A CASE OF ACUTE CEREBELLAR ENCEPHALITIS : CASE REPORT AND REVIEW

急性小脳炎の7歳女児例を報告する。発症2週間後のT_2強調磁気共鳴画像では, 左小脳半球に高信号領域を認めた。患児の小脳症状は2ヵ月間で徐々に改善した。発症6ヵ月後再度撮影した磁気共鳴画像でも, 前回同様の残存病変を認めた。この希で自然軽快する疾患の症状, 鑑別診断を簡単に論じる。A 7-year-old female patient with acute cerebellar encephalitis (CE) is reported. Magnetic resonance imaging (MRI) with a T2-weighted sequence revealed a high signal lesion in the left cerebellar hemisphere at two weeks after the onset. The cerebellar symptoms improved gradually over 2 months. Repeat MRI, performed 6 months later, revealed the lesion remained. The signs, symptoms and differential diagnosis of this rare, self-limiting condition are briefly discussed

Increased expression of α4β7 integrin on food allergen-stimulated CD4+ T cells in active food allergic enterocolitis

We used flow cytometry to investigate the expression of α4β7 integrin on peripheral blood CD4+ T cells stimulated with αs-casein, one of the major allergens in milk allergy, in patients with milk-induced enterocolitis. In the active state of the disease, the levels of α4β7 integrin on αs-casein-stimulated CD4+ T cells, as well as the numbers of positive cells, were higher than in the age-matched control. Upon outgrowing milk allergy, α4β7 integrin levels decreased to the same levels as in the healthy control. The proliferative responses of peripheral blood mononuclear cells to αs-casein in the active state did not differ from those in the outgrown state, suggesting that the expression of α4β7 integrin on milk allergen-activated T cells is a marker of the activation state leading to the pathogenesis of milk-allergic enterocolitis

Mutations in BMP4 Are Associated with Subepithelial, Microform, and Overt Cleft Lip

Cleft lip with or without cleft palate (CL/P) is a complex trait with evidence that the clinical spectrum includes both microform and subepithelial lip defects. We identified missense and nonsense mutations in the BMP4 gene in 1 of 30 cases of microform clefts, 2 of 87 cases with subepithelial defects in the orbicularis oris muscle (OOM), 5 of 968 cases of overt CL/P, and 0 of 529 controls. These results provide confirmation that microforms and subepithelial OOM defects are part of the spectrum of CL/P and should be considered during clinical evaluation of families with clefts. Furthermore, we suggest a role for BMP4 in wound healing