Observational Δν\Delta\nu-ρˉ\bar\rho relation for δ\delta Sct stars using eclipsing binaries and space photometry

Delta Scuti ($\delta$ Sct) stars are intermediate-mass pulsators, whose intrinsic oscillations have been studied for decades. However, modelling their pulsations remains a real theoretical challenge, thereby even hampering the precise determination of global stellar parameters. In this work, we used space photometry observations of eclipsing binaries with a $\delta$ Sct component to obtain reliable physical parameters and oscillation frequencies. Using that information, we derived an observational scaling relation between the stellar mean density and a frequency pattern in the oscillation spectrum. This pattern is analogous to the solar-like large separation but in the low order regime. We also show that this relation is independent of the rotation rate. These findings open the possibility of accurately characterizing this type of pulsator and validate the frequency pattern as a new observable for $\delta$ Sct stars.Comment: 11 pages, including 2 pages of appendix, 2 figures, 2 tables, accepted for publication in ApJ

Caracterización de tintas de cemento de fosfato de calcio con adición de Poloxámero 407 para su posible aplicación en impresión 3D

3D printing of biomaterials is a growing technology in the manufacture of grafts suitable for the repair of bone defects with complex geometries. Calcium phosphate cements (CFC) are bioceramics used in orthopedic medicine due to their similarity to the mineral phase of bone, the ability to be molded as a paste and to harden in situ. The 3D printing of CFC would potentialize their application by allowing reconstructive surgeries of defects with complex geometries, however, a limitation is the low injectability of CFCs due to the phase separation that occurs during the injection of the paste. In this work, the implementation of a thermosensitive polymer such as Poloxamer 407 has been studied to generate an injectable ink. Such ink has been formulated to contain 5% of carbonated hydroxyapatite type B as a biocompatible and biodegradable nucleating agent. Additions of 0 %, 20 % and 40 % Wt aqueous solutions of Poloxamer 407 were evaluated as gel phase at a liquid/powder ratio of 0.75 mL/g. The injectability coefficient, the cohesion of the inks and the compressive strength of the cements using Weibull´s analysis were implemented, determining that the addition of polymer decreases the mechanical properties of the CFC by 52.68 % and 81.23 %, respectively with relation to the control CFC (0%), attributed to a lower densification of the cement. It was concluded that the additions of Poloxamer 407 do not interfere in the precipitation of calcium-deficient hydroxyapatite nor in the in vitro degradation of cements and favors the ink behavior for its possible implementation in 3D printing.La impresión 3D de biomateriales es una tecnología de gran auge para la fabricación de injertos aptos para la reparación de defectos óseos con geometrías complejas. Los cementos de fosfato de calcio (CFC) son biocerámicos empleados en la medicina ortopédica debido a su similitud con la fase mineral del hueso, la capacidad para ser moldeados como una pasta y endurecer in situ. La impresión 3D de CFC potencializaría su aplicación al permitir cirugías reconstructivas de defectos con geometrías complejas, sin embargo, una limitante es la baja inyectabilidad de los CFC debido a la separación de fases que ocurre durante la inyección de la pasta. En este trabajo se ha estudiado la implementación de un polímero termosensible como el Poloxámero 407 para generar una tinta inyectable. Dicha tinta ha sido formulada para contener 5 % de hidroxiapatita carbonatada tipo B como agente nucleante biocompatible y biodegradable. Se evaluaron adiciones de soluciones acuosas de Poloxámero 407 al 0 %, 20 % y 40 % en peso como fase gel a una relación líquido/polvo de 0,75 mL/g. Se determinó el coeficiente de inyectabilidad, la cohesión de las tintas y se caracterizó la resistencia a la compresión de los cementos empleando análisis Weibull, determinado que la adición de polímero disminuye las propiedades mecánicas de los CFC en un 52,68 % y 81,23 %, respectivamente, en relación con el CFC de control (0%), atribuido a una menor densificación del cemento. Se concluyó que las adiciones del Poloxámero 407 no interfieren en la precipitación de hidroxiapatita deficiente en calcio ni en la degradación in vitro de los cementos y favorece el comportamiento de la tinta para su posible implementación en impresión 3D

La Acción Tutorial en la Facultad de Económicas: perspectivas presentes y futuras

