398 research outputs found
Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer
- Author
- A Isidoro
- A Salas
- A Zelezniak
- AA Johnson
- AD Ortega
- AJ Levine
- B Vogelstein
- C Jose
- D Harman
- D Harman
- D Wang
- F Lopez-Rios
- HA Coller
- HR Lee
- HT Jacobs
- I Tomlinson
- J Cairns
- J Marx
- Jacintha O'Sullivan
- Jason H. Bielas
- Jesse J. Salk
- JH Bielas
- JH Bielas
- JH Bielas
- JJ Salk
- K Ishikawa
- K Polyak
- KA Brand
- KD Siegmund
- Kieran Sheahan
- LA Loeb
- LA Loeb
- M Vermulst
- M Yoshida
- Marc Vermulst
- Mariola Kulawiec
- MG Vander Heiden
- MJ Longley
- Nolan G. Ericson
- O Warburg
- RG Jones
- RS Arnold
- RW Taylor
- Susan M. Rosenberg
- T Wai
- Y He
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Genome instability is regarded as a hallmark of cancer. Human tumors frequently carry clonally expanded mutations in their mitochondrial DNA (mtDNA), some of which may drive cancer progression and metastasis. The high prevalence of clonal mutations in tumor mtDNA has commonly led to the assumption that the mitochondrial genome in cancer is genetically unstable, yet this hypothesis has not been experimentally tested. In this study, we directly measured the frequency of non-clonal (random) de novo single base substitutions in the mtDNA of human colorectal cancers. Remarkably, tumor tissue exhibited a decreased prevalence of these mutations relative to adjacent non-tumor tissue. The difference in mutation burden was attributable to a reduction in C∶G to T∶A transitions, which are associated with oxidative damage. We demonstrate that the lower random mutation frequency in tumor tissue was also coupled with a shift in glucose metabolism from oxidative phosphorylation to anaerobic glycolysis, as compared to non-neoplastic colon. Together these findings raise the intriguing possibility that fidelity of mitochondrial genome is, in fact, increased in cancer as a result of a decrease in reactive oxygen species-mediated mtDNA damage
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Respective impacts of Arctic sea ice decline and increasing greenhouse gases concentration on Sahel precipitation
- Author
- A Kitoh
- A Seth
- A Voldoire
- AR Stine
- AT Evan
- B Fontaine
- B Luo
- B Pu
- C Deser
- C Deser
- C Lavaysse
- C Lavaysse
- CB Skinner
- CD Thorncroft
- CD Thorncroft
- D Luo
- D Salas Mélia
- DM Smith
- DP Rowell
- E Hawkins
- E Mohino
- E Sanchez-Gomez
- Emilia Sanchez-Gomez
- ER Martin
- F Massonnet
- G Magnusdottir
- G Wang
- HT Hewitt
- I Polo
- I Simmonds
- J Noilhan
- J Noilhan
- J Villamayor
- J-Y Lee
- JA Screen
- JA Screen
- JC Stroeve
- JCH Chiang
- JG Dwyer
- JG Dwyer
- JP Grist
- JR Knight
- KE McCusker
- KE Taylor
- KE Trenberth
- KE Trenberth
- KH Cook
- LM Druyan
- M Biasutti
- M Biasutti
- M Gaetani
- M Ting
- MC Serreze
- ME Mann
- ME Mann
- MI Lélé
- P Peyrillé
- P-A Monerie
- P-A Monerie
- P-A Monerie
- P-A Monerie
- Paul-Arthur Monerie
- R Blackport
- R James
- R Roehrig
- R Seager
- R Zhang
- RJ Haarsma
- S Talento
- SE Nicholson
- SM Kang
- Thomas Oudar
- Y Liu
- Y Peings
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
