Performance of Retrieval Information System For Medical Images

Problem statement : In this article the principles of building knowledge and retrieval information system will be applied to medical images in some studied hospital. Since there is a huge number of medical images this system will organizes and manages the operation of retrieving and displaying such images to the persons who need such images in short time and in high quality services. Approach : From relevance assessments we can compute measures of retrieval performance such as: Recall (R), discrimination DC, and Precision. Results: both recall and precision of the system are linearly depend on relevant items correctly retrieved. Conclusion : Number of retrieved images from huge total number of medical images in some hospital determine the systems' recall, discrimination, and precision of the retrieval information system

Diversity of active constituents in Cichorium endivia and Cynara cornigera extracts

The present study attempts to explore the phytochemical constituents of different extracts from Cynara cornigera and Cichorium endivia plant materials. The two species studied are native in Egypt. Five different solvents, viz., aqueous, methylene chloride, petroleum ether, ethyl acetate, and n-butanol were used. Phytochemical analysis revealed the presence of phenols, flavonoids, sterols (stigmasterol and beta-sitosterol), terpenes (α-amyrin, ursolic and oleanolic acid), and hydrocarbons (n-alkane), the latter found in low amount. The ethyl acetate and water extracts of C. cornigera root showed lower mass fractions of phenolic compounds ranged from 20 to 81 g/100 g, and higher amounts in ethyl acetate extract of the inflorescences and butanol extract of the root where values ranged from 195 to 399 g/100 g. The β-sitosterol and stigmasterol were present in all plant extracts. Oleanolic and ursolic acids were detected in roots, leaves and inflorescences of C. cornigera and in C. endivia shoot. The ethyl acetate extracts from C. cornigera leaf and inflorescence attained higher chemical diversity than the other extracts. Alternatively, sterols and triterpenes were the major constituents. The high chemical diversity of active constituents justifies the future potential use of the two species at commercial level

Distribution Systems Efficiency

This paper constructing a measurement system for determining the efficiency of the distributed system. This efficiency depends on many parameters like number of terminals, number of customers and kind of information, number of nodes, and number of messages. It is found that the efficiency depends strongly on number of messages sent or received inside the distributed system, as the number of messages increased the efficiency decreased. Keywords: distributed system, terminals, efficiency

Tapping uncultured microorganisms through metagenomics for drug discovery

Natural products have been an important historical source of therapeutic agents. Microorganisms are major source of bioactive natural products, and several microbial products including antibiotics, anti-inflammatory, anti-tumour, immunosuppressants and others are currently used as therapeutic agents for human and  domestic animals. Most of these products were obtained from cultured environmental microorganisms. However, it is widely accepted that a very large majority of the microorganisms present in natural  environments are not readily cultured under laboratory conditions, and therefore are not accessible for drug  discovery. Metagenomics is a recent culture-independent approach that has been developed to access the  collective genomes of natural bacterial populations. It enables discovery of the diverse biosynthetic pathways encoded by diverse microbial assemblages that are known to be present in the environment but not-yet  cultured. Recently, several new bioactive molecules and proteins have been discovered using a metagenomic approach. This review highlights the recent methodologies, limitations, and applications of metagenomics for the discovery of new drugs. Moreover, it shows how a multidisciplinary approach combining metagenomics with other technologies can expedite and revolutionize drug discovery from diverse environmental microorganisms.Key words: Microbial diversity, metagenomics, natural products, drug discovery, microbial ecology

Isolation and identification of pathogenic fungi on Oreochromis aureus(Steindachner,1864)in the university of Basrah fish ponds

1213-1216Thirty samples of Oreochromis aureus were collected from University of Basra fish ponds during the period from February until June 2014.Thirteen fish samples showed fungal infection. A sterile swab was taken from outer surface of body (head, skin, gills, abdomen, caudal fin, dorsal fin and pectoral fin). Potato dextrose agar and glucose yeast agar was used for fungal isolation.In this study six genera were identified and the most common were Aspergillus sp., Alternaria sp., Mucor sp., Penicillium sp., Brachiomyces sp. and Ichthyophonus sp. Gills and abdomen were the most affected parts of fish. Among the generaobservedAspergillus sp. and Mucor sp. were the most prevalent fungi infecting these fishes

