Evaluation of users’ perspective on VOIP’s security vulnerabilities

Voice over Internet protocol (VoIP) represents a major newish trend in telecommunications and an alternative to traditional phone systems. VoIP uses IP networks and therefore inherits their vulnerabilities. Adding voice traffic to IP networks complicates security issues and introduces a range of vulnerabilities. A VoIP system may face either an exclusive attack or an attack to the underlying IP network. The significance of security and privacy in VoIP communications are well known, and many studies mostly from the technical perspective have been published. However to date, no known research has been conducted to evaluate users’ perspectives on these issues. In light of this scarcity, we carried out a survey to evaluate users’ awareness of VoIP security vulnerabilities, and their attitudes towards privacy in VoIP communications. An overall finding highlights the fact that the majority of participants are neither concerned about VoIP privacy (eavesdropping) or VoIP security

Online Social Networking Has a Greater Effect on Others than on Me: A Third-Person Effect Perspective

To date, much research has been conducted on the positive and negative effects of online social networking (OSN). However, how users perceive others and themselves being subject to these effects and the consequences of users’ perceptions are understudied. Drawing from the third-person effect theory, this study examines the self-other perceptual gap for positive and negative effects of OSN and the consequences of perceptions for negative effects. Findings from our online survey (N=187) and interviews (N=8) suggested a significant difference between the perceived positive and negative effects on self and on others. Furthermore, the link between the third-person perception for usage risks of OSN and support for taking privacy protection actions was confirmed. We also found that the self–other discrepant perceptions were not influenced by age, time spent on OSN, number of OSN friends. However, gender emerged as a key difference in the third-person effects gap for privacy risks

Making Decisions about Self-Disclosure in Online Social Networks

This paper explores privacy calculus decision making processes for online social networks (OSN). Content analysis method is applied to analyze data obtained from face-to-face interviews and online survey with open-ended questions of 96 OSN users from different countries. The factors users considered before self-disclosing are explored. The perceived benefits and risks of using OSN and their impact on self-disclosure are also identified. We determine that the perceived risks of OSN usage hinder self-disclosure. It is not clear, however, whether the perceived benefits offset the impact of the risks on self-disclosure behavior. The findings as a whole do not support privacy calculus in OSN settings

