The status of extrasyllabic consonants in english and german

Since the advent of nonlinear phonology many linguists have either assumed or argued explicitly that many languages have words in which one or more segment does not belong structurally to the syllable. Three commonly employed adjectives used to describe such consonants are 'extrasyllabic', 'extrametrical' or 'stray'. Other authors refer to such segments as belonging to the 'appendix'. [...] Various non-linear representations have been proposed to express the 'extrasyllabicity' of segments [...]. The ones I am concerned with in the present article analyze [...] consonants [...] structurally as being outside of the syllable [...]. For transparency I ignore here both subsyllabic constituency as well as higher level prosodic constituents to which the stray consonants are sometimes assumed to attach. For reasons to be made clear below I refer to syllables [...] in which the stray consonant is situated outside of the syllable, as abstract syllables

Towards a typology of stop assibilation

In this article we propose that there are two universal properties for phonological stop assibilations, namely (i) assibilations cannot be triggered by /i/ unless they are also triggered by /j/, and (ii) voiced stops cannot undergo assibilations unless voiceless ones do. The article presents typological evidence from assibilations in 45 languages supporting both (i) and (ii). It is argued that assibilations are to be captured in the Optimality Theoretic framework by ranking markedness constraints grounded in perception which penalize sequences like [ti] ahead of a faith constraint which militates against the change from /t/ to some sibilant sound. The occurring language types predicted by (i) and (ii) will be shown to involve permutations of the rankings between several different markedness constraints and the one faith constraint. The article demonstrates that there exist several logically possible assibilation types which are ruled out because they would involve illicit rankings

The phonetic motivation for phonological stop assibilation

In the following study we present the results of three acoustic experiments with native speakers of German and Polish which support implications (a) and (b). In our experiments we measured the friction phase after the /t d/ release before the onset of the following high front vocoid for four speakers of German and Polish. We found that the friction phase for /tj/ was significantly longer than that of /ti/, and that the friction phase of /t/ in the assibilation context is significantly longer than that of /d/

A study in synchronic and diachronic phonology

Synopsis: Velar Fronting (VF) is the name for any synchronic or diachronic phonological process shifting the velar place of articulation to the palatal region of the vocal tract. A well-known case of VF in Standard German is the rule specifying that the fricative [x] assimilates to [ç] after front segments. VF also refers to the change from velar sounds like [ɣ k g ŋ] to palatals ([ʝ c ɟ ɲ]). The book provides a thorough investigation of VF in German dialects: Data are drawn from over 300 original sources for varieties that are (or were) spoken in Germany, Austria, Switzerland, and other countries. VF differs geographically along three parameters: (A) triggers, (B) targets, and (C) outputs. VF triggers (=A) are typically defined according to vowel height: In some systems VF is induced only by high front vowels, in others by high and mid front vowels, and in yet others by high, mid, and low front vowels. Some varieties treat consonants ([r l n]) as triggers, while others do not. VF can be nonassimilatory, in which case the rule applies even in the context of back segments. In many varieties of German, VF targets (=B) consist of the two fricatives [x ɣ], but in other dialects the targets comprise [x] but not [ɣ]. In some places, VF affects not only [x ɣ], but also velar stops and the velar nasal. The output of VF (=C) is typically palatal [ç] (given the input [x]), but in many other places it is the alveolopalatal [ɕ]. A major theme is the way in which VF interacts with synchronic and diachronic changes creating or eliminating structures which can potentially undergo it or trigger it. In many dialects the relationship between velars ([x]) and palatals ([ҫ]) is transparent because velars only occur in the back vowel context and palatals only when adjacent to front sounds. In that type of system, independent processes can either feed VF (by creating additional structures which the latter can undergo), or they can bleed it (by eliminating potential structures to which VF could apply). In other dialects, VF is opaque. In one opaque system, both velars ([x]) and palatals ([ҫ]) surface in the context of front segments. Thus, in addition to expected front vowel plus palatal sequences ([…iç…]), there are also unexpected ones consisting of front vowel plus velar ([…ix…]). In a second type of opaque system, velars and palatals are found in the context of back segments; hence, expected sequences such as […iç…] occur in addition to unexpected ones like […ɑç…]

