Ultrahigh energy neutrino scattering: an update

We update our estimates of charged and neutral current neutrino total cross sections on isoscalar nucleons at ultrahigh energies using a global (x, Q^2) fit, motivated by the Froissart bound, to the F_2 (electron-proton) structure function utilizing the most recent analysis of the complete ZEUS and H1 data sets from HERA I. Using the large Q^2, small Bjorken-x limits of the "wee" parton model, we connect the ultrahigh energy neutrino cross sections directly to the large Q^2, small-x extrapolation of our new fit, which we assume saturates the Froissart bound. We compare both to our previous work, which utilized only the smaller ZEUS data set, as well as to recent results of a calculation using the ZEUS-S based global perturbative QCD parton distributions using the combined HERA I results as input. Our new results substantiate our previous conclusions, again predicting significantly smaller cross sections than those predicted by extrapolating pQCD calculations to neutrino energies above 10^9 GeV.Comment: 8 pages, 1 figure, 3 table

Decoupling the coupled DGLAP evolution equations: an analytic solution to pQCD

Using Laplace transform techniques, along with newly-developed accurate numerical inverse Laplace transform algorithms, we decouple the solutions for the singlet structure function $F_s(x,Q^2)$ and $G(x,Q^2)$ of the two leading-order coupled singlet DGLAP equations, allowing us to write fully decoupled solutions: F_s(x,Q^2)={\cal F}_s(F_{s0}(x), G_0(x)), G(x,Q^2)={\cal G}(F_{s0}(x), G_0(x)). Here ${\cal F}_s$ and $\cal G$ are known functions---found using the DGLAP splitting functions---of the functions $F_{s0}(x) \equiv F_s(x,Q_0^2)$ and $G_{0}(x) \equiv G(x,Q_0^2)$, the chosen starting functions at the virtuality $Q_0^2$. As a proof of method, we compare our numerical results from the above equations with the published MSTW LO gluon and singlet $F_s$ distributions, starting from their initial values at $Q_0^2=1 GeV^2$. Our method completely decouples the two LO distributions, at the same time guaranteeing that both distributions satisfy the singlet coupled DGLAP equations. It furnishes us with a new tool for readily obtaining the effects of the starting functions (independently) on the gluon and singlet structure functions, as functions of both $Q^2$ and $Q_0^2$. In addition, it can also be used for non-singlet distributions, thus allowing one to solve analytically for individual quark and gluon distributions values at a given $x$ and $Q^2$, with typical numerical accuracies of about 1 part in $10^5$, rather than having to evolve numerically coupled integral-differential equations on a two-dimensional grid in $x, Q^2$, as is currently done.Comment: 6 pages, 2 figure

Effects of the Mobility-Fit Physical Activity Program on Strength and Mobility in Older Adults in Assisted Living: A Feasibility Study

Physical activity programs focusing on fall prevention often overlook upper-limb strength, which is important for transferring, balance recovery, and arresting a fall. We developed and evaluated a physical activity program, Mobility-Fit for older adults in Assisted Living (AL) that includes upper-limb strengthening, agility, coordination, and balance exercises. Thirty participants (85 ± 6 years) were recruited from two AL facilities; 15 were assigned to Mobility-Fit (three times/week, 45 min/session for 12 weeks) and 15 maintained usual care. Twenty-two participants (11 in each group) completed the study. We compared outcome changes between groups and interviewed participants and staff to explore the effectiveness and feasibility of the program. Among participants who attended Mobility-Fit, knee extension strength increased by 6%, reaction time decreased by 16%, and five-time sit-to-stand duration decreased by 15%. Conversely, participants in the usual care group had a 6% decrease in handgrip strength. Changes of these outcomes were significantly different between two groups (p < 0.05). Participants enjoyed the program and staff suggested some changes to improve attendance. Our results indicate that Mobility-Fit is feasible to deliver and beneficial for older adults in AL and may guide future clinical trials to evaluate the effectiveness of upper limb strengthening on safe mobility of older adults in care facilities

Age-related changes in afferent pathways and urothelial function in the male mouse bladder

