28 research outputs found
Lipid-specific IgM antibodies in multiple sclerosis and viral immunity
- Author
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and the leading cause of disability in young adults. Over the last 20 years, a plethora of drugs have been approved for the treatment of MS, many of which target the immune response to reduce CNS inflammation. Although effective, many of these therapies have been associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), a fatal infection of the CNS by the John Cunningham virus. As a result, these effective therapeutics are used with caution pending the establishment of reliable risk stratification tools.
A recent association between intrathecal lipid-reactive IgM synthesis and reduced incidence of PML in natalizumab-treated MS prompted our investigation into the antiviral properties of lipid-reactive IgM antibodies. Using murine heterogenous CNS cultures, we investigated the antiviral properties of both human and mouse IgMs. Initial investigations focused on the sulfatide-reactive IgM O4, a major target of the IgM response in MS patients. Using microarray analysis, RT-qPCR, and fluorescence in situ hybridisation, alongside genetic knock-out cultures and a range of pharmacological inhibitors, it was deduced that O4 could stimulate microglia to upregulate interferon beta (IFN-β) in a cGAS-STING-dependent manner, triggering global interferon stimulated gene (ISG) expression in major cell-types of the CNS. This interferon (IFN) response limited the replication of two genetically unrelated viruses, with final experiments focused on developing an in vivo model to investigate these antiviral IgMs.
The data presented in this thesis provide a plausible explanation for the association between intrathecal IgM synthesis and reduced incidence of PML in natalizumab-treated MS patients. This research will aid risk stratification of MS patients, allowing safe access to effective therapeutics. Further understanding of the mechanism of this antibody-mediated response could lead to the development of an antiviral therapy for use as a co-treatment in MS or as a broad-spectrum therapeutic for the treatment of viral encephalitis
Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/08/2020
- Field of study
Progressive multi-focal leukoencephalopathy (PML) is a potentially fatal encephalitis caused by JC polyomavirus (JCV). PML principally affects people with a compromised immune system, such as patients with multiple sclerosis (MS) receiving treatment with natalizumab. However, intrathecal synthesis of lipid-reactive IgM in MS patients is associated with a markedly lower incidence of natalizumab-associated PML compared to those without this antibody repertoire. Here we demonstrate that a subset of lipid-reactive human and murine IgMs induce a functional anti-viral response that inhibits replication of encephalitic Alpha and Orthobunyaviruses in multi-cellular central nervous system cultures. These lipid-specific IgMs trigger microglia to produce IFN-β in a cGAS-STING-dependent manner, which induces an IFN-α/β-receptor 1-dependent antiviral response in glia and neurons. These data identify lipid-reactive IgM as a mediator of anti-viral activity in the nervous system and provide a rational explanation why intrathecal synthesis of lipid-reactive IgM correlates with a reduced incidence of iatrogenic PML in MS
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
- Author
- Abbott Tom
- Abdul Nazar
- Abercrombie John
- Abraham Ajit
- Ackland Gareth
- Adams Ferdinand
- Adegoke Kenneth
- Agarwal Banwari
- Agostini Helen
- Akhtar Mansoor
- Al Shama Majed
- Alegria Ana
- Alexander Peter
- Ali Dhiraj
- Allen Katherine
- Anderson Iain
- Andrews Sam
- Ankers Alastair
- Aravind Biju
- Arnold Glenn
- Aryal Kamal
- Asaria Miqdad
- Baig Faisal
- Bailey Flora
- Bailey Lindsay
- Bailey Simon
- Baillie Kirsty
- Baker Susie
- Baldwin Lee
- Banerjea Ayan
- Banks Victoria
- Barker Jonathon
- Bartlett Rachel
- Baxter Linden
- Baxter Stephen
- Beavis Sarah
- Belagodu Zakaulla
- Bell Louise
- Bell Stephanie
- Bengeri Sheshagiri
- Benlloch Raoul
- Bews-hair Maria
- Bhardwaj Sian
- Bhowmick Arnab
- Bion Julian
- Bion Julian
- Black Helen
- Blazeby Jane
- Blenk Karl
- Blunt Mark
- Bodger Phoebe
- Borgeaud Nathan
- Bothma Pieter
- Bothma Pieter
- Bottomley David
- Bowery Sarah
- Boyd Christine
- Bradburn Mike
- Bradburn Mike
- Brady Will
- Brennan Andrew
- Brennan Emma
- Brescia Giovanni
- Brett Stephen
- Broad Dan
- Brodbeck Andreas
- Bromilow James
- Bronder Christine
- Browell David
- Brown James
- Brown Stephanie
- Bryce Gavin
- Buckley Sarah
- Bunker Nick
- Burns Karen
- Burrow James
- Burrow James
- Burrows Lorna
- Burtenshaw Andrew
- Cabreros Leilani
- Cain Kathryn
- Cain Martyn
- Calder Verity
- Campbell Marta
- Campbell-smith Tim
- Carey Kate
- Carmichael Jack
- Cartmell Mark
- Cartwright Charles
- Cecconi Maurizio
- Chadwick Michael
- Chambers Rob
- Chan Peter
- Chana Avninder
- Chatzimichail Stelios
- Chitre Vivek
- Christie Iain
- Cirstea Emanuel
- Claxton Andrew
- Clement Ian
- Coldwell Chris
- Coleman Mark
- Colley Julie
- Collins Paddy
- Conway Daniel
- Cook Esther
- Cook Fabian
- Cook Nicola
- Cooke Katie
- Cope Sean
- Cornforth Belinda
- Correia Carmen
- Corson John
- Crabtree Michael
- Craven Rachael
- Cromwell David
- Cruickshank Neil
- Cuming Tamzin
