GERM as a tool for space station documentation

GERM as a tool for space station documentation is presented in the form of viewgraphs. The following subject areas are covered: problem statement, hypermedia as a tool for documentation, description of GERM, technical approach, application development, and results and conclusions

Exploratory research for the development of a computer aided software design environment with the software technology program

Field studies were conducted by MCC to determine areas of research of mutual interest to MCC and JSC. NASA personnel from the Information Systems Directorate and research faculty from UHCL/RICIS visited MCC in Austin, Texas to examine tools and applications under development in the MCC Software Technology Program. MCC personnel presented workshops in hypermedia, design knowledge capture, and design recovery on site at JSC for ISD personnel. The following programs were installed on workstations in the Software Technology Lab, NASA/JSC: (1) GERM (Graphic Entity Relations Modeler); (2) gIBIS (Graphic Issues Based Information System); and (3) DESIRE (Design Recovery tool). These applications were made available to NASA for inspection and evaluation. Programs developed in the MCC Software Technology Program run on the SUN workstation. The programs do not require special configuration, but they will require larger than usual amounts of disk space and RAM to operate properly

Enzymatic hydrolysis of corn gluten meal

Corn gluten meal was hydrolyzed with Alcalase 2.4L, an alkaline protease. The effects of enzyme concentration and gluten size reduction on the hydrolysis were studied. Extent of reaction was expressed in terms of both the degree of hydrolysis (using the pH-stat technique) and the concentration of soluble protein. Linear and product inhibition kinetic models were compared to the experimental results after parameter estimation by minimizing the residual sum of squares. The models describe the time-dependent behavior of three protein/peptide pools-insoluble protein, TCA-insoluble proteins, and TCA-soluble peptides. A simplified product inhibition model gave the best fit to the experimental data

Preventing suicides in public places: A practice resource

This practice resource is for those with responsibility for suicide prevention in local authorities and their partner agencies. It has been developed to help them contribute to the delivery of the national suicide prevention strategy for England, in particular area 3 of the strategy, ‘Reduce access to the means of suicide’. It replaces the ‘Guidance on action to be taken at suicide hotspots’ published in 2006 by the National Institute for Mental Health in England (NIMHE). It has a broader focus, includes learning from those who have tried to take their own lives in public places, draws on recent research and expert opinion, and provides examples of innovative practice from England and around the world. This document sits alongside PHE’s ‘Guidance for developing a local suicide prevention action plan’: www.gov.uk/government/publications/suicide-prevention-developing-a-local-action-planPublic Health Englan

Community access to marketing opportunities: options for remote areas. Malawi case study (NRI report no. 2450)

The findings of this research are based on the results of a project funded by DFID' s Crop Post-Harvest Research Programme between Aprill998 and March 1999, with fieldwork taking place in Malawi, Mali, and Uganda. The project was mainly concerned with policy and institutional aspects. It was concluded that holistic approaches are required to improve community access to marketing opportunities in remote areas of Sub-Saharan Africa, but that initiatives needed to be prioritised

Perfectionism and Attitudes Towards Doping in Athletes: The Mediating Role of Achievement Goal Orientations

Doping is of increasing concern for those involved in sport. With this in mind, researchers have sought to determine factors that increase the risk of doping. Perfectionism is one such factor. Perfectionism is a multidimensional personality characteristic comprised of excessively high personal standards (perfectionistic strivings) and overly critical evaluations (perfectionistic concerns). While numerous studies have shown that perfectionistic strivings and perfectionistic concerns predict attitudes towards doping in athletes, it is currently unclear why this is the case. In this regard, achievement goal orientations may be important. Goal orientations reflect tendencies to judge success based on the development and demonstration of self-referenced (task) or normative (ego) competence. Perfectionistic strivings and concerns are related to both task- and ego-orientations (albeit to different degrees). Consequently, the present study provided a first examination of whether achievement goal orientations mediated the relationship between perfectionism and attitudes towards doping. Following institutional ethical approval, 135 athletes (mean age 24.4 years) completed measures of perfectionistic strivings, perfectionistic concerns, ego-orientation, task-orientation, and attitudes towards doping. Using bias-corrected bootstrapping of indirect effects, ego-orientation mediated the relationships between perfectionistic strivings and attitudes towards doping (indirect effect = .07, 95% CI = .01,.18) and perfectionistic concerns and attitudes towards doping (indirect effect = .08, 95% CI = .01,.20). Overall, the findings imply that both perfectionistic strivings and perfectionistic concerns may instil the belief that success is defined by beating others. This belief may impart the tendency to consider doping as socially acceptable and necessary. Keywords: Perfectionism, achievement goals, doping, athlete

Living in the climate crisis: young people in Uganda

Youth Futures Programme, The British Academy, School of Technology Seed Funding, University of Cambridg

The Use of the Thoracodorsal Artery Perforator Flap in Both Autologous and Implant Based Breast Reconstruction Salvage Surgery

Introduction: Since its introduction by Angrigiani the Thoracodorsal Artery Perforator (TDAP) flap has become a popular choice in partial breast reconstruction for volume replacement. Although mainly used to provide volume, it has also been reported as an adjunct to implant-based breast reconstruction. Methods: Patients undergoing salvage breast reconstruction surgery with the TDAP flap in the last 20 years were identified from the senior author’s logbook and their clinical data collected from EpicTM, the hospital electronic medical records system. Results: Two such patients, aged 44 and 52 years, were identified. The first had “impending failure” of a subpectoral implant reconstruction following severe cutaneous radiation reaction and poor quality soft tissues overlying the implant, coupled with recurrent seromas. The second had partial SIEA abdominal free flap fat necrosis, leading to volume loss, severe cutaneous scarring and significant deformity. The flap dimensions were 10 cm × 25 cm and 8 cm × 25 cm, respectively. They were each based on a single vascular perforator– one arising from the horizontal and the other from the vertical branch of the thoracodorsal vessels. Both flap transfers were successful and resulted in viable reconstructions despite the challenging indications. Discussion and Conclusion: The TDAP flap was successfully used to perform salvage breast reconstruction in both prosthetic and autologous cases which presented with ongoing challenges. We believe our technique of the TDAP flap for tertiary breast reconstruction provides adequate soft tissue replacement with minimal donor morbidity, and advocate that it be considered for difficult salvage cases when other options are not available

Importance of long-term monitoring of patients with breast reconstructions: a case of 10-year cancer recurrence

We report a case of breast cancer recurrence in a 41 -year old female ten years post mastectomy, and two years post tertiary DIEP flap reconstruction. Reconstructed patients, especially those with aggressive cancers, must be informed of long term risk of recurrence and monitored long term following mastectomy and reconstruction

Cdc28 Activates Exit from Mitosis in Budding Yeast

The activity of the cyclin-dependent kinase 1 (Cdk1), Cdc28, inhibits the transition from anaphase to G1 in budding yeast. CDC28-T18V, Y19F (CDC28-VF), a mutant that lacks inhibitory phosphorylation sites, delays the exit from mitosis and is hypersensitive to perturbations that arrest cells in mitosis. Surprisingly, this behavior is not due to a lack of inhibitory phosphorylation or increased kinase activity, but reflects reduced activity of the anaphase-promoting complex (APC), a defect shared with other mutants that lower Cdc28/Clb activity in mitosis. CDC28-VF has reduced Cdc20- dependent APC activity in mitosis, but normal Hct1- dependent APC activity in the G1 phase of the cell cycle. The defect in Cdc20-dependent APC activity in CDC28-VF correlates with reduced association of Cdc20 with the APC. The defects of CDC28-VF suggest that Cdc28 activity is required to induce the metaphase to anaphase transition and initiate the transition from anaphase to G1 in budding yeast