Relação entre pressão arterial e atividade física em adultos de 20 a 65 anos

A healthy diet, physically active lifestyle and maintaining normal weight constitute the cornerstones of prevention of several chronic diseases. The objective of this study is to determine the relationship between physical activity, Consumption of fruits and vegetables, high blood pressure. In this descriptive-analytical study, 1452 citizens (744 men and 708 women) in Sabzevar (Khorasan Razavi Province) aged between 20 to 65 years old were randomly selected in 2016. The population completed the International Physical Activity Questionnaire (IPAQ) and their systolic and diastolic blood pressure was measured using a Digital Blood Pressure Monitor. Details of the nutritional status of the subjects under sex. SPSS software was used to analyze data. In the present study, the dairy consumption of the majority of people (48.1%) had a share of dairy consumption per day (milk and yogurt, cheese, cream and cheese), and 46.9% of the subjects were less than one share per day Dairy products. This study revealed that the level of physical activity is low in 46.2% of men and 44.2% of women that is less than 600 MET per week. In addition, 0.059% of the total population suffered from systolic blood pressure above 140 mm Hg and 10% of the total population had a diastolic blood pressure above 90 mm Hg.Una dieta saludable, un estilo de vida físicamente activo y mantener un peso normal constituyen las piedras angulares de la prevención de varias enfermedades crónicas. El objetivo de este estudio es determinar la relación entre la actividad física, el consumo de frutas y verduras, la presión arterial alta. En este estudio analítico descriptivo, 1452 ciudadanos (744 hombres y 708 mujeres) en Sabzevar (provincia de Khorasan Razavi) de 20 a 65 años de edad fueron seleccionados al azar en 2016. La población completó el Cuestionario Internacional de Actividad Física (IPAQ) y su sistólica y la presión arterial diastólica se midió utilizando un monitor digital de presión arterial. Detalles del estado nutricional de los sujetos bajo sexo. Se utilizó el software SPSS para analizar los datos. En el presente estudio, el consumo de lácteos de la mayoría de las personas (48,1%) tuvo una proporción del consumo de lácteos por día (leche y yogur, queso, crema y queso), y el 46,9% de los sujetos fue menos de una acción por día. Productos lácteos. Este estudio reveló que el nivel de actividad física es bajo en el 46.2% de los hombres y el 44.2% de las mujeres, que es menos de 600 MET por semana. Además, el 0,059% de la población total sufría de presión arterial sistólica por encima de 140 mm Hg y el 10% de la población total tenía una presión arterial diastólica por encima de 90 mm Hg.Uma dieta saudável, estilo de vida fisicamente ativo e manter o peso normal constituem os pilares da prevenção de diversas doenças crônicas. O objetivo deste estudo é determinar a relação entre atividade física, consumo de frutas e hortaliças, hipertensão arterial. Neste estudo descritivo-analítico, 1452 cidadãos (744 homens e 708 mulheres) em Sabzevar (província de Khorasan Razavi) com idade entre 20 e 65 anos foram selecionados aleatoriamente em 2016. A população completou o Questionário Internacional de Atividade Física (IPAQ) e sua sistólica. e a pressão arterial diastólica foi medida usando um monitor digital de pressão arterial. Detalhes do estado nutricional dos sujeitos em sexo. O software SPSS foi utilizado para analisar dados. No presente estudo, o consumo de lácteos da maioria das pessoas (48,1%) teve uma participação no consumo de produtos lácteos por dia (leite e iogurte, queijo, creme e queijo) e 46,9% dos participantes tinham menos de uma ação por dia. Lacticínios. Este estudo revelou que o nível de atividade física é baixo em 46,2% dos homens e em 44,2% das mulheres que é inferior a 600 MET por semana. Além disso, 0,059% da população total sofria de pressão arterial sistólica acima de 140 mmHg e 10% da população total tinha pressão arterial diastólica acima de 90 mmHg

A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery [preprint]

Nonsense suppressors (NonSups) treat premature termination codon (PTC) disorders by inducing the selection of near cognate tRNAs at the PTC position, allowing readthrough of the PTC and production of full-length protein. Studies of NonSup-induced readthrough of eukaryotic PTCs have been carried out using animals, cells or crude cell extracts. In these studies, NonSups can promote readthrough directly, by binding to components of the protein synthesis machinery, or indirectly, by inhibiting nonsense-mediated mRNA decay or by other mechanisms. Here we utilize a highly-purified in vitro system (Zhang et al., 2016. eLife 5: e13429) to measure exclusively direct NonSup-induced readthrough. Of 17 previously identified NonSups, 13 display direct effects, apparently via at least two different mechanisms. We can monitor such direct effects by single molecule FRET (smFRET). Future smFRET experiments will permit elucidation of the mechanisms by which NonSups stimulate direct readthrough, aiding ongoing efforts to improve the clinical usefulness of NonSups

The effect of Tai Chi on quality of life in male older people: A randomized controlled clinical trial

Background and purpose Physical activity can improve the mental and physical functioning of older people. This study investigated the impact of Tai Chi exercise on the quality of life of older men. Materials and methods This randomized controlled clinical trial was conducted on 132 older men in an urban area of Iran. The subjects were randomly assigned into two groups: a Tai Chi intervention group and a control group (n = 66 per group). Quality of life was evaluated using the Leiden-Padua quality of life questionnaire before and after the intervention. Data analysis was performed using analytical statistics via the SPSS software. Results After eight weeks of Tai Chi exercise, the mean scores of quality of life in different areas demonstrated a statistically significant difference between the two groups (p < 0 0.05). Conclusion This study illustrated that the 8-week Tai Chi intervention had a positive effect on the quality of life in older men

