30 research outputs found
Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma
- Author
- Aigner Clemens
- Berger Walter
- Bilecz Agnes
- Brcic Luka
- Döme Balázs
- Fillinger János
- Hegedus Balazs
- Hoda Mir A
- Jakopovic Marko
- Kern Izidor
- Klepetko Walter
- Klikovits Thomas
- Kovács Ildikó
- Laszlo Viktória
- Muellauer Leonhard
- Oberndorfer Felicitas
- Pirker Christine
- Plönes Till
- Samarzija Miroslav
- Schuler Martin
- Stockhammer Paul
- Theegarten Dirk
- Publication venue
- 'Wiley'
- Publication date
- 01/07/2020
- Field of study
Aims: Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remarkable morphological variability, the prognostic role of the five defined morphologies, the impact of the nuclear grading system and the mitosis-necrosis score were investigated in this study.
Methods and results: Tumour specimens of 192 patients with epithelioid MPM from five European centres were histologically subtyped. Nuclear grading and mitosis-necrosis score were determined and correlated with clinicopathological parameters and overall survival (OS). Digital slides of 55 independent cases from The Cancer Genome Atlas (TCGA) database were evaluated for external validation. Histological subtypes were collapsed into three groups based on their overlapping survival curves. The tubulopapillary/microcystic group had a significantly longer OS than the solid/trabecular group (732 days versus 397 days, P = 0.0013). Pleomorphic tumours had the shortest OS (173 days). The solid/trabecular variants showed a significant association with high nuclear grade and mitosis-necrosis score. The mitosis-necrosis score was a robust and independent prognostic factor in our patient cohort. The prognostic significance of all three parameters was externally validated in the TCGA cohort. Patients with tubulopapillary or microcystic tumours showed a greater improvement in OS after receiving multimodal therapy than those with solid or trabecular tumours.
Conclusions: Histological subtypes of epithelioid MPM have a prognostic impact, and might help to select patients for intensive multimodal treatment approaches
A post-colonial analysis of agile software development methods in ICT4D
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
There is evidence that agile approaches to information system development can improve product quality and developer productivity. However, successful
adoption of these approaches appears to depend on adaptation to specific contexts.
This research contributes to a broader goal to understand what it means to “be
agile” in the presence of adaptations to the specific context.
To pursue our research objectives, we have performed 31 semi-structured recorded
and transcribed practitioner interviews from three companies in Lebanon. The interview transcripts were analysed using an approach informed by grounded theory.
Agile methods enable learning and improvement through team conversations.
Yet, the practitioners in our study shun public self-evaluation, finding it difficult
to discuss areas for improvement in public. We also found legacy “top down”
management practices that undermine team autonomy and local client companies
lack experience of engaging with agile processes. In a more positive vein, we found
evidence of rich use of various communications channels to overcome geographical
distance.
