1,263 research outputs found
A narrow bimalleolar width is a risk factor for ankle inversion injury in male military recruits: A prospective study
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Background: Ankle inversion injuries are one of the most common and burdensome
injuries in athletic populations. Research that prospectively identifies characteristics
associated with this injury is lacking. This prospective study compared baseline
anthropometric and biomechanical gait characteristics of military recruits who sustained
an ankle inversion injury during training, with those who remained injury-free.
Methods: Bilateral plantar pressure and three-dimensional lower limb kinematics were
recorded in 1065 male, injury-free military recruits, during barefoot running. Injuries that
occurred during the 32-week recruit training programme were subsequently recorded.
Data were compared between recruits who sustained an ankle inversion injury during
training (n=27) and a sample (n=120) of those who completed training injury-free. A
logistic regression analysis was used to identify risk factors for this injury.
Findings: A narrower bimalleolar width and an earlier peak pressure under the fifth
metatarsal were predictors of ankle inversion injury. Those who sustained an ankle
inversion injury also had a lower body mass, body mass index, and a smaller calf girth
than those who completed training injury-free.
Interpretation: Anthropometric and dynamic gait characteristics have been identified
that may predispose recruits to an ankle inversion injury during Royal Marine recruit
training, allowing identification of recruits at higher risk at the start of training
Development of a laboratory system and 2D routing analysis to determine solute mixing within aquatic vegetation
A laser induced fluorometry (LIF) system was developed to quantify mixing within spatially variable aquatic vegetation. A comparison is made between intrusive fluorometry techniques and the application of LIF, to quantify mixing in real vegetation in the laboratory setting. LIF provides greater spatial resolution when compared to point fluorometry. Furthermore, LIF is non-intrusive. A two-dimensional routing procedure is used to calculate the longitudinal and transverse velocities and mixing coefficients from a single pulse injection of tracer within a vegetation patch
The personal experience of parenting a child with Juvenile Huntington’s Disease: perceptions across Europe
The study reported here presents a detailed description of what it is like to parent a child with juvenile Huntington’s disease in families across four European countries. Its primary aim was to develop and extend findings from a previous UK study. The study recruited parents from four European countries: Holland, Italy, Poland and Sweden,. A secondary aim was to see the extent to which the findings from the UK study were repeated across Europe and the degree of commonality or divergence across the different countries. Fourteen parents who were the primary caregiver took part in a semistructured interview. These were analyzed using an established qualitative methodology, interpretative phenomenological analysis. Five analytic themes were derived from the analysis: the early signs of something wrong; parental understanding of juvenile Huntington’s disease; living with the disease; other people’s knowledge and understanding; and need for support. These are discussed in light of the considerable convergence between the experiences of families in the United Kingdom and elsewhere in Europe
Observing Brownian motion in vibration-fluidized granular matter
At the beginning of last century, Gerlach and Lehrer observed the rotational
Brownian motion of a very fine wire immersed in an equilibrium environment, a
gas. This simple experiment eventually permitted the full development of one of
the most important ideas of equilibrium statistical mechanics: the very
complicated many-particle problem of a large number of molecules colliding with
the wire, can be represented by two macroscopic parameters only, namely
viscosity and the temperature. Can this idea, mathematically developed in the
so-called Langevin model and the fluctuation-dissipation theorem be used to
describe systems that are far from equilibrium? Here we address the question
and reproduce the Gerlach and Lehrer experiment in an archetype non-equilibrium
system, by immersing a sensitive torsion oscillator in a granular system of
millimetre-size grains, fluidized by strong external vibrations. The
vibro-fluidized granular medium is a driven environment, with continuous
injection and dissipation of energy, and the immersed oscillator can be seen as
analogous to an elastically bound Brownian particle. We show, by measuring the
noise and the susceptibility, that the experiment can be treated, in first
approximation, with the same formalism as in the equilibrium case, giving
experimental access to a ''granular viscosity'' and an ''effective
temperature'', however anisotropic and inhomogeneous, and yielding the
surprising result that the vibro-fluidized granular matter behaves as a
''thermal'' bath satisfying a fluctuation-dissipation relation
Discrete R-symmetries and Anomaly Universality in Heterotic Orbifolds
We study discrete R-symmetries, which appear in 4D low energy effective field
theory derived from hetetoric orbifold models. We derive the R-symmetries
directly from geometrical symmetries of orbifolds. In particular, we obtain the
corresponding R-charges by requiring that the couplings be invariant under
these symmetries. This allows for a more general treatment than the explicit
computations of correlation functions made previously by the authors, including
models with discrete Wilson lines, and orbifold symmetries beyond
plane-by-plane rotational invariance. Surprisingly, for the cases covered by
earlier explicit computations, the R-charges differ from the previous result.