- Cunha Pedro
- Cupitt Jason
- Curtis Edward
- D'souza Rovan
- Davies Peter
- Davis Emma
- Davis Huw
- Dawson Chris
- Debrunner Robert
- Desikan Somi
- Dhingsa Rajpal
- Dickinson Natalie
- Divekar Nandita
- Dodd Phil
- Dorman Frankie
- Doughan Samer
- Dowling Susan
- Downey Sarah
- Doyle Donna
- Drake Sharon
- Dreyer Fanus
- Dumpala Rajesh
- Durant Emma
- Edwards Jennifer
- Edwards Mark
- El-damatty Essam
- El-masry Nabil
- Engel Arnth
- Escofet Xavier
- Evans Thomas
- Everingham Kirsty
- Evley Rachel
- Faiz Omar
- Farhat Sami
- Farrow Catherine
- Fawcet Adrian
- Felipe Rowena
- Fernandes Roy
- Finch Guy
- Fitton Laura
- Fitzgerald Peter
- Fletcher Simon
- Fletcher Steve
- Flint Neil
- Forbes Gordon
- Freshwater-turner Dan
- Full Jens
- Furneval Julie
- Ganepola Ranjit
- Gardner Matt
- Garg Sudha
- Gaughan Matthew
- Gay Mike
- Geary Tim
- Gerrard David
- Gerstina Nabua
- Gibbs Richard
- Gibson Bruce
- Gibson Simon
- Gill Kathryn
- Gillies Michael
- Girgis Amira
- Girling Alan
- Gokhale Jay
- Gordon Anthony
- Graham Laura
- Graham Linda
- Greenwood Jamie
- Griffin Ruth
- Griffith John
- Griffiths Ewen
- Griffiths Megan
- Grocott Mike
- Gursevak Singh
- Gurung Sarada
- Guruswamy Raman
- Hadi Nada
- Haigh Fran
- Hale Beth
- Hales Dawn
- Hall Elizabeth
- Hall Elizabeth
- Hanousek Jan
- Harper Nick
- Harris James
- Harris Simon
- Harrison Ewen
- Harrison Paul
- Hartopp Richard
- Harvard Tim
- Harwood Elizabeth
- Haslop Richard
- Hayden Paul
- Henderson Steven
- Henwood Mark
- Hermandes Anil
- Hester Simon
- Hill Oliver
- Hilton Valerie
- Hodges Stacy
- Hollister Nigel
- Holt Peter
- Holtham Anitha
- Hool Alison
- Hopkins Phil
- Hopper John
- Horner Chris
- Howard-griffin Richard
- Howell Simon
- Howes Helen
- Hu Ying
- Hudson Liam
- Humes David
- Hurford Dom
- Husain Tariq
- Hutchinson Steve
- Iftikhar Syed
- Ijaz Sami
- Inglis David
- Iqbal Qamar
- Ishaan Maitra
- Jah Asif
- Jain Susan
- Janokowski Stas
- Januszewska Marta
- Jardine Catherine
- Jemmet Kim
- Jennings Adrian
- Jhamatt Anita
- Jovaisa Tomas
- Jovestani Keiarash
- Kahan Brennan
- Kahan Brennan
- Karat Isabella
- Karlikowsk Michael
- Karvonen Jyrki
- Kerry Sally
- Kerry Sally
- Khalaf Wael
- Khater Magdy
- Kightly Lynsey
- Kirby-bott James
- Kirk-bayley Justin
- Knight Georgia
- Knowles Charles
- Kocman David
- Kuduvalli Preeti
- Kukreja Neil
- Kuldip Rai
- Kumar Peeyush
- Kunst Gudrun
- Kushakovsky Vlad
- Laba Damian
- Lake Stephen
- Lal Roshan
- Lamb Peter
- Lams Edward
- Langton Helen
- Lawson Maria
- Lawton Greg
- Leno Emma
- Leuwer Martin
- Leuwer Martin
- Lewis Chris
- Lewis Ricky
- Liasis Lampros
- Lilford Richard
- Limb James
- Lindner Andrew
- Linnett Vanessa
- Lobo Dileep
- Lourtie Jose
- Lyness Craig
- Lynne Kaighan
- Lythell Nicola
- Machesney Michael
- Mackinnon John
- Macklin Christopher
- Mahajan Ravi
- Mahroof Razeen
- Maiya Bala
- Makris Nikolaos
- Marangoni Gabriele
- Martin Graham
- Martin Graham
- Martin Graham
- Martin Michael
- Marwick Jeremy
- Mason Nick
- Mateo Dolores
- May Denzil
- Mcafee Sean
- Mcarthur Carol
- Mccairn Amanda
- Mccullough Jonathan
- Mcilveen Erin
- Mclachan Jenny
- Mclaren Paul
- Mcmenemie Fiona
- Mcmullan Sean
- Mcnelis Una
- Medici Thomas
- Melville David
- Menezes Flavia
- Mercer Stuart
- Miller Andrew
- Millican Dean
- Milne Gordon
- Minto Gary
- Minto Gary
- Mirza Nazzia
- Misane Inga
- Modha Jigna
- Mohanty Manab
- Mohr Otto
- Mohsen Yasser
- Mole Jonathon
- Moncaster Gareth
- Monk David
- Monkhouse Diane
- Moonesinghe Ramani
- Morgan Richard
- Morgan-jones Tom
- Morris Craig
- Morrison Alan
- Mosley Frances
- Moug Susan
- Mukherjee Dipankar
- Mull Ajaya
- Mullenheim Jost
- Munro Mark
- Murray Dave
- Murray David
- Murray Diane
- Murray Therese
- Muthuswamy Babu
- Myers Alister
- Mythen Monty
- Nadarajavan Senthil
- Naik Veena
- Narula Harjeet
- Nash Guy
- Natarajan Nat
- Niebrzegowska Edyta
- Noble Hamish
- Noble Paul
- Noblett Sophie
- Northey Martin
- Nutt Chris
- O'carroll-kuehn Britta
- O'connell Gillian
- O'dwyer Grainne
- O'loughlin Paul
- Obichere Marion
- Obideyi Ayodele
- Odejinmi Oluremi
- Omer Abdel
- Outram Matt
- Owen Tom
- Owen Tom
- Paddle Jonathan
- Panikkar Kumar
- Papagrigoriadis Savvas
- Parker Thomas
- Parrington Simon
- Parry Jones Jack
- Parsons Anthony
- Patel Hitesh
- Patel Panna
- Patel Rajan
- Patel Sanjiv
- Patil Vishal
- Patrick Abigail
- Pearse Rupert
- Pearse Rupert M
- Peden Carol
- Peden Carol J
- Pemberton Phillippa
- Perrin-brown Laura
- Phull Mandeep
- Pick Sara
- Pickford Alison
- Pitman Catherine
- Pogson David
- Porter Helen
- Pow Colin
- Prabhudesai Ash
- Pratt Heather
- Prematie Andreou
- Prestwich Stewart
- Protopapas Michael
- Pulletz Mark
- Pulsa Stefan
- Pushpa Nathan
- Radford Nicola
- Rafi Amir
- Raj Ashok
- Rajagopal Ramesh
- Raju Pasupathy
- Raulusaite Ilona
- Razouk Khaled
- Reed Helen
- Rehman Almas
- Richardson Gerry
- Richardson Gerry
- Richardson Peter
- Riddington David
- Riddington Sid
- Rimmer Catherine
- Ritzema Jenny
- Rivett Kate
- Rivett Kate
- Robert Glenn
- Robin Nicole
- Rochester Chloe
- Rooney Kevin
- Rooney Laura
- Rope Tamsin
- Rose Alastair
- Ross-anderson Davina
- Roth Sally
- Rousseau Guy
- Roy Alistair
- Rubulotta Francesca
- Sagadai Saravanna
- Sanders Grant
- Sange Mansoor
- Saran Taj
- Sarfi Shameem
- Satisha Mallikarjunappa
- Saunders David
- Saunders David
- Scase Anne
- Schwarz Magen