The impact of climate change on Sahel precipitation is uncertain and has to be widely documented. Recently, it has been shown that Arctic sea ice loss leverages the global warming effects worldwide, suggesting a potential impact of Arctic sea ice decline on tropical regions. However, defining the specific roles of increasing greenhouse gases (GHG) concentration and declining Arctic sea ice extent on Sahel climate is not straightforward since the former impacts the latter. We avoid this dependency by analysing idealized experiments performed with the CNRM-CM5 coupled model. Results show that the increase in GHG concentration explains most of the Sahel precipitation change. We found that the impact due to Arctic sea ice loss depends on the level of atmospheric GHG concentration. When the GHG concentration is relatively low (values representative of 1980s), then the impact is moderate over the Sahel. However, when the concentration in GHG is levelled up, then Arctic sea ice loss leads to increased Sahel precipitation. In this particular case the ocean-land meridional gradient of temperature strengthens, allowing a more intense monsoon circulation. We linked the non-linearity of Arctic sea ice decline impact with differences in temperature and sea level pressure changes over the North Atlantic Ocean. We argue that the impact of the Arctic sea ice loss will become more relevant with time, in the context of climate change
2 nd Brazilian Consensus on Chagas Disease, 2015
- Author
- Abad-Franch F
- Abad-Franch F
- Abad-Franch F
- Abad-Franch F
- Abad-Franch F
- Abílio Augusto Fragata Filho
- Acquatella H
- Akhavan D
- Alberto Novaes Ramos Jr.
- Alejandro Luquetti
- Alejandro Marcel Hasslocher-Moreno
- Alessandra Viana Cardoso
- Almeida EA
- Almeida EA
- Almeida EA
- Almeida EA
- Almeida-Filho OC
- Altclas J
- Altclas JD
- Alves RM
- Ana Maria Jansen
- Ana Yecê das Neves Pinto
- Andrade AL
- Andrade SG
- Andréa Silvestre de Sousa
- Angheben A
- Anis Rassi
- Anis Rassi Jr.
- Antonio Walter Ferreira
- Antônio Carlos Silveira
- Barcán L
- Baroldi G
- Barreto ML
- Bern C
- Bern C
- Bern C
- Bern C
- Bern C
- Bestetti RB
- Bestetti RB
- Bestetti RB
- Bitto C
- Bocchi EA
- Bocchi EA
- Bocchi EA
- Brener Z
- Brener Z
- Britto CC
- Brutus L
- Brücher BL
- Bua J
- Buekens P
- Camargo ME
- Camargo ME
- Camargo ME
- Camargo ME
- Campos SV
- Cançado JR
- Carlier Y
- Carlier Y
- CarlierI Y
- Carrasco HA
- Carvalho VB
- Castro AM
- Castro CN
- Castro I
- Cerisola JA
- Cerisola JA
- Chagas C
- Chiale PA
- Chiari E
- Chiari E
- Chiari E
- Chippaux JP
- Constança Felícia De Paoli de Carvalho Britto
- Cordova E
- Coura JR
- Coura JR
- Coura JR
- Coura JR
- Coura JR
- Coura JR
- Coura JR
- Cunha GP
- D'Albuquerque LA
- Dalmo Correia
- Davila DF
- Dayse Elisabeth Campos
- De Rissio AM
- Del Castilho M
- Dias E
- Dias JC
- Dias JC
- Dias JC
- Dias JC
- Dias JCP
- Dias JCP
- Dias JCP
- Dias JCP
- Dias JCP
- Dias JCP
- Dias JCP
- Dias JCP
- Dias JCP
- Dias JP
- Divina Seila de Oliveira Marques
- Drumond JAG
- Duhamel B
- Egler Chiari
- Eliane Dias Gontijo
- Eliane Furtado Moreira
- Eliane Lages Silva
- Eros Antonio de Almeida
- Fabbro DL
