Creating the on-line documentary: a satellite solution

[Abstract]: The online documentary, A Satellite Solution, is a case study investigation into how digital communications (primarily satellite TV) have impacted the quality of life of a rural community comprising 50 households in southeast Queensland (Australia) between 1999 and 2006. The production depicts a community-mediated process by which these residents adopted and then responded to receiving free-to-air TV services for the first time. The author, instigated and facilitated the project in the community and as well, recorded and produced all the material contained in the in the documentary. The paper will highlight the production components of the research set against the context of this participatory activity.This online documentary is a web site containing research materials (policy documents, significant correspondence and reports) video interviews and location sequences, maps and technical information such as, how to install a satellite system, where to find free-to-air satellite services and what satellite broadband incentives are available etc. Importantly it also represents innovation in film and television and particularly, the researcher's selected art form, the documentary. This paper, takes a practice focus and will document the production of the web site and how this new form impacts on the production style of traditional linear production and as well, what filmmakers working in this emerging non-linear form may need to plan for. This project formed the practical component for a recently completed research degree, Doctor of Visual Arts (Griffith), by the author

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

Developing a mindset for a digital future: the importance of recognising and encouraging innovation, experimentation and support

There is an urgency to adjust the way Australians think about and respond to digital technologies. In all forms of information processing the current growth rate is nearing exponential. Together with the anticipated convergence of new technologies and the subsequent transformational reach of change into all aspects of our daily lives, whether culturally, socially or technologically, Australians are going to need urgent support to handle the revolution at their doorstep. I suggest also that these citizens should be openly encouraged to contribute innovative ideas as to how these ubiquitous new tools might be used. An analogue past relied on straight-line logic and linear presentation whereas the contemporary digital future will require Australians to evolve and practise a versatile non-linear ethos in order to successfully engage and exploit it for its creative potential. Using a practice focus this paper will draw upon research findings (inductive reasoning) from my recent work conducted in both secondary and tertiary teaching in media production as well as my facilitation (participant observation) of a small rural community's attempts to establish a self-help satellite television service. This research is supported by my thirty-four years of production experience in the Australian Television and Video industry. This paper suggests that, due to the all pervasive spread of digital technologies into every facet of life, people over 25 years of age, that is those not of the net generation, are likely to need remedial help with digital uptake. Further it argues, that recognizing and addressing the need to understand this complex phenomenon is a major step towards integrating it into our lives

Building quality production outcomes in undergraduate screen media group production courses: a case study

Undergraduate university productions in screen media have consistently proved problematic in achieving quality production outcomes, particularly in group production courses. Historically most universities and film schools have long debated the question of what quality to expect from student productions and how to best assess their work at this level. This paper provides a case study account of the authors’ efforts to improve the standard of third year student productions in the Bachelor of Creative Arts (BCA) at the University of Southern Queensland. During the creation of two films Emerge (Hetherington, et al., 2016) and City Fragments Toowoomba (Hetherington, et al., 2016) the authors focused on production quality, the student experience of industry practice, and working collaboratively. These efforts were underpinned by the belief that time management needed to reflect industry practice, rather than academic constraints and an un-interrogated valuing of collaboration. As well as providing creative skill development, this research found that improving time management strategies and working collaboratively provides for a more realistic experiential learning atmosphere

Accepting Authoritative Decisions: Humans as Wary Cooperators

Why are people more willing to accept some governmental decisions than others? In this article, we present results from a series of original experiments showing that people’s reactions to a given outcome are heavily influenced by the procedure employed to produce the outcome.We find that subjects reactmuch less favorably when a decision maker intentionally keeps a large payoff, thereby leaving the subject with a small payoff, than when that same payoff results from a procedure based on chance or on desert. Moreover, subjects react less favorably to outcomes rendered by decision makers who want to be decision makers than they do to identical outcomes selected by reluctant decision makers. Our results are consistent with increasingly prominent theories of behavior emphasizing people’s aversion to being played for a “sucker,” an attitude that makes perfect sense if people’s main goal is not to acquire as many tangible goods as possible but to make sure they are a valued part of a viable group composed of cooperative individuals

Institutional Trust and Subjective Well-Being across the EU

This paper analyzes the impact of institutions upon happiness through their intermediary impact upon individual trust. The empirical work is based on Eurobarometer data covering the 15 countries of the EU prior to its expansion in 2004. With respect to trust, we present evidence that, although it is endogenous with respect to the performance of the institution, changes in the individual's personal circumstances can also have an impact, indicating that trust is not simply learned at an early age. Hence unemployed people tend to have lower levels of trust not only in the main economic institutions - government and the Central Bank - but in other state institutions too such as the police and the law. Trust also differs in a systematic manner with respect to education and household income, increases (decreases) in either increase (decrease) trust in most institutions. If we assume that more educated people make better judgments, this suggests that on average people tend to have too little trust in institutions. However, it is also possible that both of these variables impact on the interaction between institutions such as the police and other government agencies and the citizen, with prosperous, well educated people being at an advantage and possibly able to command more respect. Age too impacts on institutional trust. For the UN, the unions, big business, voluntary organizations and the EU, trust first declines and then increases with the estimated turning points ranging between 44 and 56 years. For most other organizations trust significantly increases with age. Turning to subjective well-being, we find the standard set of socio-economic variables to be significant. But the focus here is on the impact of institutional trust. We find that trust (mistrust) in the European Central Bank, the EU, national government, the law and the UN all impact positively (negatively) on well-being. Hence overall our results support the conclusion that happiness does not solely lie within the realm of the individual, but that institutional performance also has a direct impact upon subjective well-being. Copyright 2006 Blackwell Publishing Ltd..