1,008 research outputs found
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
- Brewer Mathew
- Briand William
- Brink Matilda
- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
- Campbell Robert
- Cao Qinhao
- Cao Yixin
- Cao Yuze
- Carrillo Leo
- Carter Jonah
- Casas Alexis
- Castillo Nora Esther Torres
- Castillo Sandra
- Cave John
- Chai Ruochen
- Chamiec-Case Elizabeth
- Chan Janice
- Chan Yuan-Yao
- Chandramouli Priyanka
- Chang Annabel
- Chang Catherine
- Chang Kevin
- Chang Thomas
- Chang Ting-Chen
- Chang Yu-Ci
- Chapman Tyler
- Chater Dounia
- Chau Anthony
- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
- Chun Ng Tsz
- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
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- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
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- Cohen Katherine
- Colant Noelle
- Coleman Sarah
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- Corre Christophe
- Costa Ben
- Cott Rachel Van
- Craw Darilyn
- Crispim Larissa de Souza
- Crone Michael Andrew
- Crooijmans Marjolein
- Crosby Laurel Constanti
- Crowley Peter
- Cruz Frida
- Cubukcu Hande
- Culfogienis Dylan
- Czekster Clarissa
- Dai Leijie
- Dalangin Rochelin
- Daniel Benjamin
- Daniels Lea
- Das Neves Laura
- Das Diptatanu
- Davis Christina
- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
- DeKloe Jackson
- Del Toro Mariano
- Delalez Nicolas
- Delgadillo Sabrina
- Delhomme Jean
- Demchuk Aubrey
- Deng Nian Ruei
- Deng Rui
- Denter Jennifer
- Deshmukh-Reeves Ed
- Despres Philippe C.
- Devi Velvizhi
- Dhaliwal Gurpreet
- Diaz Fernanda
- Ding Shizhi
- Ding Yiming
- Ding Zhipeng
- Dingyue Tang
- Dirven Yvette
- Dissmann Jil-Sophie
- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
- Dong Jason
- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
- Doyle David
- Doyle Shannon
- Dube Alexandre
- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
- Eidloth Franziska
- Eijkens Bruno
- Eilers Keno
- El Moubayed Yorgo
- Elcin Evrim
- Elias Noel
- Elikan Max
- Ellermeier Craig
- Elliott Hannah
- Elsa Yeung Hoi Lam
- Emilov Kristian
- Espinoza Diego
- Evans Rhys
- Faidh Mohammed
- Falgenhauer Elisabeth
- Fan Catherine
- Fang Chengzhu
- Fang Choco
- Fang Xiangyi
- Farhi Einan
- Farias Sebastian
- Farny Natalie
- Farny Natalie G.
- Farrell Jennifer
- Fassler Jan
- Faurdal David
- Faustova Ilona
- Feng Xinhua
- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
- Foda Asmaa
- Fong Yuhui Deborah
- Forman Victor
- Frank Stefanie
- Frankel Eva
- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
- Fu Wenhan
- Fu Yousi
- Fuentes Ernie
- Fulton Leah
- Fung Ip Ning
- Fung Yam Shing
- Gabrielli Jacopo
- Gahagan Maddison
- Gaitt Tobias
- Gaizauskaite Aukse
- Gallegos Isabella
- Gamoneda Diego
- Gandhi Rishi
- Gao Cecily
- Garavito Paula
- Garcia Chrismar
- Garcia David
- Garrido Delia
- Garulli Elisa
- Gaspar Camila
- Gaudi Alex
- Ge Gao
- Ge Yubin
- George Stephan
- Gerard Antoine
- Gershater Markus
- Ghosh Souvik
- Giannopoulos Alexandros Dimitriou
- Giannoula Yvoni
- Gilman Daniel Barber James
- Glockner Eleanor
- Goenka Anushya
- Goetz Marley
- Gogineni Namrata
- Gokul [NO FIRST NAME IN SCOPUS]
- Gonzalo Gonzalo Saiz
- Goodson Michael
- Gopaul Deshmukh
- Gou Yanchen
- Govers Jolijn
- Graaf Floor de
- Grace Tsui Shing Yan
- Graves Daniel
- Grazulyte Inga
- Greenwald Matthew
- Gu Jiajun
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- Guenther James
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- Ha Jacqueline
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- Han Weitang
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- Hanrong Zhu
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- Hao Junyao
- Hao Mei
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- Haoran Xu
- Haralsvik Anne Kristin
- Hariyani Imtiyaz
- Hartley Zach
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- Hau Sion
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- Imgold Markus
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- Isaacs Farren
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- Iyer Tvarita Shivakumar
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- Jacq Annick
- Jain Rishabh
- Jain Shubham
- Jainarayanan Ashwin Kumar
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- Markiv Anatoliy
- Marquina D.