- Fabiane Scalabrini Pinto
- Ferguson MK
- Fernando Abad-Franch
- Ferreira AW
- Ferreira HO
- Ferreira HO
- Ferreira MS
- Fonseca FM
- Fragata Filho AA
- França LCM
- Freilij H
- Freitas H
- Freitas VL
- Gallerano RH
- Garcia S
- Garzon SA
- Gebrekristos HT
- Glaucia Manzan Queiroz Andrade
- Gontijo ED
- González-Tomé MI
- Guariento ME
- Heller E
- Herwaldt BL
- Higuchi ML
- Higuchi ML
- Higuchi ML
- Hijar G
- Hotez PJ
- Hotez PJ
- Howard EJ
- Ianni BM
- Inoue H
- Joffre Marcondes de Rezende
- José Antonio Marin-Neto
- José Renan da Cunha Melo
- José Rodrigues Coura
- João Carlos Pinto Dias
- Junqueira AC
- Jörg ME
- Júnior Rassi A
- Lana M
- Leeuwenburgh I
- Lima-Costa MF
- Livramento JA
- Lopes ER
- Lorosa ES
- Lugones HS
- Luquetti AO
- Luquetti AO
- Luquetti AO
- Luquetti AO
- Lúcia Maria da Cunha Galvão
- Macêdo VO
- Macêdo VO
- Mady C
- Maegawa FA
- Maguire JH
- Mahoney RT
- Mallimaci MC
- Maria Aparecida Shikanai-Yasuda
- Marin-Neto JA
- Marin-Neto JA
- Marin-Neto JA
- Marin-Neto JA
- Marin-Neto JA
- Martes ACB
- Martinelli Filho M
- Martins-Melo FR
- Martins-Melo FR
- Martins-Melo FR
- Martins-Melo FR
- Martins-Melo FR
- Martins-Melo FR
- Martins-Melo FR
- Mayara Maia Lima
- Medeiros MB
- Meier-Ruge WA
- Mendes EV
- Messenger LA
- Molina I
- Moncayo A
- Montera MW
- Moraes-Souza H
- Morais BB
- Morillo CA
- Mougabure-Cueto G
- Nishioka SA
- Nisida IV
- Norman FF
- Noya BA
- Noêmia Barbosa Carvalho
- Nóbrega AA
- Nóbrega AA
- Oliveira Júnior W
- Oliveira Júnior W
- Oliveira RB
- Ostermayer AL
- Ozaki Y
- Padilla-Torres SD
- Parada H
- Pasricha PJ
- Passos ADC
- Pazin-Filho A
- Pereira Barretto AC
- Perez-Ramirez L
- Pessoa GCA
- Pessoa GCA
- Pinazo MJ
- Pinotti HW
- Pinto AY
- Pinto AY
- Pinto AYN
- Pinto AYN
- Pinto AYN
- Portela-Lindoso AAB
- Porto CC
- Prata A
- Prata A
- Prata A
- Prata A
- Pérez-Ayala A
- Pérez-Molina JA
- Rafaella Albuquerque e Silva
- Ramos G
- Ramos Júnior AN
- Ramos Júnior AN
- Ramos Júnior AN
- Rassi A
- Rassi A
- Rassi Jr A
- Rassi Júnior A
- Rassi Júnior A
- Rassi Júnior A
- Rassi Júnior A
- Rassi Júnior A
- Reis-Neto JA
- Renato Vieira Alves
- Requena-Méndez A
- Rezende JM
- Riarte A
- Ribeiro dos Santos R
- Roberti RR
- Rocha A
- Rocha MOC
- Rodriguez-Salas LA
- Romaña C
- Roque AL
- Roque AL
- Rosália Morais Torres
- Roux E
- Roux E
- Russomando G
- Salas NA
- Salvatella R
- Samuel J
- Sangenis LH
- Santo AH
- Santos CB
- Sartori AM
- Scanavacca M
- Scapellato PG
- Schijman AG
- Schmunis GA
- Sebastião Aldo da Silva Valente
- Sergio Salles Xavier
- Shaw J
- Shikanai-Yasuda MA
- Shikanai-Yasuda MA
- Shikanai-Yasuda MA
- Silva CP
- Silvana Eloi Santos
- Silveira AC
- Silveira AC
- Silveira AC
- Silveira C
- Silveira JF
- Simone Monzani Vivaldini
- Simões MV
- Sosa Estani S
- Sosa-Estani S
- Sousa AA
- Sousa AS
- Souza DSM
- Spiess AE
- Spina-França A
- Stavropoulos SN
- Strasen J
- Suelene Mamede Oliveira
- Swanstrom LL
- Sánchez-Camargo CL
- Torrico F
- Valença-Barbosa C
- Ventura-Garcia L
- Vera da Costa Valente
- Veruska Maia da Costa
- Victora CG
- Victora CG
- Villela E
- Vinhaes MC
- Viotti R
- Viotti R
- Viotti RJ
- Voller A
- Wendell S
- Wilson de Oliveira Jr.
