Internationalism as A Current in The Peace Movement: A Symposium

Internationalism as A Current in The Peace Movement: A Symposiu

Hello Dolly, well hello Dolly, it\u27s so nice to have you back [first line]

Performers: Carol Channing, David Burns, Eileen Brennan, Sondra Lee, Charles Nelson ReillyPiano, Voice and Chord

Selective Inhibitor of Proteasome's Caspase-like Sites Sensitizes Cells to Specific Inhibition of Chymotrypsin-like Sites

SummaryProteasomes degrade most proteins in mammalian cells and are established targets of anticancer drugs. All eukaryotic proteasomes have three types of active sites: chymotrypsin-like, trypsin-like, and caspase-like. Chymotrypsin-like sites are the most important in protein degradation and are the primary target of most proteasome inhibitors. The biological roles of trypsin-like and caspase-like sites and their potential as cotargets of antineoplastic agents are not well defined. Here we describe the development of site-specific inhibitors and active-site probes of chymotrypsin-like and caspase-like sites. Using these compounds, we show that cytotoxicity of proteasome inhibitors does not correlate with inhibition of chymotrypsin-like sites and that coinhibition of either trypsin-like and/or caspase-like sites is needed to achieve maximal cytotoxicity. Thus, caspase-like and trypsin-like sites must be considered as cotargets of anticancer drugs

Sexuality and succession law: beyond formal equality

This article endeavours to open up a dialogue between succession law and the field of gender, sexuality and the law. It presents a detailed analysis of five cases concerning inheritance disputes relating to lesbians or gay men. The sexuality of the parties in the cases is ‘doctrinally irrelevant’ but the analysis demonstrates the significance of sexuality in the resolution of the legal disputes. In doing so it identifies how legal discourse remains a critical site for the production of societal norms and in particular how lesbian and gay perspectives reveal the gendered assumptions underlying a number of key succession law doctrines. It emphasises the importance of taking difference seriously and the limits to formal legal equality

Social Problem Construction and National Context: News Reporting on "Overweight" and "Obesity" in the United States and France

Drawing on analyses of American and French news reports on "overweight" and "obesity," this article examines how national context—including position in a global field of nation states, as well as different national politics and culture—shapes the framing of social problems. As has been shown in previous research, news reports from France—the economically dominated but culturally dominant nation of the two—discuss the United States more often than vice versa, typically in a negative way. Our contribution is to highlight the flexibility of anti-American rhetoric, which provides powerful ammunition for a variety of social problem frames. Specifically, depending on elite interests, French news reports may invoke anti-American rhetoric to reject a given phenomenon as a veritable public problem, or they may use such rhetoric to drum up concern over an issue. We further show how diverse cultural factors shape news reporting. Despite earlier work showing that a group-based discrimination frame is more common in the United States than in France, we find that the U.S. news sample is no more likely to discuss weight-based discrimination than the French news sample. We attribute this to specific barriers to this particular framing, namely the widespread view that body size is a behavior, akin to smoking, rather than an ascribed characteristic, like race. This discussion points, more generally, to some of the mechanisms limiting the diffusion of frames across social problems