Energy and land use in the Pamir-Alai Mountains

In a comparative study of energy resources and energy consumption patterns in the Pamir-Alai Mountains of Kyrgyzstan and Tajikistan, the relations between energy consumption, land use, and livelihoods were investigated. An approach that presents energy flow through an ecosystem was developed, in particular to highlight ecosystem services and the scope of action for human interventions in the energy-land management nexus. Qualitative data were collected during a field study in October 2009 through household interviews and group discussions. Based on the relationship between energy supply and ecosystem services, typical village profiles depicting the flows of energy and financial assets are presented that illustrate the relation between energy resources, land use, and livelihood assets. The household interviews reflect situations in the different villages and allow a distinction to be made between the energy consumption patterns of poor and wealthier families. This case study in the Pamir-Alai Mountains emphasizes that a reappraisal of energy as a central focus within mountain ecosystems and their services to the population is necessary for both ecosystem preservation and poverty reduction

Parity detection and entanglement with a Mach-Zehnder interferometer

A parity meter projects the state of two qubits onto two subspaces with different parities, the states in each parity class being indistinguishable. It has application in quantum information for its entanglement properties. In our work we consider the electronic Mach-Zehnder interferometer (MZI) coupled capacitively to two double quantum dots (DQDs), one on each arm of the MZI. These charge qubits couple linearly to the charge in the arms of the MZI. A key advantage of an MZI is that the qubits are well separated in distance so that mutual interaction between them is avoided. Assuming equal coupling between both DQDs and the arms and the same bias for each DQD, this setup usually detects three different currents, one for the odd states and two for each even state. Controlling the magnetic flux of the MZI, we can operate the MZI as a parity meter: only two currents are measured at the output, one for each parity class. In this configuration, the MZI acts as an ideal detector, its Heisenberg efficiency being maximal. For a class of initial states, the initially unentangled DQDs become entangled through the parity measurement process with probability one.Comment: 9 pages, 2 figure

Current-voltage correlations in interferometers

We investigate correlations of current at contacts and voltage fluctuations at voltage probes coupled to interferometers. The results are compared with correlations of current and occupation number fluctuations at dephasing probes. We use a quantum Langevin approach for the average quantities and their fluctuations. For higher order correlations we develop a stochastic path integral approach and find the generating functions of voltage or occupation number fluctuations. We also derive a generating function for the joint distribution of voltage or occupation number at the probe and current fluctuations at a terminal of a conductor. For energy independent scattering we found earlier that the generating function of current cumulants in interferometers with a one-channel dephasing or voltage probe are identical. Nevertheless, the distribution function for voltage and the distribution function for occupation number fluctuations differ, the latter being broader than that of former in all examples considered here.Comment: 23 pages, 10 figures, minor changes, additional appendix, added reference

A half-century of studies on a chromosomal hybrid zone of the house mouse

The first natural chromosomal variation in the house mouse was described nearly 50 years ago in Val Poschiavo on the Swiss side of the Swiss–Italian border in the Central Eastern Alps. Studies have extended into neighboring Valtellina, and the house mice of the Poschiavo-Valtellina area have been subject to detailed analysis, reviewed here. The maximum extent of this area is 70 km, yet it has 4 metacentric races and the standard 40-chromosome telocentric race distributed in a patchwork fashion. The metacentric races are characterized by highly reduced diploid numbers (2n = 22–26) resulting from Robertsonian fusions, perhaps modified by whole-arm reciprocal translocations. The races hybridize and the whole Poschiavo-Valtellina area can be considered a “hybrid zone.” The studies of this area have provided insights into origin of races within hybrid zones, gene flow within hybrid zones and the possibility of speciation in hybrid zones. This provides a case study of how chromosomal rearrangements may impact the genetic structure of populations and their diversification.Fil: Giménez, Mabel Dionisia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; Argentina. University of York; Reino UnidoFil: Förster, Daniel W.. Leibniz-institute For Zoo And Wildlife Research; Alemania. University of York; Reino UnidoFil: Jones, Eleanor P.. University of York; Reino Unido. Fera Science; Reino UnidoFil: Jóhannesdóttir, Fríđa. University of York; Reino Unido. Cornell University; Estados UnidosFil: Gabriel, Sofia I.. Universidade de Lisboa; Portugal. University of York; Reino UnidoFil: Panithanarak, Thadsin. Burapha University; Tailandia. University of York; Reino UnidoFil: Scascitelli, Moira. University of York; Reino UnidoFil: Merico, Valeria. Universita Di Pavia; ItaliaFil: Garagna, Silvia. Universita Di Pavia; ItaliaFil: Searle, Jeremy B.. University of York; Reino Unido. Cornell University; Estados UnidosFil: Hauffe, Heidi C.. Instituto Agrario San Michele All'adige Fondazione Edmund Mach. Centro Ricerca E Innovazione; Italia. University of York; Reino Unid

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Background: Current phenotyping of chronic rhinosinusitis (CRS) into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) might not adequately reflect the pathophysiologic diversity within patients with CRS. Objective: We sought to identify inflammatory endotypes of CRS. Therefore we aimed to cluster patients with CRS based solely on immune markers in a phenotype-free approach. Secondarily, we aimed to match clusters to phenotypes. Methods: In this multicenter case-control study patients with CRS and control subjects underwent surgery, and tissue was analyzed for IL-5, IFN-gamma, IL-17A, TNF-alpha, IL-22, IL-1 beta, IL-6, IL-8, eosinophilic cationic protein, myeloperoxidase, TGF-beta 1, IgE, Staphylococcus aureus enterotoxin-specific IgE, and albumin. We used partition-based clustering. Results: Clustering of 173 cases resulted in 10 clusters, of which 4 clusters with low or undetectable IL-5, eosinophilic cationic protein, IgE, and albumin concentrations, and 6 clusters with high concentrations of those markers. The group of IL-5-negative clusters, 3 clusters clinically resembled a predominant chronic rhinosinusitis without nasal polyps (CRSsNP) phenotype without increased asthma prevalence, and 1 cluster had a T(H)17 profile and had mixed CRSsNP/CRSwNP. The IL-5-positive clusters were divided into a group with moderate IL-5 concentrations, a mixed CRSsNP/CRSwNP and increased asthma phenotype, and a group with high IL-5 levels, an almost exclusive nasal polyp phenotype with strongly increased asthma prevalence. In the latter group, 2 clusters demonstrated the highest concentrations of IgE and asthma prevalence, with all samples expressing Staphylococcus aureus enterotoxin-specific IgE. Conclusion: Distinct CRS clusters with diverse inflammatory mechanisms largely correlated with phenotypes and further differentiated them and provided a more accurate description of the inflammatory mechanisms involved than phenotype information only

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

Persistent virus infection drives follicular T helper cell differentiation