- Xavier SC
- Xavier SC
- Xavier SS
- Xavier SS
- Yun O
- Zicker F
- Zimerman LI
- Zingales B
- Zingales B
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2016
- Field of study
Abstract Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on the articulation and strategic contribution of renowned Brazilian experts with knowledge and experience on various aspects of the disease. It is the result of a close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. It is hoped that this document will strengthen the development of integrated actions against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research
Energy balance and obesity: what are the main drivers?
- Author
- A Jaworowska
- A Papadimitriou
- A Romero-Corral
- A Thorogood
- AE Locke
- AG Renehan
- AK Kant
- AN Funtikova
- B Lauby-Secretan
- Barrie Margetts
- C Hawkes
- CA Monteiro
- CG Victora
- Chizuru Nishida
- CT Miller
- D Hanahan
- D Romaguera
- DK Tobias
- E Han
- E Le Chatelier
- E Perez-Morales
- EV Bandera
- F Bonomini
- FB Hu
- G Buckland
- G Jenkin
- GN Healy
- H Schroder
- Hervé M. Blottière
- HM Blottiere
- HT Tie
- I Darnton-Hill
- I Ismail
- I Ramirez-Silva
- I Romieu
- Isabelle Romieu
- J Pearce
- J Salas-Salvado
- JA Nettleton
- Jacob Seidell
- JC Moubarac
- JE Blundell
- JE Donnelly
- K Kooy van der
- KB Michels
- KD Hall
- Klaas Westerterp
- L Schwingshackl
- L Te Morenga
- Laure Dossus
- LC Kong
- LM Richter
- LS Adair
- M Beer de
- M Ng
- M Onis de
- M Wabitsch
- MA McCrory
- MA Pereira
- Magdalena Stepien
- Marc Gunter
- Martin Wiseman
- MC Dao
- MH Rouhani
- Michael Leitzmann
- Nahla Hwalla
- Nancy Potischman
- NM Mirza
- P Baker
- P Vangay
- Pan American Health Organization
- Pattanee Winichagoon
- Paul W. Franks
- PM Emmett
- PW Franks
- PW Franks
- Q Qi
- Q Sun
- R Shrimpton
- S Ahmad
- S Barquera
- S Basu
- SA Norris
- Scientific Advisory Committee on Nutrition
- Scientific Advisory Committee on Nutrition
- SD Hursting
- SF Weng
- SG Glickman
- Simón Barquera
- SJ Dijk van
- SL Gortmaker
- SM Wilson
- Stephen D. Hursting
- T Hu
- T Lobstein
- T Lobstein
- TN Robinson
- TO Kilpelainen
- TT Fung
- V Chajes
- VS Malik
- Walter C. Willett
- World Cancer Research Fund/American Institute for Cancer Research
- Y Fatima
- Y Liao
- YF Wang
- Youfa Wang
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
CADA—computer-aided DaTSCAN analysis
- Author
- A Skanjeti
- AJ Hughes
- AR Kupsch
- CG Goetz
- CG Goetz
- D Salas-Gonzalez
- DSW Djang
- F Segovia
- FJ Martinez-Murcia
- G Gerasimou
- H Bernheimer
- H Kung
- HO Hartley
- HT Benamer
- HTS Benamer
- IA Illán
- J Darcourt
- J Gallego
- J Jankovic
- K Badiavas
- L Tossici-Bolt
- L Wang
- M Jenkinson
- M Jenkinson
- M Ziebell
- MA Balafar
- MA Piggott
- MJ Kaufman
- P Calvini
- R Bhidayasiri
- RB Innis
- S Asenbaum
- S Mirzaei
- S Takada
- V Marshall
- W Koch
- W Koch
- W Pirker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen JV
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akilli E
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FLL
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparo MA
- Aranda CP
- Aranzabal N
- Araya ST
- Arcangeletti C
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asawatavonvanich T
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmasiddha PA
- Augsten K
- Austrup VA
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Backman F
- Bagnaia P
- Bahilo JJL
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barron U
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer P
- Bawa HS
- Bayirli A
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beisiegel F
- Belfkir M
- Bella G
- Bella LA
- Bellagamba L
- Bellerive A
- Bello FAD
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen JM
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birch-sykes CJ