- Marta Britany
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- Martinez Victor Javier Robledo
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- Meyfarth Oda-Emilia
- Miao Xinyi
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- Milshtein Eliya
- Ming Shaw Kar
- Mingge Li
- Mishler Dennis M.
- Mishra Vibhu
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- Mo Yilin
- Mohan Kumar B.S.
- Moncayo Eduardo
- Moreira Natalia Torres
- Mori Yuya
- Morrison Shikei
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- Mubeen Sara
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- Otto Matthias
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- Pedrolli Danielle Biscaro
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- Peng Jiarong
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- Preetha R.
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- Ptak Jeffrey
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- Rastogi Tashi
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- Reaney Bethany
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- Ren Wenan
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- Resendiz Armando Cortes
- Reshamwala Shamlan M. S.
- Rettedal Neil
- Ribeiro Nathan Vinicius
- Ries Anna
- Rigon Luca
- Ripp Steven
- Ritmejeris Justas
- Rivas Paula
- Rivera Mario Loya
- Roberts Luc
- Robin Marina
- Rodriguez Guillermo Fernandez
- Roige Biel Badia
- Rokaitis Irmantas
- Rolfsnes Rebekka Rekkedal
- Romeo Yves
- Rong Ziyue
- Rosa Caio Gomes Tavares
- Rouleau Francois D.
- Ruhnau Johannes
- Ruhnau Johannes
- Run Zhouyan
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- Ruzicka Alex
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- Sabuwala Burhanuddin
- Sackey Juliana
- Saha Margaret
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- Sande Amanda
- Sander Edward
- Sang Jonathan Cheng Hon
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- Santamaria Stefanie
- Santos Ana
- Saragliadis Athanasios
- Satoh Takehito
- Sauter Antoni Planas
- Sauvageau Dominic
- Saville Luke
- Saville Luke
- Sawant Maithili
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- Sayous Victor
- Schaaf Kaitlin
- Schacht Makayla
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- Schmidtchen Lisbeth
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- Selvarajah Vinoo
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- Shengjuan Jiang
- Shi Ruyi
- Shi Ruyi
- Shi Wei
- Shi Yingying
- Shinde Mousami
- Shkolnikov Irene
- Shola Chemay
- Shuan Cheah Matthew Yun
- Shuan Yun
- Shulun [NO FIRST NAME IN SCOPUS]
- Shuyu Shi
- Sia Nympha Elisa M.
- Siemer Jessica
- Sillner Cassandra
- Silva Bruna Fernandes
- Silva Dewuni De
- Simona Magda Faijes
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- Sun Kai
- Sun Shiyu
- Sun Ting
- Suss Beatrix
- Swart Pim
- Sweet Bailey
- Tairan Li
- Takeyasu Reanna
- Tamayo Diana
- Tan Huishuang
- Tan Li Yang
- Tang Cassie
- Tang Christian
- Tang Erting
- Tang Jiaqi
- Tang Weiyi
- Tang Yu-Cheng
- Tang Yu-Hsin
- Tao Yibing
- Tapia Jennifer
- Tariq Ali
- Taskar Poorva
- Taylor Max
- Telesz Lauren
- ten Dam Marjolijn
- Tharp Darron
- Thokachichu Pranav
- Thomas Sophie
- Thormar Eirikur Andri
- Throsberg Christian
- Tian Hong
- Tian Qinghe
- Tian Ruonan
- Tianyi Chang
- Ting Weiyu
- Tirad Alice
- Toanen Marion
- Tobin David
- Toghani Dorsa
- Torell Agnes
- Toro Bibiana
- Torres Ares
- Totten Stephanie
- Trevizo Cynthia Lizeth Gonzalez
- Trivellin Cecilia
- Trujillo-Rodriguez Lidimarie
- Tsai Leona
- Tsai You-Yang
- Tsang Helen
- Tsitsilonis Ourania E.
