Grid Global Behavior Prediction

Complexity has always been one of the most important issues in distributed computing. From the first clusters to grid and now cloud computing, dealing correctly and efficiently with system complexity is the key to taking technology a step further. In this sense, global behavior modeling is an innovative methodology aimed at understanding the grid behavior. The main objective of this methodology is to synthesize the grid's vast, heterogeneous nature into a simple but powerful behavior model, represented in the form of a single, abstract entity, with a global state. Global behavior modeling has proved to be very useful in effectively managing grid complexity but, in many cases, deeper knowledge is needed. It generates a descriptive model that could be greatly improved if extended not only to explain behavior, but also to predict it. In this paper we present a prediction methodology whose objective is to define the techniques needed to create global behavior prediction models for grid systems. This global behavior prediction can benefit grid management, specially in areas such as fault tolerance or job scheduling. The paper presents experimental results obtained in real scenarios in order to validate this approach

Evaluación al programa de tutorías de la F.I.M.E., de la U.A.N.L. Desempeño del tutor

La Facultad de Ingeniería Mecánica y Eléctrica ha sido una de las Facultades pioneras en la implementación del Programa de Tutorías dentro de la UANX., Existe un programa de tutor de inducción al alumno, el Tutor de carrera y el área de apoyo psicopedagógico. El programa de Tutorías tiene como objetivos: contribuir a elevar la calidad del proceso educativo a través de la promoción del desarrollo de actitudes, habilidades y hábitos positivos en los tutorados. Promover mayor comunicación en las relaciones profesor - alumno, teniendo como parte fundamental, el conocimiento de los problemas de los alumnos. Así como, el contribuir a mejorar el índice de aprobación, deserción y eficiencia terminal

Triiodothyronine is required for the stimulation of type II 5'-deiodinase mRNA in rat brown adipocytes

10 pages, 6 figures.Type II 5'-iodothyronine deiodinase (D2), produces triiodothyronine (T(3)) and is stimulated by cold exposure via norepinephrine (NE) release in brown adipose tissue. Cultured rat brown adipocytes require T(3) for the adrenergic stimulation of D2 activity. D2 mRNA expression in cultured brown adipocytes is undetectable with the use of basal conditions or NE without T(3). Full D2 expression is achieved using NE + T(3), especially after prolonged T(3) exposure. beta(3)-Adrenergic agonists mimic the NE action, whereas cAMP analogs do not. Prolonged exposure to T(3) alone increases D2 mRNA. High T(3) doses (500 nM) inhibit the adrenergic stimulation of D2 activity while increasing D2 mRNA. The effects obtained with NE + T(3) or T(3) alone are suppressed by actinomycin, but not by cycloheximide, which leads to accumulation of short D2 mRNA transcripts. Prolonged or short exposure to T(3) did not change D2 mRNA half-life, but T(3) seemed to elongate it. In conclusion, T(3) is an absolute requirement for the adrenergic stimulation of D2 mRNA in brown adipocytes. T(3) upregulates D2 mRNA, an effect that might involve stimulation of factors required for transcription or for stabilization of D2 mRNA.This work was supported by research grants PB 95–0097 from Dirección General de Investigación Científica y Técnica, FISS 94/0274 and 99/0813 from Fondo de Investigaciones Sanitarias (FIS), and CAM 08.6/0030/1998 from Comunidad de Madrid (CAM) (Spain). R. Martínez de Mena was supported by research grants FISS 94/0274 (predoctoral studies) and CAM 08.6/0030/1998 (as postdoctoral).Peer reviewe

Swine Dendritic Cell Response to Porcine Reproductive and Respiratory Syndrome Virus : An Update

