Human histology. Manual of practicals

123 p.In Medicine, the samples use to come from patients from whom a portion of tissue is extracted, which is called a biopsy. They also come from material obtained by surgical treatment (surgical specimens) and, of course, from people who have died of some type of disease and whose family authorizes the autopsy to be performed (clinical autopsy). Many of the studies are carried out using extensions of exudates on slides, aspirated material or smears, which are generically known as cytology and/or extensions. The material must be obtained with great care, trying not to deform or damage the tissue: appropriate and sharp material must be used. The origin of the samples largely determines the “quality” of the material. It is extremely important that as little time as possible elapses between obtaining the sample and its fixation in order to have the highest degree of resemblance to the “in vivo” state. In the following, we will refer to the study methods most commonly used in daily practice

Predicting Suicidal Behavior: Are We Really that Far Along? Comment on “Discovery and Validation of Blood Biomarkers for Suicidality”

A recent publication focused on biomarkers of future suicidal behaviors identifies several genes expressed in high-risk states among four samples. We discuss the implications of this study as well as the current state of research regarding biomarkers of suicidal behavior

Prácticas de histología humana

La Histología en su quehacer diario es una disciplina eminentemente práctica. La docencia de la Histología Humana se desarrolla básicamente a través de clases magistrales, seminarios y clases prácticas. Para la realización de estas últimas el alumno dispone de un microscopio óptico y diferentes preparaciones histológicas, así como de fotografías de microscopía electrónica. El programa práctico de la asignatura se desglosa a lo largo de veinticinco temas, que comienzan con la Histología General, donde se estudian los tejidos, para dar paso a la Histología Especial. Los temas se ordenan de forma paralela al desarrollo del programa teórico de la asignatura. De esta manera el alumno adquiere los conocimientos teóricos y después los aplica a la práctica. Sin embargo, el desarrollo del curso académico hace que esta sincronización tan solo sea posible durante las primeras prácticas, y llega un momento en el que las prácticas llegan a preceder al estudio teórico. Para ello, en la presente guía de “Prácticas de Histología Humana” se hacen comentarios que si bien pueden parecer algo “extraños” a una persona con conocimiento de la disciplina, si es cierto que se revelan muy útiles al alumno, como nos ha enseñado su utilización en el aula práctica a lo largo de los años

Mejorar la rentabilidad con la toma de decisiones para el área de ventas en laboratorio farmacéutico

El sector farmacéutico es un entorno cada vez más competitivo vinculado a la salud, las compañías farmacéuticas nacionales necesitan ser más eficientes para rentabilizar sus beneficios en base a las ventas. El desafío es conseguir transformar los grandes volúmenes de información en conocimiento, en un mínimo tiempo, que permita tomar decisiones acertadas y oportunas para conseguir mejores resultados de rentabilidad. Por esta razón, el presente proyecto propone mejorar la rentabilidad con mecanismo de estrategia y gestión de información aplicado al área de ventasen un laboratorio farmacéutico con el objetivo Incrementar las Ventas en un 10%.La presente tesis propone una solución que permite recabar, registrar y analizarlos datos que se encuentren bajo un patrón y comportamiento en la base de datos excluyendo datos inconsistentes, para la gestión de datos en el área de ventas. se plantea la creación de una plataforma de datos como suministro que se enlace directamente con la base de datos donde el usuario puede visualizar el reporte en línea a través de la web de reportes y obtener los indicadores de negocios.Campus Lima Centr

Planeación y control de los procesos de mantenimiento para la mejora de la Productividad de la planta de Efluentes en Confipetrol Andina S.A., Cajamarquilla, 2018

la presente tesis cuyo título es Planeación y Control de los procesos de mantenimiento para la mejora de la Productividad de la planta de Efluentes en Confipetrol Andina S.A., Cajamarquilla, 2018. El objetivo es determinar cómo la Planeación y control de los procesos de mantenimiento mejora la productividad de la planta de efluentes en Confipetrol Andina s.a., Cajamarquilla, 2018. La tesis se desarrolló con un diseño cuasi experimental, el tipo de investigación es aplicada y un nivel explicativo, la finalidad es mejorar la productividad de servicio en la empresa Confipetrol S.A. para esta investigación el problema principal se concentra en la baja productividad del servicio de mantenimiento, los problemas que se tiene son: altos costos de mantenimiento, demora en el cumplimiento y entrega de órdenes de trabajo al cliente, falta de procedimientos claros también la baja disponibilidad de los equipos, donde se generan inconformidades y reclamos de parte de nuestros clientes. La población estará constituida por los datos cuantitativos tomados en el área de mantenimiento de la planta de Efluentes, con una frecuencia diaria y consolidada mensualmente, a lo largo de 6 meses antes y 6 meses después de aplicar la mejora de planeación y control de los procesos de mantenimiento siendo la muestra igual a la población. Para realizar el análisis de datos, se utilizó el programa estadístico SPSS versión 22. Los resultados estadísticos de la comparación de medias que se realizaron con la prueba T student para muestras relacionadas en el pretest y postest donde se corrobora la aceptación de la hipótesis general, demostrando que la Planeación y Control mejora 9.1% en este año. También se confirma la aceptación de la hipótesis específica, demostrando que la Eficiencia mejora 7.3% este año, también se demuestra que la hipótesis especifica 2 Eficacia mejora un 15.7%