- Tsui Jennifer
- Tunaj Brigit
- Turner Matthew
- Turton Kristi
- Tutuianu Anna
- Tuzov Vladislav
- Twisk Simone
- Ucan Kutay
- Uday Adwaith B.
- Ueding Elisa
- Unal Tunc
- Urban Julia
- Uslu Attila
- Vaidya Anjali
- Vaitkus Dovydas
- Vanini Nadine Vaz
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- Vardi Omri
- Velasco Maria Antonia Luna
- Velikov Lukas
- Vella Toni
- Venclovas Tomas
- Venkatraghavan Sankalpa
- Verhagen Mick
- Verma Yashna
- Vignoni Alejandro
- Vincent Annette
- Vincent Sara
- Viswanathan Ashwin
- Vitkute Kornelija
- von Schoenberg Sophie
- Voort Gemma van der
- Vornholt Tobias
- Vries Philip Gorter de
- Waard Jazzy de
- Wadhams George
- Wagner Camille
- Wai Leung Chung
- Wan Chan Tsey
- Wan Leon
- Wan Mitchell
- Wang Cheng-Chieh
- Wang Chenxi
- Wang Choi Seong
- Wang Hao
- Wang Huichao
- Wang Kai
- Wang Kelsey
- Wang Kelsey
- Wang Ken
- Wang Li
- Wang Pengying
- Wang Ping
- Wang Qiupeng
- Wang Raven
- Wang Sibo
- Wang Sihan
- Wang Tian
- Wang Wei
- Wang Xiangxuan
- Wang Xin
- Wang Xinyue
- Wang Xuan
- Wang Xueyao
- Wang Yaling
- Wang Yi
- Wang Yifan
- Wang Yuefei
- Wang Yunyi
- Wang Yuyang
- Wang Yuyao
- Wang Zihao
- Wang Ziru
- Wang Ziyu
- Wanji Li
- Warzecha Heribert
- Watson Emily
- Wawrzyniak Dominika
- Weber Elisa
- Wei Zemeng
- Weile Carl
- Wenhao Xu
- Went Sam
- Whalen Kathleen
- Whiteside Jonny
- Whittle Michaella
- Wickiser Ken
- Windo Joe
- Wintermute Edwin
- Withanage Shamal
- Wolfbeisz Chiara
- Wong Angel
- Wong Hei Man
- Wong Joanne
- Woodward Noble
- Workman C. T.
