Microdosimetric Modeling of Biological Effectiveness for Boron Neutron Capture Therapy Considering Intra- and Intercellular Heterogeneity in 10B Distribution

We here propose a new model for estimating the biological effectiveness for boron neutron capture therapy (BNCT) considering intra- and intercellular heterogeneity in 10B distribution. The new model was developed from our previously established stochastic microdosimetric kinetic model that determines the surviving fraction of cells irradiated with any radiations. In the model, the probability density of the absorbed doses in microscopic scales is the fundamental physical index for characterizing the radiation fields. A new computational method was established to determine the probability density for application to BNCT using the Particle and Heavy Ion Transport code System PHITS. The parameters used in the model were determined from the measured surviving fraction of tumor cells administrated with two kinds of 10B compounds. The model quantitatively highlighted the indispensable need to consider the synergetic effect and the dose dependence of the biological effectiveness in the estimate of the therapeutic effect of BNCT. The model can predict the biological effectiveness of newly developed 10B compounds based on their intra- and intercellular distributions, and thus, it can play important roles not only in treatment planning but also in drug discovery research for future BNCT

The aim of the measurement of Epstein‐Barr virus DNA in hydroa vacciniforme and hypersensitivity to mosquito bites

Epstein‐Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosquito bites (HMB) to understand the clinical significance of EBV DNA load. All 30 patients showed high DNA loads in the PBMCs over the cut‐off level. Of 16 plasma samples, extremely high in two samples obtained from patients with hemophagocytic lymphohistiocytosis (HLH). The amount of cell‐free DNA in plasma was correlated to the serum levels of lactate dehydrogenase and inversely correlated to platelet counts. These results indicate that the EBV DNA load in PBMCs can provide one of the diagnostic indicators for HV and HMB and marked elevation of cell‐free EBV DNA in plasma might be related to cytolysis such as that observed in HLH

Simple syntheses of 1,3,4,5-tetrahydropyrrole[4,3,2-DE}-quinoline and 5-hydroxy-4-nitroindole (synthetic study for indole having a nitrogen containing functional group at the 4-position)

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

Dilaton Gravity in 2+ϵ2+\epsilon Dimensions

Quantum theory of dilaton gravity is studied in $2+\epsilon$ dimensions. Divergences are computed and renormalized at one-loop order. The mixing between the Liouville field and the dilaton field eliminates $1/\epsilon$ singularity in the Liouville-dilaton propagator. This smooth behavior of the dilaton gravity theory in the $\epsilon \rightarrow 0$ limit solves the oversubtraction problem which afflicted the higher orders of the Einstein gravity in $2+\epsilon$ dimensions. As a nontrivial fixed point, we find a dilaton gravity action which can be transformed to a CGHS type action.Comment: 26 pages, TIT/HEP-254, STUPP-94-13

Canine impaction – A review of the prevalence, etiology, diagnosis and treatment

The signs and symptoms of canine impaction can vary, with patients only noticing symptoms when they are suffering from unsightly esthetics, faulty occlusion, or poor cranio-facial development. While various surgical interventions have been proposed to expose and help erupt impacted canines, these treatment modalities have a high degree of difficulty compared to other types of dental cosmetic surgeries. This paper focuses on multi-disciplinary strategies for treating and managing canine impaction, reviews patient and clinical selection criteria, and discusses the evidence underlying existing interventions to reduce complications and improve patient-centered outcomes following treatment