Cosmic evolution of extragalactic C 1, C 2, and CO luminosity

Carbon is the fourth most abundant element in the Galaxy with an abundance of approximately 4 x 10(exp -4) relative to hydrogen. Of all abundant metals it is the easiest to observe in the interstellar medium (ISM). Carbon can be found in four dominant forms: dust grains, C 2, C 1, and CO. The latter is the most abundant molecule (next to H2) in molecular clouds. All three gas-phase forms produce strong sub-mm wavelength emission lines and are the principal tracers of the warm and dense neutral phases of the ISM. We calculate the gas-phase abundances of neutral carbon (C 1), ionized carbon (C 2), and carbon monoxide (CO) as a function of cosmic time or redshift z in an idealized scenario of galactic evolution

Live strong and prosper: the importance of skeletal muscle strength for healthy ageing

Due to improved health care, diet and infrastructure in developed countries, since 1840 life expectancy has increased by approximately 2years per decade. Accordingly, by 2050, a quarter of Europe’s population will be over 65years, representing a 10% rise in half a century. With this rapid rise comes an increased prevalence of diseases of ageing and associated healthcare expenditure. To address the health consequences of global ageing, research in model systems (worms, flies and mice) has indicated that reducing the rate of organ growth, via reductions in protein synthetic rates, has multi-organ health benefits that collectively lead to improvements in lifespan. In contrast, human pre-clinical, clinical and large cohort prospective studies demonstrate that ageing leads to anabolic (i.e. growth) impairments in skeletal muscle, which in turn leads to reductions in muscle mass and strength, factors directly associated with mortality rates in the elderly. As such, increasing muscle protein synthesis via exercise or protein-based nutrition maintains a strong, healthy muscle mass, which in turn leads to improved health, independence and functionality. The aim of this review is to critique current literature relating to the maintenance of muscle mass across lifespan and discuss whether maintaining or reducing protein synthesis is the most logical approach to support musculoskeletal function and by extension healthy human ageing

Detecting heat stress in dairy cattle using neck-mounted activity collars

Collar based activity sensors are in common use as a means of detecting oestrus to optimise farm fertility and hence productivity. More recently the same acceleration-derived signals have been processed to detect the time spent ruminating and eating which together give an insight into animal welfare. Here the use of neck-mounted accelerometers to provide a quantifiable measure of the time period that an individual animal exhibits signs of heat stress is reported. Heat stress has a significant impact on both animal welfare and productivity. Cattle studied during elevated temperatures were found to exhibit signs of exaggerated breathing motions, an indicator of heat stress, for 8 hours on average per day. This exceeds the time that cattle spend feeding and is similar to daily rumination times which could impact on both animal welfare and production. No similar cases were recorded on the cooler conditions of a Scottish winter. The approach offers a cost effective measure of heat stress and a potential tool to quantify its impact more generally

The Development of the WISE (Writing to Inspire Successful Education) Writing Mentoring Program: A University-School Collaboration

Abstract This paper describes the development of a service learning writing mentoring program designed to close the achievement gap in writing proficiency for economically disadvantaged seventh grade students. Compared to writing mentoring studies found in the published literature, this program has three distinguishing components. First, it focused on economically disadvantaged middle school students. Second, it provided writing mentoring through a university-school partnership in which college students provided the intervention in collaboration with a seventh-grade teacher. Third, the program used technology to facilitate the mentoring process. Over the course of an academic year, mentors created videos with feedback on 19 writing assignments. The writing mentoring program was associated with a four-fold increase in the percentage of students who were graded as ‘proficient’ on a state standardized writing exam. These results suggest that semi-virtual, intensive writing mentoring and individualized feedback from college students can close the achievement gap and improve the quality of middle level education provided to economically disadvantaged students