Interactome analysis and docking sites of MutS homologs reveal new physiological roles in arabidopsis thaliana

Due to their sedentary lifestyle, plants are constantly exposed to different stress stimuli. Stress comes in variety of forms where factors like radiation, free radicals, "replication errors, polymerase slippage", and chemical mutagens result in genotoxic or cytotoxic damage. In order to face "the base oxidation or DNA replication stress", plants have developed many sophisticated mechanisms. One of them is the DNA mismatch repair (MMR) pathway. The main part of the MMR is the MutS homologue (MSH) protein family. The genome of Arabidopsis thaliana encodes at least seven homologues of the MSH family: AtMSH1, AtMSH2, AtMSH3, AtMSH4, AtMSH5, AtMSH6, and AtMSH7. Despite their importance, the functions of AtMSH homologs have not been investigated. In this work, bioinformatics tools were used to obtain a better understanding of MSH-mediated DNA repair mechanisms in Arabidopsis thaliana and to understand the additional biological roles of AtMSH family members. In silico analysis, including phylogeny tracking, prediction of 3D structure, interactome analysis, and docking site prediction, suggested interactions with proteins were important for physiological development of A. thaliana. The MSH homologs extensively interacted with both TIL1 and TIL2 (DNA polymerase epsilon catalytic subunit), proteins involved in cell fate determination during plant embryogenesis and involved in flowering time repression. Additionally, interactions with the RECQ protein family (helicase enzymes) and proteins of nucleotide excision repair pathway were detected. Taken together, the results presented here confirm the important role of AtMSH proteins in mismatch repair and suggest important new physiological roles

Hibiscus cannabinus seeds assisted spherical silver nanoparticles and its antibacterial and photocatalytic applications

Green nanomaterial manufacture limits hazardous substances and encourages noxious-free environments. The fields of photocatalysis and antibacterial resistance are more promising because of their chemical reductants and sterile environments. Here, we used Hibiscus Cannabinus seed as a bio source and developed a simple, environmentally friendly approach for the biosynthesis of AgNPs. Researchers and scientists have recently shown a strong interest in the green synthesis of silver nanoparticles due to their ease, eco-friendliness, non-toxicity, low cost, and ability to function as an antibacterial agent. Research goals include producing environmentally friendly, bacteriocidal, and photocatalytic dye removal products that can be applied to biomedical and water reuse applications. In this paper, we have reported spherical-shaped silver nanoparticles synthesized from Hibiscus cannabinus seeds and their characterization by X-ray Diffraction method, UV-Visible Spectroscopy, and Transmission Electron Micrograph. The surface functionalization of prepared silver particles by phenolic compounds in Hibiscus cannabinus seeds enhances antibacterial activity. Both Staphylococcus aureus and Escherichia coli are inhibited by the prepared silver nanoparticles. By preparing silver nanoparticles at a significantly higher extract concentration, we were able to obtain effective and increased bactericidal activity. The photocatalytic degradation of congo red by prepared silver particles was studied under 150 min of UV light irradiation. The produced silver nanoparticles' structural, optical, morphological, compositional, and bactericidal activity are all shown to be dependent on the concentration of Hibiscus cannabinus seeds extract that is attached to the silver surface

Botany, nutritional value, phytochemical composition and biological activities of quinoa

Quinoa is a climate-resilient food grain crop that has gained significant importance in the last few years due to its nutritional composition, phytochemical properties and associated health benefits. Quinoa grain is enriched in amino acids, fiber, minerals, phenolics, saponins, phytosterols and vitamins. Quinoa possesses different human-health promoting biological substances and nutraceutical molecules. This review synthesizes and summarizes recent findings regarding the nutrition and phytochemical properties of quinoa grains and discusses the associated biological mechanisms. Quinoa grains and grain-based supplements are useful in treating different biological disorders of the human body. Quinoa is being promoted as an exceptionally healthy food and a gluten-free super grain. Quinoa could be used as a biomedicine due to the presence of functional compounds that may help to prevent various chronic diseases. Future research needs to explore the nutraceutical and pharmaceutical aspects of quinoa that might help to control different chronic diseases and to promote human health.King Saud University | Ref. RG-1440-05