On the one hand, agile methods represent a “northern” idea being propagated
to the Global South. And yet, on the other hand, the agile concept of self-organising
teams has the potential to be empowering and emancipatory. Post-colonial theory
helps us understand the phenomenon of agile tailoring, where development process
ceremonies are adapted to suite a specific local context
Management of malignant pleural mesothelioma—part 2: therapeutic approaches
- Author
- A Mathy
- A Santoro
- A Scherpereel
- AO Clive
- B Ghanim
- B Ghanim
- B Hasan
- Barbara Machan
- BC Cho
- Bernhard Baumgartner
- C BTSSoC
- C Cao
- C Cao
- C Cao
- C Manegold
- Christian Geltner
- CQ Cao
- D Rice
- DJ Sugarbaker
- DJ Sugarbaker
- DJ Sugarbaker
- E Marcq
- G Zalcman
- HL Kindler
- I Opitz
- J Remon
- J Stebbing
- Josef Eckmayr
- JP Meerbeeck van
- JS Friedberg
- JS Friedberg
- Jörg Hutter
- K Suzuki
- Karin Dieckmann
- L Calabrò
- LL Garland
- M Ried
- Madeleine Arns
- Martin Flicker
- MG Zauderer
- Michael Studnicka
- Mir Alireza Hoda
- NJ Vogelzang
- O Lauk
- O Rena
- P Baas
- P Baas
- Peter Cerkl
- Peter Errhalt
- PH Sugarbaker
- R Govindan
- RC Rintoul
- RM Flores
- Sabine Zöchbauer-Müller
- T Berghmans
- T Treasure
- Thomas Klikovits
- TR Tilleman
- V Rusch
- W Weder
- WA Buikhuisen
- Walter Klepetko
- WG Richards
- Wolfgang Pohl
- YC Lee
- ZH Yao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Management of malignant pleural mesothelioma – part 1: epidemiology, diagnosis, and staging
- Author
- A Kanbay
- A Reid
- A Scherpereel
- AU Dogan
- B Duysinx
- Barbara Machan
- BD Grigoriu
- Bernhard Baumgartner
- BP Lanphear
- BW Robinson
- C Bianchi
- CA Barlow
- Christian Geltner
- EK Park
- EK Park
- Gerhard Ambrosch
- Helmut Popper
- HI Pass
- I Roushdy-Hammady
- JC Wagner
- JE Herndon
- Josef Eckmayr
- M Goldberg
- Mir Alireza Hoda
- MM Maule
- NS Offermans
- Peter Errhalt
- R Spirtas
- RJ Delfino
- RS Finn
- Thomas Klikovits
- V Bourdes
- VW Rusch
- Walter Klepetko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Management of malignant pleural mesothelioma – part 3
- Author
- A Linton
- A Scherpereel
- Barbara Machan
- Bernhard Baumgartner
- C Cao
- C Cao
- C Cao
- Christian Geltner
- CQ Cao
- D Rice
- DJ Sugarbaker
- E Taioli
- Josef Eckmayr
- JP Steele
- Jörg Hutter
- Klaus Kirchbacher
- M Britton
- M Goldberg
- Madeleine Arns
- Martin Flicker
- Michael Studnicka
- Mir Alireza Hoda
- N Zandwijk van
- NJ Vogelzang
- O Lauk
- P Baas
- PE Schil Van
- Peter Cerkl
- Peter Errhalt
- RA Damhuis
- RC Rintoul
- RM Flores
- RT Lin
- Thomas Klikovits
- V Rusch
- VW Rusch
- VW Rusch
- Walter Klepetko
- Wolfgang Pohl
- Yawen Dong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of the W-boson mass in pp collisions at s√=7TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam E Romero
- Adamczyk L
- Adams DL
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Alberich L Cerda
- Albert J
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty M
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amorim A
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anghinolfi F
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Aranda C Padilla
- Araque JP
- Araya S Tapia
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Bagiacchi P
- Bagnaia P
- Baines JT
- Bajic M
- Baker OK
- Baldin EM
- Balek P
- Balestri T
- Balli F
- Balunas WK
- Banas E
- Banerjee Sw
- Bannoura AAE
- Barajas CA Chavez
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HP
- Becker K
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- Beckingham M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behr JK
- Bell AS
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertolucci F
- Bertram IA
- Bertsche C
- Bertsche D
- Besjes GJ
- Bessner M
- Besson N
- Betancourt C
- Bethani A
- Bethke S
- Bevan AJ
- Bianchi RM
- Bianco M
- Biebel O
- Biedermann D
- Bielski R
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bilokon H
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Bisanz T
- Bittrich C
- Bjergaard DM
- Black CW
- Black JE
- Black KM
- Blackburn D
- Blair RE
- Blanchard J-B
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blum W
- Blumenschein U
- Blunier S
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Bock C
- Boehler M
- Boeriu OE Vickey
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev AS
- Bomben M
- Bona M
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Bortolotto V
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- Boscherini D
- Bosman M
- Boudreau J
- Bouffard J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bracinik J
- Brandt A
- Brandt G
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- Bratzler U
- Brau B
- Brau JE
- Bravo A Gascon
