Phenomenological Implications of Supersymmetry Breaking by the Dilaton

We investigate the low energy properties of string vacua with spontaneously broken $N=1$ supersymmetry by a dilaton $F$-term. As a consequence of the universal couplings of the dilaton, the supersymmetric mass spectrum is determined in terms of only three independent parameters and more constrained than in the minimal supersymmetric Standard Model. For a $\mu$-term induced by the \K\ potential the parameter space becomes two-dimensional; in the allowed regions of this parameter space we find that most supersymmetric particles are determined solely by the gluino mass. The Higgs is rather light and the top-quark mass always lower than 180 GeV.Comment: 14 pages, (4 figures not included, available upon request), CERN-TH.6856/93 (In the previous version of this article the gaugino masses were given incorrectly. As a consequences the quantitative analysis of the low energy spectrum changes.

Ultrafast and nonlinear spectroscopy of brilliant green-based nanoGUMBOS with enhanced near-infrared emission

The synthesis, characterization, ultrafast dynamics, and nonlinear spectroscopy of 30 nm nanospheres of brilliant green–bis(pentafluoroethylsulfonyl)imide ([BG][BETI]) in water are reported. These thermally stable nanoparticles are derived from a group of uniform materials based on organic salts (nanoGUMBOS) that exhibit enhanced near-infrared emission compared with the molecular dye in water. The examination of ultrafast transient absorption spectroscopy results reveals that the overall excited-state relaxation lifetimes of [BG][BETI] nanoGUMBOS are longer than the brilliant green molecular dye in water due to steric hindrance of the torsional degrees of freedom of the phenyl rings around the central carbon. Furthermore, the second harmonic generation signal of [BG][BETI] nanoGUMBOS is enhanced by approximately 7 times and 23 times as compared with colloidal gold nanoparticles of the same size and the brilliant green molecular dye in water, respectively. A very clear third harmonic generation signal is observed from the [BG][BETI] nanoGUMBOS but not from either the molecular dye or the gold nanoparticles. Overall, these results show that [BG][BETI] nanoGUMBOS exhibit altered ultrafast and nonlinear spectroscopy that is beneficial for various applications including nonlinear imaging probes, biomedical imaging, and molecular sensing

N=2 supersymmetry breaking at two different scales

We study N=2 spontaneous supersymmetry breaking at two different scales with matter fields in hypermultiplets charged under the gauge group that should involve at least two U(1) factors. Off-shell analysis is possible in the dual single-tensor formulation of the hypermultiplets. Massless fermions can naturally arise from pseudo-real representations of the gauge group that allow a reformulation of the problem of chirality in N=2 theories. The above properties are necessary ingredients towards constructing viable extensions of the Standard Model based on N=2 supersymmetry.Comment: 26 page

Accumulation of driver and passenger mutations during tumor progression

Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. In the current study, we provide a novel mathematical model that begins to address this challenge. We model tumors as a discrete time branching process that starts with a single driver mutation and proceeds as each new driver mutation leads to a slightly increased rate of clonal expansion. Using the model, we observe tremendous variation in the rate of tumor development - providing an understanding of the heterogeneity in tumor sizes and development times that have been observed by epidemiologists and clinicians. Furthermore, the model provides a simple formula for the number of driver mutations as a function of the total number of mutations in the tumor. Finally, when applied to recent experimental data, the model allows us to calculate, for the first time, the actual selective advantage provided by typical somatic mutations in human tumors in situ. This selective advantage is surprisingly small, 0.005 +- 0.0005, and has major implications for experimental cancer research

Capturing Plasmon-Molecule Dynamics in Dye Monolayers on Metal Nanoparticles Using Classical Electrodynamics with Quantum Embedding

A multiscale hybrid quantum/classical approach using classical electrodynamics and a collection of discrete three-level quantum systems is used to simulate the coupled dynamics and spectra of a malachite green monolayer adsorbed to the surface of a spherical gold nanoparticle (NP). This method utilizes finite difference time domain (FDTD) to describe the plasmonic response of the NP within the main FDTD framework and a three-level quantum description for the molecule via a Maxwell/Liouville framework. To avoid spurious self-excitation, each quantum molecule has its own auxiliary FDTD subregion embedded within the main FDTD grid. The molecular parameters are determined by fitting the experimental extinction spectrum to Lorentzians, yielding the energies, transition dipole moments, and the dephasing lifetimes. This approach can be potentially applied to modeling thousands of molecules on the surface of a plasmonic NP. In this paper, however, we first present results for two molecules with scaled oscillator strengths to reflect the optical response of a full monolayer. There is good agreement with experimental extinction measurements, predicting the plasmon and molecule depletions. Additionally, this model captures the polariton peaks overlapped with a Fano-type resonance profile observed in the experimental extinction measurements. This technique can be generalized to any nanostructure/multichromophore system, where the molecules can be treated with essentially any quantum method

