1,904 research outputs found

    Does Disclosure of Performance Information Influence Street-level Bureaucrats' Enforcement Style?

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    Governments use different regulatory instruments to ensure that businesses owners or "inspectees" comply with rules and regulations. One tool that is increasingly applied is disclosing inspectees' performance information to other stakeholders. Disclosing performance information has consequences for street-level bureaucrats because it increases the visibility of their day-to-day work. Using a survey (n =507) among Dutch inspectors of the Netherlands Food and Consumer Product Safety Authority, this article shows that the disclosure of performance information has an impact on enforcement style at the street level. Findings show that perceived disclosed performance information positively enhances all three dimensions of street-level bureaucrats' enforcement style (legal, facilitation, and accommodation). This effect is strongest for facilitation and accommodation and weakest for the legal style. Perceived resistance by inspectees partly explains this effect. Contrary to expectations, more perceived disclosure does not result in more but in less perceived resistance of inspectees by street-level bureaucrats

    Blaming the bureaucrat: does perceived blame risk influence inspectors’ enforcement style?

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    Is there a relation between street-level bureaucrats’ enforcement style and their perception of the risk of getting blamed? This article answers this question on the basis of a survey (n = 507) among inspectors of the Netherlands Food and Product Safety Authority. We included perceived media attention on their work as a factor that might influence street-level bureaucrats’ perception of blame risk and their enforcement style. Three dimensions of enforcement style were distinguished from earlier research: legal, facilitative and accommodative. We found that when inspectors perceive more blame risk, they employ a slightly less legal style and, instead, employ a more accommodative style. Thus, they act a little less formally and less coercively (i.e. legal) and take greater account of their peers’ opinions (i.e. accommodative). However, perceived media attention did not have a significant influence on enforcement style. Points for practitioners: 1. When inspectors perceive more blame risk, they tend to pay more attention to the opinion of peers (other inspectors, supervisors, etc.). 2. Blame risk does not lead to the use of a more formal inspection style. 3. Media attention does not play an important role in enhancing the blame risk perception of inspectors. 4. This media and blame risk is less important than often found in the case of politicians. This may be connected to the fact that the work of inspectors as street-level bureaucrats is less visible to the wider public (and the media)

    Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH.

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    Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with small but clinically relevant tumor areas may pass undetected due to intra-tumor heterogeneity and/or the presence of contaminating normal cells. Here, we show that the combination of laser capture microdissection, phi29 DNA polymerase-mediated isothermal genomic DNA amplification, and array CGH allows genomic profiling of very limited numbers of cells. Moreover, by means of simple statistical models, we were able to bypass the exclusion of amplification distortions and variability prone areas, and to detect tumor-specific chromosomal gains and losses. We applied this new combined experimental and analytical approach to the genomic profiling of colorectal adenomatous polyps and demonstrated our ability to accurately detect single copy gains and losses affecting either whole chromosomes or small genomic regions from as little as 2 ng of DNA or 1000 microdissected cells

    Electron correlation vs. stabilization: A two-electron model atom in an intense laser pulse

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    We study numerically stabilization against ionization of a fully correlated two-electron model atom in an intense laser pulse. We concentrate on two frequency regimes: very high frequency, where the photon energy exceeds both, the ionization potential of the outer {\em and} the inner electron, and an intermediate frequency where, from a ``single active electron''-point of view the outer electron is expected to stabilize but the inner one is not. Our results reveal that correlation reduces stabilization when compared to results from single active electron-calculations. However, despite this destabilizing effect of electron correlation we still observe a decreasing ionization probability within a certain intensity domain in the high-frequency case. We compare our results from the fully correlated simulations with those from simpler, approximate models. This is useful for future work on ``real'' more-than-one electron atoms, not yet accessible to numerical {\em ab initio} methods.Comment: 8 pages, 8 figures in an extra ps-file, submitted to Phys. Rev. A, updated references and shortened introductio

    No antidepressant effects of low intensity transcranial pulsed electromagnetic fields for treatment resistant depression

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    Background: Noninvasive neurostimulation with transcranial Pulsed Electromagnetic Fields (tPEMF) may be a promising method for treatment resistant depression (TRD). Studies shown substantial improvement of depressive symptoms in patients with TRD, but there is no information on long-term antidepressant effects. The aim of this study was to investigate the short- and long-term efficacy of tPEMF in participants with TRD. Methods: Eligible participants with TRD in this sham-controlled double-blind multicenter trial were randomly assigned to five weeks either daily active or sham tPEMF. Severity of depression and anxiety was assessed preand directly post-treatment and five and fifteen weeks post-treatment. Primary outcome was change on the 17item Hamilton depression rating scale directly post-treatment. Secondary outcome was change on the Hamilton17 during follow-up and change on the Inventory of Depressive Symptomatology Self-Report and the Beck Anxiety Index. Results: Of the 55 included participants, 50 completed the treatment protocol. Depressive symptoms improved over time in both groups. The improvement continued until the last follow-up measure. There was no difference in outcome between the active and the sham group on change in depression post-treatment or on any secondary measure. Conclusion: Treatment with this type of active tPEMF was not superior to sham in patients with TRD. This is in contrast to a previous study using a similar design and power calculation, but a higher magnetic field strength, that reported improvement of depression after treatment with tPEMF compared to sham. An important limitation of our study was the fact that no different dosing regimens were tried

    Driving pressure during general anesthesia for open abdominal surgery (DESIGNATION) : study protocol of a randomized clinical trial

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    Background Intraoperative driving pressure (Delta P) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (V-T) is kept constant, Delta P may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. Delta P may decrease if PEEP leads to a recruitment of collapsed lung tissue but will increase if PEEP mainly causes pulmonary overdistension. This study tests the hypothesis that individualized high PEEP, when compared to fixed low PEEP, protects against PPC in patients undergoing open abdominal surgery. Methods The "Driving prESsure durIng GeNeral AnesThesIa for Open abdomiNal surgery trial" (DESIGNATION) is an international, multicenter, two-group, double-blind randomized clinical superiority trial. A total of 1468 patients will be randomly assigned to one of the two intraoperative ventilation strategies. Investigators screen patients aged >= 18 years and with a body mass index <= 40 kg/m(2), scheduled for open abdominal surgery and at risk for PPC. Patients either receive an intraoperative ventilation strategy with individualized high PEEP with recruitment maneuvers (RM) ("individualized high PEEP") or one in which PEEP of 5 cm H2O without RM is used ("low PEEP"). In the "individualized high PEEP" group, PEEP is set at the level at which Delta P is lowest. In both groups of the trial, V-T is kept at 8 mL/kg predicted body weight. The primary endpoint is the occurrence of PPC, recorded as a collapsed composite of adverse pulmonary events. Discussion DESIGNATION will be the first randomized clinical trial that is adequately powered to compare the effects of individualized high PEEP with RM versus fixed low PEEP without RM on the occurrence of PPC after open abdominal surgery. The results of DESIGNATION will support anesthesiologists in their decisions regarding PEEP settings during open abdominal surgery

    Technical Note: The Forensic Anthropology Society of Europe (FASE) Map of Identified Osteological Collections

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    Identified (documented) osteological collections represent an important resource in the development of forensic anthropology standards and methods as well as a precious tool for learning and training of practitioners. Even though the number of papers presenting identified collections worldwide increases, many of the collections have still not been divulged to the scientific community in sufficient detail to ascertain their exact number. The Forensic Anthropology Society of Europe (FASE) therefore developed a tool that goes beyond sporadic publications: the FASE Map of Identified Osteological Collections, which is freely accessible and continuously updated and revised. The online map is available at http://forensicanthropology.eu/osteological-collections/. The map of skeletal collections was created in 2017 and currently displays information on 153 identified osteological collections (43 of them categorized as contemporary) located in 41 different countries. This article offers a short analysis of the type, geographical location and content of the collections included in the map. The aim of this article and the map as such is to provide a useful resource to facilitate research planning and teaching in forensic anthropology and related disciplines.info:eu-repo/semantics/publishedVersio
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