A.; Onaindia De La Rivaherrera, E. (2016). Parallel heuristic search in forward partial-order planning. Knowledge Engineering Review. 31(5):417-428. https://doi.org/10.1017/S0269888916000230S41742831

Genome-wide insights into introgression and its consequences for genome-wide heterozygosity in the Mytilus species complex across Europe.

The three mussel species comprising the Mytilus complex are widespread across Europe and readily hybridize when they occur in sympatry, resulting in a mosaic of populations with varying genomic backgrounds. Two of these species, M. edulis and M. galloprovincialis, are extensively cultivated across Europe, with annual production exceeding 230,000 tonnes. The third species, M. trossulus, is considered commercially damaging as hybridization with this species results in weaker shells and poor meat quality. We therefore used restriction site associated DNA sequencing to generate high-resolution insights into the structure of the Mytilus complex across Europe and to resolve patterns of introgression. Inferred species distributions were concordant with the results of previous studies based on smaller numbers of genetic markers, with M. edulis and M. galloprovincialis predominating in northern and southern Europe respectively, while introgression between these species was most pronounced in northern France and the Shetland Islands. We also detected traces of M. trossulus ancestry in several northern European populations, especially around the Baltic and in northern Scotland. Finally, genome-wide heterozygosity, whether quantified at the population or individual level, was lowest in M. edulis, intermediate in M. galloprovincialis, and highest in M. trossulus, while introgression was positively associated with heterozygosity in M. edulis but negatively associated with heterozygosity in M. galloprovincialis. Our study will help to inform mussel aquaculture by providing baseline information on the genomic backgrounds of different Mytilus populations across Europe and by elucidating the effects of introgression on genome-wide heterozygosity, which is known to influence commercially important traits such as growth, viability, and fecundity in mussels

Multigenerational exposures of Daphnia magna to pristine and aged silver nanoparticles:epigenetic changes and phenotypical ageing related effects

Engineered nanoparticles (NPs) undergo physical, chemical, and biological transformation after environmental release, resulting in different properties of the ‘aged’ versus ‘pristine’ forms. While many studies have investigated the ecotoxicological effects of silver (Ag) NPs, the majority focus on ‘pristine’ Ag NPs in simple exposure media, rather than investigating realistic environmental exposure scenarios with transformed NPs. Here, we systematically evaluate the effects of ‘pristine’ and ‘aged’ Ag NPs with different surface coatings on Daphnia magna over four generations, comparing continuous exposure versus parental only exposure to assess recovery potential for three generations. Biological endpoints including survival, growth and reproduction and genetic effects associated with Ag NP exposure were investigated. Parental exposure to ‘pristine’ Ag NPs had an inhibitory effect on reproduction, induced expression of antioxidant stress related genes and reduced survival. Pristine Ag NPs also induced morphological changes including tail losses and lipid accumulation associated with aging phenotypes in the heart, abdomen and abdominal claw. These effects were epigenetic remaining two generations post-maternal exposure (F2 and F3). Exposure to identical Ag NPs (same concentrations) aged for 6 months in environmentally realistic water containing natural organic matter showed considerably reduced toxicological effects in continuously exposed generations and to the recovery generations