Eiger triggers death from afar

Cells undergoing programmed cell death release signals that can trigger the death of cells at remote locations.Peer Reviewe

Gold-catalyzed 1, 3-Thiazine formation and uncommon tautomer isolation

This work represents the first example of a gold-catalyzed formation of 1, 3-thiazine/1, 3-thiazinane by means of a catalytic approach and further uncommon isolation of the two tautomers. The developed protocol gives rise to a broad scope of 1, 3-thiazine derivatives with excellent yields in short reaction times. Interestingly, different isomers could be obtained depending on the state of the compound, and in the crystal state the 1, 3-thiazinane isomer is obtained, while in solution the 1, 3-thiazine is the unique isomer. This work represents an interesting approach for the synthesis of potential biologically relevant molecules and a crucial precedent in tautomerism isolation and characterization. © 2022 American Chemical Society. All rights reserved

Effect of gypsum content in sprayed cementitious matrices: Early age hydration and mechanical properties

© 2018 Elsevier Ltd Sprayed materials must present short setting times and a fast early strength development for safety and productivity reasons. In order to improve these characteristics, the construction industry has focused on the development of new formulations of accelerators. Research and improvement of other components of the mix, such as cement or additions, have not advanced at the same rate despite being also crucial for the reaction kinetics. The objective of this work is to evaluate the influence of gypsum content on the hydration and mechanical strength development in sprayed mixes. Sprayed pastes and mortars were prepared with one type of cement, two types of accelerators and different gypsum contents. Kinetics, mechanisms of hydration and mechanical properties were evaluated. Results showed a better performance in sprayed mixes that contain ideal doses of gypsum. Such approach provides valuable information for the improvement of the formulation of cement used in sprayed concrete applications

Selecting Undergraduate Students as Library Research Subjects from a Diversity Perspective

Undergraduate students are usually the largest populations in higher education institutions. More information about qualitative aspects of learning practices and deeper knowledge about student needs is necessary to understand and promote a more implicated role of libraries in undergraduate student learning. The project reported at this poster is developed by researchers from two private universities libraries in Mexico. The research methodology used is mixed. After analysis and discussion of initial data some student’s characteristics were established as diversity markers which we expect will facilitate to select students for deep interview in order to listen the variety of undergraduate voices and analyze them to guide the design of new library spaces, collections and services We expect also that the methodology developed will help to select participants from other library user groups from a diversity perspective

Design of a case management model for people with chronic disease (Heart Failure and COPD). Phase I: modeling and identification of the main components of the intervention through their actors: patients and professionals (DELTA-ICE-PRO Study

Background Chronic diseases account for nearly 60% of deaths around the world. The extent of this silent epidemic has not met determined responses in governments, policies or professionals in order to transform old Health Care Systems, configured for acute diseases. There is a large list of research about alternative models for people with chronic conditions, many of them with an advanced practice nurse as a key provider, as case management. But some methodological concerns raise, above all, the design of the intervention (intensity, frequency, components, etc). Methods/Design Objectives: General: To develop the first and second phases (theorization and modeling) for designing a multifaceted case-management intervention in people with chronic conditions (COPD and heart failure) and their caregivers. Specific aims: 1) To identify key events in people living with chronic disease and their relation with the Health Care System, from their point of view. 2) To know the coping mechanisms developed by patients and their caregivers along the story with the disease. 3) To know the information processing and its utilization in their interactions with health care providers. 4) To detect potential unmet needs and the ways deployed by patients and their caregivers to resolve them. 5) To obtain a description from patients and caregivers, about their itineraries along the Health Care System, in terms of continuity, accessibility and comprehensiveness of care. 6) To build up a list of promising case-management interventions in patients with Heart Failure and COPD with this information in order to frame it into theoretical models for its reproducibility and conceptualization. 7) To undergo this list to expert judgment to assess its feasibility and pertinence in the Andalusian Health Care. Design: Qualitative research with two phases: For the first five objectives, a qualitative technique with biographic stories will be developed and, for the remaining objectives, an expert consensus through Delphi technique, on the possible interventions yielded from the first phase. The study will be developed in the provinces of Almería, Málaga and Granada in the Southern Spain, from patients included in the Andalusian Health Care Service database with the diagnosis of COPD or Heart Failure, with the collaboration of case manager nurses and general practitioners for the assessment of their suitability to inclusion criteria. Patients and caregivers will be interviewed in their homes or their Health Centers, with their family or their case manager nurse as mediator. Discussion First of a series of studies intended to design a case-management service for people with heart failure and COPD, in the Andalusian Health Care System, where case management has been implemented since 2002. Accordingly with the steps of a theoretical model for complex interventions, in this study, theorization and intervention modeling phases will be developed.This research was carried out with the support of one research grant, awarded by the Regional Health Ministry of Andalusia (Exp. 0222/2008

Invitations to interview on the role of the library in the undergraduate academic life: survey to select participants from diverse origin through posters and digital social networks

Undergraduate students are usually the largest populations in higher education institutions. More information about qualitative aspects of learning practices and deeper knowledge about student needs is necessary to understand and promote a more implicated role of libraries in undergraduate student learning. The project reported at this poster is developed by researchers from two private universities libraries in Mexico. The research methodology used is mixed. After analysis and discussion of initial data some student’s characteristics were established as diversity markers which we expect will facilitate to select students for deep interview in order to listen the variety of undergraduate voices and analyze them to guide the design of new library spaces, collections and services We expect also that the methodology developed will help to select participants from other library user groups from a diversity perspective

