The Representation of Queer Teen Identities in Sex Education (Netflix, 2019-)

This article provides an analysis of the representation of LGBTIQ+ teen identities in the first two seasons of ‘Sex Education’ (Netflix, 2019-). Utilising a methodology of analysis anchored in Queer Theory and in the concept of intersectionality, we will study the construction of those characters whose gender expression and/or sexual orientation defy the limits established by cisheteronormativity, as well as those whose desires (whether straight or not) do not fit within what Western societies understand as «normal», since we consider the rejection of the norm as a constitutive element of queerness. The main objectives are a.) to determine which images, knowledge and epistemological constructions regarding sexogenic diversity are disseminated by the show; and b.) to define which discourses are articulated regarding queer (non)identities and the violence suffered by LGBTIQ+ people

Designing bioactive porous titanium interfaces to balance mechanical properties and in vitro cells behavior towards increased osseointegration

Titanium implant failures are mainly related to stress shielding phenomenon and the poor cell interaction with host bone tissue. The development of bioactive and biomimetic Ti scaffolds for bone regeneration remains a challenge which needs the design of Ti implants with enhanced osseointegration. In this context, 4 types of titanium samples were fabricated using conventional powder metallurgy, fully dense, dense etched, porous Ti, and porous etched Ti. Porous samples were manufactured by space holder technique, using ammonium bicarbonate particles as spacer in three different ranges of particle size (100–200 μm, 250–355 μm and 355–500 μm). Substrates were chemically etched by immersion in fluorhydric acid at different times (125 and 625 s) and subsequently, were characterized from a micro-structural, topographical and mechanical point of view. Etched surfaces showed an additional roughness preferentially located inside pores. In vitro tests showed that all substrates were biocompatible (80% of cell viability), confirming cell adhesion of premioblastic cells. Similarly, osteoblast showed similar cell proliferation rates at 4 days, however, higher cell metabolic activity was observed in fully dense and dense etched surfaces at 7 days. In contrast, a significant increase of alkaline phosphatase enzyme expression was observed in porous and porous etched samples compared to control surfaces (dense and dense etched), noticing the suitable surface modification parameters (porosity and roughness) to improve cell differentiation. Furthermore, the presence of pores and rough surfaces of porous Ti substrates remarkably decreased macrophage activation reducing the M1 phenotype polarization as well M1 cell marker expression. Thus, a successful surface modification of porous Ti scaffolds has been performed towards a reduction on stress shielding phenomenon and enhancement of bone osseointegration, achieving a biomechanical and biofunctional equilibrium.Ministry of Economy and Competitiveness of Spain grant MAT2015-71284-PJunta de Andalucía – FEDER (Spain) Project Ref. P12-TEP-140

Gestante con mutación heterocigótica del gen de la protrombina y antecedente de trombosis venosa cerebral

La mutación G20210A deriva en una sustitución de guanina por adenina en el gen que codifica la protrombina. La prevalencia de este polimorfismo es mayor en el sur de Europa (2%-6%) que en el norte de Europa (1%-2%), siendo muy rara en Asia. Los pacientes afectos de esta mutación presentan concentraciones plasmáticas de protrombina elevadas respecto a la normalidad que oscilan entre un 30% superiores en portadores heterocigotos a un 70% en portadores homocigotos, alterando de este modo la vía común de la coagulación. Esta alteración constituye un riesgo de trombosis venosa profunda (y posiblemente arterial), que se suma a otros factores de riesgo como embarazo, puerperio, cirugía y otros por todos conocidos. Además, varios estudios han intentado relacionar esta mutación como factor independiente para el desarrollo de una trombosis venosa cerebral (1,2). El manejo de los pacientes con esta mutación protrombótica no difiere del que llevamos a cabo en pacientes con otras trombofilias hereditarias, pero es necesario conocer las complicaciones a las que nos enfrentamos, evitar en lo posible factores de riesgo añadidos y plantear un buen plan anestésico – quirúrgico

Incidencia de la personalidad y resiliencia en la aparición del burnout en una muestra de deportistas españoles

The aim of this research was to know the level of burnout in athletes and the relation between this syndrome and personality from Costa and McCrae’s five factors model, adding also the resilience. The sample consisted of 141 athletes (M = 21.20; SD = 3.64). IBD-R, NEO-FFI, Resilience Scale, and IPAQ were used to record and measure the variables previously mentioned. Results indicated that the participants had moderated levels in all dimensions of burnout. Also, being a man was associated to higher burnout levels, as well as being federated, participating in an individual sport and spending a higher quantity of hours training. Age didn’t turn out to be an influential variable in the suffering of this syndrome. Moreover, results indicated a vulnerable personality pattern from Five Factors Model, consisting on high levels of neuroticism and low levels of responsibility, kindness, openness and extraversion. Lastly, resilience was also a protective variable for burnout.El objetivo principal de esta investigación fue conocer los niveles de burnout en deportistas y la relación de este síndrome con la personalidad desde el Modelo de los Cinco Factores de Costa y McCrae, añadiendo asimismo la resiliencia. La muestra estuvo constituida por 141 hombres y mujeres. Se utilizaron el IBD-R, NEO-FFI, Escala de Resistencia, e IPAQ para registrar y medir las variables anteriormente mencionadas. Los resultados apuntaron a que los participantes presentaban niveles moderados en todas las dimensiones del burnout. Además, ser hombre estaba asociado a mayores niveles de burnout, así como estar federado, participar en un deporte individual y pasar un mayor número de horas de entrenamiento. La edad no resultó ser una variable influyente en el padecimiento de este síndrome. Asimismo, los resultados indicaron un patrón de personalidad vulnerable del Modelo de los Cinco Factores, consistente en altos niveles de neuroticismo y bajos niveles de responsabilidad, amabilidad, apertura y extraversión. Por último, la resiliencia también fue una variable protectora del burnout

