150 research outputs found
Probing Bino-Wino Coannihilation at the LHC
We study bino-wino coannihilation scenario in the so-called spread or
mini-split supersymmetry. We show that, in this model, a neutral wino has a
macroscopic decay length in a wide range of parameter space. This
characteristic feature could be observed as a displaced vertex plus missing
transverse energy event at the LHC. In this paper, we study the current
constraints and future prospects on the scenario based on the displaced vertex
search performed by the ATLAS collaboration. It is found that a sizable
parameter region can be probed at the 8 TeV LHC run. This search strategy will
considerably extend its reach at the next stage of the LHC running, and thus
play a crucial role to examine a possibility of bino dark matter in the
mini-split type supersymmetric models.Comment: 21 pages, 7 figures; version accepted for publication in JHE
Higgsino Dark Matter or Not: Role of Disappearing Track Searches at the LHC and Future Colliders
Higgsino in supersymmetric standard models is known to be a promising
candidate for dark matter in the Universe. Its phenomenological property is
strongly affected by the gaugino fraction in the Higgsino-like state. If this
is sizable, in other words, if gaugino masses are less than TeV,
we may probe the Higgsino dark matter in future non-accelerator experiments
such as dark matter direct searches and measurements of electric dipole
moments. On the other hand, if gauginos are much heavier, then it is hard to
search for Higgsino in these experiments. In this case, due to a lack of
gaugino components, the mass difference between the neutral and charged
Higgsinos is uniquely determined by electroweak interactions to be around
MeV, which makes the heavier charged state rather long-lived, with a decay
length of about cm. In this letter, we argue that a charged particle with a
flight length of cm can be probed in disappearing-track searches
if we require only two hits in the pixel detector. Even in this case, we can
reduce background events with the help of the displaced-vertex reconstruction
technique. We study the prospects of this search strategy at the LHC and future
colliders for the Higgsino dark matter scenario. It is found that an almost
pure Higgsino is indeed within the reach of the future TeV collider
experiments. We then discuss that the interplay among collider and
non-accelerator experiments plays a crucial role in testing the Higgsino dark
matter scenarios. Our strategy for disappearing-track searches can also enlarge
the discovery potential of pure wino dark matter as well as other
electroweak-charged dark matter candidates.Comment: 7 pages, 3 figure
Extending the LHC Reach for New Physics with Sub-Millimeter Displaced Vertices
Particles with a sub-millimeter decay length appear in many models of physics
beyond the Standard Model. However, their longevity has been often ignored in
their LHC searches and they have been regarded as promptly-decaying particles.
In this letter, we show that, by requiring displaced vertices on top of the
event selection criteria used in the ordinary search strategies for
promptly-decaying particles, we can considerably extend the LHC reach for
particles with a decay length of . We discuss a way of
reconstructing sub-millimeter displaced vertices by exploiting the same
technique used for the primary vertex reconstruction on the assumption that the
metastable particles are always pair-produced and their decay products contain
high- jets. We show that, by applying a cut based on displaced
vertices on top of standard kinematical cuts for the search of new particles,
the LHC reach can be significantly extended if the decay length is . In addition, we may measure the lifetime of the target
particle through the reconstruction of displaced vertices, which plays an
important role in understanding the new physics behind the metastable
particles.Comment: 18 pages, 6 figure
Looking for the left sneutrino LSP with displaced-vertex searches
We analyze a displaced dilepton signal expected at the LHC for a tau left
sneutrino as the lightest supersymmetric particle with a mass in the range
- GeV. The sneutrinos are pair produced via a virtual , or
in the channel and, given the large value of the tau Yukawa
coupling, their decays into two dileptons or a dilepton plus missing transverse
energy from neutrinos can be significant. The discussion is carried out in the
SSM, where the presence of -parity violating couplings involving
right-handed neutrinos solves the problem and can reproduce the neutrino
