Vulnerability of caregivers for the elderly with dementia: integrative review

Objective: To analyze the vulnerability of caregivers of elderly with dementia. Method: This is an integrative review of quantitative and qualitative nature. The data collection period was from 01/09/14 to 10/30/14. Results: Of the articles analyzed, 26% point interventions to relieve overload; 20% analyze the depression load; 16% of studies address caregiver burden; 14% guided their discussions in physical and spiritual well-being, psychological and social well-being and damage to quality of life; 12% adress stress. Conclusion: Researchers from several countries show the care impact on the life of the caregiver, highlighting: the emotional overload, routine stress, and depressive symptoms. However, there are mitigation measures identified through the research that can contribute to the everyday stress relief, such as the daily practice of yoga meditation, religion, the positive relationship between the family, the elderly and the caregiver

Estudo Sobre a Anorexia e Bulimia Nervosa em Universitárias

To detect prevalence that indicates Anorexia and Bulimia in university students, considering marital status, course, BMI, depression and physical activity. The Eating Attitudes Test (EAT-26) and the Body Shape Questionnaire (BSQ) were administered to 352 female students. In comparison with the other courses, students of the nutrition course showed higher positive prevalence of Anorexia (20,2%), depression (23,2%), and practitioners of physical activity (19,2%). Occupational therapy and non practitioners showed higher negative prevalence. As for Bulimia, obese persons (35,7%) and over weight persons (21,1%) showed serious concern about their body image. Persons under weight did not show this concern (93,8%). The nutrition course showed higher prevalence that indicates Anorexia and depressed people tend to have worse outcomes on both instruments.  Detectar as prevalências indicativas de Anorexia e Bulimia em estudantes universitárias, considerando estado civil, curso, IMC, depressão e atividade física. Aplicaram-se em 352 alunas o Eating Attitudes Test (EAT-26) e o Body Shape Questionnaire (BSQ). O curso de nutrição apresentou maior prevalência positiva de Anorexia (20,2%), as pessoas com depressão (23,2%) e praticantes de atividade física (19,2%). A Terapia Ocupacional e não praticantes apresentaram maior prevalência negativa. Quanto à Bulimia, as pessoas obesas (35,7%) e com sobre peso (21,1%) apresentaram preocupação grave com a imagem corporal; as pessoas abaixo do peso não apresentaram (93,8%). O curso de nutrição apresentou maior prevalência indicativa de Anorexia; e pessoas com depressão tendem a resultados piores nos dois instrumentos. &nbsp

DORMANCY OF SEEDS AND PLANTS PRODUCTION OF Dimorphandra mollis Benth.

Dimorphandra mollis Benth. \ue9 uma esp\ue9cie florestal nativa, encontrada nos biomas Cerrado e Caatinga, de grande import\ue2ncia em fun\ue7\ue3o de sua utilidade econ\uf4mica e ecol\uf3gica, o que justifica a exist\ueancia de programas de produ\ue7\ue3o de mudas. Este trabalho teve por objetivo estudar metodologias eficientes para supera\ue7\ue3o da dorm\ueancia das sementes e avaliar, em viveiro florestal, os efeitos de diferentes substratos e da fertiliza\ue7\ue3o sobre o crescimento inicial das mudas. Foram realizados os seguintes tratamentos para supera\ue7\ue3o de dorm\ueancia: T1 - testemunha (sementes sem escarifica\ue7\ue3o); T2 - escarifica\ue7\ue3o manual com lixa no50; T3 - imers\ue3o em \ue1gua a 80\ub0C e (T4) a 100\ubaC at\ue9 atingir a temperatura ambiente; T5 - fervura em \ue1gua a 100\ubaC durante 10, (T6) 30 e (T7) 60 segundos; T8 - escarifica\ue7\ue3o qu\uedmica com \ue1cido sulf\ufarico durante 20, (T9) 30 e (T10) 40 minutos. Para a produ\ue7\ue3o de mudas, o delineamento experimental adotado foi o inteiramente casualizado, em arranjo fatorial 4 x 2 (quatro substratos: Tropstrato\uae puro, e os demais: Tropstrato\uae, p\uf3 de coco e vermiculita com composto org\ue2nico; sem e com fertiliza\ue7\ue3o). Os melhores resultados para a supera\ue7\ue3o da dorm\ueancia s\ue3o obtidos com a escarifica\ue7\ue3o manual com lixa para metal n\uba50 ou fervura em \ue1gua durante 10 segundos. O p\uf3 de coco e a vermiculita, combinados com composto org\ue2nico, s\ue3o bons substratos para produ\ue7\ue3o de mudas de Dimorphandra mollis.Dimorphandra mollis Benth. is an important native forest species coming from Cerrado and Caatinga due to its economical and ecological use, what justifies the existence of programs of seedling production. This paper aimed to study the efficient methodology to overcome dormancy in seeds and to evaluate, in natural nursery, the effects of distinct substrates and the fertilization on the initial growth of plants. The following treatments applied: T1 - control (seeds whithout scarification); T2 \u2013 manual scarification with sandpaper number 50; T3 - immersion in water at 80 and (T4) at 100\ubaC; T5 - boil in water at 100\ubaC for 10, (T6) 30 and (T7) 60 seconds; T8 - chemical scarification with sulfuric acid for 20, (T9) 30 and (T10) 40 minutes. For the seedling production, the experiment was arranged in 4 x 2 factorial, complete randomized design (4 substrates: Tropstrato\uae pure, and the others: Tropstrato\uae, coconut fiber and vermiculite with organic compost; without and with fertilization). The best results for overcoming dormancy are obtained with the manual scarification with sandpaper n\uba50 or boil in water at 100\ubaC for 10 seconds. The coconut fiber and the vermiculite with organic compost are good substrates for the seedling production of Dimorphandra mollis

