Thermal Forming of Glass — Experiment vs. Simulation

Thermal forming is a technique for forming glass foils precisely into a desired shape. It is widely used in the automotive industry. It can also be used for shaping X-ray mirror substrates for space missions, as in our case. This paper presents the initial results of methods used for automatic data processing of in-situ measurements of the thermal shaping process and a comparison of measured and simulatated values. It also briefly describes improvements of the overall experimental setup currently being made in order to obtain better and more precise results

anti-tick vaccines to prevent tick-borne diseases in Europe

Ixodes ricinus transmits bacterial, protozoal and viral pathogens, causing disease and forming an increasing health concern in Europe. ANTIDotE is an European Commission funded consortium of seven institutes, which aims to identify and characterize tick proteins involved in feeding and pathogen transmission. The knowledge gained will be used to develop and evaluate anti- tick vaccines that may prevent multiple human tick-borne diseases. Strategies encompassing anti-tick vaccines to prevent transmission of pathogens to humans, animals or wildlife will be developed with relevant stakeholders with the ultimate aim of reducing the incidence of tick-borne diseases in humans

Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission

BACKGROUND: Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa. We hypothesized that a vaccine targeting tick proteins that are involved in attachment and feeding might affect feeding success and possibly reduce tick-borne transmission of T. parva. Here we report the evaluation of a multivalent vaccine cocktail of tick antigens for their ability to reduce R. appendiculatus feeding success and possibly reduce tick-transmission of T. parva in a natural host-tick-parasite challenge model. METHODS: Cattle were inoculated with a multivalent antigen cocktail containing recombinant tick protective antigen subolesin as well as two additional R. appendiculatus saliva antigens: the cement protein TRP64, and three different histamine binding proteins. The cocktail also contained the T. parva sporozoite antigen p67C. The effect of vaccination on the feeding success of nymphal and adult R. appendiculatus ticks was evaluated together with the effect on transmission of T. parva using a tick challenge model. RESULTS: To our knowledge, this is the first evaluation of the anti-tick effects of these antigens in the natural host-tick-parasite combination. In spite of evidence of strong immune responses to all of the antigens in the cocktail, vaccination with this combination of tick and parasite antigens did not appear to effect tick feeding success or reduce transmission of T. parva. CONCLUSION: The results of this study highlight the importance of early evaluation of anti-tick vaccine candidates in biologically relevant challenge systems using the natural tick-host-parasite combination

Calculation of the efficacy of vaccines against tick infestations on cattle

Articles in International JournalsCattle ticks are responsible for great economic losses in cattle farming worldwide, and their main control method, chemicals, has been showing problems, whether resulting from the development of resistant strains of ticks or environmental contamination. Research studies directed toward developing vaccines against ticks are emerging. One way to evaluate those vaccines is to calculate the percentage of efficacy. The aim of this study was to analyze scientific publications archived in PubMed that used this method of assessment and discuss the main factors that may affect its calculation. Thus, 25 articles addressing this subject were selected. The percentage of efficacy was usually calculated in one of two ways, with one considering the reduced fertility of eggs and the other not. The latter method may underestimate the vaccine efficacy, and the most complete formula for calculating the efficacy reflects how much the vaccine actually affects the infestation. In our view, the use of the complete formula for calculating the percentage of efficacy is broader and more representative of the vaccine effect on the tick population.RESUMO - Carrapatos de bovinos são responsáveis por grandes perdas econômicas para a pecuária bovina mundial e seu principal método de controle, o químico, vem apresentando problemas, seja pelo desenvolvimento de amostras de carrapatos resistentes ou pela contaminação ambiental. Na tentativa de diminuir a utilização dos acaricidas, surgem pesquisas direcionadas ao desenvolvimento de vacinas contra carrapatos. Uma maneira de avaliar essas vacinas é pelo cálculo de percentagem de eficácia. O objetivo deste trabalho foi analisar as publicações científicas indexadas no PubMed que utilizaram este método de avaliação e discutir os principais fatores que podem interferir no seu cálculo. Dessa maneira, selecionaram-se 25 artigos que tratavam desse assunto. A percentagem de eficácia apareceu sendo calculada de duas formas, uma considerando a redução da fertilidade dos ovos e a outra não. Essa última pode subestimar a eficiência da vacina, e a fórmula de cálculo da eficácia mais completa representa o quanto da infestação a vacina realmente reduziu. Em nosso entendimento, a utilização da fórmula completa para o cálculo da percentagem de eficácia é mais abrangente e representativa do efeito da vacina na população de carrapatos

Economic Valuation of Mountain Landscapes and Ecosystems: A Meta-Analysis of Case Studies

The paper is focused on the value of the European mountain landscape/ecosystem and evaluates the impact of agriculture and agricultural policy on the value of this public good. Based on the meta-analysis of 22 landscape/ecosystem valuation studies, it was found that the average value of the European mountain landscape/ecosystem is 3,068 EUR per hectare per year, and 3.91 EUR per person per day. However, there are regions with a significantly higher value – Tatra in Poland and Alpujarran in Spain. The value is influenced by the position of agriculture in the national economy. Higher values of the mountain landscape/ ecosystem were achieved in countries where the contribution of agriculture to the gross value added is above average. On the other hand, there is no significant relationship between the proportion of farming in the LFA and the value of the mountain landscape/ecosystem. Public support was found to be insufficient to cover the cost of landscape services performed by farmers

Valuation of Public Goods: The Case of Emissions from Livestock Holdings in the Czech Republic

Designed paper is focused on the analysis of public goods in the form of greenhouse gas emissions in livestock production in Czechia. The main aim of the paper is to quantify the amount and valuation of greenhouse gas emissions produced in beef cattle breed (dairy and meat), pig breed, and poultry breed (meat and eggs). The partial aim of this paper is to compare greenhouse gas emissions production across sectors of livestock production and to evaluate a development of volume, value and share of emissions as a form of public goods. The methodology is based on the conceptual model MITERRA-Europe (The model was developed to assess the effects and interactions of policies and measures in agriculture on N losses and P balances at a regional level in EU-27), which is partly based on the CAPRI (Common Agricultural Policy Regionalised Impact) and the GAINS (Greenhouse Gas and Air Pollution Interactions and Synergies) models using the tools for quantification of the emission factors indicators defined by the IPCC (Intergovernmental Panel for Climate Change) organizations. Part of the solution is to determine the value of public goods quantified through a European platform for carbon emissions trading with its futures contract based on the EU Allowances. The result of this paper is quantified emission value of public goods in livestock production in Czechia and their appreciation in the period 2000-2014. In the final consequence is quantified the proportion of the value of public goods in the total production of the analyzed livestock sector

Identification and Valuation of Public Goods within the Vertical of Cattle Breeding

The paper identifies and discusses the production of public goods in the vertical of cattle breeding. The cattle breeding vertical was divided into four basic levels – producer, processor, retailer, and consumer and main public goods were determined and discussed. Moreover, it provides the methods for the valuation of public goods. The method is applied in the estimation of manure shadow price. Using the fitted multiple output distance function with two market and one non-market output and applying the Lagrange method and the Shephard’s dual lemma the shadow price of manure was calculated. The results show that the shadow prices differ significantly among the groups of farmers. This especially holds for the classification of groups according to the size and technology of production