Views of healthcare professionals to linkage of routinely collected healthcare data : a systematic review

Peer reviewedPublisher PD

Linked health data for pharmacovigilance in children : Perceived legal and ethical issues for stakeholders and data guardians

Peer reviewedPublisher PD

Advanced Gas Turbine (AGT) powertrain system

A 74.5 kW(100 hp) advanced automotive gas turbine engine is described. A design iteration to improve the weight and production cost associated with the original concept is discussed. Major rig tests included 15 hours of compressor testing to 80% design speed and the results are presented. Approximately 150 hours of cold flow testing showed duct loss to be less than the design goal. Combustor test results are presented for initial checkout tests. Turbine design and rig fabrication is discussed. From a materials study of six methods to fabricate rotors, two have been selected for further effort. A discussion of all six methods is given

Hydrological simulation of extreme flood scenarios for operational flood management at the Middle Elbe river

Operational flood management at the Middle Elbe river requires comprehensive knowledge about the magnitude and characteristics of possible extreme flood events. Since these events are not sufficiently included in available historical records, an extended sample of extreme flood events was generated by hydrological scenario simulation. Present paper emphasises simulations in the German part of the catchment of the Middle Elbe river and introduces the stochastic-conceptual precipitation-runoff model which was developed for this task. After validation of this model and its coupling with the weather forecast model COSMO and hydraulic-numerical models, a set of 25 flood scenarios could be simulated and provided for a planning of flood protection measures. Analysis of simulated scenarios reveal that extreme flood events at the Mulde and Middle Elbe rivers may have a wide spectrum of characteristics and may considerably exceed the magnitude of past flood events (e.g., those of August 2002)

A robot hand testbed designed for enhancing embodiment and functional neurorehabilitation of body schema in subjects with upper limb impairment or loss.

Many upper limb amputees experience an incessant, post-amputation "phantom limb pain" and report that their missing limbs feel paralyzed in an uncomfortable posture. One hypothesis is that efferent commands no longer generate expected afferent signals, such as proprioceptive feedback from changes in limb configuration, and that the mismatch of motor commands and visual feedback is interpreted as pain. Non-invasive therapeutic techniques for treating phantom limb pain, such as mirror visual feedback (MVF), rely on visualizations of postural changes. Advances in neural interfaces for artificial sensory feedback now make it possible to combine MVF with a high-tech "rubber hand" illusion, in which subjects develop a sense of embodiment with a fake hand when subjected to congruent visual and somatosensory feedback. We discuss clinical benefits that could arise from the confluence of known concepts such as MVF and the rubber hand illusion, and new technologies such as neural interfaces for sensory feedback and highly sensorized robot hand testbeds, such as the "BairClaw" presented here. Our multi-articulating, anthropomorphic robot testbed can be used to study proprioceptive and tactile sensory stimuli during physical finger-object interactions. Conceived for artificial grasp, manipulation, and haptic exploration, the BairClaw could also be used for future studies on the neurorehabilitation of somatosensory disorders due to upper limb impairment or loss. A remote actuation system enables the modular control of tendon-driven hands. The artificial proprioception system enables direct measurement of joint angles and tendon tensions while temperature, vibration, and skin deformation are provided by a multimodal tactile sensor. The provision of multimodal sensory feedback that is spatiotemporally consistent with commanded actions could lead to benefits such as reduced phantom limb pain, and increased prosthesis use due to improved functionality and reduced cognitive burden

Innovació a l'ensenyament de la Geografia

"Los profesores de Geografía, la innovación de la enseñanza y su profesionalización: el lugar de los materiales curriculares", la tesi doctoral de Viviana Zenobi, llegida al Departament de Didàctica de la Llengua i la Literatura, i de les Ciències Socials de la UAB, pretén conèixer quin és el paper de determinats materials que s'utilitzen en l'ensenyament de la Geografia en l'elaboració de propostes innovadores dins dels currículums d'aquesta matèria. A més, també vol ajudar als organismes de gestió en la presa de decisions sobre la producció d'aquests materials millorant així la formació dels professors i incentivant aquesta innovació."Los profesores de Geografía, la innovación de la Enseñanza y su profesionalización: El lugar de los materiales curriculares", la tesis doctoral de Viviana Zenobi, leída en el Departamento de Didáctica de la Lengua y la Literatura, y de las Ciencias Sociales de la UAB, pretende conocer cuál es el papel de determinados materiales que se utilizan en la enseñanza de la Geografía en la elaboración de propuestas innovadoras dentro de los currículos de esta materia. Además, también quiere ayudar a los organismos de gestión en la toma de decisiones sobre la producción de estos materiales mejorando así la formación de los profesores e incentivando esta innovación."Los profesores de Geografía, la innovación de la Enseñanza y su profesionalización: El lugar de los materiales curriculares", Viviana Zenobi's thesis, read at the Department of Language and Literature education, and Social Sciences education at the UAB, pretends a better understanding of the role of certain teaching materials used in geography in the development of innovative curricula in this area. In addition, this thesis also attempts to help management agencies in the decision making on the production of these materials, improving teacher's training and encouraging this innovation