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- Brennan AJ
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- Bret M Cano
- Briglin DL
- Bristow TM
- Britton D
- Britzger D
- Brochu FM
- Brock I
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- Brooijmans G
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- Brosamer J
- Brost E
- Broughton JH
- Bruncko D
- Bruni A
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- Brunt BH
- Bruschi M
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- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
- Bugge MK
- Bulekov O
- Bullock D
- Burckhart H
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
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- Butler JM
- Buttar CM
- Butterworth JM
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- Buzatu A
- Buzykaev AR
- Bylund O Bessidskaia
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- Cairo VM
- Cakir I Turk
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- Calandri A
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- Casolino M
- Casper DW
- Castelijn R
- Castelli A
- Castillo I Santoyo
- Castillo LR Flores
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
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- Ceradini F
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- Cervelli A
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- Chafaq A
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- Chatterjee A
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- Chekulaev SV
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- Chernyatin V
- Cheu E
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
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- Chow BKB
- Christodoulou V
- Chromek-Burckhart D
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- Chudoba J
- Chuinard AJ
- Chwastowski JJ
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- Cioara IA
- Ciocca C
- Ciocio A
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- Collaboration ATLAS
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- Coutinho Y Amaral
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- Crawley SJ
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- Crescioli F
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- Damazio D Oliveira
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- de Renstrom PA Bruckman
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- Della Pietra M
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- Delsart PA
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- Demilly A
- Denisov SP
- Denysiuk D
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- Deviveiros PO
- Dewhurst A
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- Di Ciaccio A
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- Di Donato C
- Di Girolamo A
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- Dumitriu AE
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- Farthouat P
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- Fassouliotis D
- Favareto A
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- Fedin OL
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- Feigl S
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- Fenyuk AB
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- Ferrando J
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- Ferraz V Araujo
- Ferrer A
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- Ferrere D
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- Fiedler F
- Filho L Manhaes de Andrade
- Filipcic A
- Filipuzzi M
- Filthaut F
- Fincke-Keeler M
- Finelli KD
- Fiolhais MCN
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- Fischer J
- Fisher WC
- Flaschel N
- Fleck I
- Fleischmann P
- Fletcher RRM
- Flick T
- Flierl BM
- Flowerdew MJ
- Forcolin GT
- Formica A
- Forti A
- Foster AG
- Fournier D
- Fox H
- Fracchia S
- Francavilla P
- Franchini M
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- Franconi L
- Franklin M
- Frate M
- Fraternali M
- Freeborn D
- Fressard-Batraneanu SM
- Freund B
- Froidevaux D
- Frost JA
- Fukunaga C
- Fusayasu T
- Fuster J
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- Gabrielli A
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- Gadomski S
- Gagliardi G
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- Gagnon P
- Galea C
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- Gallop BJ
- Gallus P
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- Garcia BR Mellado
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- Garcia-Sciveres M
- Gardner RW
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- Garonne V
- Garrido MDM Capeans
- Garzon G Otero Y
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- Gatti C
