Determination of Optimal Vehicle Selection of Logistics Companies with AHP-ARAS Hybrid Method

One of the serious problems in the logistics sector is the failure to make mistakes that cause economic consequences in the bulk purchases of trucks which are the important elements of road transport. Logistics Businesses can make in place and right decisions by using multi-criteria decision-making methods in the face of similar decision problems. In this study; Logistics, transportation, criteria for purchasing of vehicles and information about the decision analysis methods ARAS (Additive Ratio Assesment) and AHP (Analytic hierarchy Proses) were given. In particular, the applicability and results of the scientific methods are emphasized in the decision of procurement of bulk vehicles by logistics companies. The study's logistic decision problem was analyzed using ARAS and AHP methods together. It can be used in different decision problems of other logistics companies by making a partial change in the alternatives and criteria of the created solution model. The model for the study was applied to the decision problem of purchasing bulk vehicles in a Georgia-based logistics company. Managers of the business as decision makers have been accepted. Criteria and alternatives have been identified by the managers, independently of each other by scoring these elements. As a result of analysis of related decision problem by AHP-ARAS hybrid method; A1 (Volvo) has become the preferred brand for bulk vehicle purchasing by the company in the first place. In addition, the analysis results are shared with the business

Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

Objectives: The present study aims to investigate the role of oxidant-antioxidant status in young women with polycystic ovary syndrome (PCOS).Material and methods: Seventy-one women with PCOS and 53 healthy controls are compared in aspect of demographic characteristics, biochemical data, hormones, and oxidant-antioxidant status.Results: The PCOS group had significantly lower zinc, higher malondialdehyde and gluthathione peroxidase and lower serum catalase levels than the control group (p = 0.016, p < 0.001, p = 0.043 and p = 0.025 respectively). The PCOS patients with IR had significantly higher malondialdehyde, lower catalase and serum zinc levels than the PCOS patients without IR (p = 0.015, p = 0.010, p = 0.001 respectively). The infertile PCOS patients had significantly higher malondialdehyde, lower catalase and serum zinc levels than the fertile PCOS patients (p = 0.022, p = 0.045,p = 0.001 respectively). There was a statistically significant and positive correlation between HOMA-IR and malondialdehyde values (r = 0.523, p = 0.001), between HOMA-IR and glutathione peroxidase values (r = 0.468, p = 0.001) and between HOMA-IR and zinc values (r = 0.601, p = 0.001). There was a statistically significant and negative correlation between HOMA-IR and catalase values (r = –0.493, p = 0.001).Conclusions: The patients with PCOS are under oxidative stress and this oxidative stress seems to be the highest in patients with IR and with infertility. Despite the prominent increase in the oxidative stress, there was a variation in the antioxidant response

Recent Advances in Health Biotechnology During Pandemic

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put for- ward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, mi- crobiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biol- ogy, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Force Feedback Simulation Design for Fruit Hardness

2nd International Congress on Human-Computer Interaction, Optimization and Robotic Applications (HORA) -- JUN 26-27, 2020 -- TURKEY -- IEEE Turkey SectHardness value is one of the decisive criteria for fruit harvest period. It is important for harvest yield that the harvesting personnel knows the differences of this value with respect to the fruits. Especially in industrial harvesting, the use of simulations in personnel training and student education in agricultural faculties will be efficient in terms of saving time. Within the scope of this study, the hardness values of the selected fruits (apple and tomato) were measured using a penetrometer. Data from the penetrometer were transferred to objects (fruit) modeled in high resolution. User interface design has been realized by using various graphic libraries. In the interaction (collision) of the objects displayed in the graphic interface provided by the software developed within the scope of the research with the haptic cursor, a force feedback was transmitted to the user via the haptic device. In this way, a simulation design has been made that allows users to conceptualize and distinguish the hardness values of certain fruits by touching them. This study can be extended in the next steps by adding fruits with different hardness values to the simulation.Kirklareli University Scientific Research the reality of the simulation; Flesh Projects Program [KLUBAP -169]This research was supported by Kirklareli University Scientific Research the reality of the simulation. Flesh Projects Program (KLUBAP -169).WOS:00064440430007

Postpartum dönemdeki, anadolu eşeklerinde, folliküler gelişme, uterus involusyonu, plazma progesteron, 20?-oh-progesteron ve total östrojen düzeyleri