El Programa de Acción Tutorial de Económicas, conocido coloquialmente como PATEC, cumple su novena edición en el presente curso académico 2013-2014. Desde sus inicios el PATEC se ha adaptado a las distintas titulaciones adscritas al Centro gracias a su gran flexibilidad, aspecto fundamental si tenemos en cuenta el tamaño y la heterogeneidad de nuestro Centro y las diferentes características de nuestros estudiantes. El objetivo de esta comunicación es dar a conocer el PATEC, sus objetivos, características y datos más relevantes, así como analizar su evolución lo que nos permitirá obtener una radiografía completa del Programa. Teniendo en cuenta las dificultades encontradas en la implementación del Programa en sus distintas ediciones trataremos de abordar planteamientos alternativos entre los que se encuentra la creación de una Red de Tutores que persigue optimizar la labor tutorial y facilitar el trabajo de futuros tutores. Asimismo, se expondrán diferentes experiencias innovadoras llevadas a cabo con el objetivo de incrementar la participación del alumnado

Cómo mejorar el PATEC: comparativa de experiencias en universidades públicas españolas

En este curso 2014-2015 se cumplen 10 años del inicio del Programa de Acción Tutorial de la Facultad de Económicas (PATEC). En estos años este programa se ha ido consolidando e incrementando su relevancia en la Facultad y, en especial, a través de su web. Además, este programa se ofrece a todos los alumnos del centro con independencia del curso o la titulación en la que estén matriculados y se diseñan actividades complementarias que contribuyen a la formación integral del alumnado. En este sentido, la experiencia acumulada permite tener una amplia perspectiva para reflexionar sobre cómo debe ser el PATEC en los próximos años. No sólo teniendo en cuenta esta experiencia sino también considerando la organización y funcionamiento de otros programas de acción tutorial que existen en otras universidades españolas. Así, el objetivo de este trabajo es analizar el funcionamiento de programas de acción tutorial implantados en otros centros para identificar las mejores prácticas con el fin de estudiar la posibilidad de introducirlas en el funcionamiento del PATEC. De esta manera podemos reflexionar sobre nuestras prácticas y mejorar la eficiencia del PATEC para ofrecer a todo su alumnado un servicio de calidad adaptado a sus necesidades académicas, profesionales y personales

Pretreatment of urine samples with SDS improves direct identification of urinary tract pathogens with matrix-assisted laser desorption ionization-time of flight mass spectrometry

[EN]We pretreated with SDS 71 urine samples with bacterial counts of >10(5) CFU/ml and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) identification scores of <2, in order to minimize failure rates. Identification improved in 46.5% of samples, remained unchanged in 49.3%, and worsened in 4.2%. The improvement was more evident for Gram-negative (54.3%) than for Gram-positive (32%) bacteria

Urinary Excretion of Mimosine Metabolites by Hair Sheep Fed Foliage of \u3cem\u3eLeucaena leucocephala\u3c/em\u3e

Leucaena leucocephala is an adapted legume widely distributed in the tropical regions of Mexico. The high crude protein content of leucaena leaves renders it appropriate for ruminant feeding under commercial conditions. However, the foliage contains the non-protein amino acid mimosine, which, if consumed in high amounts, may induce toxicity in animals which have not previously consumed the legume or without microorganisms capable of degrading mimosine and its derivatives 2,3-DHP (dihydroxypyridine) and 3,4-DHP (Hammond 1995, Palmer et al. 2010, Dalzell et al. 2012). Barros-Rodríguez et al. (2012) found that dry matter intake and weight gain were reduced when sheep grazed paddocks with 55,000 plants of leucaena per hectare. Early work in Australia led to the isolation of Synergistes jonesii, an anaerobic bacterium able to degrade 3,4-DHP and 2,3-DHP to non-toxic compounds (Allison et al. 1992). In Mexico, the presence of this microorganism in the rumen has not yet been confirmed. Inoculation of non-accustomed animals with rumen liquor of ruminants adapted to the consumption of leucaena can reduce the impact of mimosine and its metabolites on animal health (Ghosh et al. 2009; Palmer et al. 2010). The aim of the present work was to evaluate the effects of transferring rumen liquor of cows adapted to the consumption of L. leucocephala to sheep without experience of consumption, on urinary excretion of 3.4-DHP and 2.3-DHP by means of a colorimetric technique

Pharmacogenetics of Immunosuppressants in Solid Organ Transplantation: Time to Implement in the Clinic

