91 research outputs found
A retrospective review of fatal electrocution cases at Tygerberg Forensic Pathology Services, Cape Town, South Africa, over the 5-year period 1 January 2008 - 31 December 2012
Background. Electrocution as a cause of death has been discussed extensively in the international literature. However, research on this topic in South Africa (SA) is scarce.Objectives. To address the need for further research in this field and emphasise the necessity for preventive measures by determining the demographic and pathological profile of fatal electrocution cases seen in the Tygerberg Forensic Pathology Services, Western Cape Province, SA.Methods. The study was a retrospective and descriptive case series of all the cases of death secondary to electrocution referred to the study facility from 1 January 2008 to 31 December 2012.Results. A total of 39 cases were included. Ten victims (25.6%) were aged <13 years. The geographical area most affected by electrocution deaths was the informal settlement Khayelitsha (56.4% of cases). The primary injuries described were mainly burn wounds (34 cases, 87.2%) and abrasions (4 cases, 10.3%). Most injuries were to the upper limbs. Unfortunately, the results pertaining specifically to the pathology of electrical burn wounds were inconclusive.Conclusions. In view of discrepancies found in the reporting of electrical burn wounds, a standardised system for classifying these wounds is suggested. Although electrocution-related mortality is not a leading cause of death in high-prevalence areas, awareness should be raised
Self-trapping transition for nonlinear impurities embedded in a Cayley tree
The self-trapping transition due to a single and a dimer nonlinear impurity
embedded in a Cayley tree is studied. In particular, the effect of a perfectly
nonlinear Cayley tree is considered. A sharp self-trapping transition is
observed in each case. It is also observed that the transition is much sharper
compared to the case of one-dimensional lattices. For each system, the critical
values of for the self-trapping transitions are found to obey a
power-law behavior as a function of the connectivity of the Cayley tree.Comment: 6 pages, 7 fig
Grain Surface Models and Data for Astrochemistry
AbstractThe cross-disciplinary field of astrochemistry exists to understand the formation, destruction, and survival of molecules in astrophysical environments. Molecules in space are synthesized via a large variety of gas-phase reactions, and reactions on dust-grain surfaces, where the surface acts as a catalyst. A broad consensus has been reached in the astrochemistry community on how to suitably treat gas-phase processes in models, and also on how to present the necessary reaction data in databases; however, no such consensus has yet been reached for grain-surface processes. A team of ∼25 experts covering observational, laboratory and theoretical (astro)chemistry met in summer of 2014 at the Lorentz Center in Leiden with the aim to provide solutions for this problem and to review the current state-of-the-art of grain surface models, both in terms of technical implementation into models as well as the most up-to-date information available from experiments and chemical computations. This review builds on the results of this workshop and gives an outlook for future directions
Accretion, Outflows, and Winds of Magnetized Stars
Many types of stars have strong magnetic fields that can dynamically
influence the flow of circumstellar matter. In stars with accretion disks, the
stellar magnetic field can truncate the inner disk and determine the paths that
matter can take to flow onto the star. These paths are different in stars with
different magnetospheres and periods of rotation. External field lines of the
magnetosphere may inflate and produce favorable conditions for outflows from
the disk-magnetosphere boundary. Outflows can be particularly strong in the
propeller regime, wherein a star rotates more rapidly than the inner disk.
Outflows may also form at the disk-magnetosphere boundary of slowly rotating
stars, if the magnetosphere is compressed by the accreting matter. In isolated,
strongly magnetized stars, the magnetic field can influence formation and/or
propagation of stellar wind outflows. Winds from low-mass, solar-type stars may
be either thermally or magnetically driven, while winds from massive, luminous
O and B type stars are radiatively driven. In all of these cases, the magnetic
field influences matter flow from the stars and determines many observational
properties. In this chapter we review recent studies of accretion, outflows,
and winds of magnetized stars with a focus on three main topics: (1) accretion
onto magnetized stars; (2) outflows from the disk-magnetosphere boundary; and
(3) winds from isolated massive magnetized stars. We show results obtained from
global magnetohydrodynamic simulations and, in a number of cases compare global
simulations with observations.Comment: 60 pages, 44 figure
The composition of the protosolar disk and the formation conditions for comets
Conditions in the protosolar nebula have left their mark in the composition
of cometary volatiles, thought to be some of the most pristine material in the
solar system. Cometary compositions represent the end point of processing that
began in the parent molecular cloud core and continued through the collapse of
that core to form the protosun and the solar nebula, and finally during the
evolution of the solar nebula itself as the cometary bodies were accreting.
Disentangling the effects of the various epochs on the final composition of a
comet is complicated. But comets are not the only source of information about
the solar nebula. Protostellar disks around young stars similar to the protosun
provide a way of investigating the evolution of disks similar to the solar
nebula while they are in the process of evolving to form their own solar
systems. In this way we can learn about the physical and chemical conditions
under which comets formed, and about the types of dynamical processing that
shaped the solar system we see today.