data. To probe the tau left sneutrinos we compare the predictions of the SSM with the ATLAS search for long-lived particles using displaced lepton
pairs in collisions at TeV, allowing us to constrain the
parameter space of the model. We also consider an optimization of the trigger
requirements used in existing displaced-vertex searches by means of a High
Level Trigger that exploits tracker information. This optimization is
generically useful for a light metastable particle decaying into soft charged
leptons. The constraints on the sneutrino turn out to be more stringent. We
finally discuss the prospects for the TeV LHC searches as well as further
potential optimizations.Comment: Version published in PRD, discussions expanded, references added, LEP
and LHC constraints discussed in more detail, 29 pages, 9 figures, 9 table
Searching for Metastable Particles with Sub-Millimeter Displaced Vertices at Hadron Colliders
A variety of new-physics models predict metastable particles whose decay
length is mm. Conventional displaced-vertex searches are less
sensitive to this sub-millimeter decay range, and thus such metastable
particles have been looked for only in usual prompt decay searches. In this
paper, we show that an additional event-selection cut based on the vertex
reconstruction using charged tracks considerably improves the sensitivity of
ordinary searches which rely only on kinematic selection criteria, for
particles with a decay length of . To that end, we
consider a metastable gluino as an example, and study the impact of this new
event-selection cut on gluino searches at the LHC by simulating both the signal
and Standard Model background processes. Uncertainty of the displaced-vertex
reconstruction due to the limited resolution of track reconstruction is taken
into account. We also discuss possibilities for optimization of the kinematic
selection criteria, which takes advantage of significant reduction of
background through the requirement of displaced vertices. In addition, we
demonstrate that using the method discussed in this paper it is possible to
measure the lifetime of metastable particles with an accuracy at
the high-luminosity LHC. Implications for a future 100 TeV collider are also
studied, where produced particles tend to be more boosted and thus it is easier
to detect the longevity of metastable particles.Comment: 55 pages, 24 figure
Cornering Higgsino: Use of Soft Displaced Track
Higgsino has been intensively searched for in the LHC experiments in recent
years. Currently, there is an uncharted region beyond the LEP Higgsino mass
limit where the mass splitting between the neutral and charged Higgsinos is
around - GEV, which is unexplored by either the soft di-lepton or
disappearing track searches. This region is, however, of great importance from
a phenomenological point of view, as many supersymmetric models predict such a
mass spectrum. In this letter, we propose a possibility of filling this gap by
using a soft micro-displaced track on top of the mono-jet event selection,
which allows us to discriminate a signature of the charged Higgsino decay from
the Standard Model background. It is found that this new strategy is
potentially sensitive to a Higgsino mass of GeV at the
LHC Run 2 (HL-LHC) for a charged-neutral mass splitting of GeV.Comment: 6 pages, 2 figure
Antidepressants Inhibit P2X4 Receptor Function: a Possible Involvement in Neuropathic Pain Relief
BACKGROUND: Neuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to known treatments such as non-steroidal anti-inflammatory drugs or even opioids. It has been reported that some antidepressants are effective for treating neuropathic pain. However, the underlying molecular mechanisms are not well understood. We have recently demonstrated that blocking P2X(4 )receptors in the spinal cord reverses tactile allodynia after peripheral nerve injury in rats, implying that P2X(4 )receptors are a key molecule in neuropathic pain. We investigated a possible role of antidepressants as inhibitors of P2X(4 )receptors and analysed their analgesic mechanism using an animal model of neuropathic pain. RESULTS: Antidepressants strongly inhibited ATP-mediated Ca(2+ )responses in P2X(4 )receptor-expressing 1321N1 cells, which are known to have no endogenous ATP receptors. Paroxetine exhibited the most powerful inhibition of calcium influx via rat and human P2X(4 )receptors, with IC(50 )values of 2.45 μM and 1.87 μM, respectively. Intrathecal administration of paroxetine produced a striking antiallodynic effect in an