Ajuts: Consejo Nacional de Ciencia y Tecnología 222973Dendritic cells (DCs) are the most potent antigen-presenting cells, unique to initiate and coordinate the adaptive immune response. In pigs, conventional DCs (cDCs), plasmacytoid DCs (pDCs), and monocyte-derived DCs (moDCs) have been described in blood and tissues. Different pathogens, such as viruses, could infect these cells, and in some cases, compromise their response. The understanding of the interaction between DCs and viruses is critical to comprehend viral immunopathological responses. Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important respiratory pathogen in the global pig population. Different reports support the notion that PRRSV modulates pig immune response in addition to their genetic and antigenic variability. The interaction of PRRSV with DCs is a mostly unexplored area with conflicting results and lots of uncertainties. Among the scarce certainties, cDCs and pDCs are refractory to PRRSV infection in contrast to moDCs. Additionally, response of DCs to PRRSV can be different depending on the type of DCs and maybe is related to the virulence of the viral isolate. The precise impact of this virus-DC interaction upon the development of the specific immune response is not fully elucidated. The present review briefly summarizes and discusses the previous studies on the interaction of in vitro derived bone marrow (bm)- and moDCs, and in vivo isolated cDCs, pDCs, and moDCs with PRRSV1 and 2

Using accessibility criteria for dwelling rehabilitation in Spain. Inclusive responses for human and social diversity

Las Viviendas de Promoción Pública, que tienen como misión satisfacer la necesidad de vivienda de ciudadanos con rentas bajas, pierden este fin cuando las mismas no dan respuesta a las necesidades de la población que atienden, partiendo de la premisa de que las mismas fueron diseñadas al margen de criterios de accesibilidad y de lo que se entiende en la actualidad como Design for all. Cuando la población que hacía uso de las mismas era joven e independiente respondía al derecho a la vivienda, pero ahora esa población es una población envejecida, con recursos reducidos y espoleada por la crisis económica; nos encontramos así con un sector de población doblemente excluido, son mayores, dependientes y con bajos recursos, si a todo esto unimos a las personas con discapacidad tanto de origen como sobrevenida, forman parte de una población doblemente excluida e invalidada por el entorno hostil de la vivienda en la que residen, convirtiéndose en obstáculos imposibles de remover por falta de recursos y de estrategia adaptada para intervenir en este sector

Volatile organic compounds and consumer preference for meat from suckling goat kids raised with natural or replacers milk

Most of European Union goats are slaughtered with carcase weights between 5 kg and 11 kg. Some farmers rear kids with milk replacers to produce cheese with the dams’ milk. The aim of this experiment was to study the volatile compounds (VOCs) of meat of suckling light kids reared with natural milk or milk replacers and to study the influence of consumers’ psychographic characteristics on the sensory preference for meat. Gas chromatography-mass spectrometry was performed to identify the VOCs and consumers evaluated the flavour, juiciness and overall acceptability. Thirty-five VOCs were detected and 44.3%, 25.1%, 6.9% and 2.3%, were aldehydes, hydrocarbons, ketones and alcohols, respectively. The influence of the rearing system on VOCs clearly depended on the breed. The use of milk replacers did not affect the percentage of linear aldehydes compared to the use of natural milk. However, the major aldehyde, hexanal (34.8%), was related to the use of natural milk and correlated positively with both the flavour (r = 0.21) and overall acceptability (r = 0.24). On the other hand, hydrocarbons such as hexane were related to MR, and 2-methyl-pentane and 3-methyl pentane were correlated with the acceptability of flavour (r = −0.22 and −0.25, respectively) and with the overall acceptability (r = −0.21 and −0.24). The 2-penthyl furan and 2-ethyl-1-hexanol were correlated with the overall acceptability (r = −0.22 and −0.22, respectively). Therefore, the acceptability of meat from suckling kids fed natural milk was greater for older consumers and people with a moderate consumption of meat.Unión Europea, Ministerio de Economía y Competitividad (MINECO). [RTA2012-0023-C03]; CYTED [116RT0503