Aislaciones en climas fríos

Independientemente de la fuente que provee energía térmica a un edificio, es necesario aislarlo a fin de aumentar su eficiencia energética. En el presente trabajo se evalúa el comportamiento de los cerramientos aislados de los edificios ante la acción de los procesos de transferencia de masa y de calor que en ellos ocurren. En función de este conocimiento y la aplicación de un modelo apropiado se pretende configurar una estructura de aislaciones que permita la predicción de los efectos perjudiciales que producen la condensación de vapor de agua interna o la formación destructiva de hielo. Se incluyen aplicaciones a sistemas de aislación habituales con materiales de uso corriente en la construcción local, que contradicen viejos preconceptos sobre el tema.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Methodology of the Virtual Reconstruction of Arquitectonic Heritage: Ambassador Vich's Palace in Valencia

The 19th century was disastrous as far as the conservation of architectonic heritage is concerned. The awareness of the importance of preserving monuments that has prevailed since the end of the last century was dazzlingly absent in the previous, leading both to the disappearance of representative heritage works and the plundering of many others. The present study establishes the methodological basis to proceed with the virtual reconstruction of many disappeared architectures, representative of emblematic architectonic typologies. A method based on the combination of deduction and induction allows benchmarks to be created that signify a starting point to which the key and specific elements of each building are later incorporated, from the data extracted from the conserved parts and the graphic, literary and archive documents. The result is the virtual recovery of the general outlines of the architecture: morphology of the plot, volumetry, exterior and interior facades, and the functional layout. The good results obtained in the study of the disappeared Ambassador Vich's Palace, allow the methodology to be extended to the analysis of other similar examples, serving investigators as a tool to carry out an arduous task of deciphering a trail that is increasingly fading with the passing of time.Galiana Agullo, M.; Mas Tomas, MDLA.; Lerma Elvira, C.; Peñalver Martínez, MJ.; Conesa Tejada, S. (2014). Methodology of the Virtual Reconstruction of Arquitectonic Heritage: Ambassador Vich's Palace in Valencia. International Journal of Architectural Heritage. 8(1):94-123. doi:10.1080/15583058.2012.672623S9412381Boix, V. 1979.Historical and topographic Valencia[in Spanish]. Vol. I261 S. A. Printing J. Rius.Estaban Chapapría, J. (2001). Impostación del patio del Embajador Vich en el ex-convento del Carmen (Valencia). Loggia, Arquitectura & Restauración, (12), 26. doi:10.4995/loggia.2001.3605Morrish, S. W., & Laefer, D. F. (2010). Web-Enabling of Architectural Heritage Inventories. International Journal of Architectural Heritage, 4(1), 16-37. doi:10.1080/15583050902731056Lotz, W. 1995.Architecture in Italy 1500–1600 [in Italian]35–37. ed. RizzoliYale University Press.Lourenço, P. B., Peña, F., & Amado, M. (2010). A Document Management System for the Conservation of Cultural Heritage Buildings. International Journal of Architectural Heritage, 5(1), 101-121. doi:10.1080/15583050903318382Vila Ferrer, S. (2001). La recuperación del patio del palacio del Embajador Vich (Valencia). Loggia, Arquitectura & Restauración, (12), 44. doi:10.4995/loggia.2001.3606Zonta, D., Pozzi, M., & Zanon, P. (2008). Managing the Historical Heritage Using Distributed Technologies. International Journal of Architectural Heritage, 2(3), 200-225. doi:10.1080/1558305080206369

Categorías vinculantes en la construcción interinstitucional de teoría fundamentada para conocer el rol de bibliotecas en la vida universitaria

Este trabajo surge en el contexto de una investigación cualitativa sobre la función de las bibliotecas en la formación universitaria, un fenómeno tradicionalmente estudiado desde perspectivas cuantitativas a partir de la percepción del usuario sobre los servicios y en el contexto educativo respecto del impacto en el usuario en su experiencia estudiantil. El objetivo es compartir el proceso con el que, a partir del paradigma de la teoría fundamentada (TF), se construyeron “categorías vinculantes” como una estrategia de visión integrada del objeto de estudio tomando como base las categorías o familias generadas por dos equipos de investigación a partir de la codificación abierta de entrevistas a estudiantes de dos universidades privadas en México: la Universidad Iberoamericana Ciudad de México e ITESO, Universidad Jesuita de Guadalajara. Este texto se estructura en seis apartados: 1. Introducción, donde se abordan las características de este proyecto de investigación interinstitucional, 2. Cooperación para el estudio de la vida universitaria, con los principios teóricos y la ruta metodológica que sustentan la propuesta; 3. Diversidad, muestreo y lógica comparativa, que presenta la conformación de marcadores de diversidad y su rol en los criterios de conformación de la muestra siguiendo los lineamientos de la TF; 4. Codificación y familias con los resultados del análisis en categorías centradas en la pluralidad de formas de estudio, de estilos de vida estudiantil y en las experiencias e idiosincrasia de estudiantes de licenciatura; 5. Categorías vinculantes, donde se explica la propuesta comparativa y se muestran las categorías resultantes a partir de los vínculos entre dos grupos de investigadores provenientes de diferentes disciplinas y dos formas distintas de codificación; y 6. Lógica comparativa interinstitucional como una vía de construcción de TF que a manera de conclusión presenta la discusión sobre los alcances del método propuesto al permitir la construcción de categorías teóricas a partir de lo dicho por los estudiantes mediante el análisis y conceptualización de las dimensiones que integran la vida universitaria. Los resultados de este proceso serán la base para ajustar los instrumentos de recolección de datos para la siguiente fase de la investigación