animal model of neuropathic pain. Co-administration of WAY100635, ketanserin or ondansetron with paroxetine induced no significant change in the antiallodynic effect of paroxetine. Furthermore, the antiallodynic effect of paroxetine was observed even in rats that had received intrathecal pretreatment with 5,7-dihydroxytryptamine, which dramatically depletes spinal 5-hydroxytryptamine. CONCLUSION: These results suggest that paroxetine acts as a potent analgesic in the spinal cord via a mechanism independent of its inhibitory effect on serotonin transporters. Powerful inhibition on P2X(4 )receptors may underlie the analgesic effect of paroxetine, and it is possible that some antidepressants clinically used in patients with neuropathic pain show antiallodynic effects, at least in part via their inhibitory effects on P2X(4 )receptors
Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays
A growing body of evidence indicates that P2X receptors (P2XRs), a family of ligand-gated cation channels activated by extracellular ATP, play an important role in pain signaling. In contrast to the role of the P2X3R subtype that has been extensively studied, the precise roles of others among the seven P2XR subtypes (P2X1R-P2X7R) remain to be determined because of a lack of sufficiently powerful tools to specifically block P2XR signaling in vivo. In the present study, we investigated the behavioral phenotypes of a line of mice in which the p2rx4 gene was disrupted in a series of acute and chronic pain assays. While p2rx4-/- mice showed no major defects in pain responses evoked by acute noxious stimuli and local tissue damage or in motor function as compared with wild-type mice, these mice displayed reduced pain responses in two models of chronic pain (inflammatory and neuropathic pain). In a model of chronic inflammatory pain developed by intraplantar injection of complete Freund's adjuvant (CFA), p2rx4-/- mice exhibited attenuations of pain hypersensitivity to innocuous mechanical stimuli (tactile allodynia) and also of the CFA-induced swelling of the hindpaw. A most striking phenotype was observed in a test of neuropathic pain: tactile allodynia caused by an injury to spinal nerve was markedly blunted in p2rx4-/- mice. By contrast, pain hypersensitivity to a cold stimulus (cold allodynia) after the injury was comparable in wild-type and p2rx4-/- mice. Together, these findings reveal a predominant contribution of P2X4R to nerve injury-induced tactile allodynia and, to the lesser extent, peripheral inflammation. Loss of P2X4R produced no defects in acute physiological pain or tissue damaged-induced pain, highlighting the possibility of a therapeutic benefit of blocking P2X4R in the treatment of chronic pain, especially tactile allodynia after nerve injury
Sampling the μν SSM for displaced decays of the tau left sneutrino LSP at the LHC
Within the framework of the μνSSM , a displaced dilepton signal is expected at the LHC from the decay of a tau left sneutrino as the lightest supersymmetric particle (LSP) with a mass in the range 45–100 GeV. We compare the predictions of this scenario with the ATLAS search for long-lived particles using displaced lepton pairs in pp collisions, considering an optimization of the trigger requirements by means of a high level trigger that exploits tracker information. The analysis is carried out in the general case of three families of right-handed neutrino superfields, where all the neutrinos get contributions to their masses at tree level. To analyze the parameter space, we sample the μνSSM for a tau left sneutrino LSP with proper decay length cτ>0.1mm using a likelihood data-driven method, and paying special attention to reproduce the current experimental data on neutrino and Higgs physics, as well as flavor observables. The sneutrino is special in the μνSSM since its couplings have to be chosen so that the neutrino oscillation data are reproduced. We find that important regions of the parameter space can be probed at the LHC run 3.Fil: Kpatcha, Essodjolo. Universidad Autónoma de Madrid; EspañaFil: Lara, Iñaki. Universidad Autónoma de Madrid; España. Institute for Basic Science. Center for Theoretical Physics of the Universe; Corea del NorteFil: Lopez, Daniel Elbio. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Muñoz, Carlos. Universidad Autónoma de Madrid; EspañaFil: Nagata, Natsumi. University Of Tokyo; JapónFil: Otono, Hidetoshi. Kyushu University; JapónFil: de Austri, Roberto Ruiz. Instituto de Física Corpuscular; Españ
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