The D/H Ratio in the Interstellar Medium toward the White Dwarf PG0038+199

We determine the D/H ratio in the interstellar medium toward the DO white dwarf PG0038+199 using spectra from the Far Ultraviolet Spectroscopic Explorer (FUSE), with ground-based support from Keck HIRES. We employ curve of growth, apparent optical depth and profile fitting techniques to measure column densities and limits of many other species (H2, NaI, CI, CII, CIII, NI, NII, OI, SiII, PII, SIII, ArI and FeII) which allow us to determine related ratios such as D/O, D/N and the H2 fraction. Our efforts are concentrated on measuring gas-phase D/H, which is key to understanding Galactic chemical evolution and comparing it to predictions from Big Bang nucleosynthesis. We find column densities log N(HI) = 20.41+-0.08, log N(DI)=15.75+-0.08 and log N(H2) = 19.33+-0.04, yielding a molecular hydrogen fraction of 0.14+-0.02 (2 sigma errors), with an excitation temperature of 143+-5K. The high HI column density implies that PG0038+199 lies outside of the Local Bubble; we estimate its distance to be 297 (+164,-104)pc (1 sigma). D/[HI+2H2] toward PG0038+199 is 1.91(+0.52,-0.42) e-5 (2 sigma). There is no evidence of component structure on the scale of Delta v > 8 km/s based on NaI, but there is marginal evidence for structure on smaller scales. The D/H value is high compared to the majority of recent D/H measurements, but consistent with the values for two other measurements at similar distances. D/O is in agreement with other distant measurements. The scatter in D/H values beyond ~100pc remains a challenge for Galactic chemical evolution.Comment: 59 pages, 7 tables, 18 figures (1 standalone), accepted by ApJ v2 minor typos correcte

FUSE Observation of the Ultramassive White Dwarf PG1658+441

We present an analysis of the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of the ultramassive (M = 1.31 solar mass), magnetic (B_s = 2.3 MG) white dwarf PG 1658+441. The far ultraviolet (FUV) spectrum exhibits very broad Lyman lines and quasi-molecular Lyman beta satellites, but weak Lyman gamma satellites may also be present. PG 1658+441 is the hottest white dwarf known to show these satellite features. We fit the Lyman lines with stellar models and obtain atmospheric parameters consistent with a published analysis of the Balmer lines. By averaging results obtained for the different FUSE segments, we determine Teff = 29,620 +/- 500K and log g = 9.31 +/- 0.07. The models match the data over large portions of the spectrum but discrepancies remain near the satellite features. Finally, no trace elements have been identified in the FUV spectrum, and we provide abundance upper limits for C, N, Si, and P.Comment: 17 pages, 4 figure

Increased FAT/CD36 Cycling and Lipid Accumulation in Myotubes Derived from Obese Type 2 Diabetic Patients

BACKGROUND: Permanent fatty acid translocase (FAT/)CD36 relocation has previously been shown to be related to abnormal lipid accumulation in the skeletal muscle of type 2 diabetic patients, however mechanisms responsible for the regulation of FAT/CD36 expression and localization are not well characterized in human skeletal muscle. METHODOLOGY/PRINCIPAL FINDINGS: Primary muscle cells derived from obese type 2 diabetic patients (OBT2D) and from healthy subjects (Control) were used to examine the regulation of FAT/CD36. We showed that compared to Control myotubes, FAT/CD36 was continuously cycling between intracellular compartments and the cell surface in OBT2D myotubes, independently of lipid raft association, leading to increased cell surface FAT/CD36 localization and lipid accumulation. Moreover, we showed that FAT/CD36 cycling and lipid accumulation were specific to myotubes and were not observed in reserve cells. However, in Control myotubes, the induction of FAT/CD36 membrane translocation by the activation of (AMP)-activated protein kinase (AMPK) pathway did not increase lipid accumulation. This result can be explained by the fact that pharmacological activation of AMPK leads to increased mitochondrial beta-oxidation in Control cells. CONCLUSION/SIGNIFICANCE: Lipid accumulation in myotubes derived from obese type 2 diabetic patients arises from abnormal FAT/CD36 cycling while lipid accumulation in Control cells results from an equilibrium between lipid uptake and oxidation. As such, inhibiting FAT/CD36 cycling in the skeletal muscle of obese type 2 diabetic patients should be sufficient to diminish lipid accumulation

