73 research outputs found
Spectral Parameters for Scattering Amplitudes in N=4 Super Yang-Mills Theory
49 pages, 20 figures; v2: typos fixedPlanar N=4 Super Yang-Mills theory appears to be a quantum integrable four-dimensional conformal theory. This has been used to find equations believed to describe its exact spectrum of anomalous dimensions. Integrability seemingly also extends to the planar space-time scattering amplitudes of the N=4 model, which show strong signs of Yangian invariance. However, in contradistinction to the spectral problem, this has not yet led to equations determining the exact amplitudes. We propose that the missing element is the spectral parameter, ubiquitous in integrable models. We show that it may indeed be included into recent on-shell approaches to scattering amplitude integrands, providing a natural deformation of the latter. Under some constraints, Yangian symmetry is preserved. Finally we speculate that the spectral parameter might also be the regulator of choice for controlling the infrared divergences appearing when integrating the integrands in exactly four dimensions.Peer reviewe
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
Personality is influenced by genetic and environmental factors1
and associated with mental health. However, the underlying
genetic determinants are largely unknown. We identified six
genetic loci, including five novel loci2,3, significantly associated
with personality traits in a meta-analysis of genome-wide
association studies (N = 123,132–260,861). Of these genomewide
significant loci, extraversion was associated with variants
in WSCD2 and near PCDH15, and neuroticism with variants
on chromosome 8p23.1 and in L3MBTL2. We performed a
principal component analysis to extract major dimensions
underlying genetic variations among five personality traits
and six psychiatric disorders (N = 5,422–18,759). The first
genetic dimension separated personality traits and psychiatric
disorders, except that neuroticism and openness to experience
were clustered with the disorders. High genetic correlations
were found between extraversion and attention-deficit–
hyperactivity disorder (ADHD) and between openness and
schizophrenia and bipolar disorder. The second genetic
dimension was closely aligned with extraversion–introversion
and grouped neuroticism with internalizing psychopathology
(e.g., depression or anxiety)
The R*-operation for Feynman graphs with generic numerators
Abstract The R *-operation by Chetyrkin, Tkachov, and Smirnov is a generalisation of the BPHZ R-operation, which subtracts both ultraviolet and infrared divergences of euclidean Feynman graphs with non-exceptional external momenta. It can be used to compute the divergent parts of such Feynman graphs from products of simpler Feynman graphs of lower loops. In this paper we extend the R *-operation to Feynman graphs with arbitrary numerators, including tensors. We also provide a novel way of defining infrared counterterms which closely resembles the definition of its ultraviolet counterpart. We further express both infrared and ultraviolet counterterms in terms of scaleless vacuum graphs with a logarithmic degree of divergence. By exploiting symmetries, integrand and integral relations, which the counterterms of scaleless vacuum graphs satisfy, we can vastly reduce their number and complexity. A FORM implementation of this method was used to compute the five loop beta function in QCD for a general gauge group. To illustrate the procedure, we compute the poles in the dimensional regulator of all top-level propagator graphs at five loops in four dimensional ϕ 3 theory
Age of the Association between Helicobacter pylori and Man
When modern humans left Africa ca. 60,000 years ago (60 kya), they were already infected with Helicobacter pylori, and these bacteria have subsequently diversified in parallel with their human hosts. But how long were humans infected by H. pylori prior to the out-of-Africa event? Did this co-evolution predate the emergence of modern humans, spanning the species divide? To answer these questions, we investigated the diversity of H. pylori in Africa, where both humans and H. pylori originated. Three distinct H. pylori populations are native to Africa: hpNEAfrica in Afro-Asiatic and Nilo-Saharan speakers, hpAfrica1 in Niger-Congo speakers and hpAfrica2 in South Africa. Rather than representing a sustained co-evolution over millions of years, we find that the coalescent for all H. pylori plus its closest relative H. acinonychis dates to 88–116 kya. At that time the phylogeny split into two primary super-lineages, one of which is associated with the former hunter-gatherers in southern Africa known as the San. H. acinonychis, which infects large felines, resulted from a later host jump from the San, 43–56 kya. These dating estimates, together with striking phylogenetic and quantitative human-bacterial similarities show that H. pylori is approximately as old as are anatomically modern humans. They also suggest that H. pylori may have been acquired via a single host jump from an unknown, non-human host. We also find evidence for a second Out of Africa migration in the last 52,000 years, because hpEurope is a hybrid population between hpAsia2 and hpNEAfrica, the latter of which arose in northeast Africa 36–52 kya, after the Out of Africa migrations around 60 kya
All-mass n-gon integrals in n dimensions
We explore the correspondence between one-loop Feynman integrals and
(hyperbolic) simplicial geometry to describe the "all-mass" case: integrals
with generic external and internal masses. Specifically, we focus on
-particle integrals in exactly space-time dimensions, as these integrals
have particularly nice geometric properties and respect a dual conformal
symmetry. In four dimensions, we leverage this geometric connection to give a
concise dilogarithmic expression for the all-mass box in terms of the
Murakami-Yano formula. In five dimensions, we use a generalized Gauss-Bonnet
theorem to derive a similar dilogarithmic expression for the all-mass pentagon.
We also use the Schl\"afli formula to write down the symbol of these integrals
for all . Finally, we discuss how the geometry behind these formulas depends
on space-time signature, and we gather together many results related to these
integrals from the mathematics and physics literature.Comment: 49 pages, 8 figure
Sequencing technologies and genome sequencing
The high-throughput - next generation sequencing (HT-NGS) technologies are currently the hottest topic in the field of human and animals genomics researches, which can produce over 100 times more data compared to the most sophisticated capillary sequencers based on the Sanger method. With the ongoing developments of high throughput sequencing machines and advancement of modern bioinformatics tools at unprecedented pace, the target goal of sequencing individual genomes of living organism at a cost of $1,000 each is seemed to be realistically feasible in the near future. In the relatively short time frame since 2005, the HT-NGS technologies are revolutionizing the human and animal genome researches by analysis of chromatin immunoprecipitation coupled to DNA microarray (ChIP-chip) or sequencing (ChIP-seq), RNA sequencing (RNA-seq), whole genome genotyping, genome wide structural variation, de novo assembling and re-assembling of genome, mutation detection and carrier screening, detection of inherited disorders and complex human diseases, DNA library preparation, paired ends and genomic captures, sequencing of mitochondrial genome and personal genomics. In this review, we addressed the important features of HT-NGS like, first generation DNA sequencers, birth of HT-NGS, second generation HT-NGS platforms, third generation HT-NGS platforms: including single molecule Heliscope™, SMRT™ and RNAP sequencers, Nanopore, Archon Genomics X PRIZE foundation, comparison of second and third HT-NGS platforms, applications, advances and future perspectives of sequencing technologies on human and animal genome research
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