- Wu Chenhai
- Wu Justin
- Wu Kangjie
- Wu Mengxuan
- Wu Michelle
- Wu Yaxuan
- Wu Yi
- Wu Yuxuan
- Wu Zishi
- Xi Yukun
- Xia Ruoyu
- Xiang Meredith
- Xiang Yuening
- Xiao Ziyang
- Xiaojin Li
- Xiaowen Mao
- Xilei Peng
- Xin Li
- Xin Tian
- Xing Jinming
- Xinguang Chen
- Xinlei Fang
- Xinyu Liu
- Xinyu Liu
- Xinyu Teng
- Xinyue Ma
- Xiong Xin
- Xiong Zhenyu
- Xirui Chen
- Xiu Yao
- Xiujing Hong
- Xu Guiyang
- Xu Hanning
- Xu Hao
- Xu Huandi
- Xu Sheng
- Xu Shirly
- Xu Xia
- Xu Xin
- Xu Yinsong
- Xuan Chen Zi
- Xue Fang
- Xue Han
- Xun Shu
- Yadav Ravineet
- Yadav Yash
- Yadi Liu
- Yan Calvin
- Yan Cathy
- Yan Han
- Yan Hongfa
- Yan Qingyan
- Yan Tsui Shing
- Yan Yeung Wing
- Yan Yining
- Yang Chao
- Yang Chenghao
- Yang Chuyi
- Yang Fan
- Yang Fuqiang
- Yang Hanyeol
- Yang Jake
- Yang Jianzhe
- Yang Jindian
- Yang Jinshu
- Yang Jun
- Yang Leyi
- Yang Ruofan
- Yang Shaobo
- Yang Shuting
- Yang Xilin
- Yang Yuchen
- Yang Zhuoyi
- Yang Zisang
- Yang Zon En
- Yao Andrew
- Yarbrough Hayden
- Yaxi Zhang
- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
- Yin Jiacheng
- Yin Lee Ka
- Yin Xianqi
- Yong Nur Liyana Binte Ayub Ow
- Yong Zhangxiang
- Yongjie Lin
- Yoo Hojun
- Yoon Soohyun
- You Jaewon
- Young Cam
- Yu Haimeng
- Yu Jiacheng
- Yu Kai-Chiang
- Yu Liuhong
- Yu Tam Chi
- Yu Wenfei
- Yu Yuen Wai
- Yuan Hetian
- Yuan Long
- Yuan Xing
- Yuan Zhe
- Yuanxu Jiang
- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
- Zhang Jianxiang
- Zhang Jige
- Zhang Jinhan
- Zhang Kaida
- Zhang Kecheng
- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L.
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Elders Petra J. M.
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K.
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson S
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M.'t
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Ingelsson Erik
- Irvin Marguerite R.
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Lamina Claudia
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jun
- Liu Junfeng
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Nielsen Aneta A.
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J.
- Obura Morgan O.
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E.
- Penninx Brenda
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- Qu Jia
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D. C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universitat Autònoma de Barcelona
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weir David R.
- Weiss Stefan
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu X
- Zhu Xiang
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S
- Adams Hieab H H
- Adeyemo Adebowale A
- Aguilar-Salinas Carlos A
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W
- Bennett David A
- Bentley Amy R
- Beulens Joline W J
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brown Christopher D
- Brown Michael R
- Brown Morris
- Brumpton Ben M
- Buring Julie E
- Burtt Noël P
- Böger Carsten A
- Cade Brian E
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C
- Chandak Giriraj R
- Chang Kyong-Mi
- Chasman Daniel I
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M
- Dantoft Thomas M
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J
- de Graaf Jacqueline
- De Jager Philip L
- de Kleijn Dominique
- de Silva H Janaka
- de Vries Paul S
- Dedoussis George
- Delgado Graciela E
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P
- Elders Petra J M
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K
- Farmaki Aliki-Eleni
- Faul Jessica D
- Feitosa Mary F
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Zishan
- Gaziano John M
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E
- Grant Struan F A
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M 't
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon
- Hayes M Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W
- Hidalgo Bertha
- Hilliard Austin T
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A
- Hunt Steven C
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Ingelsson Erik
- Irvin Marguerite R
- Jackson Rebecca D
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Jung Bettina
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L R
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus A L M
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E
- Koh Woon-Puay
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O
- Kraft Peter
- Krauss Ronald M
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L
- Laakso Markku
- Lamina Claudia
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Long Jirong
