Quiescent and flaring X-ray emission from the nearby M/T dwarf binary SCR 1845-6357

We investigate an XMM-Newton observation of SCR 1845-6357, a nearby, ultracool M8.5/T5.5 dwarf binary. The binary is unresolved in the XMM detectors, however the X-ray emission is very likely from the M8.5 dwarf. We compare its flaring emission to those of similar very low mass stars and additionally present an XMM observation of the M8 dwarf VB 10. We detect quasi-quiescent X-ray emission from SCR 1845-6357 at soft X-ray energies in the 0.2-2.0 keV band, as well as a strong flare with a count rate increase of a factor of 30 and a duration of only 10 minutes. The quasi-quiescent X-ray luminosity of log L_x = 26.2 erg/s and the corresponding activity level of log L_x/L_bol = -3.8 point to a fairly active star. Coronal temperatures of up to 5 MK and frequent minor variability support this picture. During the flare, that is accompanied by a significant brightening in the near-UV, plasma temperatures of 25-30 MK are observed and an X-ray luminosity of L_x= 8 x 10^27 erg/s is reached. SCR 1845-6357 is a nearby, very low mass star that emits X-rays at detectable levels in quasi-quiescence, implying the existence of a corona. The high activity level, coronal temperatures and the observed large flare point to a rather active star, despite its estimated age of a few Gyr.Comment: Accepted by A&A, 6 pages, 5 figure

Probing jet properties via two particle correlation method

The formulae for calculating jet fragmentation momentum, $$, and parton transverse momentum,$$, and conditional yield are discussed in two particle correlation framework. Additional corrections are derived to account for the limited detector acceptance and inefficiency, for cases when the event mixing technique is used. The validity of our approach is confirmed with Monte-carlo simulation.Comment: Proceeding for HotQuarks2004 conference. 11 pages, 8 figures, corrected for typo

Importance and hurdles to drug discovery for neurological disease

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110873/1/ana23997.pd

Re-Focusing - Building a Future for Entrepreneurial Education & Learning

The field of entrepreneurship has struggled with fundamental questions concerning the subject’s nature and purpose. To whom and to what means are educational and training agendas ultimately directed? Such questions have become of central importance to policy makers, practitioners and academics alike. There are suggestions that university business schools should engage more critically with the lived experiences of practising entrepreneurs through alternative pedagogical approaches and methods, seeking to account for and highlighting the social, political and moral aspects of entrepreneurial practice. In the UK, where funding in higher education has become increasingly dependent on student fees, there are renewed pressures to educate students for entrepreneurial practice as opposed to educating them about the nature and effects of entrepreneurship. Government and EU policies are calling on business schools to develop and enhance entrepreneurial growth and skill sets, to make their education and training programmes more proactive in providing innovative educational practices which help and facilitate life experiences and experiential learning. This paper makes the case for critical frameworks to be applied so that complex social processes become a source of learning for educators and entrepreneurs and so that innovative pedagogical approaches can be developed in terms both of context (curriculum design) and process (delivery methods)

Diminished Left Ventricular Dyssynchrony and Impact of Resynchronization in Failing Hearts With Right Versus Left Bundle Branch Block

ObjectivesWe compared mechanical dyssynchrony and the impact of cardiac resynchronization therapy (CRT) in failing hearts with a pure right (RBBB) versus left bundle branch block (LBBB).BackgroundCardiac resynchronization therapy is effective for treating failing hearts with conduction delay and discoordinate contraction. Most data pertain to LBBB delays. With RBBB, the lateral wall contracts early so that biventricular (BiV) pre-excitation may not be needed. Furthermore, the magnitude of dyssynchrony and impact of CRT in pure RBBB versus LBBB remains largely unknown.MethodsDogs with tachypacing-induced heart failure combined with right or left bundle branch radiofrequency ablation were studied. Basal dyssynchrony and effects of single and BiV CRT on left ventricular (LV) function were assessed by pressure-volume catheter and tagged magnetic resonance imaging, respectively.ResultsLeft bundle branch block and RBBB induced similar QRS widening, and LV function (ejection fraction, maximum time derivative of LV pressure [dP/dtmax]) was similarly depressed in failing hearts with both conduction delays. Despite this, mechanical dyssynchrony was less in RBBB (circumferential uniformity ratio estimate [CURE] index: 0.80 ± 0.03 vs. 0.58 ± 0.09 for LBBB, p < 0.04; CURE 0→1 is dyssynchronous→synchronous). Cardiac resynchronization therapy had correspondingly less effect on hearts with RBBB than those with LBBB (i.e., 5.5 ± 1.1% vs. 29.5 ± 5.0% increase in dP/dtmax, p < 0.005), despite similar baselines. Furthermore, right ventricular-only pacing enhanced function and synchrony in RBBB as well or better than did BiV, whereas LV-only pacing worsened function.ConclusionsLess mechanical dyssynchrony is induced by RBBB than LBBB in failing hearts, and the corresponding impact of CRT on the former is reduced. Right ventricular-only pacing may be equally efficacious as BiV CRT in hearts with pure right bundle branch conduction delay

