Patient involvement in diabetes-related foot ulcers: What do patients need and prefer when undergoing treatment at multidisciplinary outpatient Foot Centres?:A phenomenological hermeneutic study

We adopted a qualitative descriptive design to gain a broad understanding of the experiences, needs, and preferences. Semi-structured interviews were conducted with 21 patients with diabetes-related foot ulcers using an interview guide. Patients were recruited from the four multidisciplinary foot centres in the Eastern Danish Region of Zealand. The methodology utilised a phenomenological-hermeneutical perspective, allowing participants to share their experiences. The data analysis was inspired by Paul Ricoeur's philosophy of text interpretation. Three themes were identified: 1) Becoming dependent on patient involvement to cope and comprehend, 2) Experiences and needs regarding the involvement of relatives and equals, and 3) Being vulnerable and limited by diabetes-related foot ulcers while striving for normality. This study emphasised the complexity of, and the highly burdensome, life that the participants experienced living with treatment-required diabetes-related foot ulcers while needing individualised and family-centred approaches, which are highly dependent on the healthcare professionals' communication skills. One of the most crucial aspects of patient care is providing individualised and person-centred information. The information necessitates the enhancement of healthcare professionals' communication skills. By emphasising the need for family-centred strategies, we can improve health and well-being by involving patients, relatives, and patients' networks as active team players in the care process

Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study

We describe the qualitative and quantitative analysis of the complexation properties towards cations of a cyclic peptoid hexamer composed of alternating α- and β-peptoid monomers, which bear exclusively chiral (S)-phenylethyl side chains (spe) that have no noticeable chelating properties. The binding of a series of monovalent and divalent cations was assessed by 1H NMR, circular dichroism, fluorescence and molecular modelling. In contrast to previous studies on cations binding by 18-membered α-cyclopeptoid hexamers, the 21-membered cyclopeptoid cP1 did not complex monovalent cations (Na+, K+, Ag+) but showed selectivity for divalent cations (Ca2+, Ba2+, Sr2+ and Mg2+). Hexacoordinated C-3 symmetrical complexes were demonstrated for divalent cations with ionic radii around 1 Å (Ca2+ and Ba2+), while 5-coordination is preferred for divalent cations with larger (Ba2+) or smaller ionic radii (Mg2+)

Rapid assembly of the polyhydroxylated b-amino acid constituents of microsclerodermins C, D et E.

A very short and efficient synthesis of protected derivatives of APTO and AETD, the complex polyhydroxylated -amino acid residues present in microsclerodermins C, D, and E, is described. The targets are obtained in only five steps, in 23% and 16% overall yields, respectively. The key transformation involves the completely diastereoselective two-carbon homologation of appropriately selected intermediate chiral sulfinimine

Effect of capping groups at the N- and C-termini on the conformational preference of α,β-peptoids

invitation, special theme issue on Foldamer ChemistryInternational audienc

Enzymatic basis of "hybridity" in thiomarinol biosynthesis

Thiomarinol is a naturally occurring double-headed antibiotic that is highly potent against methicillin-resistant Staphylococcus aureus. Its structure comprises two antimicrobial subcomponents, pseudomonic acid analogue and holothin, linked by an amide bond. TmlU was thought to be the sole enzyme responsible for this amide-bond formation. In contrast to this idea, we show that TmlU acts as a CoA ligase that activates pseudomonic acid as a thioester that is processed by the acetyltransferase HolE to catalyze the amidation. TmlU prefers complex acyl acids as substrates, whereas HolE is relatively promiscuous, accepting a range of acyl-CoA and amine substrates. Our results provide detailed biochemical information on thiomarinol biosynthesis, and evolutionary insight regarding how the pseudomonic acid and holothin pathways converge to generate this potent hybrid antibiotic. This work also demonstrates the potential of TmlU/HolE enzymes as engineering tools to generate new "hybrid" molecules. The biosynthetic mechanism responsible for generating the antibiotic thiomarinol was elucidated. In contrast to previous hypotheses, TmlU acts as a CoA-ligase and works in tandem with a second enzyme, acyltransferase HolE, to link two antimicrobial warheads pseudomonic acid and holothin, creating a hybrid antibiotic (see scheme)

Molecular structure and vibrational spectra of 2(5H)-furanone and 2(5H)-thiophenone isolated in low temperature inert matrix

The structure and vibrational spectra of two five-membered heterocyclic [alpha]-carbonyl compounds have been studied. The experimental FTIR spectra 2(5H)-furanone and 2(5H)-thiophenone monomers isolated in inert argon matrices at 10 K are reported and discussed. The interpretation of the experimental data is supported by vibrational calculations at the MP2 and DFT(B3LYP) levels of theory with the 6-311++G(d,p) basis set. Spectra/structure correlations were extracted from the data calculated for the two title compounds and for their six-membered ring analogues, [alpha]-pyrone and thiapyran-2-one. The vibrational frequencies of the CO, CC, CH and CH2 moieties were correlated with the ring size, atomic charges and the nature of heteroatom. Natural bond orbital analysis revealed important details of the electronic structure and dominant intramolecular interactions in 2(5H)-furanone and 2(5H)-thiophenone and provided an additional insight into their vibrational spectra.http://www.sciencedirect.com/science/article/B6TGS-4S0YXVN-2/1/795b19eafb7371b4ccc1c1984b5e1c8

Vers la synthèse totale de microsclerodermine D

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Vers la synthèse totale de microsclerodermine D

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