Inventing Our University: Student-Faculty Collaboration in Critical University Studies

In this article, Heather Steffen reflects on her recent participation in a student-faculty collaborative research project, All Worked Up: A Project about Student Labor, and her experience teaching critical university studies. She considers the questions: What does critical university studies offer to students? What can students contribute to critical university studies? And how might such exchanges lead us beyond scholarship, enable us to build solidarity, and empower us to invent a new university, our university, that serves students, scholar-teachers, and its diverse publics rather than the imperatives of neoliberal capital? Because critical university studies has both scholarly and social justice goals, Steffen argues, we must continually look for ways to connect our research and writing to collective action. Research collaborations involving students, faculty, staff, and community members are not only important sites for learning and teaching, but also for creating the personal relationships, networks, knowledge base, and skills required to build solidarity and enact change in higher education

Reflections on Universities, Politics, and the Capitalist State: An Interdisciplinary and Intergenerational Discussion with Clyde W. Barrow

Since its publication in 1990, Clyde W. Barrow’s book, Universities and the Capitalist State: Corporate Liberalism and the Reconstruction of American Higher Education, 1894-1928, has been a touchstone text for generations of scholars studying higher education. This conversation between Barrow, Heather Steffen, and Isaac Kamola examines the book’s legacy in order to explore how the interdisciplinary study of higher education has changed over the past three decades. In doing so, they examine the space and place of academic knowledge and academic labor, offering an interdisciplinary discussion of critical praxis within the university

The Arabidopsis Synaptotagmin1 is enriched in endoplasmic reticulum-plasma membrane contact sites and confers cellular resistance to mechanical stresses

Eukaryotic endoplasmic reticulum (ER)-plasma membrane (PM) contact sites are evolutionarily conserved microdomains that have important roles in specialized metabolic functions such as ER-PM communication, lipid homeostasis, and Ca2+ influx. Despite recent advances in knowledge about ER-PM contact site components and functions in yeast (Saccharomyces cerevisiae) and mammals, relatively little is known about the functional significance of these structures in plants. In this report, we characterize the Arabidopsis (Arabidopsis thaliana) phospholipid binding Synaptotagmin1 (SYT1) as a plant ortholog of the mammal extended synaptotagmins and yeast tricalbins families of ER-PM anchors. We propose that SYT1 functions at ER-PM contact sites because it displays a dual ER-PM localization, it is enriched in microtubule-depleted regions at the cell cortex, and it colocalizes with Vesicle-Associated Protein27-1, a known ER-PM marker. Furthermore, biochemical and physiological analyses indicate that SYT1 might function as an electrostatic phospholipid anchor conferring mechanical stability in plant cells. Together, the subcellular localization and functional characterization of SYT1 highlights a putative role of plant ER-PM contact site components in the cellular adaptation to environmental stresses

Transits and secondary eclipses of HD 189733 with Spitzer

We present limits on transit timing variations and secondary eclipse depth variations at 8 microns with the Spitzer Space Telescope IRAC camera. Due to the weak limb darkening in the infrared and uninterrupted observing, Spitzer provides the highest accuracy transit times for this bright system, in principle providing sensitivity to secondary planets of Mars mass in resonant orbits. Finally, the transit data provides tighter constraints on the wavelength- dependent atmospheric absorption by the planet.Comment: 7 pages, 7 figures, submitted to proceedings of IAU Symposium No. 253 "Transiting Planets

The climate of HD 189733b from fourteen transits and eclipses measured by Spitzer

