60 research outputs found
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Microscale Freeform Integration by Directed Self Assembly
Most solid freeform fabrication (SFF) manufacturing processes assemble uniform
components such as powder particles or polymer chains to produce desired geometries. Their
capacity for producing highly functional parts (integrated actuation, sensing, and electronics)
will dramatically increase when multiple materials and functional subcomponents can be
automatically integrated. This paper addresses criteria for a system that integrates multiple
materials and components through computer-controlled self-assembly. It builds complex systems
from layers of self-assembled micro-components. The paper will address implementation
methods, present a concept demonstration, and consider its application to micro-thermoelectric
systems. This manufacturing process can be enhanced further through integration with mature
additive processes.Mechanical Engineerin
Quenching of the radio jet during the X-ray high state of GX 339-4
We have observed the black hole candidate X-ray binary GX 339-4 at radio
wavelengths before, during and after the 1998 high/soft X-ray state transition.
We find that the radio emission from the system is strongly correlated with the
hard X-ray emission and is reduced by a factor > 25 during the high/soft state
compared to the more usual low/hard state. At the points of state transition we
note brief periods of unusually optically-thin radio emission which may
correspond to discrete ejection events. We propose that in the low/hard state
black hole X-ray binaries produce a quasi-continuous outflow, in the high/soft
state this outflow is suppressed, and that state transitions often result in
one or more discrete ejection events. Future models for low/hard states, such
as ADAF/ADIOS solutions, need to take into account strong outflow of
relativistic electrons from the system. We propose that the inferred
Comptonising corona and the base of the jet-like outflow are the same thing,
based upon the strong correlation between radio and hard X-ray emission in GX
339-4 and other X-ray binaries, and the similarity in inferred location and
composition of these two components.Comment: Accepted for publication in ApJ Letter
Archaeological Investigations at Tomassee (38OC186) A Lower Cherokee Town
https://scholarcommons.sc.edu/archanth_books/1220/thumbnail.jp
Novel selective butyrylcholinesterase inhibitors incorporating antioxidant functionalities as potential bimodal therapeutics for Alzheimer’s Disease
Isosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of the present work was to address the hypothesis that the isosorbide-aryl-5-ester group could be replaced with an antioxidant functionality while maintaining inhibitor effects and selectivity. We successfully incorporated ferulic acid or lipoic acid groups producing potent selective inhibitors of butyrylcholinesterase (BuChE). The hybrid compounds were non-toxic to the murine hippocampal cell line HT-22 and lipoate esters were neuroprotective at 10 and 25 mu M when the cells were challenged with glutamate (5 mM) in a similar manner to the positive control quercetin. The benzyl carbamate 7a was a potent inhibitor of BuChE (IC50 150 nM) and it was effective in reducing glutamate toxicity to neuronal cells at >5 mu M. Representative compounds exhibited an antioxidant effect in the oxygen radical absorbance capacity assay as the lipoate 7d was not active, whereas the ferulate 8a showed a weak, but significant, activity with 0.635 +/- 0.020 Trolox Equivalent
Guest Artist Recital: Matthew Muneses Quintet
Kemp Recital HallSeptember 24, 2014Wednesday Evening8:00 p.m
Model Based Analysis and Test Generation for Flight Software
We describe a framework for model-based analysis and test case generation in the context of a heterogeneous model-based development paradigm that uses and combines Math- Works and UML 2.0 models and the associated code generation tools. This paradigm poses novel challenges to analysis and test case generation that, to the best of our knowledge, have not been addressed before. The framework is based on a common intermediate representation for different modeling formalisms and leverages and extends model checking and symbolic execution tools for model analysis and test case generation, respectively. We discuss the application of our framework to software models for a NASA flight mission
Prospectus, January 20, 1975
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Arguments Against a Configural Processing Account of Familiar Face Recognition
Face recognition is a remarkable human ability, which underlies a great deal of people's social behavior. Individuals can recognize family members, friends, and acquaintances over a very large range of conditions, and yet the processes by which they do this remain poorly understood, despite decades of research. Although a detailed understanding remains elusive, face recognition is widely thought to rely on configural processing, specifically an analysis of spatial relations between facial features (so-called second-order configurations). In this article, we challenge this traditional view, raising four problems: (1) configural theories are underspecified; (2) large configural changes leave recognition unharmed; (3) recognition is harmed by nonconfigural changes; and (4) in separate analyses of face shape and face texture, identification tends to be dominated by texture. We review evidence from a variety of sources and suggest that failure to acknowledge the impact of familiarity on facial representations may have led to an overgeneralization of the configural account. We argue instead that second-order configural information is remarkably unimportant for familiar face recognition
Can forest management based on natural disturbances maintain ecological resilience?
Given the increasingly global stresses on forests, many ecologists argue that managers must maintain ecological resilience: the capacity of ecosystems to absorb disturbances without undergoing fundamental change. In this review we ask: Can the emerging paradigm of natural-disturbance-based management (NDBM) maintain ecological resilience in managed forests? Applying resilience theory requires careful articulation of the ecosystem state under consideration, the disturbances and stresses that affect the persistence of possible alternative states, and the spatial and temporal scales of management relevance. Implementing NDBM while maintaining resilience means recognizing that (i) biodiversity is important for long-term ecosystem persistence, (ii) natural disturbances play a critical role as a generator of structural and compositional heterogeneity at multiple scales, and (iii) traditional management tends to produce forests more homogeneous than those disturbed naturally and increases the likelihood of unexpected catastrophic change by constraining variation of key environmental processes. NDBM may maintain resilience if silvicultural strategies retain the structures and processes that perpetuate desired states while reducing those that enhance resilience of undesirable states. Such strategies require an understanding of harvesting impacts on slow ecosystem processes, such as seed-bank or nutrient dynamics, which in the long term can lead to ecological surprises by altering the forest's capacity to reorganize after disturbance
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