New neighbours: V. 35 DENIS late-M dwarfs between 10 and 30 parsecs

This paper reports updated results on our systematic mining of the DENIS database for nearby very cool M-dwarfs (M6V-M8V, 2.0<I-J<3.0, photometric distance within 30 pc), We calibrate the DENIS (M_I, I-J) colour-luminosity relationship from M dwarfs with well measured parallaxes (HIP, GCTP,...), obtaining distance errors for single dwarfs of 25%. Using proper motions measured on archive Schmidt plates for stars that meet the photometric selection criteria, we eliminate the giants by a Reduced Proper Motion cutoff, which is significantly more selective than a simple proper motion cutoff. Here we present new data for 62 red dwarf candidates selected over 5700 square degrees in the DENIS database. 26 of those originate in the 2100 square degrees analysed in Paper I, with improved parameters here, and 36 were found in 3600 additional square degrees. 25 of those are new nearby dwarfs. We determine from that sample of 62 stars a stellar density for 12.0<M_I<14.0 of 2.2(+-0.4)E-3 stars/pc^3/mag. This value is consistent with photometric luminosity functions measured from deeper and smaller-field observations, but not with the nearby star luminosity function. In addition we cross-identified the NLTT and DENIS catalogues to find 15 similar stars, in parts of the sky not yet covered by the colour-selected search.Comment: Accepted by Astronomy & astrophysics. 17 pages, 8 figure

Monodromy--like Relations for Finite Loop Amplitudes

We investigate the existence of relations for finite one-loop amplitudes in Yang-Mills theory. Using a diagrammatic formalism and a remarkable connection between tree and loop level, we deduce sequences of amplitude relations for any number of external legs.Comment: 24 pages, 6 figures, v2 typos corrected, reference adde

Mood instability, mental illness and suicidal ideas : results from a household survey

Purpose: There is weak and inconsistent evidence that mood instability (MI) is associated with depression, post traumatic stress disorder (PTSD) and suicidality although the basis of this is unclear. Our objectives were first to test whether there is an association between depression and PTSD, and MI and secondly whether MI exerts an independent effect on suicidal thinking over and above that explained by common mental disorders. Methods: We used data from the Adult Psychiatric Morbidity Survey 2007 (N = 7,131). Chi-square tests were used to examine associations between depression and PTSD, and MI, followed by regression modelling to examine associations between MI and depression, and with PTSD. Multiple logistic regression analyses were used to assess the independent effect of MI on suicidal thinking, after adjustment for demographic factors and the effects of common mental disorder diagnoses. Results: There are high rates of MI in depression and PTSD and the presence of MI increases the odds of depression by 10.66 [95 % confidence interval (CI) 7.51–15.13] and PTSD by 8.69 (95 % CI 5.90–12.79), respectively, after adjusting for other factors. Mood instability independently explained suicidal thinking, multiplying the odds by nearly five (odds ratio 4.82; 95 % CI 3.39–6.85), and was individually by some way the most important single factor in explaining suicidal thoughts. Conclusions: MI is strongly associated with depression and PTSD. In people with common mental disorders MI is clinically significant as it acts as an additional factor exacerbating the risk of suicidal thinking. It is important to enquire about MI as part of clinical assessment and treatment studies are required