This paper summarizes some recent contributions to our understanding of both
cometary volatiles and the composition, structure and evolution of protostellar
disks.Comment: To appear in Space Science Reviews. The final publication is
available at Springer via http://dx.doi.org/10.1007/s11214-015-0167-
Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer: results and open issues
The medical treatment of non-small-cell lung cancer (NSCLC) has progressively changed since the introduction of “targeted therapy”. The development of one of these molecular drug categories, e. g., the epidermal growth factor receptor (EGFR) tyrosine-kinase (TK) selective inhibitors, such as the orally active gefitinib and erlotinib, offers an interesting new opportunity. The clinical response rates obtained with their employment in unselected patient populations only account for approximately 10%. Because of this, over the last two years numerous studies have been performed in order to identify the patient subsets that could better benefit from these agents. Not only patient characteristics and clinical-pathological features, such as never-smoking status, female gender, East Asian origin, adenocarcinoma histology, bronchioloalveolar subtype, but also molecular findings, such as somatic mutations in the EGFR gene, emerge as potentially useful prognostic and predictive factors in advanced NSCLC. Further, specifically designed clinical trials are still needed to completely clarify these and other open issues that are reviewed in this paper, in order to clarify all the interesting findings available in the clinical practice
ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP
Introduction of the nanobody caplacizumab was shown to be effective in the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in the acute setting. The official recommendations include plasma exchange (PEX), immunosuppression, and the use of caplacizumab for a minimum of 30 days after stopping daily PEX. This study was a retrospective, observational analysis of the use of caplacizumab in 60 patients from 29 medical centers in Germany. Immunosuppressive treatment led to a rapid normalization of ADAMTS13 activities (calculated median, 21 days). In 35 of 60 patients, ADAMTS13 activities started to normalize before day 30 after PEX; in 11 of 60 patients, the treatment was extended beyond day 30; and in 5 patients, it was extended even beyond day 58 due to persistent autoimmune activity. In 34 of 60 instances, caplacizumab was stopped before day 30 with a favorable outcome whenever ADAMTS13 activities were >10%. In contrast, 11 of 34 patients with ADAMTS13 activities <10% at the time of stopping caplacizumab treatment developed a nonfavorable outcome (disease exacerbation or relapse). In some cases, prolongation of the treatment interval to every other day was feasible and resulted in a sustained reduction of von Willebrand factor activity. ADAMTS13 activity measurements are central for a rapid diagnosis in the acute setting but also to tailor disease management. An ADAMTS13 activity-guided approach seems safe for identifying the individual time point when to stop caplacizumab to prevent overtreatment and undertreatment; this approach will result in significant cost savings without jeopardizing the well-being of patients. In addition, von Willebrand factor activity may serve as a biomarker for drug monitoring
Real-world data confirm the effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare but life-threatening condition. In 2018, the nanobody caplacizumab was approved for the treatment of adults experiencing an acute episode of aTTP, in conjunction with plasma exchange (PEX) and immunosuppression for a minimum of 30 days after stopping daily PEX. We performed a retrospective, observational analysis on the use of caplacizumab in 60 patients from 29 medical centers in Germany during acute disease management. Caplacizumab led to a rapid normalization of the platelet count (median, 3 days; mean 3.78 days). One patient died after late treatment initiation due to aTTP-associated complications. In 2 patients with initial disease presentation and in 4 additional patients with laboratory signs of an exacerbation or relapse after the initial therapy, PEX-free treatment regimens could be established with overall favorable outcome. Caplacizumab is efficacious in the treatment of aTTP independent of timing and ancillary treatment modalities. Based on this real-world experience and published literature, we propose to administer caplacizumab immediately to all patients with an acute episode of aTTP. Treatment decisions regarding the use of PEX should be based on the severity of the clinical presentation and known risk factors. PEX might be dispensable in some patients
Functional analysis of structural variants in single cells using Strand-seq
Somatic structural variants (SVs) are widespread in cancer, but their impact on disease evolution is understudied due to a lack of methods to directly characterize their functional consequences. We present a computational method, scNOVA, which uses Strand-seq to perform haplotype-aware integration of SV discovery and molecular phenotyping in single cells by using nucleosome occupancy to infer gene expression as a readout. Application to leukemias and cell lines identifies local effects of copy-balanced rearrangements on gene deregulation, and consequences of SVs on aberrant signaling pathways in subclones. We discovered distinct SV subclones with dysregulated Wnt signaling in a chronic lymphocytic leukemia patient. We further uncovered the consequences of subclonal chromothripsis in T cell acute lymphoblastic leukemia, which revealed c-Myb activation, enrichment of a primitive cell state and informed successful targeting of the subclone in cell culture, using a Notch inhibitor. By directly linking SVs to their functional effects, scNOVA enables systematic single-cell multiomic studies of structural variation in heterogeneous cell populations
Single photon extraction for FACT's SiPMs allows for novel IACT event representation
Imaging Atmospheric Cherenkov Telescopes provide large gamma-ray collection areas > 104 m2 and successfully probe the high energetic gamma-ray sky by observing extensive air-showers during the night. The First G-APD Cherenkov Telescope (FACT) explores silicon based photoelectric converters (called G-APDs or SiPMs) which provide more observation time with strong moonlight, a more stable photon gain over years of observations, and mechanically simpler imaging cameras. So far, the signal extraction methods used for FACT originate from sensors with no intrinsic quantized responses like photomultiplier tubes. This standard signal extraction is successfully used for the long time monitoring of the gamma-ray flux of bright blazars. However, we now challenge our classic signal extraction and explore single photon extraction methods to take advantage of the highly stable and quantized single photon responses of FACT’s SiPM sensors. Instead of having one main pulse with one arrival time and one photon equivalent extracted for each pixel, we extract the arrival times of all individual photons in a pixel’s time line which opens up a new dimension in time for representing extensive air-showers with an IACT.S. A. Mueller, J. Adam, M. L. Ahnen, D. Baack, M. Balbo, A. Biland, M. Blank, T. Bretz, K. Bruegge, J. Buss, A. Dmytriiev, D. Dorner, S. Einecke, D. Elsaesser, C. Hempfling, T. Herbst, D. Hildebrand, L. Kortmann, L. Linhoff, M. Mahlke, K. Mannheim, D. Neise, A. Neronov, M. Noethe, J. Oberkirch, A. Paravac, F. Pauss, W. Rhode, B. Schleicher, F. Schulz, A. Shukla, V. Sliusar, F. Temme, J. Thaele, R. Walte
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