- Scott Alexandra
- Sebastian Dominic
- Shah Tanuja
- Shankar Kirosh
- Sharma Abhiram
- Sharma Meghna
- Shaw Debbie
- Shawcross Robert
- Shenoy Shrisha
- Shukla Amit
- Silsby Joseph
- Sim Kevin
- Sim Malcolm
- Simeson Karen
- Singh Jagdeep
- Singh Satish
- Singh Surjait
- Sivasankaranand Ajit
- Sleight Simon
- Smart Simon
- Smith Hannah
- Smith Neil
- Snazelle Mark
- Somasekar Krishnamurthy
- Sonia Makvana
- Sonksen Julian
- Spimpolo Jennifer
- Stacey Brenda
- Stafford Helena
- Stanley David
- Stapleton Clare
- Stapleton Clare
- Stark Gail
- Steel Alistair
- Stephens Tim
- Stephens Tim
- Stergios Tezas
- Stevens Amanda
- Stevenson Richard
- Stewart Lynn
- Stone Julian
- Stotz Martin
- Stranix Nicola
- Stuart Hazel
- Subar Daren
- Sugavanam Anita
- Suggett Nigel
- Sunthareswaran Rame
- Surendran Karthik
- Susarla Jay
- Sutcliffe Robert
- Szakmany Tamas
- Szakmany Tamas
- Talwar Anjay
- Tan Kerwei
- Tan Melanie
- Tanqueray Tabitha
- Tansley John
- Tarrant Carolyn
- Taylor Lynn
- Thacker Andy
- Thomas Ruth
- Thomson Ann
- Thomson Ann
- Thorn Chris
- Thorniley Andrew
- Thrush Jessica
- Tierney Gill
- Tighe Sean
- Tofte Barclay
- Toth-tarsoly Piroska
- Townsend Roger
- Tucker Olga
- Tucker Vanessa
- Tutton Matthew
- Tyson Susan
- Ukoumunne Obioha
- Vaganov Sergei
- Van De Velde Niko
- Varcada Massimo
- Varma Sandeep
- Vashisht Shubha
- Velchuru Vamsi
- Verma Karan
- Vig Stella
- Vimalchandran Dale
- Visavadia Rakhee
- Vivek Chitre
- Waddy Sam
- Wakeford Julie
- Waldmann Carl
- Walker Simon
- Waring Justin
- Waring Justin
- Warusavitarne Janindra
- Watfah Josef
- Watson Geoff
- Watson Mark
- Watson Nicholas
- Watson Nick
- Watters Malcolm
- Way Carolyn
- Wells Duncan
- Wells Duncan
- Wells John
- Welsh Fenella
- Welters Ingeborg
- Wharton Richard
- White Andrew
- White Tim
- Wijeykoon Sanjay
- Wilkinson Jonny
- Wilkinson Mark
- Williams Alexandra
- Williams Dewi
- Williams Gail
- Williams Gethin
- Wilson Chris
- Wilson Graham
- Wilson Lawrence
- Wollaston Julie
- Wolverson Adam
- Wong Kate
- Wood Marcus
- Woods Justin
- Wrathall Wayne
- Wright Jenny
- Yang Fan
- Ziprin Paul
- Ziprin Paul
- Zuzan Oliver
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2019
- Field of study
Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
- Author
- Abbott
- Abdel Omer
- Abhiram Sharma
- Abigail Patrick
- Adam Wolverson
- Adrian Fawcet
- Adrian Jennings
- Aggarwal
- Ahmed
- Ajaya Mull
- Ajit Abraham
- Ajit Sivasankaranand
- Alan Girling
- Alan Morrison
- Alastair Ankers
- Alastair Rose
- Alexandra Scott
- Alexandra Williams
- Alison Hool
- Alison Pickford
- Alistair Roy
- Alistair Steel
- Alister Myers
- Almas Rehman
- Amanda McCairn
- Amanda Stevens
- Amir Rafi
- Amira Girgis
- Amit Shukla
- Ana Alegria
- Anderson
- Andreas Brodbeck
- Andreou Prematie
- Andrew Brennan
- Andrew Burtenshaw
- Andrew Claxton
- Andrew Lindner
- Andrew Miller
- Andrew Thorniley
- Andrew White
- Andy Thacker
- Anil Hermandes
- Anita Jhamatt
- Anita Sugavanam
- Anitha Holtham
- Anjay Talwar
- Ann Thomson
- Ann Thomson
- Anne Scase
- Anthony Gordon
- Anthony Parsons
- Arnab Bhowmick
- Arnth Engel
- Ash Prabhudesai
- Ashok Raj
- Asif Jah
- Auerbach
- Avninder Chana
- Ayan Banerjea
- Ayodele Obideyi
- Babu Muthuswamy
- Bala Maiya
- Banwari Agarwal
- Barclay Tofte
- Batalden
- Belinda Cornforth
- Benning
- Beth Hale
- Biju Aravind
- Bion
- Brenda Stacey
- Brennan C Kahan
- Brennan Kahan
- Britta O'Carroll-Kuehn
- Bruce Gibson
- Carl Waldmann
- Carmen Correia
- Carol J Peden
- Carol Mcarthur
- Carol Peden
- Carolyn Tarrant
- Carolyn Way
- Catherine Farrow
- Catherine Jardine
- Catherine Pitman
- Catherine Rimmer
- Charles Cartwright
- Charles Knowles
- Chitre Vivek
- Chloe Rochester
- Chris Coldwell
- Chris Dawson
- Chris Horner
- Chris Lewis
- Chris Nutt
- Chris Thorn
- Chris Wilson
- Christine Boyd
- Christine Bronder
- Christopher Macklin
- Clare Stapleton
- Clare Stapleton
- Colin Pow
- Craig Lyness
- Craig Morris
- Dale Vimalchandran
- Damian Laba
- Damschroder
- Dan Broad
- Dan Freshwater-Turner
- Daniel Conway
- Daren Subar
- Dave Murray
- David Bottomley
- David Browell
- David Cromwell
- David Gerrard
- David Humes
- David Inglis
- David Kocman
- David Melville
- David Monk
- David Murray
- David Pogson
- David Riddington
- David Saunders
- David Saunders
- David Stanley
- Davina Ross-Anderson
- Dawn Hales
- Dean Millican
- Debbie Shaw
- Denzil May
- Dewi Williams
- Dhiraj Ali
- Diane Monkhouse
- Diane Murray
- Dileep Lobo
- Dipankar Mukherjee
- Dixon-Woods
- Dolores Mateo
- Dom Hurford
- Dominic Sebastian
- Donna Doyle
- Duncan Wells
- Duncan Wells
- Edward Curtis
- Edward Lams
- Edyta Niebrzegowska
- Elizabeth Hall
- Elizabeth Hall
- Elizabeth Harwood
- Emanuel Cirstea
- Emma Brennan
- Emma Davis
- Emma Durant
- Emma Leno
- Erin Mcilveen
- Essam El-Damatty
- Esther Cook
- Everingham
- Ewen Griffiths
- Ewen Harrison
- Fabian Cook
- Faisal Baig
- Fan Yang
- Fanus Dreyer
- Fenella Welsh
- Ferdinand Adams
- Fiona McMenemie
- Flavia Menezes
- Flora Bailey
- Fran Haigh
- Frances Mosley
- Francesca Rubulotta
- Frankie Dorman
- Gabriele Marangoni
- Gail Stark
- Gail Williams
- Gareth Ackland
- Gareth Moncaster
- Gary Minto
- Gary Minto
- Gavin Bryce
- Geoff Watson
- Georgia Knight
- Gerry Richardson
- Gerry Richardson
- Gethin Williams
- Gill Tierney
- Gillian O'Connell
- Giovanni Brescia
- Glenn Arnold
- Glenn Robert
