Etatverteilung 2020: Die Universitätsbibliothek der Humboldt-Universität zu Berlin modifiziert ihr Etatverteilungsmodell

Angesichts veränderter Publikations- und Rezeptionsprozesse hat die Universitätsbibliothek der Humboldt-Universität ihr bewährtes Etatverteilungsmodell erneut modifiziert. Sie verzichtet zukünftig darauf, den Bedarf an gedruckten und elektronischen Medien getrennt zu berechnen, sondern führt beide Literaturformen in ihrem Berechnungsmodell wieder enger zusammen. Grundlage dafür sind eine neue Datenbasis im Bereich von Preisindizes und die äquivalente Betrachtung wissenschaftlicher Inhalte unabhängig von ihrer Erscheinungsform als Print- oder digitale Produkte.In consideration of changing publication and reception processes, the library of the Humboldt-Universität has adapted its established budget distribution model. The demand for printed and electronic media will no longer be calculated separately but in a modified model, where both forms of literature will be reflected jointly. The basis for this model is given by new data in the area of price indices as well as the consideration of scientific content regardless of its respective publication form as print or digital product

Timescales of self-healing in human bone tissue and polymeric ionic liquids

Strain (stress-free) relaxation in mechanically prestrained bone has a time constant of 75 s. It occurs by a reorganization of the proteoglycan-glycoprotein matrix between collagen fibers, which requires ionic interactions. Dissolving and relinking the ionic bonds is thus an important tool of nature to enable plastic deformation and to develop self-healing tissues. A way to transfer this approach to technical materials is the attachment of ionic end groups to polymeric chains. In these classes of materials, the so-called polymeric ionic liquids, structural recovery of thermally disorganized material is observed. A time constant between minutes and a week could be achieved, also by ionic rearrangement. The same mechanism, rearrangement of ionic bonds, can lead to vastly different relaxation times when the ionic interaction is varied by exchange of the cationic end groups or the anions

Fertility education for adolescent cancer patients: Gaps in current clinical practice in Europe

Objective: As adolescent cancer patients may suffer from infertility following treatment, fertility counselling is essential. Our aim was to explore the current situation in four European countries in terms of (I) education about the risk for infertility, (II) counselling on fertility preservation, (III) patients' knowledge on fertility, (IV) sufficiency of information and (V) uptake of cryopreservation. Methods: In total, 113 patients (13–20 years) at 11 study centres completed a self-report questionnaire three and six months after cancer diagnosis. Multivariate logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (CI). Results: As many as 80.2% of participants reported having received education about the risk for infertility prior to treatment, 73.2% recalled counselling on fertility preservation. Only 52.3% stated they felt sufficiently informed to make a decision. Inability to recall counselling on fertility preservation (OR = 0.03, CI: 0.00–0.47) and female gender (OR = 0.11, CI: 0.03–0.48) was associated with lower use of cryopreservation, whereas older age was associated with higher use. Conclusion: Fertility counselling was available to a relatively high proportion of patients, and it did influence the utilisation of cryopreservation. However, many patients did not feel sufficiently informed. Further improvement is needed to enable adolescent cancer patients to make an informed decision on fertility preservation

Austrian Research and Technology Report 2022

Der Forschungs-und Technologiebericht 2022 gibt einen Überblick über die aus Bundesmitteln geförderte Forschung, Technologie und Innovation (FTI) in Österreich. Neben der Darstellung aktueller forschungspolitischer Entwicklungen, die den Stand der Umsetzung der mit Ende 2020 verabschiedeten FTI-Strategie 2030, forschungsrelevante Teilstrategien und neueste Entwicklungen im Hochschulbereich behandelt, werden auf Grundlage rezenter Daten aus diversen internationalen Rankings, aus der F&E (Forschung & Entwicklung)-Erhebung 2019 und der Globalschätzung 2022 Analysen zur nationalen und internationalen FTI-Performance Österreichs erstellt

Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

<p>Abstract</p> <p>Background</p> <p>Down syndrome (DS; trisomy 21) is the most common genetic cause of mental retardation in the human population and key molecular networks dysregulated in DS are still unknown. Many different experimental techniques have been applied to analyse the effects of dosage imbalance at the molecular and phenotypical level, however, currently no integrative approach exists that attempts to extract the common information.</p> <p>Results</p> <p>We have performed a statistical meta-analysis from 45 heterogeneous publicly available DS data sets in order to identify consistent dosage effects from these studies. We identified 324 genes with significant genome-wide dosage effects, including well investigated genes like <it>SOD1</it>, <it>APP</it>, <it>RUNX1 </it>and <it>DYRK1A </it>as well as a large proportion of novel genes (N = 62). Furthermore, we characterized these genes using gene ontology, molecular interactions and promoter sequence analysis. In order to judge relevance of the 324 genes for more general cerebral pathologies we used independent publicly available microarry data from brain studies not related with DS and identified a subset of 79 genes with potential impact for neurocognitive processes. All results have been made available through a web server under <url>http://ds-geneminer.molgen.mpg.de/</url>.</p> <p>Conclusions</p> <p>Our study represents a comprehensive integrative analysis of heterogeneous data including genome-wide transcript levels in the domain of trisomy 21. The detected dosage effects build a resource for further studies of DS pathology and the development of new therapies.</p

Neue Kooperationsformen im Wissensmanagement an der Humboldt- Universität zu Berlin

Wissen – eine Ressource die an Hochschulen in Überfluss vorhanden sein müsste – ist in wissensintensiven Unternehmen schon seit Jahren Gegenstand von Managementbemühungen. An Hochschulen findet aber solch ein Wissensmanagement kaum statt. Diese Arbeit stellt anhand des Wissensmanagement-Kreislaufes von G. Probst die Möglichkeiten dar, die Zentraleinrichtungen an Hochschulen zur Unterstützung von Wissensmanagement haben und illustriert sie mit derzeitigen Projekten an der Humboldt-Universität zu Berlin