Bu çalışmada Anadolu eşeklerinde postpartum dönemde (pp) siklus uzunluğu, preovulatorik follikül büyüklüğü, ovulasyon zamanı ve bu dönemlerdeki steroid düzeylerinin ortaya konulması amaçlandı. Çalışmada gebeliğin son dönemindeki, beş adet sağlıklı dişi eşek kullanıldı. Postpartum dönemde (pp), plazma progesteron (P4), total östrojen (E2) ve 20?-OH-progesteron (20?-OH-P4) düzeyleri RIA ile ölçüldü. Uterus involusyonu ve ovaryum aktiviteleri rektal palpasyon ve transrektal ultrason muayeneleriyle belirlendi. İlk östrus davranışları en erken postpartum 6. günde gözlendi. Folliküller, preovulatorik büyüklükleri olan 30-35 mm ye östrusun 2. gününde ulaştı. Preovulatorik folliküller saptandığında, plazma P4, E2 ve 20?-OH-P4 düzeyleri sırasıyla, 0.900.40 ng/ml, 6.824.64 ng/ml ve 0.980.21 ng/ml, olarak ölçüldü. Postpartum ilk ovulasyonlar 10-15. günler arasında gözlendi. Postpartum ilk siklusda, plazma P4 düzeyi ovulasyondan 14 gün sonra en yüksek düzeye çıktı. Postpartum ikinci östrus 32.201.58 günde gözlendi. Östrus davranışlarının süresi, birinci siklusta 6.01.00 gün, ikinci siklusta 5.61.67 gün olarak belirlendi. Rektal muayenelerde uterusun, doğumu izleyen 3-4. günlerde sınırlarının belirlenebildiği, 6-9. günlerde ise tamamen palpe edilebilecek kadar invole olduğu saptandı. P4 ve 20?-OH-P4 düzeyleri arasında önemli derecede, yüksek korelasyon saptandı.In this study, it is aimed to determine the length of estrus cycle, size of the preovulatory follicle, and ovulation time during the postpartum period (pp) in Anatolian jennies and to measure steroid hormone levels during the same period. Five healthy Jennies at late-stage of gestation were included in the study. During the post partum period, plasma progesterone (P4), total estrogen (E2) and 20α-OH-progesterone (20α-OH-P4) levels were studied by RIA. Ovarian activity and uterus involution were determined by rectal palpation and ultrasound examinations. The first postpartum behavioral estrus occurred as early as 6 days pp. Follicles were reached to a preovulatoric size of 30 to 35 mm during the 2nd day of estrus, during which plasma P4, E2 and 20α-OH-P4 concentrations were 0.9±0.40 ng/ml, 6.82±4.64 ng/ml and 0.98±0.21 ng/ml, respectively. The first ovulation occurred 10-15 days after parturition. During the first postpartum cycle, plasma P4 reached to a maximum concentration 14 days after ovulation. The second estrus was observed 32.2±1.58 days postpartum period (pp). The estrus behaviour lasted 6.0±1.00 days and 5.6±1.67 days in the first and second cycles, respectively. The uterus borders were detected by rectal palpation as early as 3 and 4 days postpartum period (pp). The uterus was totally palpable 6-9 days after parturition. Importantly, a high correlation was determined between the P4 and 20α-OH-P4 concentrations

Uterine Involution, Follicle Development and Concentrations of Plasma Progesterone, 20 alpha-OH-Progesterone and Total Estrogen Levels During the Postpartum Period in Anatolian Donkeys

FINDIK, Murat/0000-0003-1408-2548WOS: 000311195800006In this study, it is aimed to determine the length of estrus cycle, size of the preovulatory follicle, and ovulation time during the postpartum period (pp) in Anatolian jennies and to measure steroid hormone levels during the same period. Five healthy Jennies at late-stage of gestation were included in the study. During the post partum period, plasma progesterone (P4), total estrogen (E2) and 20 alpha-OH-progesterone (20 alpha-OH-P4) levels were studied by RIA. Ovarian activity and uterus involution were determined by rectal palpation and ultrasound examinations. The first postpartum behavioral estrus occurred as early as 6 days pp. Follicles were reached to a preovulatoric size of 30 to 35 mm during the 2nd day of estrus, during which plasma P4, E2 and 20 alpha-OH-P4 concentrations were 0.9 +/- 0.40 ng/ml, 6.82 +/- 4.64 ng/ml and 0.98 +/- 0.21 ng/ml, respectively. The first ovulation occurred 10-15 days after parturition. During the first postpartum cycle, plasma P4 reached to a maximum concentration 14 days after ovulation. The second estrus was observed 32.2 +/- 1.58 days postpartum period (pp). The estrus behaviour lasted 6.0 +/- 1.00 days and 5.6 +/- 1.67 days in the first and second cycles, respectively. The uterus borders were detected by rectal palpation as early as 3 and 4 days postpartum period (pp). The uterus was totally palpable 6-9 days after parturition. Importantly, a high correlation was determined between the P4 and 20 alpha-OH-P4 concentrations

Protective Effect of Alpha Lipoic Acid on Rat Sciatic Nerve Ischemia Reperfusion Damage

Background: Alpha lipoic acid is a potent antioxidant that plays numerous roles in human health. This study examined the effect of ALA on rat sciatic nerve ischemia reperfusion damage