- Gaudiello A
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- Gavrilenko IL
- Gay C
- Gaycken G
- Gazis EN
- Gee CNP
- Geisen M
- Geisler MP
- Gellerstedt K
- Gemme C
- Genest MH
- Geng C
- Gentile S
- Gentsos C
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- Gerbaudo D
- Gershon A
- Ghasemi S
- Ghneimat M
- Giacobbe B
- Giagu S
- Giannelli M Faucci
- Giannetti P
- Gibson SM
- Gignac M
- Gilchriese M
- Gillberg D
- Gilles G
- Gimenez V Castillo
- Gingrich DM
- Giokaris N
- Giordani MP
- Giorgi FM
- Giraud PF
- Giromini P
- Giugni D
- Giuli F
- Giuliani C
- Giulini M
- Gjelsten BK
- Gkaitatzis S
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2017
- Field of study
A measurement of the mass of the W boson is presented based on proton–proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to 4.6 fb−1 of integrated luminosity. The selected data sample consists of 7.8×106 candidates in the W→μν channel and 5.9×106 candidates in the W→eν channel. The W-boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the W boson transverse mass in the electron and muon decay channels, yielding mW=80370=80370±7 (stat.)±11(exp. syst.)±14 (mod. syst.) MeV±19MeV, where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty. A measurement of the mass difference between the W+ and W− bosons yields mW+−mW−=−29±28 MeV
Measurement of the W-boson mass in pp collisions at s√=7TeV with the ATLAS detector
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- Meng L
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- Mengarelli A
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- Mitani T
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- Mizukami A
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- Ristic B
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- Rizatdinova F
- Rizvi E
- Rizzi C
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- Rozas A Juste
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- Ruschke A
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- Schoening A
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- Schouwenberg JFP
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- Schultz-Coulon H-C
- Schulz H
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- Schune Ph
- Schwartzman A
- Schwarz TA
- Schweiger H
- Schwemling Ph
- Schwienhorst R
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- Sforza F
- Sfyrla A
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- Shimmin CO
- Shimojima M
- Shirabe S
- Shiyakova M
- Shlomi J
- Shmeleva A
- Shochet MJ
- Shojaii S
- Shope DR
- Shrestha S
- Shulga E
- Shupe MA
- Sicho P
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- Sidebo PE
- Sidiropoulou O
- Sidorov D
- Sidoti A
- Siegert F
- Sijacki Dj
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- Silverstein SB
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- Siragusa G
- Siral I
- Sivoklokov S Yu
- Sjolin J
- Skinner MB
- Skubic P
- Slater M
- Slavicek T
- Slawinska M
- Sliwa K
- Slovak R
- Smakhtin V
- Smart BH
- Smestad L
- Smiesko J
- Smirnov LN
- Smirnov S Yu
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- Soldevila U
- Solis A Lopez
- Solodkov AA
- Soloshenko A
- Solovyanov OV
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- Sommer P
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- Sopczak A
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- Soualah R
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- Stramaglia ME
- Strandberg J
- Strandberg S
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- Sykora I
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- Tarem S
- Tartarelli GF
- Tas P
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- Tashiro T
- Tassi E
- Tayalati Y
- Taylor AC
- Taylor GN
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- Ten Kate H
- Teng PK
- Teoh JJ
- Tepel F
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- Theenhausen H Meyer Zu
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- Thomas JP
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- Tripiana MF
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- Trocme B
- Trofymov A
- Troncon C
- Trottier-McDonald M
- Trovatelli M
- Truong L
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- Trzupek A
- Tsang KW
- Tseng JC-L
- Tsiareshka PV
- Tsipolitis G
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsui KM
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tu Y
- Tudorache A
- Tudorache V
- Tulbure TT
- Tuna AN
- Tupputi SA
- Turchikhin S
- Turgeman D
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- Ucchielli G
- Ueda I
- Ughetto M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Unverdorben C
- Urban J
- Urban S Cabrera
- Urek T Javdegrees