On the existence and uniqueness of limit cycles in planar continuous piecewise linear systems without symmetry

Some techniques to show the existence and uniqueness of limit cycles, typically stated for smooth vector fields, are extended to continuous piecewise-linear differential systems. New results are obtained for systems with three linearity zones without symmetry and having one equilibrium point in the central region. We also revisit the case of systems with only two linear zones giving shorter proofs of known results.Ministerio de Ciencia e InnovaciónFondo Europeo de Desarrollo RegionalAgència de Gestió d'Ajuts Universitaris i de RecercaInstitució Catalana de Recerca i Estudis AvançatsJunta de Andalucí

A Path Planning Algorithm for a Dynamic Environment Based on Proper Generalized Decomposition

[EN] A necessity in the design of a path planning algorithm is to account for the environment. If the movement of the mobile robot is through a dynamic environment, the algorithm needs to include the main constraint: real-time collision avoidance. This kind of problem has been studied by different researchers suggesting different techniques to solve the problem of how to design a trajectory of a mobile robot avoiding collisions with dynamic obstacles. One of these algorithms is the artificial potential field (APF), proposed by O. Khatib in 1986, where a set of an artificial potential field is generated to attract the mobile robot to the goal and to repel the obstacles. This is one of the best options to obtain the trajectory of a mobile robot in real-time (RT). However, the main disadvantage is the presence of deadlocks. The mobile robot can be trapped in one of the local minima. In 1988, J.F. Canny suggested an alternative solution using harmonic functions satisfying the Laplace partial differential equation. When this article appeared, it was nearly impossible to apply this algorithm to RT applications. Years later a novel technique called proper generalized decomposition (PGD) appeared to solve partial differential equations, including parameters, the main appeal being that the solution is obtained once in life, including all the possible parameters. Our previous work, published in 2018, was the first approach to study the possibility of applying the PGD to designing a path planning alternative to the algorithms that nowadays exist. The target of this work is to improve our first approach while including dynamic obstacles as extra parameters.This research was funded by the GVA/2019/124 grant from Generalitat Valenciana and by the RTI2018-093521-B-C32 grant from the Ministerio de Ciencia, Innovacion y Universidades.Falcó, A.; Hilario, L.; Montés, N.; Mora, MC.; Nadal, E. (2020). A Path Planning Algorithm for a Dynamic Environment Based on Proper Generalized Decomposition. Mathematics. 8(12):1-11. https://doi.org/10.3390/math8122245S111812Gonzalez, D., Perez, J., Milanes, V., & Nashashibi, F. (2016). A Review of Motion Planning Techniques for Automated Vehicles. IEEE Transactions on Intelligent Transportation Systems, 17(4), 1135-1145. doi:10.1109/tits.2015.2498841Rimon, E., & Koditschek, D. E. (1992). Exact robot navigation using artificial potential functions. IEEE Transactions on Robotics and Automation, 8(5), 501-518. doi:10.1109/70.163777Khatib, O. (1986). Real-Time Obstacle Avoidance for Manipulators and Mobile Robots. The International Journal of Robotics Research, 5(1), 90-98. doi:10.1177/027836498600500106Kim, J.-O., & Khosla, P. K. (1992). Real-time obstacle avoidance using harmonic potential functions. IEEE Transactions on Robotics and Automation, 8(3), 338-349. doi:10.1109/70.143352Connolly, C. I., & Grupen, R. A. (1993). The applications of harmonic functions to robotics. Journal of Robotic Systems, 10(7), 931-946. doi:10.1002/rob.4620100704Garrido, S., Moreno, L., Blanco, D., & Martín Monar, F. (2009). Robotic Motion Using Harmonic Functions and Finite Elements. Journal of Intelligent and Robotic Systems, 59(1), 57-73. doi:10.1007/s10846-009-9381-3Bai, X., Yan, W., Cao, M., & Xue, D. (2019). Distributed multi‐vehicle task assignment in a time‐invariant drift field with obstacles. IET Control Theory & Applications, 13(17), 2886-2893. doi:10.1049/iet-cta.2018.6125Bai, X., Yan, W., Ge, S. S., & Cao, M. (2018). An integrated multi-population genetic algorithm for multi-vehicle task assignment in a drift field. Information Sciences, 453, 227-238. doi:10.1016/j.ins.2018.04.044Falcó, A., & Nouy, A. (2011). Proper generalized decomposition for nonlinear convex problems in tensor Banach spaces. Numerische Mathematik, 121(3), 503-530. doi:10.1007/s00211-011-0437-5Chinesta, F., Leygue, A., Bordeu, F., Aguado, J. V., Cueto, E., Gonzalez, D., … Huerta, A. (2013). PGD-Based Computational Vademecum for Efficient Design, Optimization and Control. Archives of Computational Methods in Engineering, 20(1), 31-59. doi:10.1007/s11831-013-9080-xFalcó, A., Montés, N., Chinesta, F., Hilario, L., & Mora, M. C. (2018). On the Existence of a Progressive Variational Vademecum based on the Proper Generalized Decomposition for a Class of Elliptic Parameterized Problems. Journal of Computational and Applied Mathematics, 330, 1093-1107. doi:10.1016/j.cam.2017.08.007Domenech, L., Falcó, A., García, V., & Sánchez, F. (2016). Towards a 2.5D geometric model in mold filling simulation. Journal of Computational and Applied Mathematics, 291, 183-196. doi:10.1016/j.cam.2015.02.043Falcó, A., & Nouy, A. (2011). A Proper Generalized Decomposition for the solution of elliptic problems in abstract form by using a functional Eckart–Young approach. Journal of Mathematical Analysis and Applications, 376(2), 469-480. doi:10.1016/j.jmaa.2010.12.003Falcó, A., & Hackbusch, W. (2012). On Minimal Subspaces in Tensor Representations. Foundations of Computational Mathematics, 12(6), 765-803. doi:10.1007/s10208-012-9136-6Canuto, C., & Urban, K. (2005). Adaptive Optimization of Convex Functionals in Banach Spaces. SIAM Journal on Numerical Analysis, 42(5), 2043-2075. doi:10.1137/s0036142903429730Ammar, A., Chinesta, F., & Falcó, A. (2010). On the Convergence of a Greedy Rank-One Update Algorithm for a Class of Linear Systems. Archives of Computational Methods in Engineering, 17(4), 473-486. doi:10.1007/s11831-010-9048-