- Loos Ruth J F
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K E
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C
- Martin Lisa Warsinger
- Martin Nicholas G
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I
- McDaid Aaron F
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M
- Miller Jason E
- Millwood Iona Y
- Mitchell Jonathan S
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Mori Trevor A
- Morris Andrew P
- Morrison Alanna C
- Munroe Patricia B
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Nielsen Aneta A
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J
- Obura Morgan O
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N A
- Pandit Anita
- Parra Esteban J
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E
- Penninx Brenda
- Peters Annette
- Petersen Eva R B
- Peyser Patricia A
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P
- Prasad Gauri
- Preuss Michael H
- Province Michael A
- Psaty Bruce M
- Pérusse Louis
- Qu Jia
- Rader Daniel J
- Raitakari Olli T
- Rallidis Loukianos S
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D C
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Ripatti Samuli
- Ritchie Marylyn D
- Rosenthal Elisabeth A
- Rotimi Charles N
- Rotter Jerome I
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Rodney J
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C
- Smith Blair H
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stark Klaus J
- Stefansson Kari
- Strachan David P
- Stringham Heather M
- Sun Yan V
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R H J
- Timpson Nicholas J
- Trembath Richard C
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L
- Tsao Philip S
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Heel David A
- van Meurs Joyce B J
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J
- Warner Sophie C
- Warren Helen R
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B
- Weir David R
- Weiss Stefan
- Whitfield John B
- Wickremasinghe Ananda R
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H
- Willemsen Allegonda H M
- Willer Cristen J
- Wilson James G
- Wilson James G
- Wilson Peter W F
- Winkler Thomas W
- Wojczynski Mary K
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wu Jer-Yuarn
- Wu Kuan-Han H
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J M
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R
- Zimmermann Martina E
- Zmuda Joseph M
- Zonderman Alan B
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S
- Adams Hieab H H
- Adeyemo Adebowale A
- Aguilar-Salinas Carlos A
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W
- Bennett David A
- Bentley Amy R
- Beulens Joline W J
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brown Christopher D
- Brown Michael R
- Brown Morris
- Brumpton Ben M
- Buring Julie E
- Burtt Noël P
- Böger Carsten A
- Cade Brian E
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C
- Chandak Giriraj R
- Chang Kyong-Mi
- Chasman Daniel I
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M
- Dantoft Thomas M
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J
- de Graaf Jacqueline
- De Jager Philip L
- de Kleijn Dominique
- de Silva H Janaka
- de Vries Paul S
- Dedoussis George
- Delgado Graciela E
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P
- Elders Petra J M
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K
- Farmaki Aliki-Eleni
- Faul Jessica D
- Feitosa Mary F
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Zishan
- Gaziano John M
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E
- Grant Struan F A
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M 't
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon
- Hayes M Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W
- Hidalgo Bertha
- Hilliard Austin T
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A
- Hunt Steven C
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Ingelsson Erik
- Irvin Marguerite R
- Jackson Rebecca D
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Jung Bettina
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L R
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus A L M
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E
- Koh Woon-Puay
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O
- Kraft Peter
- Krauss Ronald M
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L
- Laakso Markku
- Lamina Claudia
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Long Jirong
- Loos Ruth J F
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K E
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C