Evaluation of Compounds from <i>Balanites aegyptiaca</i> against Squalene Epoxidase of <i>Micropsorum gypseum</i>—In Vitro and In Silico Studies

Microsporum gypseum is a dermatophyte with a geophilic nature that is found all over the globe. It mainly causes tinea in the scalp, arms, and legs in humans. Squalene epoxidase (SE) is a crucial enzyme in M. gypseum for the biosynthesis of ergosterol. The medicinal plant Balanites aegyptiaca is an abundant supply of secondary constituents with great therapeutic values. In this research, the fruit epicarp portion was used to inhibit M. gypseum using experimental and computational techniques. The anti-dermatophytic activity of epicarp extracts on M. gypseum was evaluated using the poison plate method at five different concentrations. At 3 mg/mL, the M. gypseum was completely controlled by the fractioned chloroform extract of epicarp. The compounds from previous research were utilized for docking studies (Abuthakir et al., 2022). The ideal compounds and the drug terbinafine were then docked using Schrödinger’s Glide module. It demonstrates that (3E)-7-Hydroxy-3,7-dimethyl-3-octen-1-yl-6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside outperforms other substances and the drug terbinafine in docking analysis. Desmond, Schrödinger Molecular Dynamics simulations were also performed for (3E)-7-Hydroxy-3,7-dimethyl-3-octen-1-yl-6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside-squalene epoxidase complexes. The complex appears to be more stable, according to the MD simulation research. This study indicates that (3E)-7-Hydroxy-3,7-dimethyl-3-octen-1-yl-6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside could be used as a potential inhibitor of M. gypseum growth, and it could be studied further

Grasses in Semi-Arid Lowlands&mdash;Community Composition and Spatial Dynamics with Special Regard to the Influence of Edaphic Factors

Edaphic properties have been widely shown to influence community composition and distribution. However, the degree to which edaphic factors can affect grasses in semi-arid lowlands is still little researched. We assessed the significance of nine edaphic factors to explain the distributions of 65 grass species with various ecological traits (i.e., the ecological indicator values for their preferred habitat) in the semi-arid lowlands of Pakistan. To record information on species composition and related ecological conditions, we selected 10 random sampling locations between 2020 and 2021. For each species, we determined the important value index (IVI) and looked at the primary indicator species that were identified using the indicator species analysis approach. The major genera were Setaria, Brachiaria, and Cenchrus with 6.15% species in each followed by Aristida,&nbsp;Panicum, and Eragrostis with 4.61% wild grass species, Bothriochloa, Bromus, Phragmites, Polypogon, Saccharum, Poa, Echinochloa, and Dactyloctenium with 3.07% species, whereas other genera had a single species each. In total, 80% of the species were native, while only 20% were introduced species. Microphylls accounted for 49.23% of the leaf size spectra of the grass flora in the study area. The other frequent traits included macrophylls (21.53%), nanophylls (20%), and leptophylls (9.23%). The major life forms were therophytes (56.92%) followed by hemicryptophytes (38.46%) and geophytes (4.61%). The results of an ordination analysis indicated that the distribution of grasses was significantly (p &le; 0.002) influenced by several edaphic parameters, with pH having the greatest impact on species distribution. The analyses of indicator species showed that pH and EC were the most powerful and important edaphic factors for determining the composition of plant communities and indicator species. The significant indicator species in various ecosystems were Cynodon dactylon (L.) Pers. [email protected] and Leptochloa chinensis (L.) Nees (agroecosystem), Brachiaria reptans (L.) C.A. Gardner and C.E. Hubb, Dichanthium annulatum (Forssk.) Stapf, and Saccharum spontaneum L. (forest ecosystem), Cenchrus biflorus Roxb., Cenchrus ciliaris L., and Desmostachya bipinnata (L.) Stapf (urban ecosystem), Arundo donax L., Echinochloa crus-galli, and Phragmites australis (wetland ecosystem), and Saccharum spontaneum and Echinochloa crus-galli (L.) P. Beauv. (riparian ecosystem). We discovered that different species groupings had different habitat preferences and that soil pH had a significant beneficial effect on plant variety. These results provide a scientific roadmap for soil and plant restoration in semi-arid lowland habitats