Estimating magnetic filling factors from Zeeman–Doppler magnetograms

V.S., S.P.M., and A.J.F.acknowledge funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement No. 682393 AWESoMeStars). S.B.S. acknowledges funding via the Austrian Space Application Programme (ASAP) of the Austrian Research Promotion Agency (FFG) within ASAP11, the FWF NFN project S11601-N16 and the sub-project S11604-N16. A. A.V. acknowledges funding received from the Irish Research Council Laureate Awards 2017/2018.Low-mass stars are known to have magnetic fields that are believed to be of dynamo origin. Two complementary techniques are principally used to characterize them. Zeeman–Doppler imaging (ZDI) can determine the geometry of the large-scale magnetic field while Zeeman broadening can assess the total unsigned flux including that associated with small-scale structures such as spots. In this work, we study a sample of stars that have been previously mapped with ZDI. We show that the average unsigned magnetic flux follows an activity-rotation relation separating into saturated and unsaturated regimes. We also compare the average photospheric magnetic flux recovered by ZDI, BV, with that recovered by Zeeman broadening studies, BI. In line with previous studies, BV ranges from a few % to ~20% of BI. We show that a power-law relationship between BV and BI exists and that ZDI recovers a larger fraction of the magnetic flux in more active stars. Using this relation, we improve on previous attempts to estimate filling factors, i.e., the fraction of the stellar surface covered with magnetic field, for stars mapped only with ZDI. Our estimated filling factors follow the well-known activity-rotation relation, which is in agreement with filling factors obtained directly from Zeeman broadening studies. We discuss the possible implications of these results for flux tube expansion above the stellar surface and stellar wind models.Publisher PDFPeer reviewe

Controversy and consensus on the management of elevated sperm DNA fragmentation in male infertility: A global survey, current guidelines, and expert recommendations

Purpose Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. Materials and Methods An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method. Results A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4–6 months and 38.1% recommend 3 months. For men with unexplained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respondents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical varicocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated. Conclusions This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians

Assessment of the models for the estimation of the CO2 releases toxic effects

Currently, INERIS is involved in European and French projects regarding the CCS chain (carbon capture and storage). Nowadays, some people consider this chain as a future device to fight against the global warming due to high concentration of CO2 in the atmosphere. However, in case of massive accidental leak of CO2, this substance could be the origin of toxic effects for human. Now, carbon dioxide concentrations considered as potentially toxic get close to 10 0000 ppm. To estimate precisely the distances reached by this hazardous level of concentrations, an efficient understanding of the CO2 release phenomena, from the assessment of the mass flow rate to the atmospheric dispersion, is necessary. Whereas the carbon dioxide is often stored and handled under 2-phase or supercritical conditions associated to storage pressure, CO2 ice formation is possible in case of accidental leak in the atmosphere due to specific properties regarding its triple point. Then, this CO2 flakes creation may be followed by the liquid/solid CO2 pool formation on the ground. Due to the important pressure drop of the fluid during the leak, a significant expansion phase, a high rate of air entrainment and a huge temperature drop followed by a dense and cold cloud formation should be considered. Concerning these specific points, a few of atmospheric dispersion softwares take into account the carbon dioxide specific conditions of release. And moreover, some calculations carried out with other software seem to provide different results in terms of hazardous distances for instantaneous or continuous releases. A focus on the models used by the softwares appears interesting to let a better understanding of this difference in the risk assessment context