- Gordon Forbes
- Gordon Milne
- Graham Martin
- Graham Martin
- Graham Martin
- Graham Wilson
- Grainne O'Dwyer
- Grant Sanders
- Greg Lawton
- Gudrun Kunst
- Guy Finch
- Guy Nash
- Guy Rousseau
- Hamish Noble
- Hannah Smith
- Harjeet Narula
- Haynes
- Hazel Stuart
- Heather Pratt
- Helen Agostini
- Helen Black
- Helen Howes
- Helen Langton
- Helen Porter
- Helen Reed
- Helena Stafford
- Hitesh Patel
- Huddart
- Hussey
- Huw Davis
- Iain Anderson
- Iain Christie
- Ian Clement
- Ilona Raulusaite
- Inga Misane
- Ingeborg Welters
- Isabella Karat
- Jack Carmichael
- Jack Parry Jones
- Jagdeep Singh
- James Bromilow
- James Brown
- James Burrow
- James Burrow
- James Harris
- James Kirby-Bott
- James Limb
- Jamie Greenwood
- Jan Hanousek
- Jane Blazeby
- Janindra Warusavitarne
- Jason Cupitt
- Jay Gokhale
- Jay Susarla
- Jennifer Edwards
- Jennifer Spimpolo
- Jenny McLachan
- Jenny Ritzema
- Jenny Wright
- Jens Full
- Jeremy Marwick
- Jessica Thrush
- Jigna Modha
- John Abercrombie
- John Corson
- John Griffith
- John Hopper
- John Mackinnon
- John Tansley
- John Wells
- Jonathan Mccullough
- Jonathan Paddle
- Jonathon Barker
- Jonathon Mole
- Jonny Wilkinson
- Jose Lourtie
- Josef Watfah
- Joseph Silsby
- Jost Mullenheim
- Julian Bion
- Julian Bion
- Julian Sonksen
- Julian Stone
- Julie Colley
- Julie Furneval
- Julie Wakeford
- Julie Wollaston
- Justin Kirk-Bayley
- Justin Waring
- Justin Waring
- Justin Woods
- Jyrki Karvonen
- Kahan
- Kahan
- Kaighan Lynne
- Kamal Aryal
- Karan Verma
- Karen Burns
- Karen Simeson
- Karl Blenk
- Karthik Surendran
- Kate Carey
- Kate Rivett
- Kate Rivett
- Kate Wong
- Katherine Allen
- Kathryn Cain
- Kathryn Gill
- Katie Cooke
- Keiarash Jovestani
- Kenneth Adegoke
- Kerwei Tan
- Kevin Rooney
- Kevin Sim
- Khaled Razouk
- Kim Jemmet
- Kirosh Shankar
- Kirsty Baillie
- Kirsty Everingham
- Krishnamurthy Somasekar
- Kumar Panikkar
- Kuper
- Lampros Liasis
- Langley
- Laura Fitton
- Laura Graham
- Laura Perrin-Brown
- Laura Rooney
- Lawrence Wilson
- Leatherman
- Lee Baldwin
- Leilani Cabreros
- Liam Hudson
- Linda Graham
- Linden Baxter
- Lindsay Bailey
- Lorna Burrows
- Louise Bell
- Lynn Stewart
- Lynn Taylor
- Lynsey Kightly
- Magdy Khater
- Magen Schwarz
- Maitra Ishaan
- Majed Al Shama
- Makvana Sonia
- Malcolm Sim
- Malcolm Watters
- Mallikarjunappa Satisha
- Manab Mohanty
- Mandeep Phull
- Mansoor Akhtar
- Mansoor Sange
- Marcus Wood
- Maria Bews-Hair
- Maria Lawson
- Marion Obichere
- Mark Blunt
- Mark Cartmell
- Mark Coleman
- Mark Edwards
- Mark Henwood
- Mark Munro
- Mark Pulletz
- Mark Snazelle
- Mark Watson
- Mark Wilkinson
- Marta Campbell
- Marta Januszewska
- Martin
- Martin Leuwer
- Martin Leuwer
- Martin Northey
- Martin Stotz
- Martyn Cain
- Massimo Varcada
- Matt Gardner
- Matt Outram
- Matthew Gaughan
- Matthew Tutton
- Maurizio Cecconi
- Megan Griffiths
- Meghna Sharma
- Melanie Tan
- Michael Chadwick
- Michael Crabtree
- Michael Gillies
- Michael Karlikowsk
- Michael Machesney
- Michael Martin
- Michael Protopapas
- Michie
- Mike Bradburn
- Mike Bradburn
- Mike Gay
- Mike Grocott
- Miqdad Asaria
- Moller
- Monty Mythen
- Moraros
- Morgan
- Nabil El-Masry
- Nabua Gerstina
- Nada Hadi
- Nandita Divekar
- Nat Natarajan
- Natalie Dickinson
- Nathan Borgeaud
- Nathan Pushpa
- Nazar Abdul
- Nazzia Mirza
- Neil Cruickshank
- Neil Flint
- Neil Kukreja
- Neil Smith
- Nicholas Watson
- Nick Bunker
- Nick Harper
- Nick Mason
- Nick Watson
- Nicola Cook
- Nicola Lythell
- Nicola Radford
- Nicola Stranix
- Nicole Robin
- Nigel Hollister
- Nigel Suggett
- Niko Van De Velde
- Nikolaos Makris
- Obioha Ukoumunne
- Olga Tucker
- Oliver Hill
- Oliver Zuzan
- Oluremi Odejinmi
- Omar Faiz
- Otto Mohr
- Paddy Collins
- Panna Patel
- Pannick
- Pasupathy Raju
- Paul Harrison
- Paul Hayden
- Paul Mclaren
- Paul Noble
- Paul O'Loughlin
- Paul Ziprin
- Paul Ziprin
- Pedro Cunha
- Peeyush Kumar
- Peter Alexander
- Peter Chan
- Peter Davies
- Peter Fitzgerald
- Peter Holt
- Peter Lamb
- Peter Richardson
- Phil Dodd
- Phil Hopkins
- Phillippa Pemberton
- Phoebe Bodger
- Pieter Bothma
- Pieter Bothma
- Piroska Toth-Tarsoly
- Preeti Kuduvalli
- Presseau
- Qamar Iqbal
- Rachael Craven
- Rachel Bartlett
- Rachel Evley
- Rai Kuldip
- Rajan Patel
- Rajesh Dumpala
- Rajpal Dhingsa
- Rakhee Visavadia
- Raman Guruswamy
- Ramani Moonesinghe
- Rame Sunthareswaran
- Ramesh Rajagopal
- Ranjit Ganepola
- Raoul Benlloch
- Ravi Mahajan
- Razeen Mahroof
- Richard Gibbs
- Richard Hartopp
- Richard Haslop
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- Shubha Vashisht
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- Simon Hester
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- Simon Parrington
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- Singh Gursevak
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- Sophie Noblett
- Stacy Hodges
- Stas Janokowski
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- Stephanie Brown
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- Stephen Brett
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- Stephens
- Steve Fletcher
- Steve Hutchinson
- Steven Henderson
- Stewart Prestwich
- Stuart Mercer
- Sudha Garg
- Surjait Singh
- Susan Dowling
- Susan Jain
- Susan Moug
- Susan Tyson
- Susie Baker
- Syed Iftikhar
- Tabitha Tanqueray
- Taj Saran
- Tamas Szakmany
- Tamas Szakmany
- Tamsin Rope