Far-Ultraviolet Absorption Lines in the Remnant of SN 1006

We have obtained a far-ultraviolet spectrum (1150-1600 Å) of a hot subdwarf star behind the remnant of supernova 1006 with the Faint Object Spectrograph (FOS) on the Hubble Space Telescope. The high-quality spectrum is used to test previous identifications of the strong absorption features discovered with the International Ultraviolet Explorer. These features have FWHM = 4000 (±300) km s-1 and are not at the rest wavelengths of known interstellar lines, as opposed to the broader (~8000 km s-1 FWHM) Fe II lines from the remnant centered at 0 km s-1 in near-UV FOS spectra. We confirm that the broad absorption features are principally due to redshifted Si II, Si III, and Si IV lines, which are centered at a radial velocity of 5100 (±200) km s-1. The Si II λ1260.4 profile is asymmetric, with a nearly flat core and sharp red wing, unlike the Si II λ1526.7 and Si IV λλ1393.8, 1402.8 profiles. One possible explanation is additional absorption from another species. Previous work has suggested that S II λλ1250.6, 1253.8, 1259.5 at a radial velocity of ~6000 km s-1 is responsible, but this would require a sulfur-to-silicon abundance ratio that is at least a factor of 10 higher than expected. Another possible explanation is that the Si II and Si IV profiles are intrinsically different, but this does not explain the symmetric (albeit weaker) Si II λ1526.7 profile

NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function

The Rrf2 family transcription factor NsrR controls expression of genes in a wide range of bacteria in response to nitric oxide (NO). The precise form of the NO-sensing module of NsrR is the subject of controversy because NsrR proteins containing either [2Fe-2S] or [4Fe-4S] clusters have been observed previously. Optical, Mössbauer, resonance Raman spectroscopies and native mass spectrometry demonstrate that Streptomyces coelicolor NsrR (ScNsrR), previously reported to contain a [2Fe-2S] cluster, can be isolated containing a [4Fe-4S] cluster. ChIP-seq experiments indicated that the ScNsrR regulon is small, consisting of only hmpA1, hmpA2, and nsrR itself. The hmpA genes encode NO-detoxifying flavohemoglobins, indicating that ScNsrR has a specialized regulatory function focused on NO detoxification and is not a global regulator like some NsrR orthologues. EMSAs and DNase I footprinting showed that the [4Fe-4S] form of ScNsrR binds specifically and tightly to an 11-bp inverted repeat sequence in the promoter regions of the identified target genes and that DNA binding is abolished following reaction with NO. Resonance Raman data were consistent with cluster coordination by three Cys residues and one oxygen-containing residue, and analysis of ScNsrR variants suggested that highly conserved Glu-85 may be the fourth ligand. Finally, we demonstrate that some low molecular weight thiols, but importantly not physiologically relevant thiols, such as cysteine and an analogue of mycothiol, bind weakly to the [4Fe-4S] cluster, and exposure of this bound form to O2 results in cluster conversion to the [2Fe-2S] form, which does not bind to DNA. These data help to account for the observation of [2Fe-2S] forms of NsrR

The Internet of Things enhancing animal welfare and farm operational efficiency

The growth in wirelessly enabled sensor network technologies has enabled the low cost deployment of sensor platforms with applications in a range of sectors and communities. In the agricultural domain such sensors have been the foundation for the creation of decision support tools that enhance farm operational efficiency. This Research Reflection illustrates how these advances are assisting dairy farmers to optimise performance and illustrates where emerging sensor technology can offer additional benefits. One of the early applications for sensor technology at an individual animal level was the accurate identification of cattle entering into heat (oestrus) to increase the rate of successful pregnancies and thus optimise milk yield per animal. This was achieved through the use of activity monitoring collars and leg tags. Additional information relating to the behaviour of the cattle, namely the time spent eating and ruminating, was subsequently derived from collars giving further insights of economic value into the wellbeing of the animal, thus an enhanced range of welfare related services have been provisioned. The integration of the information from neck-mounted collars with the compositional analysis data of milk measured at a robotic milking station facilitates the early diagnosis of specific illnesses such as mastitis. The combination of different data streams also serves to eliminate the generation of false alarms, improving the decision making capability. The principle of integrating more data streams from deployed on-farm systems, for example, with feed composition data measured at the point of delivery using instrumented feeding wagons, supports the optimisation of feeding strategies and identification of the most productive animals. Optimised feeding strategies reduce operational costs and minimise waste whilst ensuring high welfare standards. These IoT-inspired solutions, made possible through Internet-enabled cloud data exchange, have the potential to make a major impact within farming practices. This paper gives illustrative examples and considers where new sensor technology from the automotive industry may also have a role