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjørke K
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Boeriu OEV
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bolanos GR
- Bold T
- Bomben M
- Bona M
- Bonilla JS
- Boonekamp M
- Booth CD
- Borbély AG
- Borecka-Bielska HM
- Borgna LS
- Borisov A
- Borissov G
- Bortoletto D
- Bosca SR
- Boscherini D
- Bosman M
- Bostanabad MG
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Bourdarios CA
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Brendlinger K
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Bret MC
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks WK
- Brost E
- Bruncko D
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- Bryngemark L
- Brüers B
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buddenbrock SEV
- Bugge MK
- Bulekov O
- Bullard BA
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Buschmann E
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buzykaev AR
- Bylund OB
- Büscher V
- Cabras G
- Caforio D
- Cai H
- Cairo VMM
- Cakir IT
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camarda S
- Camarri P
- Camelia EA
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cantero J
- Cao Y
- Capriles FGD
- Capua M
- Cardarelli R
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carratta G
- Carrá S
- Carter JWS
- Carter TM
- Casado MP
- Casha AF
- Castiglia EG
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavasinni V
- Celebi E
- Celli F
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chau CC
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen B
- Chen C
- Chen CH
- Chen H
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
Muon reconstruction and identification efficiency in ATLAS using the full Run 2 pp collision data set at \sqrt{s}=13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
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- Zhemchugov A
- Zheng Z
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- Zieminska D
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- Zivkovic L
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- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2021
- Field of study
This article documents the muon reconstruction and identification efficiency obtained by the ATLAS experiment for 139 \hbox {fb}^{-1} of pp collision data at \sqrt{s}=13 TeV collected between 2015 and 2018 during Run 2 of the LHC. The increased instantaneous luminosity delivered by the LHC over this period required a reoptimisation of the criteria for the identification of prompt muons. Improved and newly developed algorithms were deployed to preserve high muon identification efficiency with a low misidentification rate and good momentum resolution. The availability of large samples of Z\rightarrow \mu \mu and J/\psi \rightarrow \mu \mu decays, and the minimisation of systematic uncertainties, allows the efficiencies of criteria for muon identification, primary vertex association, and isolation to be measured with an accuracy at the per-mille level in the bulk of the phase space, and up to the percent level in complex kinematic configurations. Excellent performance is achieved over a range of transverse momenta from 3 GeV to several hundred GeV, and across the full muon detector acceptance of |\eta |<2.7
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
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- Zuniga JDH
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
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- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
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- Abusleme Hoffman AC
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- Zhemchugov A
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
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