Root canal contamination or exposure to lipopolysaccharide differentially modulate prostaglandin E2 and leukotriene B4 signaling in apical periodontitis

Purpose: To evaluate the kinetics of apical periodontitis development in vivo , induced either by contamination of the root canals by microorganisms from the oral cavity or by inoculation of bacterial lipopolysaccharide (LPS) and the regulation of major enzymes and receptors involved in the arachidonic acid metabolism. Methodology: Apical periodontitis was induced in C57BL6 mice (n=96), by root canal exposure to oral cavity (n=48 teeth) or inoculation of LPS (10 µL of a suspension of 0.1 µg/µL) from E. coli into the root canals (n= 48 teeth). Healthy teeth were used as control (n=48 teeth). After 7, 14, 21 and 28 days the animals were euthanized and tissues removed for histopathological and qRT-PCR analyses. Histological analysis data were analyzed using two-way ANOVA followed by Sidak’s test, and qRT-PCR data using two-way ANOVA followed by Tukey’s test (α=0.05). Results: Contamination by microorganisms led to the development of apical periodontitis, characterized by the recruitment of inflammatory cells and bone tissue resorption, whereas inoculation of LPS induced inflammatory cells recruitment without bone resorption. Both stimuli induced mRNA expression for cyclooxygenase-2 and 5-lipoxygenase enzymes. Expression of prostaglandin E2 and leukotriene B4 cell surface receptors were more stimulated by LPS. Regarding nuclear peroxisome proliferator-activated receptors (PPAR), oral contamination induced the synthesis of mRNA for PPARδ, differently from inoculation of LPS, that induced PPARα and PPARγ expression. Conclusions: Contamination of the root canals by microorganisms from oral cavity induced the development of apical periodontitis differently than by inoculation with LPS, characterized by less bone loss than the first model. Regardless of the model used, it was found a local increase in the synthesis of mRNA for the enzymes 5-lipoxygenase and cyclooxygenase-2 of the arachidonic acid metabolism, as well as in the surface and nuclear receptors for the lipid mediators prostaglandin E2 and leukotriene B4

Pulp Tissue Dissolution Capacity of Sodium Hypochlorite Combined with Cetrimide and Polypropylene Glycol

This study evaluated the influence of the addition of cetrimide and polypropylene glycol to sodium hypochlorite (NaOCl) on its capacity to dissolve pulp tissue. Bovine pulp fragments with standardized weight and volume were immersed for 5, 15 and 30 min in 2 mL of NaOCl and Hypoclean (NaOCl added with cetrimide and polypropylene glycol) solutions at 5.25%, 2.5%, 1%, 0.5% and 0.25% and afterwards re-weighted. Distilled water was used as a control. The percentage of tissue loss was considered for statistical analysis (univariate ANOVA, SPSS, v. 17.0) at 5% significance level. There was no tissue dissolution in the control group. NaOCl added with surfactants (Hypoclean) dissolved more pulp tissue (p<0.05) than NaOCl alone. Tissue dissolution was directly dependent on the concentration of solutions (p<0.05), and also on the time range (p<0.05). The combination of NaOCl at high and low concentrations with the surfactants cetrimide and polypropylene glycol increased significantly its capacity to dissolve pulp tissue