The Specificity of the FOXL2 c.402C>G Somatic Mutation: A Survey of Solid Tumors

A somatic mutation in the FOXL2 gene is reported to be present in almost all (97%; 86/89) morphologically defined, adult-type, granulosa-cell tumors (A-GCTs). This FOXL2 c.402C>G mutation changes a highly conserved cysteine residue to a tryptophan (p.C134W). It was also found in a minority of other ovarian malignant stromal tumors, but not in benign ovarian stromal tumors or unrelated ovarian tumors or breast cancers.Herein we studied other cancers and cell lines for the presence of this mutation. We screened DNA from 752 tumors of epithelial and mesenchymal origin and 28 ovarian cancer cell lines and 52 other cancer cell lines of varied origin. We found the FOXL2 c.402C>G mutation in an unreported A-GCT case and the A-GCT-derived cell line KGN. All other tumors and cell lines analyzed were mutation negative.In addition to proving that the KGN cell line is a useful model to study A-GCTs, these data show that the c.402C>G mutation in FOXL2 is not commonly found in a wide variety of other cancers and therefore it is likely pathognomonic for A-GCTs and closely related tumors

Doxorubicin-induced renal inflammation in rats: Protective role of Plantago major

Objective: The aim of the present study was to evaluate the possible protective effect of Plantago major (P. major) extract against doxorubicin (DXR)-induced renal inflammation in rats. Materials and Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR, and Ext1200+DXR. Duration of the study was 35 days and DXR was intravenously injected on the 7th day of the experiment. Tumor necrosis factor-alpha (TNF-α) production and monocyte chemoattractant protein-1 (MCP-1) expression levels were assessed in the left kidney. Serum creatinine concentration and osmolarity were determined on the 1st, 14th, 21st, 28th and 35th days of the experiment. Results: DXR caused a significant increase in renal expression of MCP-1 and TNF-α production compared to control animals. Administration of dexamethasone, vitamin E and P. major extract significantly improved the expression of these inflammatory mediators compared to DXR group. Compared to day 1 in DXR group, serum osmolarity showed a significant increase on days 21, 28 and 35. Also, on these days, serum osmolarity in DXR group was significantly higher than that on the same days in control group. In Vit E+DXR and Ext 1200+DXR groups, there was no significant changes in serum osmolarity among different days of the study. However, in these groups, serum osmolarity on days 21, 28 and 35 showed a significant decrease compared to the same days in DXR group. Conclusion: Present results suggest that hydroethanolic extract of P. major protected renal tissue against DXR–induced renal inflammation

deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data

Gene fusions created by somatic genomic rearrangements are known to play an important role in the onset and development of some cancers, such as lymphomas and sarcomas. RNA-Seq (whole transcriptome shotgun sequencing) is proving to be a useful tool for the discovery of novel gene fusions in cancer transcriptomes. However, algorithmic methods for the discovery of gene fusions using RNA-Seq data remain underdeveloped. We have developed deFuse, a novel computational method for fusion discovery in tumor RNA-Seq data. Unlike existing methods that use only unique best-hit alignments and consider only fusion boundaries at the ends of known exons, deFuse considers all alignments and all possible locations for fusion boundaries. As a result, deFuse is able to identify fusion sequences with demonstrably better sensitivity than previous approaches. To increase the specificity of our approach, we curated a list of 60 true positive and 61 true negative fusion sequences (as confirmed by RT-PCR), and have trained an adaboost classifier on 11 novel features of the sequence data. The resulting classifier has an estimated value of 0.91 for the area under the ROC curve. We have used deFuse to discover gene fusions in 40 ovarian tumor samples, one ovarian cancer cell line, and three sarcoma samples. We report herein the first gene fusions discovered in ovarian cancer. We conclude that gene fusions are not infrequent events in ovarian cancer and that these events have the potential to substantially alter the expression patterns of the genes involved; gene fusions should therefore be considered in efforts to comprehensively characterize the mutational profiles of ovarian cancer transcriptomes