Velar fronting in German dialects

Velar Fronting (VF) is the name for any synchronic or diachronic phonological process shifting the velar place of articulation to the palatal region of the vocal tract. A well-known case of VF in Standard German is the rule specifying that the fricative [x] assimilates to [ç] after front segments. VF also refers to the change from velar sounds like [ɣ k g ŋ] to palatals ([ʝ c ɟ ɲ]). The book provides a thorough investigation of VF in German dialects: Data are drawn from over 300 original sources for varieties that are (or were) spoken in Germany, Austria, Switzerland, and other countries. VF differs geographically along three parameters: (A) triggers, (B) targets, and (C) outputs. VF triggers (=A) are typically defined according to vowel height: In some systems VF is induced only by high front vowels, in others by high and mid front vowels, and in yet others by high, mid, and low front vowels. Some varieties treat consonants ([r l n]) as triggers, while others do not. VF can be nonassimilatory, in which case the rule applies even in the context of back segments. In many varieties of German, VF targets (=B) consist of the two fricatives [x ɣ], but in other dialects the targets comprise [x] but not [ɣ]. In some places, VF affects not only [x ɣ], but also velar stops and the velar nasal. The output of VF (=C) is typically palatal [ç] (given the input [x]), but in many other places it is the alveolopalatal [ɕ]. A major theme is the way in which VF interacts with synchronic and diachronic changes creating or eliminating structures which can potentially undergo it or trigger it. In many dialects the relationship between velars ([x]) and palatals ([ҫ]) is transparent because velars only occur in the back vowel context and palatals only when adjacent to front sounds. In that type of system, independent processes can either feed VF (by creating additional structures which the latter can undergo), or they can bleed it (by eliminating potential structures to which VF could apply). In other dialects, VF is opaque. In one opaque system, both velars ([x]) and palatals ([ҫ]) surface in the context of front segments. Thus, in addition to expected front vowel plus palatal sequences ([…iç…]), there are also unexpected ones consisting of front vowel plus velar ([…ix…]). In a second type of opaque system, velars and palatals are found in the context of back segments; hence, expected sequences such as […iç…] occur in addition to unexpected ones like […ɑç…]

A randomized controlled trial of a decision aid for women considering genetic testing for breast and ovarian cancer risk

PURPOSE: To measure the effectiveness of a tailored decision aid (DA) designed to help women make informed decisions about genetic testing for breast/ovarian cancer risk. METHODS: A total of 145 women were randomized to receive the DA or a control pamphlet at the end of their first genetic counseling consultation. Of these, 120 (82.8%) completed two questionnaires, 1 week and 6 months post-consultation. RESULTS: While the DA had no effect on informed choice, post-decisional regret or actual genetic testing decision, the trial showed that women who received the DA had higher knowledge levels and felt more informed about genetic testing than women who received the control pamphlet (chi(2)(2) = 6.82; P = 0.033; chi(2)(1) = 4.86; P = 0.028 respectively). The DA also helped women who did not have blood drawn at their first consultation to clarify their values with regards to genetic testing (chi(2)(1) = 5.27; P = 0.022). Women who received the DA were less likely to share the information with other family members than women in the control condition (chi(2)(1) = 8.78; P = 0.003). CONCLUSIONS: Decision aids are an effective decision-support strategy for women considering genetic testing for breast/ovarian cancer risk, and are most effective before the patient has made a decision, which is generally at the point of having blood drawn

Ten-year mortality, disease progression, and treatment-related side effects in men with localised prostate cancer from the ProtecT randomised controlled trial according to treatment received

Background The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy. Objective To report outcomes according to treatment received in men in randomised and treatment choice cohorts. Design, setting, and participants This study focuses on secondary care. Men with clinically localised prostate cancer at one of nine UK centres were invited to participate in the treatment trial comparing AM, radical prostatectomy, and radiotherapy. Intervention Two cohorts included 1643 men who agreed to be randomised and 997 who declined randomisation and chose treatment. Outcome measurements and statistical analysis Analysis was carried out to assess mortality, metastasis and progression and health-related quality of life impacts on urinary, bowel, and sexual function using patient-reported outcome measures. Analysis was based on comparisons between groups defined by treatment received for both randomised and treatment choice cohorts in turn, with pooled estimates of intervention effect obtained using meta-analysis. Differences were estimated with adjustment for known prognostic factors using propensity scores. Results and limitations According to treatment received, more men receiving AM died of PCa (AM 1.85%, surgery 0.67%, radiotherapy 0.73%), whilst this difference remained consistent with chance in the randomised cohort (p = 0.08); stronger evidence was found in the exploratory analyses (randomised plus choice cohort) when AM was compared with the combined radical treatment group (p = 0.003). There was also strong evidence that metastasis (AM 5.6%, surgery 2.4%, radiotherapy 2.7%) and disease progression (AM 20.35%, surgery 5.87%, radiotherapy 6.62%) were more common in the AM group. Compared with AM, there were higher risks of sexual dysfunction (95% at 6 mo) and urinary incontinence (55% at 6 mo) after surgery, and of sexual dysfunction (88% at 6 mo) and bowel dysfunction (5% at 6 mo) after radiotherapy. The key limitations are the potential for bias when comparing groups defined by treatment received and changes in the protocol for AM during the lengthy follow-up required in trials of screen-detected PCa. Conclusions Analyses according to treatment received showed increased rates of disease-related events and lower rates of patient-reported harms in men managed by AM compared with men managed by radical treatment, and stronger evidence of greater PCa mortality in the AM group. Patient summary More than 95 out of every 100 men with low or intermediate risk localised prostate cancer do not die of prostate cancer within 10 yr, irrespective of whether treatment is by means of monitoring, surgery, or radiotherapy. Side effects on sexual and bladder function are better after active monitoring, but the risks of spreading of prostate cancer are more common

Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

A. Palotie on työryhmän jäsen.Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.Peer reviewe