- Tamzin Cuming
- Tanuja Shah
- Tariq Husain
- Tengberg
- Tezas Stergios
- Therese Murray
- Thomas Evans
- Thomas Medici
- Thomas Parker
- Tim Campbell-Smith
- Tim Geary
- Tim Harvard
- Tim Stephens
- Tim Stephens
- Tim White
- Tom Abbott
- Tom Morgan-Jones
- Tom Owen
- Tom Owen
- Tomas Jovaisa
- Una McNelis
- Valerie Hilton
- Vamsi Velchuru
- Vanessa Linnett
- Vanessa Tucker
- Veena Naik
- Verity Calder
- Vester-Andersen
- Victoria Banks
- Vishal Patil
- Vivek Chitre
- Vlad Kushakovsky
- Wael Khalaf
- Wayne Wrathall
- White
- White
- Will Brady
- Williams
- Xavier Escofet
- Yasser Mohsen
- Ying Hu
- Zakaulla Belagodu
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/10/2018
- Field of study
BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de Jesús Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Šuput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali Kağnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana Alícia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sánchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana María De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell Fernández
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas Stübner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
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- Anita Vuković
- Anita-Chrysolyte Kusi-Appiah
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- Judy Enamorado Enamorado
- Julia Kovaleva
- Julie Benbenishty
- Julie Benbenishty
- Julie Benbenishty
- Julie Camsooksai
- Julie Dallaire
- Julie Smith
- Julieta Canales
- Julio Ricardo Bartoli
- Julius Cranshaw
- Jun Kataoka
- Jundi Zhang
- Jung-Min Bae
- Junghyun Kim
- Junping Hao
- Justin Woods
- Justine Somerville
- Kadri Tamme
- Karely Duran
- Karen Baxter
- Karen Boulton
- Karen Burns
- Karen Cranmer
- Karen Habgood
- Karen Williams
- Karianne Dale Jensen
- Karin Kaasby
- Karin Rehnholt Pedersen
- Kathleen Ann Smiley
- Kathrin Bösl
- Keevan Singh
- Kefang Wang
- Kellie Sosnowski
- Kelly Fletcher
- Kelly Fletcher
- Kelly Matthews
- Kelly Matthews
- Kenji Takahashi
- Kerrie Martin
- Kerry Wright
- Kevin Hatton
- Kewei Liu
- Khaled Al Qawasmeh
- Khalid Abidi
- Khalid Abidi
- Khalid Mahmood Khan Nafees
- Khalid Mahmood Khan Nafees
- Kishore Mangal
- Kit Weng Foong
- Koen De Decker
- Koji Fujimoto
- Konlawij Trongtrakul
- Konlawij Trongtrakul
- Konlawij Trongtratul
- Konstantina Nestora
- Konstantinos Mandis
- Konstantinos Pagioulas
- Konstantinos Psarulis
- Kounougeri Katerina
- Kristina Mariana Matei Stalika
- Kristina Reinertsen Monstad
- Kristy Masters
- Kumi Maruyama
- Kunal Karamchandani
- Kyeongman Jeon
- Kyriaki Tsikritsaki
- Kyung Chan Kim
- Laetitia Boyer
- Laila Kamaliah Kamalul Bahrin
- Lakshay Bhakhtiani
- Lamia Besbes
- Lamia Ouanes Besbes
- Lamprini Avramopoulou
- Laura Bormans
- Laura Cespedes
- Laura Claramunt Domenech
- Laura Martinez Reyes
- Laura Maulicino
- Laura Pedro
- Laura Van Gulik
- Lea Albrecht
- Leah Flores
- Leanne Parsons
- Lee Yeon-Joo
- Lei Chen
- Lei Lei
- Lei Tan
- Lei Yang
- Leif Saager
- Leif Saager
- Leif Saager
- Lena Napolitano
- Lenneke Haas
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- Leticia Serpa
- Lettie Van Den Berg
- Li Chuntang Li
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- Li Ping Hu
- Li Xixi
- Li Yin
- Libing Zhang
- Lidia Glinka
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- Liesbet Demarré
- Lihong Liu
- Liivi Maddison
- Liivi Maddison
- Lijuan Zhao
- Lili Hu
- Lili Tuo
- Limei Fan
- Limei Miao
- Lin InSu
- Lina Xiao
- Lina Xu
- Lina Zhao
- Ling Li
- Ling Liu
- Ling Zhang
- LingLing Wang
- Linlin Luan
- LiPing Huang
- Lisa Dunne
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- Liu Hong
- Liudmila Fadeeva
- Liudmila Grishina
- Liuyan Ge
- Liz Wilby
- Llesley Chadwick
- Lomangisi Dlamini-Sserumaga
- Lorena Del Rio Cabajo
- Lorna Merritt-Charles
- Lorna Merritt-Charles
- Lorraine Thompson
- Losune Cano Sanchez
- Lotta Johansson
- Lotti Orvelius
- Louise Barr
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- Louise Rose
- Louise Rose
- Lu Liu
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- Luciano Bonaccorso
- Lucie Mouton
- Luis Alejandro Sanchez-Hurtado
- Luis Camputaro
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- Luis Sánchez-Hurtado
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- Ly Yuemen
- Lydia Gallego Aguirre
- Lynette Morrison
- Lynette Newby
- Lynne Williams
- Léa Soulisse
- M Del Rosario Villar Redondo
- M Llaurado-Serra
- Ma Hong
- Maarit Ahtiala
- Madeleine Powell
- Madhu Balasubramanian
- Madiha Hashmi
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- Maksim Tribulev
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- Malgorzata Mikaszewska-Sokolewicz
- Man Liu
- Man Ye
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- Maria Del Mar Diaz Salcedo
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- Maria Fernanda García
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- Maria Luisa Blasco
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- Mariangeles Gabriela Nocheretti
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- Mark Fielding
- Mark Fielding
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- Martina Lausch
- Mary Coman
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- Masakatsu Nananmori
- Masako Shimizu
- Matias Guereschi