We present observations of seven transits and seven eclipses of the transiting planet system HD 189733 taken with Spitzer IRAC at 8 microns. We use a new correction for the detector ramp variation with a double-exponential function. Our main findings are: (1) an upper limit on the variability of the day-side planet flux of 2.7% (68% confidence); (2) the most precise set of transit times measured for a transiting planet, with an average accuracy of 3 seconds; (3) a lack of transit-timing variations, excluding the presence of second planets in this system above 20% of the mass of Mars in low-order mean-motion resonance at 95% confidence; (4) a confirmation of the planet's phase variation, finding the night side is 64% as bright as the day side, as well as an upper limit on the night-side variability of 17% (68% confidence); (5) a better correction for stellar variability at 8 micron causing the phase function to peak 3.5 hrs before secondary eclipse, confirming that the advection and radiation timescales are comparable at the 8 micron photosphere; (6) variation in the depth of transit, which possibly implies variations in the surface brightness of the portion of the star occulted by the planet, posing a fundamental limit on non-simultaneous multi-wavelength transit absorption measurements of planet atmospheres; (7) a measurement of the infrared limb-darkening of the star, in agreement with stellar atmosphere models; (8) an offset in the times of secondary eclipse of 69 sec, which is mostly accounted for by a 31 sec light travel time delay and 33 sec delay due to the shift of ingress and egress by the planet hot spot; this confirms that the phase variation is due to an offset hot spot on the planet; (9) a retraction of the claimed eccentricity of this system due to the offset of secondary eclipse; and (10) high precision measurements of the parameters of this system.Comment: 18 pages, 19 figures, accepted for publication in the Astrophysical Journa

Solution pans and linear sand bedforms on the bare-rock limestone shelf of the Campeche Bank, Yucatán Peninsula, Mexico

A high-resolution, near-surface geophysical survey was conducted in 2013 on the Campeche Bank, a carbonate platform offshore of Yucatán, Mexico, to provide a hazard assessment for future scientific drilling into the Chicxulub impact crater. It also provided an opportunity to obtain detailed information on the seafloor morphology and shallow stratigraphy of this understudied region. The seafloor exhibited two morphologies: (1) small-scale (<2 m) bare-rock karstic features, and (2) thin (<1 m) linear sand accumulations overlying the bedrock. Solution pans, circular to oblong depressions featured flat bottoms and steep sides, were the dominant karstic features; they are known to form subaerially by the pooling of rainwater and dissolution of carbonate. Observed pans were 10–50 cm deep and generally 1–8 m wide, but occasionally reach 15 m, significantly larger than any solution pan observed on land (maximum 6 m). These features likely grew over the course of many 10's of thousands of years in an arid environment while subaerially exposed during lowered sea levels. Surface sands are organized into linear bedforms oriented NE-SW, 10's to 100's meters wide, and kilometers long. These features are identified as sand ribbons (longitudinal bedforms), and contained asymmetric secondary transverse bedforms that indicate NE-directed flow. This orientation is incompatible with the prevalent westward current direction; we hypothesize that these features are storm-generated

Engagement Effects of Player Rating System-Based Matchmaking for Level Ordering in Human Computation Games

Human computation games lack established ways of balancing the difficulty of tasks or levels served to players, potentially contributing to their low engagement rates. Traditional player rating systems have been suggested as a potential solution: using them to rate both players and tasks could estimate player skill and task difficulty and fuel player-task matchmaking. However, neither the effect of difficulty balancing on engagement in human computation games nor the use of player rating systems for this purpose has been empirically tested. We therefore examined the engagement effects of using the Glicko-2 player rating system to order tasks in the human computation game Paradox. An online experiment (n=294) found that both matchmaking-based and pure difficulty-based ordering of tasks led to significantly more attempted and completed levels than random ordering. Additionally, both matchmaking and random ordering led to significantly more di cult tasks being completed than pure difficulty-based ordering. We conclude that poor balancing contributes to poor engagement in human computation games, and that player rating system-based difficulty rating may be a viable and efficient way of improving both

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.

When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-folding capacity to restore protein-folding homeostasis. Unfolded proteins activate UPR signaling across the ER membrane to the nucleus by promoting oligomerization of IRE1, a conserved transmembrane ER stress receptor. However, the coupling of ER stress to IRE1 oligomerization and activation has remained obscure. Here, we report that the ER luminal co-chaperone ERdj4/DNAJB9 is a selective IRE1 repressor that promotes a complex between the luminal Hsp70 BiP and the luminal stress-sensing domain of IRE1α (IRE1LD). In vitro, ERdj4 is required for complex formation between BiP and IRE1LD. ERdj4 associates with IRE1LD and recruits BiP through the stimulation of ATP hydrolysis, forcibly disrupting IRE1 dimers. Unfolded proteins compete for BiP and restore IRE1LD to its default, dimeric, and active state. These observations establish BiP and its J domain co-chaperones as key regulators of the UPR

The role of Raptor in lymphocytes differentiation and function

Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation