Synthesis of Novel Cyclobutane Nucleoside Analogues

A synthesis of cyclobutane nucleosides is described. The method involved the triflation of a -hydroxymethyl-cyclobutanone and its subsequent displacement by a 6-chloropurinyl anion to generate N-7 and N-9 regioisomers. The stereoselective reduction of the N-alkylated ketones yielded the cis-alcohols quantitatively and the geometric configuration was confirmed by spectroscopic data and X-ray diffraction. Photolysis of N-7 and N-9 coupled ketones was carried out in methanol using quartz tubes to promote ring-expansion isonucleoside products. Photolysis did not yield any ring-expansion or cycloelimination products, rather, the products are suspected to be cyclopropanes from decarbonylation of the ketones, since these are less polar and show shielding of protons in their corresponding NMR spectra, consistent with substituted cyclopropanes

Impact of Crew Training and Safety Management System on Operational Management in Aviation Industry of Pakistan

Aviation plays a fundamental role in the growth of trade, tourism, economy as well as sustainable development in Pakistan. The two main influential factors Crew Training and Safety Management impacting operations of Engineering Management was found on the basis of literature and analyzed. Primarily, the numerous organizations training methodologies to get their crew staff training was collected from both primary sources that’s questionnaire instrument and secondary sources which is Literature. The reliability and validity of the instrument was tested with the help of Cronbach Alpha and the survey questionnaire was distributed to obtain primary data. The used Non-Probability Sampling technique analyzed thru Statistical Package for Social Sciences software. It was revealed that both the variables i-e Crew Training and Safety Management have a significant impact on improving aviation operational management. Therefore, the management should take remedial measures to work out on Crew Training and Safety Management factors that may augment aviation operational management according to latest National Aviation Policy 2019

Determination of the anti-diabetic effect of methanolic extract of Sphaeranthus indicus L. on alloxan induced diabetic rabbits

The aim of present study was to determine the anti-diabetic effect of methanolic extract of Sphaeranthus indicus L. (SMe) in alloxan induced diabetic rabbits. It was further aimed to determine the effect of SMe on various biochemical parameters, namely blood glucose levels, total cholesterol, lipoproteins (HDL and LDL), liver functions (SGOT and SGPT), serum creatinine and urea level in alloxan induced diabetic rabbits. Rabbits were divided into five groups: one non-diabetic control, treated with vehicle and four experimental (diabetic) groups. The experimental groups can be described as diabetic negative control, treated with vehicle, diabetic positive control, treated with 80 mg/kg of diamicron, a reference drug; and diabetic treated with 150 or 300 mg/kg of SMe. Pre- and post-experimental lipid profile, liver function and kidney function of rabbits was determined. The SMe at the dose of 300 mg/Kg body weight significantly (p 0.05).Colegio de Farmacéuticos de la Provincia de Buenos Aire

Determination of the anti-diabetic effect of methanolic extract of Sphaeranthus indicus L. on alloxan induced diabetic rabbits

The aim of present study was to determine the anti-diabetic effect of methanolic extract of Sphaeranthus indicus L. (SMe) in alloxan induced diabetic rabbits. It was further aimed to determine the effect of SMe on various biochemical parameters, namely blood glucose levels, total cholesterol, lipoproteins (HDL and LDL), liver functions (SGOT and SGPT), serum creatinine and urea level in alloxan induced diabetic rabbits. Rabbits were divided into five groups: one non-diabetic control, treated with vehicle and four experimental (diabetic) groups. The experimental groups can be described as diabetic negative control, treated with vehicle, diabetic positive control, treated with 80 mg/kg of diamicron, a reference drug; and diabetic treated with 150 or 300 mg/kg of SMe. Pre- and post-experimental lipid profile, liver function and kidney function of rabbits was determined. The SMe at the dose of 300 mg/Kg body weight significantly (p 0.05).Colegio de Farmacéuticos de la Provincia de Buenos Aire

Frequency of Surgical Impactions of Mandibular Third Molar in Orthodontic Patients with Different Antegonial Notching

Background: Few studies have been reported so far on the frequency of lower third molar impactions in patients with different morphological characteristics. Our aim in this study was to find out the frequency of impacted lower third molars in orthodontic patients with different antegonial notch depths. Material and Methods: This cross-sectional research was conducted at Orthodontics Department of Dental Section, Faisalabad Medical University, Faisalabad, and de’Montmorency College of Dentistry, Lahore, Pakistan from June 2017 to June 2019. A total of 60 orthopantomograms (OPGs) of patients with impacted lower third molars were included. The depth of antegonial notch was calculated on all the selected OPGs by measuring distance between the deepest area of the notch cavity and the tangent on the inferior border of the mandible. The patients with depth of antegonial notch of 1 mm or less were labeled as having shallow antegonial notch, while those with 3 mm or more were considered as having deep antegonial notch. Percentages and mean + SD were calculated for different variables. Depth of antegonial notching was compared between genders using ANOVA with P-value <0.5 considered as significant. Results: Of 60 orthodontic patients, there was an equal number of male and female patients (n=30). The average age of the patients was 25.5±4 years. Overall frequency of impactions was similar in both the genders and frequency of impacted lower third molars was found to be greater in patients with deeper antegonial notches. Conclusion: Mandibular third molar impactions were most frequent in orthodontic patients with deep antegonial notche

Correlation analysis of vital signs to monitor disease risks in ubiquitous healthcare system

Healthcare systems for chronic diseases demand continuous monitoring of physiological parameters or vital signs of the patients’ body. Through these vital signs’ information, healthcare experts attempt to diagnose the behavior of a disease. Identifying the relationship between these vital signs is still a big question for the research community. We have proposed a sophisticated way to identify the affiliations between vital signs of three specific diseases i.e., Sepsis, Sleep Apnea, and Intradialytic Hypotension (IDH) through Pearson statistical correlation analysis. Vital signs data of about 32 patients were taken for analysis. Experimental results show significant affiliations of vital signs of Sepsis and IDH with average correlation coefficient of 0.9 and 0.58, respectively. The stability of the mentioned correlation is about 75% and 90%, respectively

Determination of the anti-diabetic effect of methanolic extract of Sphaeranthus indicus L. on alloxan induced diabetic rabbits

The aim of present study was to determine the anti-diabetic effect of methanolic extract of Sphaeranthus indicus L. (SMe) in alloxan induced diabetic rabbits. It was further aimed to determine the effect of SMe on various biochemical parameters, namely blood glucose levels, total cholesterol, lipoproteins (HDL and LDL), liver functions (SGOT and SGPT), serum creatinine and urea level in alloxan induced diabetic rabbits. Rabbits were divided into five groups: one non-diabetic control, treated with vehicle and four experimental (diabetic) groups. The experimental groups can be described as diabetic negative control, treated with vehicle, diabetic positive control, treated with 80 mg/kg of diamicron, a reference drug; and diabetic treated with 150 or 300 mg/kg of SMe. Pre- and post-experimental lipid profile, liver function and kidney function of rabbits was determined. The SMe at the dose of 300 mg/Kg body weight significantly (p 0.05).Colegio de Farmacéuticos de la Provincia de Buenos Aire

Current Status and Potential of Tire Pyrolysis Oil Production as an Alternative Fuel in Developing Countries

Current status and potential of tire pyrolysis oil production as an alternative fuel in developing countrie

Relationship between Kinesiophobia, Fall Risk and Activity Level among Elderly Females after Total Knee Arthroplasty

Objective: To determine the effect of Mulligan’s Mobilization on unilateral tibiofemoral osteoarthritis. The objective of the study was to evaluate co-relation between fall risk, kinesiophobia, and physical- activity level among elderly females after one year of TKA. Methodology: This study was a cross-sectional survey conducted on females who had their Total Knee arthroplasty from Ghurki Trust & Teaching Hospital and Punjab Medical Centre, Lahore. Data was collected from 200 (n) elderly females who had undergone their Total Knee Arthroplasty at least one year before the study was conducted. Fall risk (Berg Balance Scale), fear of movement (Tampa Scale of Kinesiophobia), and physical activity (IPAQ) were the key outcome measures. Results: Pearson correlation determined higher levels of association between fall risk, fear of movement and physical activity. Higher the berg balance score, lower the score of Kinesiophobia i.e. negatively significant correlation; r (198) = -.54, p=0.00. Higher berg balance scores were also found to be positively related to higher minutes of low, moderate and vigorous exercise per week. Kinesiophobia was found to be negatively significant for physical activity of low, moderate and vigorous intensity i.e. r (198) = -.11, p= .01, r (198) = -.03, p=.00 and r (198) = -.07, p= .02 respectively.   Conclusion: A significant negative correlation was observed between fall risk and Kinesiophobia. Moreover, a significant positive correlation was observed between fall risk and physical activity in elderly females who have had TKA. Key words: Berg balance scale, fall risk, kinesiophobia, Total Knee Arthroplast

Effect of biochar modified with magnetite nanoparticles and HNO\u3csub\u3e3\u3c/sub\u3e for efficient removal of Cr(VI) from contaminated water: A batch and column scale study

© 2020 Elsevier Ltd Chromium (Cr) poses serious consequences on human and animal health due to its potential carcinogenicity. The present study aims at preparing a novel biochar derived from Chenopodium quinoa crop residues (QBC), its activation with magnetite nanoparticles (QBC/MNPs) and strong acid HNO3 (QBC/Acid) to evaluate their batch and column scale potential to remove Cr (VI) from polluted water. The QBC, QBC/MNPs and QBC/Acid were characterized with SEM, FTIR, EDX, XRD as well as point of zero charge (PZC) to get an insight into their adsorption mechanism. The impact of different process parameters including dose of the adsorbent (1–4 g/L), contact time (0–180 min), initial concentration of Cr (25–200 mg/L) as well as solution pH (2–8) was evaluated on the Cr (VI) removal from contaminated water. The results revealed that QBC/MNPs proved more effective (73.35–93.62-%) for the Cr (VI) removal with 77.35 mg/g adsorption capacity as compared with QBC/Acid (55.85–79.8%) and QBC (48.85–75.28-%) when Cr concentration was changed from 200 to 25 mg/L. The isothermal experimental results follow the Freundlich adsorption model rather than Langmuir, Temkin and Dubinin-Radushkevich adsorption isotherm models. While kinetic adsorption results were well demonstrated by pseudo second order kinetic model. Column scale experiments conducted at steady state exhibited excellent retention of Cr (VI) by QBC, QBC/MNPs and QBC/Acid at 50 and 100 mg Cr/L. The results showed that this novel biochar (QBC) and its modified forms (QBC/Acid and QBC/MNPs) are applicable with excellent reusability and stability under acidic conditions for the practical treatment of Cr (VI) contaminated water