- Matias Jesús Flamm Zamorano
- Matjaž Groznik
- Matteo Bossolasco
- Matthew Jackson
- Matthia Mergeay
- Matty Koopmans
- Matías Baini
- Maxim Petrushin
- Mayang Indah Lestari
- Mayra Martinez-Gonzalez
- Mayumi Tsujimoto
- Mazal Azencot
- Meena Manandhar
- Megan McQuirter
- Mei Jiang
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- Meili Chen
- Melike Cengiz
- Mendsaikhan Naranpurev
- Mendsaikhan Naranpurev
- Meneses Dayan
- Mengmeng Lv
- Meraj Ahmad
- Mercedes Del Cotillo
- Mercè Girona
- Meritxell Tapia Fores
- Merja Merilainen
- Meropi Mpouzika
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- Metaxia Papanikolaou
- Mette From
- Mette Lund
- Mhamed Sami Mebazaa
- Mia Hylen
- Mia Thorning Miller
- Miao Li
- Miao Liu
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- Miquel Sanz
- Mireia Llaurado-Serra
- Mireia Llaurado-Serra
- Mirjam Evers
- Mirjana Shosholcheva
- Mirjana Shosolcheva
- Miroslaw Czuczwar
- Misa Fister
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- Mohamed Benlamin
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- Mohan Gurjar
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- Mohd Nazri Ali
- Mohd Zulfakar Mazlan
- Mohd Zulfakar Mazlan
- Mona Ringdal
- Monica Adriana Scutariu
- Monica Garcia Diaz
- Monica Gomez
- Monica Popescu
- Monica Recio Losilla
- Monica Rocco
- Monika Rothenfusser
- Montserrat Venturas Nieto
- Morena Milic
- Moris Rosati
- Moritoki Egi
- Morten Bestle
- Mrina Oikonomou
- Mu Jianhong
- Muhammed Elhadi
- Muhommed Ridwaan Syed
- Mukta Singh
- Murat Emre Tokur
- Muriel Fartoukh
- Mustafa Akker
- Mustafa Ay
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- Nadezhda Zubareva
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- Nafseen Mostafa
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- Nathalie Fox
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- Nayeli Rocio Cañas Padilla
- Nebia Peker
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- Nicola Horrigan
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- Nicolas De Schryver
- Nie Bocui
- Niels Van Regenmortel
- Nigel White
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- Nika Zorko
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- Nikolaj Kamenshchikov
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- Nikolaos Kazakos
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- Nikolina Udiljak
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- Ning Li
- Nisha Bhandari Subedi
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- Orla Smith
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- Oscar Fernandez
- Oscar Fernández Rostello
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- Oyebola Adekola
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- Pablo Garcia Olivares
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- Pablo Monedero
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- Pamela Rocha
- Panagiotis Ioannides
- Paola Araya
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- Paraskevi Alexandropoulou
- Pascal Beuret
- Pasquale Iozzo
- Patricia Albert
- Patricia Brizuela
- Patricia Delgado
- Patricia Gordon
- Patricia Wijnands
- Patrick Biston
- Patrick M Honore
- Patrick M Honore
- Patrick M Honoré
- Patrick Meybohm
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- Paula Cabrita
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- Pedro Gutierrez
- Pedro Mogrovejo
- Pedro Silva
- Penny Parsons
- Peter Creber
- Peter Delve
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- Peter Van Vliet
- Petr Piza
- Petra Crone
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- Phil Broadhurst
- Philipp Douschan
- Philipp Eller
- Philipp Eller
- Philipp Simon
- Philippe Montravers
- Phumele Jali
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- Pierina Arias Campos
- Pieter Hoste
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- Pina Migliorino
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- Poon Shing Tak
- Prabha Gautam
- Prabha Gautam
- Preveen Banwarie
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- Prune Avogadro
- Przemyslaw Jasiewicz
- Purificacion Sanchez Zamora
- Qi Bo
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- Qi Zeng
- Qian Zhao
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- Qing Li
- Qingli Zhao
- Qingping Huang
- Qiong Liang
- Qiong Ran
- Qun Xia Jiang
- Rachael Parke
- Rachael Parke
- Rachel Baumber
- Rachel Jarman
- Radmilo Jankovic
- Radmilo Jankovic
- Radmilo Jankovic
- Rafael Gonzalez
- Rafael Sierra
- Rajnish Saha
- Ramanathan Lakshmanan
- Ramon Molina Chueca
- Rand Butcher
- Rannveig J Jonasdottir
- Ranveig Lind
- Raquel Cavaco
- Raquel Garcia Alvarez
- Raquel Jimenez
- Rayanne Santos
- Raysa Cristina Schmidt
- Regina Martinez
- Regina Mulvey
- Reimer Riessen
- Renata Curic Radivojevic
- Reni Jacob
- René Favre
- René Schmutz
- Rhian Bull
- Rica Dagooc
- Ricardo Gregorio
- Richard Lebon
- Richard Whitticase
- Rihard Knafelj
- Rihard Knafelj
- Rik T Gerritsen
- Rima Song
- Rishi Ghosh
- Rita Foss Hargott
- Ritoo Kapoor
- Rob Wilting
- Robert Villa
- Robert Wise
- Roberto Gonzalez
- Rodney Rosalia
- Romina Esposito
- Romina Marconi
- Romuald Hentchoya
- Romuald Hentchoya
- Rong Fen Huang
- Rong Hua Zhao
- Ronghua Zhao
- Rongjun Ling Hu
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- Rosa Garcia
