Responses to habitat variation by small mammal individuals and populations at different spatial scales (Ontario).

Small mammal habitat selection was studied at different spatial and temporal scales at Point Pelee National Park, Ontario. At a relatively large scale, small mammals were censused in nine different locations over the 450 hectares of the park, and compared temporally for censuses performed in the same sites in 1971 and 1996. The nine locations represented a variety of habitats at different stages of ecological succession, and some of them changed significantly between 1971 and 1996. Habitat preferences observed for three rodent species in 1971 were used to predict which habitats in 1996 would contain populations of these species. Predictions were upheld in some cases, but population cycles and the extinction risk to small populations suggested reasons for unexpected absences. Another study examined responses of two rodent species to habitat variation at much smaller spatial (2.125 ha) and temporal (one summer) scales. In the first analysis, abundances of the two species varied with habitat type, and the relationship was similar at two spatial scales. In the second analysis, I found that home range size and overlap were not consistently affected by habitat type, and significant relationships were not always observed in the same habitats that were significant in the abundance regressions. One explanation for inconsistencies is that large-scale habitat cues affect initial home range placement, and home range size and overlap are adjusted afterward in response to local conditions.Dept. of Biological Sciences. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1998 .H45. Source: Masters Abstracts International, Volume: 39-02, page: 0443. Adviser: Robert T. M\u27Closkey. Thesis (M.Sc.)--University of Windsor (Canada), 1998

StreamJIT: A Commensal Compiler for High-Performance Stream Programming

There are many domain libraries, but despite the performance benefits of compilation, domain-specific languages are comparatively rare due to the high cost of implementing an optimizing compiler. We propose commensal compilation, a new strategy for compiling embedded domain-specific languages by reusing the massive investment in modern language virtual machine platforms. Commensal compilers use the host language's front-end, use host platform APIs that enable back-end optimizations by the host platform JIT, and use an autotuner for optimization selection. The cost of implementing a commensal compiler is only the cost of implementing the domain-specific optimizations. We demonstrate the concept by implementing a commensal compiler for the stream programming language StreamJIT atop the Java platform. Our compiler achieves performance 2.8 times better than the StreamIt native code (via GCC) compiler with considerably less implementation effort.United States. Dept. of Energy. Office of Science (X-Stack Award DE-SC0008923)Intel Corporation (Science and Technology Center for Big Data)SMART3 Graduate Fellowshi

‘To the land or to the sea' : diet and mobility in early medieval Frisia

This study investigated palaeodiet and population mobility in early medieval Frisia through the stable isotope analysis of individuals buried in the fifth–eighth century AD cemetery of Oosterbeintum, a terp site on the northern coast of the Netherlands. The results cast new light on the role of the northern Netherlands in trade and migration in the early medieval period, and have significance for the study of interaction and movement throughout the wider North Sea region. Bone collagen and tooth enamel from humans and animals were analyzed using carbon, nitrogen, oxygen, and strontium isotopes. δ13C and δ15N results indicated that the population had a terrestrial, C3-based diet. High δ15N values were observed in humans and fauna, which are probably related to the terp's salt-marsh location. The δ18O and 87Sr/86Sr data revealed a high proportion of non-locals buried at Oosterbeintum, some of whom had probably migrated from regions as distant and varied as Scandinavia and southern England. It is suggested that this immigration may be associated with Frisian maritime trading activities. New data are also presented from a small number of contemporaneous European sites

Analytical assay validation for acute myeloid leukemia measurable residual disease assessment by multiparametric flow cytometry

Background: Measurable residual disease (MRD) assessed by multiparametric flow cytometry (MFC) has gained importance in clinical decision-making for acute myeloid leukemia (AML) patients. However, complying with the recent In Vitro Diagnostic Regulations (IVDR) in Europe and Food and Drug Administration (FDA) guidance in the United States requires rigorous validation prior to their use in investigational clinical trials and diagnostics. Validating AML MRD-MFC assays poses challenges due to the unique underlying disease biology and paucity of patient specimens. In this study, we describe an experimental framework for validation that meets regulatory expectations. Methods: Our validation efforts focused on evaluating assay accuracy, analytical specificity, analytical and functional sensitivity (limit of blank (LoB), detection (LLoD) and quantitation (LLoQ)), precision, linearity, sample/reagent stability and establishing the assay background frequencies. Results: Correlation between different MFC methods was highly significant (r = 0.99 for %blasts and r = 0.93 for %LAIPs). The analysis of LAIP specificity accurately discriminated from negative control cells. The assay demonstrated a LoB of 0.03, LLoD of 0.04, and LLoQ of 0.1%. Precision experiments yielded highly reproducible results (Coefficient of Variation &lt;20%). Stability experiments demonstrated reliable measurement of samples up to 96 h from collection. Furthermore, the reference range of LAIP frequencies in non-AML patients was below 0.1%, ranging from 0.0% to 0.04%.Conclusion: In this manuscript, we present the validation of an AML MFC-MRD assay using BM/PB patient specimens, adhering to best practices. Our approach is expected to assist other laboratories in expediting their validation activities to fulfill recent health authority guidelines.</p