Actividad antioxidante de los alcaloides de Bocconia arborea. Estudio sobre seis métodos de análisis

Antioxidative activity-guided fractionation together with chemical analysis led to the isolation of three benzophenanthridinealkaloids from methanol extract of the bark of Bocconia arborea. Identification was based on spectroscopic methods.The isolated alkaloids 6-acetonyldihydrochelerythrine, chelerythrine and dihydrochelerythrine were tested for antioxidativeactivity on thiocyanate assays, free radical scavenging activity, b-carotene bleaching method, and deoxyribose assay. Allalkaloids exhibited significant antioxidant activities in linoleic acid and b-carotene. Although afforded protection againstthe damage of deoxyribose, liposome peroxidation and microsomial lipid from peroxidation, also exhibited scavengingeffects on the 1,1-diphenyl-2-picrylhydrazyl radicals.El fraccionamiento de la actividad antioxidante dirigida por actividad, junto con el análisis químico, llevaron alaislamiento de tres alcaloides de benzofenantridina del extracto de metanol de la corteza de Bocconia arborea. Laidentificación se basó en métodos espectroscópicos. Se analizó la actividad antioxidante de los alcaloides aislados 6-acetonildihidroqueleritrina, queleritrina y dihidroqueleritrina en ensayos de tiocianato, la actividad de barrido delos radicales libres, el método de decoloración del b-caroteno y el ensayo de la desoxirribosa. Todos los alcaloidesmostraron actividad antioxidante significativa en ácido linoleico y b-caroteno. Además de conceder protección frentea la desoxirribosa, la peroxidación liposómica y los lípidos microsomiales de la peroxidación, también presentaronefectos de barrido en los radicales de 1,1-difenil-2-picrilhidrazi

New palaeocurrent analysis approach from two-dimensional trough cross-strata using photographs and anisotropy of magnetic susceptibility

Palaeocurrent analysis is vital for basin analysis and helps in the interpretation of depositional environments (along-slope or downslope). For that, it is crucial to have multiple measuring methods at hand to apply palaeocurrent analysis with a wide range of different datasets (outcrops, cores and photographs). Here, two relatively underexploited palaeocurrent measurement techniques are assessed when applied to trough cross-stratification observed in the Arenazzolo Formation at Eraclea Minoa (Sicily). The first technique is a novel design of a qualitative approach to infer palaeocurrent directions from photographs of two-dimensional sedimentary structures. The second technique involves measurements of the anisotropy of magnetic susceptibility from drilled samples. A broad agreement, with overlapping uncertainty boundaries, is observed between results from both techniques. This agreement validates the use of trough cross-strata to infer palaeocurrent directions. Moreover, the addition of photographs improves reproducibility and prevents a bias towards the best-exposed troughs. The application of both techniques to outcrops and sedimentary cores provides new opportunities for palaeocurrent analysis in any type of sedimentary environment

Two decades of carbonate budget change on shifted coral reef assemblages: are these reefs being locked into low net budget states?

This is the author accepted manuscript. The final version is available from the Royal Society via the DOI in this recordThe ecology of coral reefs is rapidly shifting from historical baselines. One key-question is whether under these new, less favorable ecological conditions, coral reefs will be able to sustain key geo-ecological processes such as the capacity to accumulate carbonate structure. Here, we use data from 34 Caribbean reef sites to examine how the carbonate production, net erosion, and net carbonate budgets, as well as the organisms underlying these processes, have changed over the past 15 years in the absence of further severe acute disturbances. We find that despite fundamental benthic ecological changes, these ecologically shifted coral assemblages have exhibited a modest but significant increase in their net carbonate budgets over the past 15 years. However, contrary to expectations this trend was driven by a decrease in erosion pressure, largely resulting from changes in the abundance and size-frequency distribution of parrotfishes, and not by an increase in rates of coral carbonate production. Although in the short term the carbonate budgets seem to have benefitted marginally from reduced parrotfish erosion, the absence of these key substrate grazers, particularly of larger individuals, is unlikely to be conducive to reef recovery and will thus likely lock these reefs into low budget states.Universidad Nacional Autónoma de MéxicoRoyal SocietyMexican Council of Science and Technology (CONACYT

Inherited biotic protection in a Neotropical pioneer plant

Chelonanthus alatus is a bat-pollinated, pioneer Gentianaceae that clusters in patches where still-standing, dried-out stems are interspersed among live individuals. Flowers bear circum-floral nectaries (CFNs) that are attractive to ants, and seed dispersal is both barochorous and anemochorous. Although, in this study, live individuals never sheltered ant colonies, dried-out hollow stems - that can remain standing for 2 years - did. Workers from species nesting in dried-out stems as well as from ground-nesting species exploited the CFNs of live C. alatus individuals in the same patches during the daytime, but were absent at night (when bat pollination occurs) on 60.5% of the plants. By visiting the CFNs, the ants indirectly protect the flowers - but not the plant foliage - from herbivorous insects. We show that this protection is provided mostly by species nesting in dried-out stems, predominantly Pseudomyrmex gracilis. That dried-out stems remain standing for years and are regularly replaced results in an opportunistic, but stable association where colonies are sheltered by one generation of dead C. alatus while the live individuals nearby, belonging to the next generation, provide them with nectar; in turn, the ants protect their flowers from herbivores. We suggest that the investment in wood by C. alatus individuals permitting stillstanding, dried-out stems to shelter ant colonies constitutes an extended phenotype because foraging workers protect the flowers of live individuals in the same patch. Also, through this process these dried-out stems indirectly favor the reproduction (and so the fitness) of the next generation including both their own offspring and that of their siblings, alladding up to a potential case of inclusive fitness in plants