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release

In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis, through the sustained colonic release of RES from long-lasting mucoadhesive drug depots. The loading of RES into nanoparticles (NPs) was optimized regarding two independent variables: RES/polymer ratio, and temperature. Twenty experiments were carried out and a Box–Behnken experimental design was used to evaluate the significance of these independent variables related to encapsulation efficiency (EE). The enhanced RES EE values were achieved in 24 h at 39 °C and at RES/polymer ratio of 0.75:1 w/w. Sizes and polydispersities of the optimized NPs were studied by dynamic light scattering (DLS). Chitosan (CTS) dispersions containing the RES-loaded NPs were ionically gelled with tricarballylic acid to yield CTS-NPs composites. Macro- and microscopic features (morphology and porosity studied by SEM and spreadability), thermal stability (studied by TGA), and release kinetics of the RES-loaded CTS-NPs were investigated. Release patterns in simulated colon conditions for 48 h displayed significant differences between the NPs (final cumulative drug release: 79–81%), and the CTS-NPs composites (29–34%)

El momento óptimo para invertir en una empresa de la agroindustria del café (Una Aplicación de la Teoría de las Opciones Reales)

(The Optimal Time to Invest in A Coffee Agribusiness Company: an Application of the Real Options Theory)The high volatility of the real price of coffee in the international market makes traditional valuation insufficient to value investment projects in the coffee agribusiness. This work illustrates how to quantify and incorporate uncertainty in the valuation to determine the optimal timing when a coffee company would invest to market its coffee, as roasted coffee and green coffee, in the national market. Using the optimal time to invest model, the real options theory helps decide whether or not to invest through a critical value. For the case of the social enterprise under study, it was found that the investment must be carried out since the project value ( ) is greater than the critical value ( ). If the company only sells green coffee ( ), its decision would be not to invest ( ). When volatility is high, the investment must be deferred. With its volatility in mind, the “true value” of the investment could be estimated to help management in the decision-making process.La alta volatilidad del precio real del café en el mercado internacional hace que la valoración tradicional sea insuficiente para valorar proyectos de inversión en la agroindustria de café. El presente trabajo muestra como cuantificar e incorporar la incertidumbre en la valoración para determinar el momento más oportuno en el cual una empresa de café invertiría para comercializar su café como café oro verde y tostado en el mercado nacional. La teoría de las opciones reales a través del modelo del momento de inversión óptima permite decidir si invertir o no mediante un valor crítico. Para la empresa social en estudio, se encontró que la inversión se debe llevar acabo puesto que, el valor del proyecto ( ) es superior al valor crítico ( ). Si la empresa vendiera solo café oro verde ( ) su decisión sería no invertir ( ). Cuando la volatilidad es alta la inversión debe ser diferida. Al tomar en cuenta la volatilidad de la inversión se podría estimar su “verdadero valor” permitiendo a la directiva tomar mejores decisiones

Estrategias metodológicas para mejorar los procesos de aprendizaje de la asignatura de Ciencias Naturales en séptimo grado “A” en el instituto Rubén Darío comunidad el Regadío del municipio de Estelí departamento de Estelí durante el año 2022

El presente estudio está enfocado en la línea educativa Calidad Educativa, específicamente relacionado con las estrategias metodológicas que aplican las docentes en la asignatura de Ciencias Naturales en los estudiantes de séptimo grado A del instituto Rubén Darío de la comunidad el Regadío del municipio de Estelí, durante el segundo semestre del año 2022. El estudio fue realizado con el propósito de valorar la efectividad de la aplicación de estrategias metodológicas, las cuales dieron resultados positivos durante su aplicación logrando la participación activa, despertando la motivación e integración de los estudiantes en los procesos educativos. La información fue recolectada a través de la aplicación de instrumentos de recolección como la entrevistas, la cual fue analizada y procesada conforme a los objetivos propuestos en el proceso de investigación, el enfoque con que se llevó a cabo esta investigación es cualitativo que permitió describir y analizar los principales datos recolectados a partir de la muestra seleccionada. La metodología utilizada nos remite analizar más a fondo el tema en estudio y que nos conduzca a contribuir significativamente para la mejora de los aprendizajes en los estudiantes con la aplicación de diversas estrategias metodológicas que fortalezcan la práctica pedagógica del docente y mejore el aprendizaje en los estudiantes en la asignatura de Ciencias Naturales. Para la realización del estudio fueron consultadas diferentes fuentes que tuvieran relación con la temática seleccionada, quienes aportaron para la fundamentación científica del tema