- Urquijo P
- Urrejola P
- Usai G
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- Vacavant L
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- Vachon B
- Valderanis C
- Valencic N
- Valentinetti S
- Valero A
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- van Eldik N
- Van Gemmeren P
- Van Nieuwkoop J
- Van Vulpen I
- Van Woerden MC
- Vanadia M
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- Vanguri R
- Vaniachine A
- Vankov P
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- Veeraraghavan V
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- Venturi N
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- Vercesi V
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- Verkerke W
- Vermeulen JC
- Verzini MJ Alconada
- Vetterli MC
- Viazlo O
- Vichou I
- Vickey T
- Viehhauser GHA
- Viel S
- Vigani L
- Villa M
- Villara DI Narrias
- Vilucchi E
- Vincter MG
- Vinogradov VB
- Vishwakarma A
- Vittori C
- Vivarelli I
- Vlachos S
- Vlasak M
- Vogel M
- Vokac P
- Volpi M
- Volpia G
- Von der Schmitt H
- von Toerne E
- Vorobel V
- Vorobev K
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- Vukotic I
- Wagner P
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- Wallangen V
- Walls FM Garay
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- Wanotayaroj C
- Warburton A
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- Wardrope DR
- Washbrook A
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- Weber MS
- Weber SA
- Weber SW
- Webster JS
- Weidberg AR
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- Weingarten J
- Weiser C
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- Wenaus T
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- Wharton AM
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- White MJ
- White R
- Whiteson D
- Wickens FJ
- Wiedenmann W
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- Wiglesworth C
- Wiik-Fuchs LAM
- Wildauer A
- Wilk F
- Wilkens HG
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf TMH
- Wolff R
- Wolter MW
- Wolters H
- Wong KH Yau
- Worm SD
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamaguchi D
- Yamaguchi Y
- Yamamoto A
- Yamamoto S
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang Y
- Yang Z
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhanga G
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2017
- Field of study
A measurement of the mass of the W boson is presented based on proton–proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to 4.6 fb−1 of integrated luminosity. The selected data sample consists of 7.8×106 candidates in the W→μν channel and 5.9×106 candidates in the W→eν channel. The W-boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the W boson transverse mass in the electron and muon decay channels, yielding mW=80370=80370±7 (stat.)±11(exp. syst.)±14 (mod. syst.) MeV±19MeV, where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty. A measurement of the mass difference between the W+ and W− bosons yields mW+−mW−=−29±28 MeV
Measurement of the W-boson mass in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
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- Abramowicz H
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- Wong KHY
- Worm SD
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
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- Yildirim E
- Yildiz HD
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- Yoshihara K
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- Youssef S
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- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
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- Zerwas D
- Zhang D
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- Zhanga G
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
A measurement of the mass of the W boson is
presented based on proton–proton collision data recorded in
2011 at a centre-of-mass energy of 7 TeV with the ATLAS
detector at the LHC, and corresponding to 4.6 fb−1 of
integrated luminosity. The selected data sample consists of
7.8 × 106 candidates in the W → μν channel and 5.9 × 106
candidates in the W → eν channel. The W-boson mass is
obtained from template fits to the reconstructed distributions
of the charged lepton transverse momentum and of the W
boson transverse mass in the electron and muon decay channels,
yielding
mW = 80370 ± 7 (stat.) ± 11(exp. syst.)
± 14 (mod. syst.) MeV
= 80370 ± 19 MeV,
where the first uncertainty is statistical, the second corresponds
to the experimental systematic uncertainty, and the
third to the physics-modelling systematic uncertainty. A measurement
of the mass difference between the W+ and W−
bosons yields mW+ − mW− = − 29 ± 28 MeV