We study the anomalies associated with these R-symmetries, and comment on the
results.Comment: 21 pages, 2 figures. Minor changes, typos corrected. Matches JHEP
published versio
Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration
Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a role in mediating ethanol-related behaviours. We therefore investigated the consequences of deleting the α2-subunit on the ataxic and rewarding properties of ethanol in mice. Ataxic and sedative effects of ethanol were explored in GABA(A) α2-subunit wildtype (WT) and knockout (KO) mice using a Rotarod apparatus, wire hang and the duration of loss of righting reflex. Following training, KO mice showed shorter latencies to fall than WT littermates under ethanol (2 g/kg i.p.) in both Rotarod and wire hang tests. After administration of ethanol (3.5 g/kg i.p.), KO mice took longer to regain the righting reflex than WT mice. To ensure the acute effects are not due to the gabra2 deletion affecting pharmacokinetics, blood ethanol concentrations were measured at 20 minute intervals after acute administration (2 g/kg i.p.), and did not differ between genotypes. To investigate ethanol's rewarding properties, WT and KO mice were trained to lever press to receive increasing concentrations of ethanol on an FR4 schedule of reinforcement. Both WT and KO mice self-administered ethanol at similar rates, with no differences in the numbers of reinforcers earned. These data indicate a protective role for α2-subunits, against the acute sedative and ataxic effects of ethanol. However, no change was observed in ethanol self administration, suggesting the rewarding effects of ethanol remain unchange
Lime stabilisation for earthworks: a UK perspective
Lime stabilisation is a versatile technique applied during earthworks operations. Modern soil recycling units are much more efficient at pulverising fill material and intermixing the added binder/water than machinery available 20 years ago. While supplier innovation adds flexibility to the site working method, specifications have not been sufficiently updated to permit optimal application. This review paper details the physico-chemical changes instigated through the lime-clay soil reaction, updating previous reviews. It aims to assist scientific debate, current practitioners and future specification changes. For example, the application of the minimum 24 h mellowing periods (mandatory to UK specifications) with high reactivity, quicklime powders is concluded to cause increased air voids in the compacted fill. Increased air voids are associated with reduced long-term strength and potential volume change from water ingress, which is of particular concern for sulfate swelling. Shorter mellowing periods and/or use of hydrated lime may lesson this issue; however, a 'one size fits all' approach is discouraged in preference to site-specific methodologies refined to suit the fill material and project requirements. The discussion also summarises working methods which may lower the risk of sulfate swell and defines areas requiring further practical research
What is the 'problem' that outreach work seeks to address and how might it be tackled? Seeking theory in a primary health prevention programme
<b>Background</b> Preventive approaches to health are disproportionately accessed by the more affluent and recent health improvement policy advocates the use of targeted preventive primary care to reduce risk factors in poorer individuals and communities. Outreach has become part of the health service response. Outreach has a long history of engaging those who do not otherwise access services. It has, however, been described as eclectic in its purpose, clientele and mode of practice; its effectiveness is unproven. Using a primary prevention programme in the UK as a case, this paper addresses two research questions: what are the perceived problems of non-engagement that outreach aims to address; and, what specific mechanisms of outreach are hypothesised to tackle these.<p></p>
<b>Methods</b> Drawing on a wider programme evaluation, the study undertook qualitative interviews with strategically selected health-care professionals. The analysis was thematically guided by the concept of 'candidacy' which theorises the dynamic process through which services and individuals negotiate appropriate service use.<p></p>
<b>Results</b> The study identified seven types of engagement 'problem' and corresponding solutions. These 'problems' lie on a continuum of complexity in terms of the challenges they present to primary care. Reasons for non-engagement are congruent with the concept of 'candidacy' but point to ways in which it can be expanded.<p></p>
<b>Conclusions</b> The paper draws conclusions about the role of outreach in contributing to the implementation of inequalities focused primary prevention and identifies further research needed in the theoretical development of both outreach as an approach and candidacy as a conceptual framework
Hydrocephalus and diffuse choroid plexus hyperplasia in primary ciliary dyskinesia-related MCIDAS mutation
OBJECTIVE: To report a neuroradiologic phenotype associated with reduced generation of multiple motile cilia (RGMC) and mutations in the multicilin gene. We hypothesize that the observed phenotype may reflect the emerging role that ependymal cilia play in regulating CSF production. METHOD: Clinical and radiologic records were retrospectively reviewed for 7 consecutive patients diagnosed by the Leicester UK national primary ciliary dyskinesia (PCD) diagnostic laboratory. RESULTS: On MRI scanning, all patients demonstrated hydrocephalus, choroid plexus hyperplasia (CPH), and arachnoid cysts. No patient had any sign of neurologic deficit. All patients had significant lung disease. CONCLUSIONS: We conclude that there is a high incidence of hydrocephalus, arachnoid cysts, and CPH in MCIDAS-associated RGMC. In all cases, the observed hydrocephalus seems arrested in childhood without progression or adverse neurologic sequelae. Our new observation of CPH, which is associated with CSF overproduction, is the first macroscopic evidence that ependymal cilia may be involved in the regulation of CSF production and flow. We suggest that brain imaging should be performed in all cases of RGMC and that a diagnosis of PCD or RGMC be strongly considered in patients with unexplained hydrocephalus and a lifelong “wet”-sounding cough
Breast MRI and tumour biology predict axillary lymph node response to neoadjuvant chemotherapy for breast cancer
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