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- Rosario Cosano
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- Ruben Fernandez
- RuiXia Wang
- Ruth Palfrey
- Ryohey Yamamoto
- Ryszard Gawda
- Sabah Abu Shawish
- Sabina Dhakal Pathak
- Sabrina Pelz
- Saeed Mahmood
- Saira Gomez
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- Salma Kamoun
- Salvatore Girianni
- Salvatore Maurizio Maggiore
- Samantha Hagan
- Samantha North
- Samantha Smith
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- Sandra McPherson
- Sandrine Balon
- Sang-Miin Lee
- Sang-Min Lee
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- Santhana Kannan
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- Sarah Brumwell
- Sarah Buckley
- Sarah Farnell-Ward
- Sarah Grotheer
- Sarah Jane Turner
- Sarah Jones
- Sasha Sankar-Maharaj
- Satoru Hashimoto
- Saulius Vosylius
- Savino Spadaro
- Sean Bagshaw
- Sean Bagshaw
- Sean Bagshaw
- Sean Bagshaw
- Sean Bagshaw
- Sebastian Geijer
- Sebastian Schüppel
- Sebastian Stehr
- Sema Turan
- Semih Aydemir
- Senay Goksu
- Seok Chan Kim
- Seok Jeong Lee
- Serap Avcı Ay
- Serdar Efe
- Sergio Reyes Iburrigarro
- Seung Yong Park
- Seval İzdes
- Seyed Mohammadreza Hashemian
- Shaly George
- Shanshan Lv
- Shanthi Ratnam
- Shanthi Ratnam
- Shanti Ratnam
- Shanti Rudra Deva
- Sharon McDowell-Skaines
- Shella Delossantos
- Shelley Schmollgruber
- Sherissa Microys
- Sherliza Wahab
- ShiFen Wu
- Shu Chuan Chang
- Shuchi Kaushik
- Shuhui Wang
- Shumin Jiang
- Shunsuke Taito
- Shunzhu Yang
- Shuo Wang
- Sibel Ocak Serin
- Silvia Angelica Jorge
- Silvia Call Manosa
- Silvia Calvino Günther
- Silvia Calvino-Gunther
- Silvia Calvino-Gunther
- Silvia Chaparro
- Silvia De Rosa
- Silvia Fernandez
- Silvie Allaert
- Silvina Bravo
- Silvio A Ñamendys-Silva
- Simant Jha
- Simeon Olanipekun
- Simeon Olanipekun
- Simon Dolenc
- Simon Mandaroux
- Simon Whiteley
- Simona Casaioli
- Sini John
- Siobhan O'Nuallain
- Siri Hansen
- Sirley Gill
- Siti Rohayah Sulaiman
- Siv Karin Malmin
- Siw Trudvang
- Slobodan Mihaljevic
- So Young Park
- Soad Imhmed R Alkhumsi
- Sofia Dias
- Sofia Kanakaki
- Sofia Putruele
- Sofia Zepoy
- Solenne Ory
- Sonia O Labeau
- Sonia Stiban
- Sonika Agarwal
- Sophie Liu
- Souheil Elatrous
- Souzana Anisoglou
- Srđan Gavrilovic
- Stacey Watts
- Stanislas Ledochowski
- Stefan Goller
- Stefan Schaller
- Stefano Coremans
- Stella Soundoulounaki
- Stella Uba
- Stephan Graeser
- Stephanie Harris
- Stephen Brett
- Stephen J Brett
- Stephen M Pastores
- Stijn I Blot
- Stijn Van de Velde
- Styliani Bastani
- Styliani Kourelea
- Suha Bozbay
- Sun Lijuan
- Sun Zhiping
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sung Wai Ho
- Sunghoon Park
- Sunthiti Morakul
- Susana Ferreira
- Susana Pinto
- Susanna Hojden
- Susanne Fischer
- Suzana Bianchini
- Suzana Pečenković
- Suzanne Barrowcliffe
- Suzanne Bench
- Swagata Tripathy
- Swagotika Salo
- Sylvi Vullum
- Syragoula Tsikriki
- Sébastien Jochmans
- Sébastien Pili-Floury
- Taha Khaled
- Tai Sun Park
- Takoua Merhabene
- Talia Ben-Jacob
- Tamas Szakmany
- Tamas Vymazal
- Tanja Depuydt
- Tanja Goranovic
- Tao Zan
- Tara Clesi
- Tarek Dendane
- Tarja Tervo-Heikkinen
- Tatiana Patrichi
- Tatjana Beker
- Taís Pantaleao
- Teena Maguire
- Theogene Twagirumugabe
- Theogene Twagirumugabe
- Theonymfi Papavasilopoulou
- Thierry Dugernier
- Thomai Tholioti
- Thomas Dimski
- Thomas Leong
- Thomas Llewellym
- Tianfei Chen
- Ticiane Campanili
- Tien Meng Khoo
- Tim Chimunda
- Timothy Eng
- Tina Charlotte Bitsch Hansen
- Tina Damgaar Thomsen
- Tine Melgaard Frandsen
- Ting Han
- Tingting Li
- Tingting Yu
- Tobias Heinicke
- Tobias Odenthal
- Tobias Schulze
- Tom Dormans
- Tomas Jovaisa
- Tomas Jovaisa
- Tomas Vymazal
- Tomasz Torlinski
- Tomislav Mirkovic
- Tonia Onyeka
- Touraj Rastegar
- Treiza Trueman-Dawkins
- Trina Zhivotneva
- Troy Browne
- Turkay Akbas
- Ulf Guenther
- Ulla Kesti
- Ulla Sandberg
- Ulrica Mickelsson
- Ulrich Jaschinski
- Umeda Aya
- Una Gunter
- Uri Gorokhovatsky
- Uta Kolussi
- V Gusarov
- Vaarisan Ganeshalingam
- Vaibhav Bhargava
- Valentina Bendelari
- Valentina Di Gravio
- Vanda Seromenho
- Vanesa Mercado Telleria
- Vanesa Mercado Telleria
- Vanja Gievski
- Vanja Misic
- Vasileios Bekos
- Vasiliki Chantziara
- Vasilios Koulouras
- Vasilios Koulouras
- Veronica Curilen
- Veronika Kotanidi
- Vesna Bumbasirevic
- Vicent Salvà-Costa
- Victor Gonzalez
- Victoria Houghton
- Victoria Khoronenko
- Victoria Marriott
- Vilas Kushare
- Vincent Castelain
- Vincent Fraipont
- Vincianne Pleitinckx
- Virginie Souppart
- Virpi Lusenius
- Vishnu Das Sasidharan Nair
- Vitaly Gusarev
- Vitaly Gusarov
- Vitor Gomes
- Vitor Manuel Vaz Pinto
- Viveca Hamback Hellkvist
- Višnja Nesek Adam
- Vladimir Gurevich
- Vladimir Kulakov
- Vladislav Belskiy
- Volkan Inal
- Volodymyr Babych
- Vongayi Ogbeide
- W Nazaruddin W Hassan
- Walid Naija
- Walid Sellami
- Walter Swinnen
- Wan Nasrudin Wan Ismail
- Wang Zhijuan
- Wangari Waweru-Siika
- Wangari Waweru-Siika
- Wangyan Jin
- Wei Sun
- Wei Wang
- Wei Wei
- Wei Zhang
- Wei Zhang
- Weilian Yuan
- Weiwei Li
- Wenche Arntsen
- Wendy Brown
- Wendy Chaboyer
- Wendy Chaboyer
- Wendy Milner
- Wenjie Ju
- Wenmei Wang
- Wenmin Chen
- Wenwen Zhao
- Wenzhen Cao
- Wesal Ali Belkhair
- Willem Dieperink
- Windu Baskoro
- Won-Yeon Lee
- Wu Yuchen
- Xia Cui
- Xia Huang
- Xianhong Zheng
- Xianping Luo