Recommended from our members
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- Author
- Aali Amirali
- Ababneh Hazim S
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasi-Kangevari Mohsen
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdollahifar Mohammad-Amin
- Abdoun Meriem
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abebe Mesfin
- Abebe Samrawit Shawel
- Abedi Aidin
- Abegaz Kedir Hussein
- Abhilash E S
- Abidi Hassan
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abolmaali Meysam
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Gharbieh Eman
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Abualruz Hasan
- Abubakar Bilyaminu
- Aburuz Salahdein
- Accrombessi Manfred Mario Kokou
- Adal Tadele Girum
- Adamu Abdu A
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adebiyi Akindele Olupelumi
- Adekanmbi Victor
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adeyinka Daniel Adedayo
- Adeyomoye Olorunsola Israel
- Admass Biruk Adie Adie
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afolabi Aanuoluwapo Adeyimika
- Afzal Muhammad Sohail
- Afzal Saira
- Agampodi Suneth Buddhika
- Agasthi Pradyumna
- Aggarwal Manik
- Aghamiri Shahin
- Agide Feleke Doyore
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Sajjad
- Ahmad Shahzaib
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmed Ali
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Mehrunnisha Sharif
- Ahmed Meqdad Saleh
- Ahmed Muktar Beshir
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- Akinyemiju Tomi
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- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Azzam Sayer
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Omari Basem
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Alahdab Fares
- Alalalmeh Samer O
- Alalwan Tariq A
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- Alanzi Turki M
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- AlBataineh Mohammad T
- Alcalde-Rabanal Jacqueline Elizabeth
- Aldawsari Khalifah A
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- PRISCILLA TINA
- Pritchett Natalie
- Purohit Bharathi M
- Puvvula Jagadeesh
- Qasim Nameer Hashim
- Qattea Ibrahim
- Qazi Asma Saleem
- Qian Gangzhen
- Qiu Suli
- Qureshi Maryam Faiz
- Rabiee Rad Mehrdad
- Radfar Amir
- Radhakrishnan Raghu Anekal
- Radhakrishnan Venkatraman
- Raeisi Shahraki Hadi
- Rafferty Quinn
- Raggi Alberto
- Raghav Pankaja Raghav
- Raheem Nasiru
- Rahim Fakher
- Rahim Md Jillur
- Rahimi-Movaghar Vafa
- Rahman Md Mosfequr
- Rahman Mohammad Hifz Ur
- Rahman Mosiur
- Rahman Muhammad Aziz
- Rahmani Amir Masoud
- Rahmani Shayan
- Rahmanian Vahid
- Rajaa Sathish
- Rajput Prashant
- Rakovac Ivo
- Ramasamy Shakthi Kumaran
- Ramazanu Sheena
- Rana Kritika
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- Rasouli-Saravani Ashkan
- Rasul Azad
- Rathnaiah Babu Giridhara
- Rauniyar Santosh Kumar
- Ravangard Ramin
- Ravikumar Nakul
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- Rawaf Salman
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- Sao Jose Bruno Piassi
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- Saraswathy Sivan Yegnanarayana Iyer
- Saravanan Aswini
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- Sarode Gargi Sachin
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- Silva João Pedro
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- Singal Anjali
- Singh Abhinav
- Singh Balbir Bagicha
- Singh Garima
- Singh Jasbir
- Singh Narinder Pal
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- Sinto Robert
- Siraj Md Shahjahan
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- Tabatabaei Seyyed Mohammad
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- Tabatabai Shima
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- TADAKAMADLA JYOTHI
- Tadakamadla Santosh Kumar
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- Tariqujjaman Md
- Tarkang Elvis Enowbeyang
- Tavakoli Oliaee Razieh
- Tavangar Seyed Mohammad
- Taveira Nuno
- Tefera Yibekal Manaye
- Temsah Mohamad-Hani
- Temsah Reem Mohamad Hani
- Teramoto Masayuki
- Tesler Riki
- Teye-Kwadjo Enoch
- Thakur Rishu
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- Tian Jing
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- Ticoalu Jansje Henny Vera
- Tillawi Tala
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- Titova Mariya Vladimirovna
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- Tran Jasmine T
- Tran Nghia Minh
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- Truyen Thien Tan Tri Tai
- Tsatsakis Aristidis
- Tsegay Guesh Mebrahtom
- Tsermpini Evangelia Eirini
- Tumurkhuu Munkhtuya
- Tung Kang
- Tyrovolas Stefanos
- Uddin Sayed Mohammad Nazim
- Udoakang Aniefiok John
