3,246 research outputs found
Charge transport in poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers
We investigate the charge transport in synthetic DNA polymers built up from
single types of base pairs. In the context of a polaron-like model, for which
an electronic tight-binding system and bond vibrations of the double helix are
coupled, we present estimates for the electron-vibration coupling strengths
utilizing a quantum-chemical procedure. Subsequent studies concerning the
mobility of polaron solutions, representing the state of a localized charge in
unison with its associated helix deformation, show that the system for
poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers, respectively possess
quantitatively distinct transport properties. While the former supports
unidirectionally moving electron breathers attributed to highly efficient
long-range conductivity the breather mobility in the latter case is
comparatively restrained inhibiting charge transport. Our results are in
agreement with recent experimental results demonstrating that poly(dG)-poly(dC)
DNA molecules acts as a semiconducting nanowire and exhibits better conductance
than poly(dA)-poly(dT) ones.Comment: 11 pages, 5 figure
The interior of axisymmetric and stationary black holes: Numerical and analytical studies
We investigate the interior hyperbolic region of axisymmetric and stationary
black holes surrounded by a matter distribution. First, we treat the
corresponding initial value problem of the hyperbolic Einstein equations
numerically in terms of a single-domain fully pseudo-spectral scheme.
Thereafter, a rigorous mathematical approach is given, in which soliton methods
are utilized to derive an explicit relation between the event horizon and an
inner Cauchy horizon. This horizon arises as the boundary of the future domain
of dependence of the event horizon. Our numerical studies provide strong
evidence for the validity of the universal relation \Ap\Am = (8\pi J)^2 where
\Ap and \Am are the areas of event and inner Cauchy horizon respectively,
and denotes the angular momentum. With our analytical considerations we are
able to prove this relation rigorously.Comment: Proceedings of the Spanish Relativity Meeting ERE 2010, 10 pages, 5
figure
Localization Properties of Electronic States in Polaron Model of poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers
We numerically investigate localization properties of electronic states in a
static model of poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers with
realistic parameters obtained by quantum-chemical calculation. The randomness
in the on-site energies caused by the electron-phonon coupling are completely
correlated to the off-diagonal parts. In the single electron model, the effect
of the hydrogen-bond stretchings, the twist angles between the base pairs and
the finite system size effects on the energy dependence of the localization
length and on the Lyapunov exponent are given. The localization length is
reduced by the influence of the fluctuations in the hydrogen bond stretchings.
It is also shown that the helical twist angle affects the localization length
in the poly(dG)-poly(dC) DNA polymer more strongly than in the
poly(dA)-poly(dT) one. Furthermore, we show resonance structures in the energy
dependence of the localization length when the system size is relatively small.Comment: 6 pages, 6 figure
Excitonic - vibronic coupled dimers: A dynamic approach
The dynamical properties of exciton transfer coupled to polarization
vibrations in a two site system are investigated in detail. A fixed point
analysis of the full system of Bloch - oscillator equations representing the
coupled excitonic - vibronic flow is performed. For overcritical polarization a
bifurcation converting the stable bonding ground state to a hyperbolic unstable
state which is basic to the dynamical properties of the model is obtained. The
phase space of the system is generally of a mixed type: Above bifurcation chaos
develops starting from the region of the hyperbolic state and spreading with
increasing energy over the Bloch sphere leaving only islands of regular
dynamics. The behaviour of the polarization oscillator accordingly changes from
regular to chaotic.Comment: uuencoded compressed Postscript file containing text and figures. In
case of questions, please, write to [email protected]
The Ry-f(sto) gene from Solanum stoloniferum for extreme resistant to Potato virus Y maps to potato chromosome XII and is diagnosed by PCR marker GP122(718) in PVY resistant potato cultivars
Extreme events in discrete nonlinear lattices
We perform statistical analysis on discrete nonlinear waves generated though
modulational instability in the context of the Salerno model that interpolates
between the intergable Ablowitz-Ladik (AL) equation and the nonintegrable
discrete nonlinear Schrodinger (DNLS) equation. We focus on extreme events in
the form of discrete rogue or freak waves that may arise as a result of rapid
coalescence of discrete breathers or other nonlinear interaction processes. We