Neutrino Oscillations and R-parity Violating Supersymmetry

Using the neutrino oscillations and neutrinoless double beta decay experimental data we reconstructed an upper limit for the three generation neutrino mass matrix. We compared this matrix with the predictions of the minimal supersymmetric(SUSY) model with R-parity violation(\rp) and extracted stringent limits on trilinear \rp coupling constants $\lambda_{i33}, \lambda'_{i33}$. Introducing an additional $U(1)_X$ flavor symmetry which had been successful in explaining to relate various \rp parameters. In this model we found a unique scenario for the neutrino masses and the \rp couplings compatible with the neutrino oscillation data. Then we derived predictions for certain experimentally interesting observables.Comment: 19 pages, 1 figure; additional references included, minor corrections and typos fixed. Version to appear in Nucl.Phys.

Probing the colloidal gold nanoparticle/aqueous interface with second harmonic generation

a b s t r a c t The interface of 16 nm colloidal gold nanoparticles with the aqueous solution in which they are suspended is investigated using second harmonic generation. The population of malachite green freely adsorbing to the gold nanoparticle interface as a function of concentration is obtained. The experimental results are in good agreement with the modified Langmuir model, which includes depletion of the adsorbate bulk concentration. The free energy of adsorption is determined to be À15.4 ± 0.4 kcal/mol with 1.13 ± 0.04 Â 10 3 sites per nanoparticle. These results provide the first direct measurement of the isotherm of molecules adsorbing to colloidal metallic nanoparticles

Out Of This World Supersymmetry Breaking

We show that in a general hidden sector model, supersymmetry breaking necessarily generates at one-loop a scalar and gaugino mass as a consequence of the super-Weyl anomaly. We study a scenario in which this contribution dominates. We consider the Standard Model particles to be localized on a (3+1)-dimensional subspace or ``3-brane'' of a higher dimensional spacetime, while supersymmetry breaking occurs off the 3-brane, either in the bulk or on another 3-brane. At least one extra dimension is assumed to be compactified roughly one to two orders of magnitude below the four-dimensional Planck scale. This framework is phenomenologically very attractive; it introduces new possibilities for solving the supersymmetric flavor problem, the gaugino mass problem, the supersymmetric CP problem, and the mu-problem. Furthermore, the compactification scale can be consistent with a unification of gauge and gravitational couplings. We demonstrate these claims in a four-dimensional effective theory below the compactification scale that incorporates the relevant features of the underlying higher dimensional theory and the contribution of the super-Weyl anomaly. Naturalness constraints follow not only from symmetries but also from the higher dimensional origins of the theory. We also introduce additional bulk contributions to the MSSM soft masses. This scenario is very predictive: the gaugino masses, squark masses, and $A$ terms are given in terms of MSSM renormalization group functions.Comment: 42 pages, LateX, references added, corrections added as Eqs. (43, 53

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

BACKGROUND: Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms underlying sensitivity to gefitinib are unknown. METHODS: We searched for mutations in the EGFR gene in primary tumors from patients with non-small-cell lung cancer who had a response to gefitinib, those who did not have a response, and those who had not been exposed to gefitinib. The functional consequences of identified mutations were evaluated after the mutant proteins were expressed in cultured cells. RESULTS: Somatic mutations were identified in the tyrosine kinase domain of the EGFR gene in eight of nine patients with gefitinib-responsive lung cancer, as compared with none of the seven patients with no response (P<0.001). Mutations were either small, in-frame deletions or amino acid substitutions clustered around the ATP-binding pocket of the tyrosine kinase domain. Similar mutations were detected in tumors from 2 of 25 patients with primary non-small-cell lung cancer who had not been exposed to gefitinib (8 percent). All mutations were heterozygous, and identical mutations were observed in multiple patients, suggesting an additive specific gain of function. In vitro, EGFR mutants demonstrated enhanced tyrosine kinase activity in response to epidermal growth factor and increased sensitivity to inhibition by gefitinib. CONCLUSIONS: A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib. These mutations lead to increased growth factor signaling and confer susceptibility to the inhibitor. Screening for such mutations in lung cancers may identify patients who will have a response to gefitinib