Our aim in this chapter is to present the state of the art, including our own group research, in the field of immunosuppressant pharmacogenetics in the four main types of solid organ transplantation: kidney, heart, lung, and liver. The main focus will be on those findings in the field that have been widely investigated and then in those that are close to clinical implementation, mainly CYP3A5 genotyping for the adjustment of the initial tacrolimus dose. This recommendation will be discussed in more detail, explaining its clinical potential as well as its limitations. To end, a short opinion about the feasibility of implementation in the health systems as well as discussion about private companies selling pharmacogenetic tests will be presented

Social interactions and business portfolio among vegetable produc-ers in central Mexico

Objective: Analyze social interactions and business portfolio of vegetable producers in Central Mexico. Design/methodology/approach: we worked with 16 small vegetable producers. Semi-structured questionnaires and periodic monitoring were used in field to collect data. A Social Network analysis was carried out to know social interactions between producers, and the Boston Consulting Group (BCG) and Ansoff matrix for the business portfolio. Results: We found that the products with potential in the market were lettuce and nopal. Broccoli and squash represent low sales and low utility. Producers with a higher degree of centrality grow lettuce, broccoli and squash, so we suggested to develop strategies for introducing nopal. Limitations on study/implications: It was necessary to deep in market and consumers analysis.Objective: To analyze the social interactions and business portfolio of vegetable producers in central Mexico. Design/methodology/approach: Work was conducted with 16 small-scale vegetable producers. Semi-structured questionnaires and periodic monitoring were used in the field to collect data. A Social Network analysis was carried out to understand the social interactions between producers, and the Boston Consulting Group (BCG) and Ansoff matrix was used for the business portfolio. Results: The study found that the products with potential in the market were lettuce and nopal. Broccoli and squash represent low sales and low utility. Producers with a higher degree of centrality grow lettuce, broccoli and squash, so we suggested developing strategies for introducing nopal. Limitations on study/implications: It was necessary to delve into market and consumers analysis

Memoria de la Red de tutores del Programa de Acción Tutorial de la Facultad de Económicas (PATEC)

En el presente curso 2013-2014 el Programa de Acción Tutorial en la Facultad de Ciencias Económicas y Empresariales cumple su novena edición. En el curso 2007-2008, con el objetivo de que el Programa de Acción Tutorial fuera considerado una herramienta dirigida a los alumnos del Centro con identidad propia, pasó a llamarse Programa de Acción Tutorial de Económicas (PATEC) pues coloquialmente al Centro se le identifica con la Facultad de Económicas. Desde entonces, el Programa se ha ido consolidando año a año en la Facultad y son muchas las fortalezas que lo han convertido en un programa con un gran potencial. No obstante, existen ciertas debilidades que se repiten cada año a las que se ha tratado de dar respuesta en las distintas ediciones. El objetivo de la presente comunicación es dar a conocer la evolución del PATEC desde el curso 2007-2008 hasta la actualidad así como las acciones que se han llevado a cabo para subsanar las dificultades encontradas

Derivation and external validation of the SIMPLICITY score as a simple immune-based risk score to predict infection in kidney transplant recipients

Existing approaches for infection risk stratification in kidney transplant recipients are suboptimal. Here, we aimed to develop and validate a weighted score integrating non-pathogen-specific immune parameters and clinical variables to predict the occurrence of post-transplant infectious complications. To this end, we retrospectively analyzed a single-center derivation cohort of 410 patients undergoing kidney transplantation in 2008-2013 in Madrid. Peripheral blood lymphocyte subpopulations, serum immunoglobulin and complement levels were measured at one-month post-transplant. The primary and secondary outcomes were overall and bacterial infection through month six. A point score was derived from a logistic regression model and prospectively applied on a validation cohort of 522 patients undergoing kidney transplantation at 16 centers throughout Spain in 2014-2015. The SIMPLICITY score consisted of the following variables measured at month one after transplantation: C3 level, CD4+ T-cell count, CD8+ T-cell count, IgG level, glomerular filtration rate, recipient age, and infection within the first month. The discrimination capacity in the derivation and validation cohorts was good for overall (areas under the receiver operating curve of 0.774 and 0.730) and bacterial infection (0.767 and 0.734, respectively). The cumulative incidence of overall infection significantly increased across risk categories in the derivation (low-risk 13.7%; intermediate-risk, 35.9%; high-risk 77.6%) and validation datasets (10.2%, 28.9% and 50.4%, respectively). Thus, the SIMPLICITY score, based on easily available immune parameters, allows for stratification of kidney transplant recipients at month one according to their expected risk of subsequent infection