Key points •The prevalence of bladder conditions such as overactive bladder syndrome and urinary incontinence significantly increases with age, but how bladder function is altered by ageing is unclear. •Sensory nerves together with the epithelial lining of the bladder known as the urothelium play a key role in mediating bladder function. •In aged male mice we find a significant increase in natural bladder voiding, augmented afferent nerve firing during bladder filling and a significant increase in urothelial responses to purinergic receptor stimulation. •This suggests that with ageing there is increased purinergic transmission in the mouse bladder which may lead to increased sensation and result in bladder hypersensitivity. •These findings help us better understand how the function of the bladder may be affected by advancing age. Abstract The prevalence of lower urinary tract storage disorders such as overactive bladder syndrome and urinary incontinence significantly increase with age. Previous studies have demonstrated age-related changes in detrusor function and urothelial transmitter release but few studies have investigated how the urothelium and sensory pathways are affected. The aim of this study was to investigate the effect of ageing on urothelial-afferent signalling in the mouse bladder. Three-month-old control and 24-month-old aged male mice were used. In vivo natural voiding behaviour, sensory nerve activity, urothelial cell function, muscle contractility, transmitter release and gene and protein expression were measured to identify how all three components of the bladder (neural, contractile and urothelial) are affected by ageing. In aged mice, increased voiding frequency and enhanced low threshold afferent nerve activity was observed, suggesting that ageing induces overactivity and hypersensitivity of the bladder. These changes were concurrent with altered ATP and acetylcholine bioavailability, measured as transmitter overflow into the lumen, increased purinergic receptor sensitivity and raised P2X3 receptor expression in the urothelium. Taken together, these data suggest that ageing results in aberrant urothelial function, increased afferent mechanosensitivity, increased smooth muscle contractility, and changes in gene and protein expression (including of P2X3). These data are consistent with the hypothesis that ageing evokes changes in purinergic signalling from the bladder, and further studies are now required to fully validate this idea

Applications of the leading-order Dokshitzer-Gribov-Lipatov-Altarelli-Parisi evolution equations to the combined HERA data on deep inelastic scattering

We recently derived explicit solutions of the leading-order Dokshitzer-Gribov-Lipatov-Altarelli-Parisi (DGLAP) equations for the $Q^2$ evolution of the singlet structure function $F_s(x,Q^2)$ and the gluon distribution $G(x,Q^2)$ using very efficient Laplace transform techniques. We apply our results here to a study of the HERA data on deep inelastic $ep$ scattering as recently combined by the H1 and ZEUS groups. We use initial distributions $F_2^{\gamma p}(x,Q_0^2)$ and $G(x,Q_0^2)$ fixed by a global fit to the HERA data. From $F_2^{\gamma p}(x,Q_0^2)$ we obtain the singlet quark distribution $F_s(x,Q_0^2)$---using small non-singlet quark distributions taken from either the CTEQ6L or the MSTW2008LO analyses---evolve to arbitrary $Q^2$, and then convert the results to individual quark distributions. Finally, we show directly from a study of systematic trends in a comparison of the evolved $F_2^{\gamma p}(x,Q^2)$ with the HERA data, that the assumption of leading-order DGLAP evolution is inconsistent with those data.Comment: 18 pages, 7 figures, version accepted for publication in PR

Isothiourea-catalysed acylative dynamic kinetic resolution of tetra-substituted morpholinone and benzoxazinone lactols

Funding: The research leading to these results has received funding from the CSC St Andrews Scheme (PhD Scholarship to H.Z.), and the EPSRC (K.K., EP/T023643/1). The authors thank the University of Salamanca, the Spanish Government and European Union for a Margarita Salas grant (Orden UNI/551/2021, A.M.). P.H.-Y.C. and A. O. F gratefully acknowledge financial support from the Bert and Emelyn Christensen and the Stone Family of OSU. A.O.F. acknowledges the Larry W. Martin & Joyce B. O'Neill Endowed Fellowship of OSU. A.O.F. and P.H.-Y.C. acknowledge computing infrastructure in part provided by the National Science Foundation (NSF) CHE-1352663 and NSF Phase-2 CCI, Center for Sustainable Materials Chemistry (CHE-1102637).The development of methods to allow the selective acylative dynamic kinetic resolution (DKR) of tetra-substituted lactols is a recognised synthetic challenge. In this manuscript, a highly enantioselective isothiourea-catalysed acylative DKR of tetra-substituted morpholinone and benzoxazinone-derived lactols is reported. The scope and limitations of this methodology have been developed, with high enantioselectivity and good to excellent yields (up to 89 %, 99 : 1 er) observed across a broad range of substrate derivatives incorporating substitution at N(4) and C(2), di- and spirocyclic substitution at C(5) and C(6), as well as benzannulation (>35 examples in total). The DKR process is amenable to scale-up on a 1 g laboratory scale. The factors leading to high selectivity in this DKR process have been probed through computation, with an N−C=O⋅⋅⋅isothiouronium interaction identified as key to producing ester products in highly enantioenriched form.Peer reviewe