- Martin Lisa Warsinger
- Martin Nicholas G
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I
- McDaid Aaron F
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M
- Miller Jason E
- Millwood Iona Y
- Mitchell Jonathan S
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Mori Trevor A
- Morris Andrew P
- Morrison Alanna C
- Munroe Patricia B
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Nielsen Aneta A
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J
- Obura Morgan O
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N A
- Pandit Anita
- Parra Esteban J
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E
- Penninx Brenda
- Peters Annette
- Petersen Eva R B
- Peyser Patricia A
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P
- Prasad Gauri
- Preuss Michael H
- Province Michael A
- Psaty Bruce M
- Pérusse Louis
- Qu Jia
- Rader Daniel J
- Raitakari Olli T
- Rallidis Loukianos S
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D C
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Ripatti Samuli
- Ritchie Marylyn D
- Rosenthal Elisabeth A
- Rotimi Charles N
- Rotter Jerome I
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Rodney J
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C
- Smith Blair H
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stark Klaus J
- Stefansson Kari
- Strachan David P
- Stringham Heather M
- Sun Yan V
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R H J
- Timpson Nicholas J
- Trembath Richard C
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L
- Tsao Philip S
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Heel David A
- van Meurs Joyce B J
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J
- Warner Sophie C
- Warren Helen R
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B
- Weir David R
- Weiss Stefan
- Whitfield John B
- Wickremasinghe Ananda R
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H
- Willemsen Allegonda H M
- Willer Cristen J
- Wilson James F
- Wilson James G
- Wilson Peter W F
- Winkler Thomas W
- Wojczynski Mary K
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wu Jer-Yuarn
- Wu Kuan-Han H
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J M
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R
- Zimmermann Martina E
- Zmuda Joseph M
- Zonderman Alan B
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/12/2022
- Field of study
Funding GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file 32: Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.Peer reviewedPublisher PD
Observation and branching fraction measurement of the decay Ξb- → Λ0 bπ -
- Author
- Aaij R
- Abdelmotteleb ASW
- Abellan Beteta C
- Abudinen F
- Ackernley T
- Adeva B
- Adinolfi M
- Adlarson P
- Afsharnia H
- Agapopoulou C
- Aidala CA
- Ajaltouni Z
- Akar S
- Akiba K
- Albicocco P
- Albrecht J
- Alessio F
- Alexander M
- Alfonso Albero A
- Aliouche Z
- Alvarez Cartelle P
- Amalric R
- Amato S
- Amey JL
- Amhis Y
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- Anderlini L
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- Archilli F
- Artamonov A
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- Audurier B
- Bacher D
- Bachiller Perea I
- Bachmann S
- Bachmayer M
- Back JJ
- Bailly reyre A
- Baladron Rodriguez P
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- Baldini W
- Baptista de Souza Leite J
- Barbetti M
- Barbosa IR
- Barlow RJ
- Barsuk S
- Barter W
- Bartolini M
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Studies of η and η′ production in pp and pPb collisions
- Author
- Aaij R.
- Abdelmotteleb A. S. W.
- Abrantes F. Goncalves
- Abudinén F.
- Ackernley T.
- Adeva B.
- Adinolfi M.
- Adlarson P.
- Agapopoulou C.
- Aidala C. A.
- Ajaltouni Z.
- Akar S.
- Akiba K.
- Albero A. Alfonso
- Albicocco P.
- Albrecht J.
- Alessio F.
- Alexander M.
- Aliouche Z.
- Altarelli M. Pepe
- Amalric R.
- Amato S.
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- Wong C. P.
- Wormser G.
- Wotton S. A.
- Wu H.
- Wu J.
- Wu Y.
- Wyllie K.
- Xian S.
- Xiang Z.
- Xie Y.
- Xu A.
- Xu J.
- Xu L.
- Xu L.
- Xu M.
- Xu Z.
- Xu Z.
- Xu Z.
- Yang D.
- Yang S.
- Yang X.
- Yang Y.
- Yang Z.
- Yang Z.
- Yeroshenko V.
- Yeung H.
- Yin H.
- Yu C. Y.
- Yu J.
- Yuan X.
- Zaffaroni E.
- Zavertyaev M.
- Zdybal M.
- Zeng M.
- Zhang C.
- Zhang D.
- Zhang J.
- Zhang L.
- Zhang S.
- Zhang S.
- Zhang Y.
- Zhang Y.
- Zhang Y. Z.
- Zhao Y.
- Zharkova A.
- Zhelezov A.
- Zheng X. Z.
- Zheng Y.
- Zhou T.
- Zhou X.
- Zhou Y.
- Zhovkovska V.
- Zhu L. Z.
- Zhu X.
- Zhu X.
- Zhu Z.
- Zhukov V.
- Zhuo J.
- Zou Q.
- Zuliani D.
- Zunica G.