Repercussões epidemiológicas da Demência no Brasil: um perfil dos últimos 5 anos

Introduction: Dementia is a syndrome characterized by persistent cognitive deficits that affect daily activities, especially in the elderly. Its incidence has increased with population aging. Objective: To investigate the epidemiological repercussions of dementia in Brazil in the last 5 years. Methods: Descriptive observational study based on data from the Hospital Information System (SIH) of SUS and bibliographic databases. The number of hospitalizations and deaths due to dementia between 2018 and 2022 were analyzed. Results: The Southeast region concentrated the highest number of hospitalizations due to dementia (56.22%), due to the high population and elderly density. The most affected age group was 80 years or older (26.65%), reflecting aging and risks associated with dementia. Males showed a slight predominance in hospitalizations (51.57%), possibly due to risk factors. Urgent care prevailed (72.48%) due to the progressive nature of the disease and acute complications. As for deaths, 54.65% occurred in the age group of 80 years or older, related to greater vulnerability at this age. Conclusion: The study revealed significant patterns of the epidemiological repercussions of dementia in Brazil. These conclusions highlight the importance of preventive interventions and multidisciplinary management of dementia, as well as public health policies that address its complex health and social implications.Introdução: A demência é uma síndrome caracterizada por déficits cognitivos persistentes que afetam as atividades diárias, principalmente em idosos. Sua incidência tem aumentado com o envelhecimento populacional. Objetivo: Investigar as repercussões epidemiológicas da demência no Brasil nos últimos 5 anos. Métodos: Estudo observacional descritivo com base em dados do Sistema de Informações Hospitalares (SIH) do SUS e bases de dados bibliográficas. Foram analisados número de internações e óbitos por demência entre 2018 e 2022. Resultados: A região Sudeste concentrou o maior número de internações por demência (56,22%), devido à alta densidade populacional e idosa. A faixa etária mais afetada foi a de 80 anos ou mais (26,65%), refletindo o envelhecimento e riscos associados à demência. O sexo masculino apresentou ligeira predominância nas internações (51,57%), possivelmente devido a fatores de risco. O atendimento de urgência prevaleceu (72,48%) devido à natureza progressiva da doença e complicações agudas. Quanto aos óbitos, 54,65% ocorreram na faixa etária dos 80 anos ou mais, relacionados à maior vulnerabilidade nessa idade. Conclusão: O estudo revelou padrões significativos das repercussões epidemiológicas da demência no Brasil. Essas conclusões destacam a importância de intervenções preventivas e gerenciamento multidisciplinar da demência, além de políticas de saúde pública que abordem suas complexas implicações sociais e de saúde

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Genome of Herbaspirillum seropedicae Strain SmR1, a Specialized Diazotrophic Endophyte of Tropical Grasses

The molecular mechanisms of plant recognition, colonization, and nutrient exchange between diazotrophic endophytes and plants are scarcely known. Herbaspirillum seropedicae is an endophytic bacterium capable of colonizing intercellular spaces of grasses such as rice and sugar cane. The genome of H. seropedicae strain SmR1 was sequenced and annotated by The Paraná State Genome Programme—GENOPAR. The genome is composed of a circular chromosome of 5,513,887 bp and contains a total of 4,804 genes. The genome sequence revealed that H. seropedicae is a highly versatile microorganism with capacity to metabolize a wide range of carbon and nitrogen sources and with possession of four distinct terminal oxidases. The genome contains a multitude of protein secretion systems, including type I, type II, type III, type V, and type VI secretion systems, and type IV pili, suggesting a high potential to interact with host plants. H. seropedicae is able to synthesize indole acetic acid as reflected by the four IAA biosynthetic pathways present. A gene coding for ACC deaminase, which may be involved in modulating the associated plant ethylene-signaling pathway, is also present. Genes for hemagglutinins/hemolysins/adhesins were found and may play a role in plant cell surface adhesion. These features may endow H. seropedicae with the ability to establish an endophytic life-style in a large number of plant species