Bloodstream form trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes

Trypanosoma brucei possesses five metacaspase genes. Of these, MCA2 and MCA3 are expressed only in the mammalian bloodstream form of the parasite, whereas MCA5 is expressed also in the insect procyclic form. Triple RNAi analysis showed MCA2, MCA3 and MCA5 to be essential in the bloodstream form, with parasites accumulating pre-cytokinesis. Nevertheless, triple null mutants (Δmca2/3Δmca5) could be isolated after sequential gene deletion. Thereafter, Δmca2/3Δmca5 mutants were found to grow well both in vitro in culture and in vivo in mice. We hypothesise that metacaspases are essential for bloodstream form parasites, but they have overlapping functions and their progressive loss can be compensated for by activation of alternative biochemical pathways. Analysis of Δmca2/3Δmca5 revealed no greater or lesser susceptibility to stresses reported to initiate programmed cell death, such as treatment with prostaglandin D2. The metacaspases were found to colocalise with RAB11, a marker for recycling endosomes. However, variant surface glycoprotein (VSG) recycling processes and the degradation of internalised anti-VSG antibody were found to occur similarly in wild type, Δmca2/3Δmca5 and triple RNAi induced parasites. Thus, the data provide no support for the direct involvement of T. brucei metacaspases in programmed cell death and suggest that the proteins have a function associated with RAB11 vesicles that is independent of known recycling processes of RAB11-positive endosomes

Modelling spring flood in the area of the Upper Volga basin

Integrated river-basin management for the Volga river requires understanding and modelling of the flow process in its macro-scale tributary catchments. At the example of the Kostroma catchment (16 000 km²), a method combining existing hydrologic simulation tools was developed that allows operational modelling even when data are scarce. Emphasis was placed on simulation of three processes: snow cover development using a snow-compaction model, runoff generation using a conceptual approach with parameters for seasonal antecedent moisture conditions, and runoff concentration using a regionalised unit hydrograph approach. Based on this method, specific regional characteristics of the precipitation-runoff process were identified, in particular a distinct threshold behaviour of runoff generation in catchments with clay-rich soils. With a plausible overall parameterisation of involved tools, spring flood events could successfully be simulated. Present paper mainly focuses on the simulation of a 16-year sample of snowmelt events in a meso-scale catchment. An example of regionalised simulation in the scope of the modelling system "Flussgebietsmodell" shows the capabilities of developed method for application in macro-scale tributary catchments of the Upper Volga basin

Modeling the ballistic-to-diffusive transition in nematode motility reveals variation in exploratory behavior across species

A quantitative understanding of organism-level behavior requires predictive models that can capture the richness of behavioral phenotypes, yet are simple enough to connect with underlying mechanistic processes. Here we investigate the motile behavior of nematodes at the level of their translational motion on surfaces driven by undulatory propulsion. We broadly sample the nematode behavioral repertoire by measuring motile trajectories of the canonical lab strain $C. elegans$ N2 as well as wild strains and distant species. We focus on trajectory dynamics over timescales spanning the transition from ballistic (straight) to diffusive (random) movement and find that salient features of the motility statistics are captured by a random walk model with independent dynamics in the speed, bearing and reversal events. We show that the model parameters vary among species in a correlated, low-dimensional manner suggestive of a common mode of behavioral control and a trade-off between exploration and exploitation. The distribution of phenotypes along this primary mode of variation reveals that not only the mean but also the variance varies considerably across strains, suggesting that these nematode lineages employ contrasting ``bet-hedging'' strategies for foraging.Comment: 46 pages, 18 figures, 6 table