An Assessment for Roughhead Grenadier (Macrourus berglax) in NAFO Subareas 2 and 3.

It has been recognised that the recent catches of grenadiers by EU-Portugal and EU-Spain in Subarea 3, previously reported to NAFO as roundnose grenadiers, correspond to roughhead grenadier. Roughhead grenadier is taken as by-catch in the Greenland halibut fishery in the Regulatory Area mainly in Divisions 3LMN. Catches increased gradually and the largest proportion by country correspond to Spain and Portugal, with 6050 t. and 1089 t. respectively in 1998. A review of the biomass estimates from the available research surveys in Subareas 2 and 3 is presented. According to the Canadian fall surveys, it seems that the main part of the stock shifted from the northern Divisions (2GJand 3K) to the southern ones (3LN), and to greater depths (beyond 1000 m.) since early 90s. A review of the biological information available for this stock is also presented. Mean lengths (preanal fin lengths) of the catches show no decreasing trend since 1995. The age o fully recruitment to the fishery is 8, and the total mortality estimate (1997-1998) is Z = 0.43. Female age at maturity is 15, corresponding to a PFL of 26.5 cm. The Canadian fall survey series seems to be the best input for the assessment of this stock. At present the higher part of biomass is found in Div. 3L and 3N and at depths between 1000-1200 m. A yield per recruit has been performed using the input data presented in table 13. The partial recruitment vector comes from Cárdenas et al. (1995), The maturity curve at age from Murua and Motos (1997) and the mean weight at age from the 1998 agelength key. M is assumed as constant through the ages with a value of 0.2. The results of the yield per recruit analysis appears in Fig. 6. The estimated Fmax is 0.27 and F0.1 is 0.13. However it must be noted that this output is sensitive to possible changes in M, as if for instance M would be different between sexes, as suggest the results from Murua et al. (1999) and as it has been shown in the Greenland halibut (Anon. 1998). Any decreasing trend in the mean lengths, that would be an index of an excessive fishing pressure, is observed in the mean lengths of the catches since 1995 up to now. The available time series of catches at age is too short to analyse trends in the SSB, however it can be noted that only a 18 % and 10 % percent of the 1997 and 1998 catches respectively were above the female age at maturity (15 years). We have scarce information at the moment to assess an appropriate exploitation level, though survey series shows that at the current exploitation rate the biomass is increasing since 1994

Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering

The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to precisely evaluate each clone and subclone of IPS cells for their safety and efficacy. Additionally, the current state of knowledge on IPS cells advises that research on their regenerative properties is carried out in appropriate tissue and organ systems that permit a safe assessment of the long-term behavior of these reprogrammed cells. In the present paper, we discuss the mechanisms of cell reprogramming, current technical limitations of IPS cells for their use in human tissue engineering, and possibilities to overcome them in the particular case of dental regeneration