- Publication venue
- Publication date
- 26/10/2023
- Field of study
The production of η and η′ mesons is studied in proton-proton and
proton-lead collisions collected with the LHCb detector. Proton-proton
collisions are studied at center-of-mass energies of 5.02 and 13 TeV,
and proton-lead collisions are studied at a center-of-mass energy per nucleon
of 8.16 TeV. The studies are performed in center-of-mass rapidity
regions 2.5<yc.m.<3.5 (forward rapidity) and −4.0<yc.m.<−3.0
(backward rapidity) defined relative to the proton beam direction. The η
and η′ production cross sections are measured differentially as a function
of transverse momentum for 1.5<pT<10 GeV and 3<pT<10 GeV, respectively. The differential cross sections are used to
calculate nuclear modification factors. The nuclear modification factors for
η and η′ mesons agree at both forward and backward rapidity, showing
no significant evidence of mass dependence. The differential cross sections of
η mesons are also used to calculate η/π0 cross section ratios,
which show evidence of a deviation from the world average. These studies offer
new constraints on mass-dependent nuclear effects in heavy-ion collisions, as
well as η and η′ meson fragmentation.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://lhcbproject.web.cern.ch/Publications/p/LHCb-PAPER-2023-030.html (LHCb
public pages
Precision measurement of CP violation in the penguin-mediated decay Bs0→ϕϕ
- Author
- Aaij R
- Abdelmotteleb ASW
- Abellan Beteta C
- Abudinén F
- Ackernley T
- Adeva B
- Adinolfi M
- Adlarson P
- Afsharnia H
- Agapopoulou C
- Aidala CA
- Ajaltouni Z
- Akar S
- Akiba K
- Albicocco P
- Albrecht J
- Alessio F
- Alexander M
- Alfonso Albero A
- Aliouche Z
- Alvarez Cartelle P
- Amalric R
- Amato S
- Amey JL
- Amhis Y
- An L
- Anderlini L
- Andersson M
- Andreianov A
- Andreotti M
- Andreou D
- Ao D
- Archilli F
- Artamonov A
- Artuso M
- Aslanides E
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- Bachiller Perea IB
- Bachmann S
- Bachmayer M
- Back JJ
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- Baladron Rodriguez P
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- Baptista de Souza Leite J
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- Belyaev I
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- Berezhnoy A
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- Berninghoff D
- Bernstein HC
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- Bezshyiko Ia
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- Bieker MS
- Biesuz NV
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- Bishop FCR
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- Hennequin AM
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- Herd JH
- Heuel J
- Hicheur A
- Hill D
- Hilton M
- Hollitt SE
- Horswill J
- Hou R
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- Hu J
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- Hu W
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- Hulsbergen W
- Hunter RJ
- Hushchyn M
- Hutchcroft D
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- Idzik M
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- Iniukhin A
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- Jacobsson R
- Jage H
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- Jakobsen S
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- Kmiec MR
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- Konoplyannikov A
- Kopciewicz P
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- LHCb Collaboration
- Li A
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- Lin C
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- Williams I
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- Wislicki W
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- Witola L
- Wong CP
- Wormser G
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- Wyllie K
- Xiang Z
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- Yeroshenko V
- Yeung H
- Yin H
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- Yuan X
- Zaffaroni E
- Zavertyaev M
- Zdybal M
- Zeng M
- Zhang C
- Zhang D
- Zhang JZ
- Zhang L
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhao Y
- Zharkova A
- Zhelezov A
- Zheng Y
- Zhou T
- Zhou X
- Zhou Y
- Zhovkovska V
- Zhu X
- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zucchelli S
- Zuliani D
- Zunica G
- Publication venue
- Publication date
- 01/01/2023
- Field of study
A flavor-tagged time-dependent angular analysis of the decay
Bs0→ϕϕ is performed using pp collision data collected
by the LHCb experiment at % at s=13 TeV, the center-of-mass energy of
13 TeV, corresponding to an integrated luminosity of 6 fb^{-1}. The
CP-violating phase and direct CP-violation parameter are measured
to be ϕssˉs=−0.042±0.075±0.009 rad and
∣λ∣=1.004±0.030±0.009, respectively, assuming the same values
for all polarization states of the ϕϕ system. In these results, the
first uncertainties are statistical and the second systematic. These parameters
are also determined separately for each polarization state, showing no evidence
for polarization dependence. The results are combined with previous LHCb
measurements using pp collisions at center-of-mass energies of 7 and 8 TeV,
yielding ϕssˉs=−0.074±0.069 rad and ∣lambda∣=1.009±0.030. This is the most precise study of time-dependent CP violation
in a penguin-dominated B meson decay. The results are consistent with
CP symmetry and with the Standard Model predictions.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-001.html (LHCb
public pages
Fraction of χc decays in prompt J/ψ production measured in pPb collisions at sNN=8.16 TeV
- Author
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- Abdelmotteleb A. S. W.