- Xiao Fang Tian
- Xiao Xu
- XiaoChun Hu
- Xiaodi Liu
- Xiaofang Luo
- Xiaohan Li
- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
- Xiaoqiong Deng
- Xiaowu Bai
- Xiaoyan Chen
- Xiaoyan Chen
- Xiaoying Wu
- XiaoZhe Liu
- Ximena Villanueva
- Xingguo Li
- Xinhua Xia
- Xinhua Xia
- Xinjian Li
- Xinran Ding
- Xinxia Li
- Xinxia Li
- Xiuhua Fang
- Xiuhua Fang
- Xiujuan Xue
- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
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- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
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- van Amerongen Roosmarijn
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- van de Veerdonk Frank L.
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- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
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- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
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- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
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- Wahab Sherliza
- Wahlbom Ewa
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- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
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- Wang Shuo
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- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
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- Williams Lynne
- Wilting Rob
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- Woods Justin
- Wright Kerry
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- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
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- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
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- Zermeno Jorge Macias
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- Zhang Aizhi
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- Zhao Ronghua
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- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Reflections on postgraduate research training:staff and student perspectives
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2005
- Field of study
Formal research training is integral to research degrees in human geography completed in UK higher education institutions today. The Economic and Social Research Council (ESRC) has been the driving force behind the formalization of research training. Arguably less well known among the ESRC research training recommendations is the stipulation that postgraduate research students complete advanced research training. This paper will draw upon the authors' experiences of the collaborative ESRC/Royal Scottish Geographical Society Advanced Research Training for Scottish Postgraduate Human Geographers. A detailed account of the advanced research training provision will be given, followed by staff and student reflections on the training. The paper concludes by considering what advanced research training offers to the PhD process and future developments in advanced research training
Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis?
- Author
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Abstract Aims Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and other neurological and psychiatric conditions, but there is little or no consensus as to how individual FGF family members contribute to disease pathogenesis. Lesion development in MS is associated with increased expression of FGF1, FGF2 and FGF9, all of which modulate remyelination in a variety of experimental settings. However, FGF9 is also selectively upregulated in major depressive disorder (MDD) prompting us to speculate it may also have a direct effect on neuronal function and survival. Methods Transcriptional profiling of myelinating cultures treated with FGF1, FGF2 or FGF9 was performed and the effects of FGF9 on cortical neurons investigated using a combination of transcriptional, electrophysiological and immunofluorescence microscopic techniques. The in vivo effects of FGF9 were explored by stereotactic injection of adeno‐associated viral (AAV) vectors encoding either FGF9 or EGFP into the rat motor cortex. Results Transcriptional profiling of myelinating cultures after FGF9 treatment revealed a distinct neuronal response with a pronounced downregulation of gene networks associated with axonal transport and synaptic function. In cortical neuronal cultures , FGF9 also rapidly downregulated expression of genes associated with synaptic function. This was associated with a complete block in the development of photo‐inducible spiking activity, as demonstrated using multi‐electrode recordings of channel rhodopsin‐transfected rat cortical neurons in vitro and ultimately, neuronal cell death. Overexpression of FGF9 in vivo resulted in rapid loss of neurons and subsequent development of chronic grey matter lesions with neuroaxonal reduction and ensuing myelin loss. Conclusions These observations identify overexpression of FGF9 as a mechanism by which neuroaxonal pathology could develop independently of immune‐mediated demyelination in MS. We suggest targeting neuronal FGF9‐dependent pathways may provide a novel strategy to slow if not halt neuroaxonal atrophy and loss in MS, MDD and potentially other neurodegenerative diseases