- Udoh Arit
- Ullah Atta
- Ullah Irfan
- Ullah Saeed
- Ullah Sana
- Umakanthan Srikanth
- Umeokonkwo Chukwuma David
- Unim Brigid
- Unnikrishnan Bhaskaran
- Unsworth Carolyn Anne
- Upadhyay Era
- Urso Daniele
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- Vaithinathan Asokan Govindaraj
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- Varga Orsolya
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- Varthya Shoban Babu
- Vasankari Tommi Juhani
- Vasic Milena
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- Vellingiri Balachandar
- Venketasubramanian Narayanaswamy
- Verghese Nicholas Alexander
- Verma Madhur
- Veroux Massimiliano
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- Vervoort Dominique
- Villafañe Jorge Hugo
- Villanueva Gabriela Ines
- Vinayak Manish
- Violante Francesco S
- Viskadourou Maria
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
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- Wei Melissa Y
- Weintraub Robert G
- Weiss Daniel J
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- Whisnant Joanna L
- Wiangkham Taweewat
- Wickramasinghe Dakshitha Praneeth
- Wickramasinghe Nuwan Darshana
- Wilandika Angga
- Wilkerson Caroline
- Willeit Peter
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- Wojewodzic Marcin W
- Woldegebreal Demewoz H
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- Wong Yen Jun
- Wongsin Utoomporn
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- Wu Felicia
- Wu Xinsheng
- Wu Zenghong
- Xia Juan
- Xiao Hong
- Xie Yang
- Xu Suowen
- Xu Wang-Dong
- Xu Xiaoyue
- Xu Yvonne Yiru
- Yadollahpour Ali
- Yamagishi Kazumasa
- Yang Danting
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Yaribeygi Habib
- Ye Pengpeng
- Yehualashet Sisay Shewasinad
- Yesiltepe Metin
- Yesuf Subah Abderehim
- Yezli Saber
- Yi Siyan
- Yigezu Amanuel
- Yip Paul
- Yismaw Malede Berihun
- Yismaw Yazachew
- Yiğit Arzu
- Yiğit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- Yoon Seok-Jun
- You Yuyi
- Younis Mustafa Z
- Yousefi Zabihollah
- Yu Chuanhua
- Yu Yong
- Yuh Faith H
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zakham Fathiah
- Zaki Nazar
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
- Zangiabadian Moein
- Zar Heather J
- Zare Iman
- Zarrintan Armin
- Zeariya Mohammed G M
- Zeinali Zahra
- Zhang Haijun
- Zhang Jianrong
- Zhang Jingya
- Zhang Liqun
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Lei
- Ziafati Makan
- Zielińska Magdalena
- Zitoun Osama A
- Zoladl Mohammad
- Zou Zhiyong
- Zuhlke Liesl J
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Ärnlöv Johan
- Šekerija Mario
- Publication venue
- Elsevier
- Publication date
- 01/01/2024
- Field of study
BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation
A new prognostic score supporting treatment allocation for multimodality therapy for malignant pleural mesothelioma- A review of 12 years' experience
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 27/08/2015
- Field of study
INTRODUCTION Treatment of malignant pleural mesothelioma (MPM) remains a clinical challenge. The aim of this study was to identify selection factorsfor allocation of MPM patients to multimodal therapy based on survival data from 12 years of experience. METHODS Eligible patients had MPM of all histological subtypes with clinical stage T1-3 N0-2 M0. Induction chemotherapy consisted of cisplatin/gemcitabine (cis/gem) orcisplatin/pemetrexed (cis/pem), followed by extrapleural pneumonectomy (EPP).Multivariate analysis was performed to assess independent prognosticators for overall survival (OS). A Multimodality Prognostic Scorewasdeveloped based on clinical variablesavailable before surgery. RESULTS From May 1999 to August 2011, 186 MPM patients were intended to be treated with induction chemotherapy followed by EPP. Hematologic toxicity was significantly less frequent after cis/pemcompared to cis/gem, but no difference in response or OS between the regimens.128 patients underwent EPP with a30-day mortalityof4.7%. 52% percent of the patients received adjuvant radiotherapy. The median OSof patients undergoing EPP was significantly longer with 22months (95%CI:20-24) as compared to 11 months (9-12) for patients treated without EPP.Aprognostic score was defined considering tumor volume,histology, CRP,andresponsetochemotherapythat identified patient groupsnot benefittingfrom multimodality treatmentwhich was confirmed in an independent cohort. CONCLUSION Patients receiving induction chemotherapy followed by EPP for MPM of all histological subtypes and irrespective of nodal statusshowed a median survival of 22months. A prognostic score is proposed to help patient allocation for surgery after validation in an independent cohort