Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure.

Hepatitis B virus (HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma (HCC). During the last two decades, with the use of currently available anti-HBV therapies (lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBV-associated HCC (HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA (cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure (loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV

Pattern Formation in a Two-Dimensional Array of Oscillators with Phase-Shifted Coupling

We investigate the dynamics of a two-dimensional array of oscillators with phase-shifted coupling. Each oscillator is allowed to interact with its neighbors within a finite radius. The system exhibits various patterns including squarelike pinwheels, (anti)spirals with phase-randomized cores, and antiferro patterns embedded in (anti)spirals. We consider the symmetry properties of the system to explain the observed behaviors, and estimate the wavelengths of the patterns by linear analysis. Finally, we point out the implications of our work for biological neural networks

IMECE2011-64507 MASS-AREA METHOD TO MEASURE THE CONTACT ANGLE ON HYDROPHILIC SURFACES

ABSTRACT A mass-area method is proposed to overcome problems in the measurement of the equilibrium contact angles for rough and hydrophilic surfaces. A goniometer usually measures the contact angle at the top plane of a rough surface, not the contact line of the solid-liquid interface. The present method estimates the contact angle indirectly from the volume of the liquid and the size of the contact area, assuming a spherical cap and consistent with a minimization of the free energy. The present method shows a roughly linear relationship with measurements by a goniometer for smooth surfaces of various solid materials with various liquids, but the goniometer measurements are smaller. An example test and the error of the present measurement method are presented and discussed

Time-delayed Spatial Patterns in a Two-dimensional Array of Coupled Oscillators

We investigated the effect of time delays on phase configurations in a set of two-dimensional coupled phase oscillators. Each oscillator is allowed to interact with its neighbors located within a finite radius, which serves as a control parameter in this study. It is found that distance-dependent time-delays induce various patterns including traveling rolls, square-like and rhombus-like patterns, spirals, and targets. We analyzed the stability boundaries of the emerging patterns and briefly pointed out the possible empirical implications of such time-delayed patterns.Comment: 5 Figure

Solitary Dust--Acoustic Waves in a Plasma with Two-Temperature Ions and Distributed Grain Size

The propagation of weakly nonlinear dust--acoustic waves in a dusty plasma containing two ion species with different temperatures is explored. The nonlinear equations describing both the quadratic and cubic plasma nonlinearities are derived. It is shown that the properties of dust--acoustic waves depend substantially on the grain size distribution. In particular, for solitary dust--acoustic waves with a positive potential to exist in a plasma with distributed grain size, it is necessary that the difference between the temperatures of two ion species be large that that in the case of unusized grains.Comment: 16 pages, 6 figure

Modelling tsunami inundation on coastlines with characteristic form

This paper provides an indication of the likely difference in tsunami amplification and dissipation between different characteristic coastal embayments, coastal entrances and estuaries. Numerical modeling is performed with the ANU/Geoscience Australia tsunami inundation model. Characteristic coastal morphology is represented by simpler generic morphological shapes which can be applied easily in the ANUGA model, such that key non-dimensional parameters (e.g. embayment depth/bay width) can be varied. Modeling is performed with a range of bay shapes, seabed gradient and different incident tsunami wave shapes and wave angles, including sine waves, solitary waves and leading depression Nwaves. The results show a complex pattern for both large and small embayments, with wave breaking an important control on the amplification of the wave between the 20m contour and the shore. For large embayments, the wave run-up can be amplified by a factor six in comparison to the amplitude at the model boundary. For small embayments, the amplification is dependent on the location of the ocean water line, or tidal stage

Nearest pattern interaction and global pattern formation

We studied the effect of nearest pattern interaction on a globally pattern formation in a 2-dimensional space, where patterns are to grow initially from a noise in the presence of periodic supply of energy. Although our approach is general, we found that this study is relevant in particular to the pattern formation on a periodically vibrated granular layer, as it gives a unified perspective of the experimentally observed pattern dynamics such as oscillon and stripe formations, skew-varicose and crossroll instabilities, and also a kink formation and decoration

Positive psychology of Malaysian students: impacts of engagement, motivation, self-compassion and wellbeing on mental health

Malaysia plays a key role in education of the Asia Pacific, expanding its scholarly output rapidly. However, mental health of Malaysian students is challenging, and their help-seeking is low because of stigma. This study explored the relationships between mental health and positive psychological constructs (academic engagement, motivation, self-compassion, and wellbeing), and evaluated the relative contribution of each positive psychological construct to mental health in Malaysian students. An opportunity sample of 153 students completed the measures regarding these constructs. Correlation, regression, and mediation analyses were conducted. Engagement, amotivation, self-compassion, and wellbeing were associated with, and predicted large variance in mental health. Self-compassion was the strongest independent predictor of mental health among all the positive psychological constructs. Findings can imply the strong links between mental health and positive psychology, especially selfcompassion. Moreover, intervention studies to examine the effects of self-compassion training on mental health of Malaysian students appear to be warranted.N/

IgG4-related diseases: state of the art on clinical practice guidelines

Immunoglobulin G4-related diseases (IgG4-RD) are a group of chronic relapsing-remitting inflammatory conditions, characterised by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, fibrosis and a usually favourable response to steroids. In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the European Reference Network ReCONNET, aimed at evaluating existing clinical practice guidelines (CPGs) and recommendations in IgG4-RD. From 167 publications initially obtained from a systematic literature search, only one was identified as a systematic multispecialist, evidence-based, consensus guidance statement on diagnosis and treatment of IgG4-RD, which may be recommended for use as CPG in IgG4-RD. With the recognition of a limited evidence based in this increasingly recognised disease, the group discussion has identified the following unmet needs: lack of shared classification criteria, absence of formal guidelines on diagnosis, no evidence-based therapeutic recommendations and lack of activity and damage indices. Areas of unmet needs include the difficulties in diagnosis, management and monitoring and the scarcity of expert centre