- Abrantes F. Goncalves
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- Yeroshenko V.
- Yeung H.
- Yin H.
- Yu C. Y.
- Yu J.
- Yuan X.
- Zaffaroni E.
- Zavertyaev M.
- Zdybal M.
- Zeng M.
- Zhang C.
- Zhang D.
- Zhang J.
- Zhang L.
- Zhang S.
- Zhang S.
- Zhang Y.
- Zhang Y.
- Zhang Y. Z.
- Zhao Y.
- Zharkova A.
- Zhelezov A.
- Zheng X. Z.
- Zheng Y.
- Zhou T.
- Zhou X.
- Zhou Y.
- Zhovkovska V.
- Zhu L. Z.
- Zhu X.
- Zhu X.
- Zhu Z.
- Zhukov V.
- Zhuo J.
- Zou Q.
- Zuliani D.
- Zunica G.
- Publication venue
- Publication date
- 02/11/2023
- Field of study
The fraction of χc1 and χc2 decays in the prompt J/ψ
yield, Fχc=σχc→J/ψ/σJ/ψ, is measured by
the LHCb detector in pPb collisions at sNN=8.16 TeV. The study
covers the forward (1.5<y∗<4.0) and backward (−5.0<y∗<−2.5) rapidity
regions, where y∗ is the J/ψ rapidity in the nucleon-nucleon
center-of-mass system. Forward and backward rapidity samples correspond to
integrated luminosities of 13.6 ± 0.3 nb−1 and 20.8 ± 0.5
nb−1, respectively. The result is presented as a function of the J/ψ
transverse momentum pT,J/ψ in the range 1<pT,J/ψ<20 GeV/c.
The Fχc fraction at forward rapidity is compatible with the LHCb
measurement performed in pp collisions at s=7 TeV, whereas the
result at backward rapidity is 2.4 σ larger than in the forward region
for 1<pT,J/ψ<3 GeV/c. The increase of Fχc at low pT,J/ψ at backward rapidity is compatible with the suppression of the
ψ(2S) contribution to the prompt J/ψ yield. The lack of in-medium
dissociation of χc states observed in this study sets an upper limit of
180 MeV on the free energy available in these pPb collisions to dissociate or
inhibit charmonium state formation.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-028.html (LHCb
public pages
A measurement of ΔΓs
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- Publication venue
- Publication date
- 19/10/2023
- Field of study
Using a dataset corresponding to 9 fb−1 of integrated
luminosity collected with the LHCb detector between 2011 and 2018 in
proton-proton collisions, the decay-time distributions of the decay modes
Bs0→J/ψη′ and Bs0→J/ψπ+π−
are studied. The decay-width difference between the light and heavy mass
eigenstates of the Bs0 meson is measured to be ΔΓs=0.087±0.012±0.009ps−1, where the first uncertainty is
statistical and the second systematic.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-025.htm
Enhanced production of Λb0 baryons in high-multiplicity pp collisions at s=13 TeV
- Author
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- Publication venue
- Publication date
- 18/10/2023
- Field of study
The production rate of Λb0 baryons relative to B0 mesons
in pp collisions at a center-of-mass energy s=13 TeV is measured
by the LHCb experiment. The ratio of Λb0 to B0 production
cross-sections shows a significant dependence on both the transverse momentum
and the measured charged-particle multiplicity. At low multiplicity, the ratio
measured at LHCb is consistent with the value measured in e+e−
collisions, and increases by a factor of ∼2 with increasing multiplicity.
At relatively low transverse momentum, the ratio of Λb0 to
B0 cross-sections is higher than what is measured in e+e−
collisions, but converges with the e+e− ratio as the momentum
increases. These results imply that the evolution of heavy b quarks into
final-state hadrons is influenced by the density of the hadronic environment
produced in the collision. Comparisons with a statistical hadronization model
and implications for the mechanisms enforcing quark confinement are discussed.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-027.html (LHCb
public pages
- …