Alien Registration- Heward, Richard W. (Westbrook, Cumberland County)

https://digitalmaine.com/alien_docs/20111/thumbnail.jp

Momentum-space engineering of gaseous Bose-Einstein condensates

We show how the momentum distribution of gaseous Bose--Einstein condensates can be shaped by applying a sequence of standing-wave laser pulses. We present a theory, whose validity for was demonstrated in an earlier experiment [L.\ Deng, et al., \prl {\bf 83}, 5407 (1999)], of the effect of a two-pulse sequence on the condensate wavefunction in momentum space. We generalize the previous result to the case of $N$ pulses of arbitrary intensity separated by arbitrary intervals and show how these parameters can be engineered to produce a desired final momentum distribution. We find that several momentum distributions, important in atom-interferometry applications, can be engineered with high fidelity with two or three pulses.Comment: 13 pages, 4 figure

Symmetry-Breaking and Symmetry-Restoring Dynamics of a Mixture of Bose-Einstein Condensates in a Double Well

We study the coherent nonlinear tunneling dynamics of a binary mixture of Bose-Einstein condensates in a double-well potential. We demonstrate the existence of a new type of mode associated with the "swapping" of the two species in the two wells of the potential. In contrast to the symmetry breaking macroscopic quantum self-trapping (MQST) solutions, the swapping modes correspond to the tunneling dynamics that preserves the symmetry of the double well potential. As a consequence of two distinct types of broken symmetry MQST phases where the two species localize in the different potential welils or coexist in the same well, the corresponding symmetry restoring swapping modes result in dynamics where the the two species either avoid or chase each other. In view of the possibility to control the interaction between the species, the binary mixture offers a very robust system to observe these novel effects as well as the phenomena of Josephson oscillations and pi-mode

Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage

Objective To identify long noncoding RNAs (lncRNAs), including long intergenic noncoding RNAs (lincRNAs), antisense RNAs, and pseudogenes, associated with the inflammatory response in human primary osteoarthritis (OA) chondrocytes and to explore their expression and function in OA. Methods OA cartilage was obtained from patients with hip or knee OA following joint replacement surgery. Non-OA cartilage was obtained from postmortem donors and patients with fracture of the neck of the femur. Primary OA chondrocytes were isolated by collagenase digestion. LncRNA expression analysis was performed by RNA sequencing (RNAseq) and quantitative reverse transcriptase-polymerase chain reaction. Modulation of lncRNA chondrocyte expression was achieved using LNA longRNA GapmeRs (Exiqon). Cytokine production was measured with Luminex. Results RNAseq identified 983 lncRNAs in primary human hip OA chondrocytes, 183 of which had not previously been identified. Following interleukin-1β (IL-1β) stimulation, we identified 125 lincRNAs that were differentially expressed. The lincRNA p50-associated cyclooxygenase 2-extragenic RNA (PACER) and 2 novel chondrocyte inflammation-associated lincRNAs (CILinc01 and CILinc02) were differentially expressed in both knee and hip OA cartilage compared to non-OA cartilage. In primary OA chondrocytes, these lincRNAs were rapidly and transiently induced in response to multiple proinflammatory cytokines. Knockdown of CILinc01 and CILinc02 expression in human chondrocytes significantly enhanced the IL-1-stimulated secretion of proinflammatory cytokines. Conclusion The inflammatory response in human OA chondrocytes is associated with widespread changes in the profile of lncRNAs, including PACER, CILinc01, and CILinc02. Differential expression of CILinc01 and CIinc02 in hip and knee OA cartilage, and their role in modulating cytokine production during the chondrocyte inflammatory response, suggest that they may play an important role in mediating inflammation-driven cartilage degeneration in OA

Doing gender locally: The importance of ‘place’ in understanding marginalised masculinities and young men’s transitions to ‘safe’ and successful futures

Observable anxieties have been developing about the position of boys and young men in contemporary society in recent years. This is expressed as a crisis of masculinity, in which place is often implicitly implicated, but is rarely considered for its role in the shaping of young men’s practices, trajectories and aspirations. Drawing on research conducted with young people who accessed a range of social care support services, this article argues that transition means different things for young men in different locales and that local definitions of masculinity are required to better understand young men’s lives and the opportunities available to them. The authors argue that home life, street life, individual neighbourhoods, regions and nations all shaped the young men’s identities and the practices they (and the staff working with them) drew on in order to create successful futures and ‘safe’ forms of masculinity. It is suggested that this place-based approach has the potential to re-shape the ‘crisis’ discourse surrounding masculinity and the anxieties associated with young men

Bringing pupils into the ORBYTS of research

Most scientists would consider themselves lucky to publish a research paper while still an undergraduate, but a group of pupils at Highams Park School in East London has co-authored a paper at age 18, thanks to ORBYTS. Original Research By Young Twinkle Scientists (ORBYTS) comprises the core part of EduTwinkle, the education and outreach arm of the upcoming exoplanet space mission Twinkle, led by UK scientists and engineers, and is aimed at A-level students. ORBYTS was founded in 2016 by Clara Sousa-Silva, who was splitting her time teaching at Highams Park School and working as a postdoc at University College London, via the Researchers in Schools programme. This blend of education and research inspired her to set up a scheme enabling young postdoc and PhD students from her research group at UCL, ExoMol, to perform novel research with some of her sixth-form students. ORBYTS now involves more than 30 pupils in eight schools across the UK

Sorl1 as an Alzheimer's disease predisposition gene?

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) epsilon4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval