TAPAS: Building a TEI Publishing and Repository Service

This project report details the goals and development of the TEI Archiving, Publishing, and Access Service (TAPAS). The project's mission centers on providing repository and publication services to individuals and small projects working with TEI data: a constituency that typically lacks access to institutional resources such as server space, XML expertise, and programming time. In developing this service, TAPAS addresses several important challenges: the creation of a publication ecology that operates gracefully at the level of the individual project and the TAPAS corpus; the problem of the vulnerability of TEI data in cases where projects cease their activity; and the variability and complexity of TEI data. When completed, the TAPAS service will enable its contributors to upload, manage, and publish their TEI data, and it will offer a publication interface through which both individual project collections and the TAPAS collection as a whole can be read, searched, and explored. It will also provide a range of related services such as technical consulting, data curation and conversion work, TEI workshops, tutorials, and community forums. This article discusses the philosophy and rationale behind the project's current development efforts, and examines some of the challenges the project faces

Transforming 3D-printed mesostructures into multimodal sensors with nanoscale conductive metal oxides

Additively manufactured (AM) three-dimensional (3D) mesostructures exhibit geometrically optimal mechanical, thermal, and optical properties that could drive future microrobotics, energy harvesting, and biosensing technologies at the micrometer to millimeter scale. We present a strategy for transforming AM mesostructures into 3D electronics by growing nanoscale conducting films on 3D-printed polymers. This highly generalizable method utilizes precision atomic layer deposition (ALD) of conducting metal oxides on ultrasmooth photopolymer lattices printed by high-resolution microstereolithography. We demonstrate control of 3D electronic transport by tuning conformal growth of ultrathin amorphous and crystalline conducting metal oxides. To understand the scaling of 3D electrical properties, we apply graph theory to compute network resistance and precisely design the 3D mesostructures\u27 conductivity. Finally, we demonstrate 3D-enhanced multimodal sensing of chemical, thermal, and mechanical stimuli, geometrically boosting sensitivity by 100× over 2D films and enabling a new class of low-power, 3D-printable sensors

Preschoolers Focus on Others’ Intentions When Forming Sociomoral Judgments

Many studies suggest that preschoolers initially privilege outcome over intention in their moral judgments. The present findings reveal that, in contrast, even younger preschoolers can privilege intentions when evaluating characters who successfully or unsuccessfully help or hinder a third party in achieving its goal. Following a live-action puppet show originally created for infant populations, children made a forced-choice social judgment (which puppet was liked) and two forced-choice moral judgments (which puppet was nicer, which puppet should be punished), and were asked to explain their punishment allocations. In two experiments (N = 195), 3- and 4-year-olds evaluated characters with distinct intentions to help or to hinder who were associated with either positive or negative outcomes. Both ages judged characters with more positive intentions as nicer, and allocated punishment to characters with more negative intentions; neither of these tendencies depended on the outcomes the characters were associated with. Three-year-olds’ responses were somewhat less consistent than were 4-year-olds’, in that 3-year-olds’ judgments were disrupted by ambiguous harmful intent. Notably, children’s social judgments were less consistent than their moral judgments. In a third and final experiment (N = 100), children evaluated characters with the same intention but who were associated with different outcomes. Children showed inconsistent responding across age and outcome valence, but only 4-year-olds evaluating two characters with positive intentions reliably responded based on outcome. When providing informative responses in all three studies, children most frequently explained their punishment allocations by appealing to the puppet’s (attempted) hindering action or failure to help. These findings raise questions as to what underlies different patterns of response across studies in the literature, and suggests that observing live interactions may facilitate young children’s intention-based moral judgments

Creating a Social Justice Mindset: Diversity, Inclusion, and Social Justice in the Collections Directorate of the MIT Libraries

The Collections Directorate of the MIT Libraries sponsored a task force to identify opportunities for archives, technical services, preservation, scholarly communication, and collections strategy staff to manifest the values of diversity, inclusion, and social justice in their daily work. In this report the Collections Directorate Diversity, Inclusion, and Social Justice (DISJ) task force describes some of the overarching social and economic contexts for academic libraries, as well as the core professional values that guide us, and offers recommendations to the Directorate for operationalizing the values of diversity, inclusion, and social justice. The task force aims to demonstrate, through our recommendations, how DISJ values might guide every aspect of our work. We look forward to working together to foster a social justice mindset throughout the MIT Libraries’ Collections Directorate

TEI Pedagogy and TAPAS Classroom

This paper focuses on recent work by the TEI Archiving, Preservation, and Access Service (TAPAS) on pedagogy with TEI, and specifically on a recent initiative called “TAPAS Classroom” focused on exploring pedagogical uses of TEI. We provide some background on TAPAS, describe several case studies involving pedagogical partners who used TAPAS in teaching, and finally describe the TAPAS Classroom initiative and its outcomes

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.

Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial with ibrutinib, the first-in-class BTK inhibitor, for patients with relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred in 10 of 13 (77%) patients with PCNSL, including five complete responses. The only PCNSL with complete ibrutinib resistance harbored a mutation within the coiled-coil domain of CARD11, a known ibrutinib resistance mechanism. Incomplete tumor responses were associated with mutations in the B-cell antigen receptor-associated protein CD79B

Validation of an open source, remote web‐based eye‐tracking method (WebGazer) for research in early childhood

Measuring eye movements remotely via the participant's webcam promises to be an attractive methodological addition to in-person eye-tracking in the lab. However, there is a lack of systematic research comparing remote web-based eye-tracking with in-lab eye-tracking in young children. We report a multi-lab study that compared these two measures in an anticipatory looking task with toddlers using WebGazer.js and jsPsych. Results of our remotely tested sample of 18-27-month-old toddlers (N = 125) revealed that web-based eye-tracking successfully captured goal-based action predictions, although the proportion of the goal-directed anticipatory looking was lower compared to the in-lab sample (N = 70). As expected, attrition rate was substantially higher in the web-based (42%) than the in-lab sample (10%). Excluding trials based on visual inspection of the match of time-locked gaze coordinates and the participant's webcam video overlayed on the stimuli was an important preprocessing step to reduce noise in the data. We discuss the use of this remote web-based method in comparison with other current methodological innovations. Our study demonstrates that remote web-based eye-tracking can be a useful tool for testing toddlers, facilitating recruitment of larger and more diverse samples; a caveat to consider is the larger drop-out rate

SUSTAIN drilling at Surtsey volcano, Iceland, tracks hydrothermal and microbiological interactions in basalt 50 years after eruption

The 2017 Surtsey Underwater volcanic System for Thermophiles, Alteration processes and INnovative concretes (SUSTAIN) drilling project at Surtsey volcano, sponsored in part by the International Continental Scientific Drilling Program (ICDP), provides precise observations of the hydrothermal, geochemical, geomagnetic, and microbiological changes that have occurred in basaltic tephra and minor intrusions since explosive and effusive eruptions produced the oceanic island in 1963–1967. Two vertically cored boreholes, to 152 and 192 m below the surface, were drilled using filtered, UV-sterilized seawater circulating fluid to minimize microbial contamination. These cores parallel a 181 m core drilled in 1979. Introductory investigations indicate changes in material properties and whole-rock compositions over the past 38 years. A Surtsey subsurface observatory installed to 181 m in one vertical borehole holds incubation experiments that monitor in situ mineralogical and microbial alteration processes at 25–124 ∘C. A third cored borehole, inclined 55∘ in a 264∘ azimuthal direction to 354 m measured depth, provides further insights into eruption processes, including the presence of a diatreme that extends at least 100 m into the seafloor beneath the Surtur crater. The SUSTAIN project provides the first time-lapse drilling record into a very young oceanic basaltic volcano over a range of temperatures, 25–141 ∘C from 1979 to 2017, and subaerial and submarine hydrothermal fluid compositions. Rigorous procedures undertaken during the drilling operation protected the sensitive environment of the Surtsey Natural Preserve

A multilab study of bilingual infants: Exploring the preference for infant-directed speech

From the earliest months of life, infants prefer listening to and learn better from infant-directed speech (IDS) compared with adult-directed speech (ADS). Yet IDS differs within communities, across languages, and across cultures, both in form and in prevalence. This large-scale, multisite study used the diversity of bilingual infant experiences to explore the impact of different types of linguistic experience on infants’ IDS preference. As part of the multilab ManyBabies 1 project, we compared preference for North American English (NAE) IDS in lab-matched samples of 333 bilingual and 384 monolingual infants tested in 17 labs in seven countries. The tested infants were in two age groups: 6 to 9 months and 12 to 15 months. We found that bilingual and monolingual infants both preferred IDS to ADS, and the two groups did not differ in terms of the overall magnitude of this preference. However, among bilingual infants who were acquiring NAE as a native language, greater exposure to NAE was associated with a stronger IDS preference. These findings extend the previous finding from ManyBabies 1 that monolinguals learning NAE as a native language showed a stronger IDS preference than infants unexposed to NAE. Together, our findings indicate that IDS preference likely makes similar contributions to monolingual and bilingual development, and that infants are exquisitely sensitive to the nature and frequency of different types of language input in their early environments