find power law dependence in the wave amplitude distribution accompanied by an
enhanced probability for freak events close to the integrable limit of the
equation. A characteristic peak in the extreme event probability appears that
is attributed to the onset of interaction of the discrete solitons of the AL
equation and the accompanied transition from the local to the global
stochasticity monitored through the positive Lyapunov exponent of a nonlinear
map.Comment: 5 pages, 4 figures; reference added, figure 2 correcte
Candidates for a possible third-generation gravitational wave detector: comparison of ring-Sagnac and sloshing-Sagnac speedmeter interferometers
Speedmeters are known to be quantum non-demolition devices and, by potentially providing sensitivity beyond the standard quantum limit, become interesting for third generation gravitational wave detectors. Here we introduce a new configuration, the sloshing-Sagnac interferometer, and compare it to the more established ring-Sagnac interferometer. The sloshing-Sagnac interferometer is designed to provide improved quantum noise limited sensitivity and lower coating thermal noise than standard position meter interferometers employed in current gravitational wave detectors. We compare the quantum noise limited sensitivity of the ring-Sagnac and the sloshing-Sagnac interferometers, in the frequency range, from 5 Hz to 100 Hz, where they provide the greatest potential benefit. We evaluate the improvement in terms of the unweighted noise reduction below the standard quantum limit, and by finding the range up to which binary black hole inspirals may be observed. The sloshing-Sagnac was found to give approximately similar or better sensitivity than the ring-Sagnac in all cases. We also show that by eliminating the requirement for maximally-reflecting cavity end mirrors with correspondingly-thick multi-layer coatings, coating noise can be reduced by a factor of approximately 2.2 compared to conventional interferometers
Two allelic or tightly linked genetic factors at the PLRV.4 locus on potato chromosome XI control resistance to potato leafroll virus accumulation
Import of cytochrome c into mitochondria
The import of cytochrome c into mitochondria can be resolved into a number of discrete steps. Here we report on the covalent attachment of heme to apocytochrome c by the enzyme cytochrome c heme lyase in mitochondria from Neurospora crassa.
A new method was developed to measure directly the linkage of heme to apocytochrome c. This method is independent of conformational changes in the protein accompanying heme attachment. Tryptic peptides of [35S]cysteine-labelled apocytochrome c, and of enzymatically formed holocytochrome c, were resolved by reverse-phase HPLC. The cysteine-containing peptide to which heme was attached eluted later than the corresponding peptide from apocytochrome c and could be quantified by counting 35S radioactivity as a measure of holocytochrome c formation. Using this procedure, the covalent attachment of heme to apocytochrome c, which is dependent on the enzyme cytochrome c heme lyase, could be measured. Activity required heme (as hemin) and could be reversibly inhibited by the analogue deuterohemin. Holocytochrome c formation was stimulated 5–10-fold by NADH > NADPH > glutathione and was independent of a potential across the inner mitochondrial membrane. NADH was not required for the binding of apocytochrome c to mitochondria and was not involved in the reduction of the cysteine thiols prior to heme attachment. Holocytochrome c formation was also dependent on a cytosolic factor that was necessary for the heme attaching step of cytochrome c import. The factor was a heat-stable, protease-insensitive, low-molecular-mass component of unknown function.
Cytochrome c heme lyase appeared to be a soluble protein located in the mitochondrial intermembrane space and was distinct from the previously identified apocytochrome c binding protein having a similar location. A model is presented in which the covalent attachment of heme by cytochrome c heme lyase also plays an essential role in the import pathway of cytochrome c
17 ways to say yes:Toward nuanced tone of voice in AAC and speech technology
People with complex communication needs who use speech-generating devices have very little expressive control over their tone of voice. Despite its importance in human interaction, the issue of tone of voice remains all but absent from AAC research and development however. In this paper, we describe three interdisciplinary projects, past, present and future: The critical design collection Six Speaking Chairs has provoked deeper discussion and inspired a social model of tone of voice; the speculative concept Speech Hedge illustrates challenges and opportunities in designing more expressive user interfaces; the pilot project Tonetable could enable participatory research and seed a research network around tone of voice. We speculate that more radical interactions might expand frontiers of AAC and disrupt speech technology as a whole
- …